Zhi bin Lin

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi request reprint Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro
    Li Zhen Cao
    Department of Pharmacology, Health Science Center, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 24:321-6. 2003
  2. ncbi request reprint [The pharmacological study of Ganoderma spores and their active components]
    Zhi bin Lin
    Department of Pharmacology, Peking University School of Basic Medical Sciences, Beijing 100083, China
    Beijing Da Xue Xue Bao 38:541-7. 2006
  3. ncbi request reprint Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum
    Zhi bin Lin
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center
    J Pharmacol Sci 99:144-53. 2005
  4. ncbi request reprint Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms
    Zhi bin Lin
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Acta Pharmacol Sin 25:1387-95. 2004
  5. ncbi request reprint [Comparison of the immunomodulatory effects of spore polysaccharides and broken spore polysaccharides isolated from Ganoderma lucidum on murine splenic lymphocytes and peritoneal macrophages in vitro]
    Peng yun Wang
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
    Beijing Da Xue Xue Bao 37:569-74. 2005
  6. ncbi request reprint Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury
    Hong Bo Zhao
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    J Pharmacol Sci 95:294-8. 2004
  7. doi request reprint Ganoderma lucidum polysaccharides antagonize the suppression on lymphocytes induced by culture supernatants of B16F10 melanoma cells
    Li Xin Sun
    Department of Pharmacology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    J Pharm Pharmacol 63:725-35. 2011
  8. doi request reprint Enhanced MHC class I and costimulatory molecules on B16F10 cells by Ganoderma lucidum polysaccharides
    Li Xin Sun
    Department of Pharmacology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    J Drug Target 20:582-92. 2012
  9. ncbi request reprint Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide
    Qi zhen Cao
    Department of Pharmacology, Health Science Center, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 25:833-8. 2004
  10. ncbi request reprint Comparison of the effects of polysaccharides from wood-cultured and bag-cultured Ganoderma lucidum on murine spleen lymphocyte proliferation in vitro
    Li Zhen Cao
    Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 38:92-7. 2003

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro
    Li Zhen Cao
    Department of Pharmacology, Health Science Center, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 24:321-6. 2003
    ..To study the regulatory effects of Ganoderma lucidum polysaccharides (Gl-PS) on cytotoxicity and mechanism of specific cytotoxic T-lymphocytes (CTL) induced by dendritic cells (DC) in vitro during the stage of antigen presentation...
  2. ncbi request reprint [The pharmacological study of Ganoderma spores and their active components]
    Zhi bin Lin
    Department of Pharmacology, Peking University School of Basic Medical Sciences, Beijing 100083, China
    Beijing Da Xue Xue Bao 38:541-7. 2006
    ..The possible problems and their solutions in this research area are also discussed...
  3. ncbi request reprint Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum
    Zhi bin Lin
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center
    J Pharmacol Sci 99:144-53. 2005
    ..However, whole animal experiments are still needed to further establish the mechanism of the immuno-modulating effects by G. lucidum. Evidence-based clinical trials are also needed...
  4. ncbi request reprint Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms
    Zhi bin Lin
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Acta Pharmacol Sin 25:1387-95. 2004
    ..Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum...
  5. ncbi request reprint [Comparison of the immunomodulatory effects of spore polysaccharides and broken spore polysaccharides isolated from Ganoderma lucidum on murine splenic lymphocytes and peritoneal macrophages in vitro]
    Peng yun Wang
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
    Beijing Da Xue Xue Bao 37:569-74. 2005
    ..To compare the immunomodulatory effects of spore polysaccharides (Gl-SP) and broken spore polysaccharides (Gl-BSP) isolated from Ganoderma lucidum(Leyss et Fr.) Karst. on murine splenic lymphocytes and peritoneal macrophages in vitro...
  6. ncbi request reprint Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury
    Hong Bo Zhao
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    J Pharmacol Sci 95:294-8. 2004
    ..These findings suggest that Gl-PS might be useful in treating H/R-induced oxidative stress and Mn-SOD might play a critical role in the neuroprotective effect of Gl-PS against H/R injury...
  7. doi request reprint Ganoderma lucidum polysaccharides antagonize the suppression on lymphocytes induced by culture supernatants of B16F10 melanoma cells
    Li Xin Sun
    Department of Pharmacology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    J Pharm Pharmacol 63:725-35. 2011
    ..The purpose of this study was to determine the antagonistic effects of Gl-PS on the suppression induced by B16F10 melanoma cell culture supernatant (B16F10-CS) on lymphocytes...
  8. doi request reprint Enhanced MHC class I and costimulatory molecules on B16F10 cells by Ganoderma lucidum polysaccharides
    Li Xin Sun
    Department of Pharmacology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    J Drug Target 20:582-92. 2012
    ..Therefore, enhancement of MHC-I and costimulatory molecules may favor restraint of the evasion. For this purpose, Ganoderma lucidum Polysaccharides (Gl-PS) was used on B16F10 melanoma cells in this study...
  9. ncbi request reprint Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide
    Qi zhen Cao
    Department of Pharmacology, Health Science Center, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 25:833-8. 2004
    ..To investigate the antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide (GLPP)...
  10. ncbi request reprint Comparison of the effects of polysaccharides from wood-cultured and bag-cultured Ganoderma lucidum on murine spleen lymphocyte proliferation in vitro
    Li Zhen Cao
    Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 38:92-7. 2003
    ....
  11. ncbi request reprint Effect of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice
    Jing hua He
    Department of Pharmacology, Basic Medical School, Peking University Health Science Center, Beijing 100083, China
    World J Gastroenterol 11:573-6. 2005
    ..To investigate the protective effect against two immune liver injury models in mice by 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride and its possible mechanisms in Con A-induced liver damage...
  12. ncbi request reprint Immune receptors for polysaccharides from Ganoderma lucidum
    Bao Mei Shao
    Department of Immunology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    Biochem Biophys Res Commun 323:133-41. 2004
    ..Our results may have important implications for our understanding on the molecular mechanisms of immunopotentiating polysaccharides from traditional Chinese medicine...
  13. ncbi request reprint Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice
    Xiao Ling Zhu
    Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, PR China xiaolingzhu88yahoo com cn
    J Ethnopharmacol 111:219-26. 2007
    ....
  14. ncbi request reprint [Effects of leflunomide and its active metabolite on the production and mRNA expression of TNF-alpha in peritoneal macrophages and synovial cells with adjuvant arthritis in rats]
    Wei Dong Li
    Department of Pharmacology, School of Basic Medical Sciences, Medical Center of Peking University, Beijing 100083, China
    Yao Xue Xue Bao 37:767-70. 2002
    ....
  15. ncbi request reprint In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage
    Hui Na Zhang
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, PR China
    Life Sci 73:2307-19. 2003
    ....
  16. ncbi request reprint [Antioxidant effect of Ganoderma polysaccharide peptide]
    Yu Hong You
    Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 38:85-8. 2003
    ..To study the antioxidant effect of Ganoderma polysaccharide peptide (GLPP) and its mechanism...
  17. ncbi request reprint Hypoglycemic effect of Ganoderma lucidum polysaccharides
    Hui Na Zhang
    Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 25:191-5. 2004
    ..To investigate the hypoglycemic effect of Ganoderma lucidum polysaccharides (Gl-PS) in the normal fasted mice and its possible mechanism...
  18. ncbi request reprint Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides
    Li Zhen Cao
    Department of Pharmacology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, People s Republic of China
    Immunol Lett 83:163-9. 2002
    ..Gl-PS was shown to promote not only the maturation of cultured murine bone marrow derived DC in vitro, but also the immune response initiation induced by DC...
  19. ncbi request reprint Ganoderma total sterol (GS) and GS1 protect rat cerebral cortical neurons from hypoxia/reoxygenation injury
    Hong Bo Zhao
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, P R China
    Life Sci 76:1027-37. 2005
    ..These findings demonstrated that GS(1) is the main component in GS; and play a critical role in the neuroprotective effect of GS against H/R...
  20. ncbi request reprint Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice
    Guo Liang Zhang
    Department of Pharmacology, School of Basic Medical Sciences, Beijing University, Beijing 100083, China
    World J Gastroenterol 8:728-33. 2002
    ..To examine the effect of ganoderma lucidum polysaccharide (GLP) on the immune liver injury induced by BCG infection, and investigate the relationship between degrees of hepatic damage and NO production in mice...
  21. ncbi request reprint [Immunopharmacological action of sinomenine, an alkaloid isolated from Sinomenium acutum, and its mechanism of action in treating rheumatoid arthritis]
    Ji Hong Liu
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
    Yao Xue Xue Bao 40:127-31. 2005
    ..To observe the effects of sinomenine on the immune functions and apoptosis of murine lymphocyte as well as on human synovial fibroblast proliferation...
  22. doi request reprint Effects of Ganoderma lucidum polysaccharides on IEC-6 cell proliferation, migration and morphology of differentiation benefiting intestinal epithelium healing in vitro
    Li Xin Sun
    Department of Pharmacology, Basic Medical School, Peking University Health Science Center, Beijing Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China
    J Pharm Pharmacol 63:1595-603. 2011
    ..To identify potential effects, a non-transformed small-intestinal epithelial cell line, IEC-6 cells, was used...
  23. ncbi request reprint Effects of Ganoderma lucidum polysaccharides on proliferation and cytotoxicity of cytokine-induced killer cells
    Xiao Ling Zhu
    Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center, Beijing 100083, China
    Acta Pharmacol Sin 26:1130-7. 2005
    ....
  24. doi request reprint Ganoderma lucidum polysaccharides reduce methotrexate-induced small intestinal damage in mice via induction of epithelial cell proliferation and migration
    Li Hua Chen
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Acta Pharmacol Sin 32:1505-12. 2011
    ..To study the effects of Ganoderma lucidum polysaccharides (Gl-PS) on methotrexate (MTX)-induced small intestinal damage in mice and the underlying mechanisms...
  25. doi request reprint Promoting effects of Ganoderma lucidum polysaccharides on B16F10 cells to activate lymphocytes
    Li Xin Sun
    Department of Pharmacology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
    Basic Clin Pharmacol Toxicol 108:149-54. 2011
    ....
  26. ncbi request reprint Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species
    Yu Hong You
    Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center, Beijing 100083, China
    Acta Pharmacol Sin 23:787-91. 2002
    ..To study the protective effects of Ganoderma lucidum polysaccharides peptide (GLPP) on the mice peritoneal macrophages injured by reactive oxygen species (ROS), derived from tert-butylhydroperoxide (tBOOH) in vitro and in vivo...
  27. doi request reprint Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes
    Lu Tie
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, and Institute of System Biomedicine, Peking University, Beijing, China
    Cell Physiol Biochem 29:583-94. 2012
    ..The present study was designed to determine the protective effect of Ganoderma lucidum polysaccharide (Gl-PS) on diabetic wound healing and investigate underlying mechanisms...
  28. ncbi request reprint Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats
    Wei Dong Li
    Department of Pharmacology, Health Science Center of Peking University, Beijing 100083, China
    Acta Pharmacol Sin 23:752-6. 2002
    ....
  29. ncbi request reprint [Advances of pharmacological effects of triterpenes from Ganoderma lucidum]
    Jun Luo
    Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 37:574-8. 2002
  30. ncbi request reprint Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell
    Qi zhen Cao
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100083, China
    Life Sci 78:1457-63. 2006
    ....
  31. ncbi request reprint [Establishment of immune insulin resistance model in the rats by i.v. injection of BCG]
    Yu xiao Guo
    Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 37:321-5. 2002
    ..To observe the stability of BCG-induced insulin resistance model...
  32. ncbi request reprint Wild type p53 increased chemosensitivity of drug-resistant human hepatocellular carcinoma Bel7402/5-FU cells
    Yu xiu Li
    Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100083, China
    Acta Pharmacol Sin 25:76-82. 2004
    ..To study the effect of wild type (wt) p53 gene transfection on drug resistant human hepatocellular carcinoma (HCC) cells induced by 5-Fluorouracil (5-FU)...
  33. ncbi request reprint Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats
    Xin Wang
    Department of Pharmacology, Basic Medical School, Beijing Peking University, Beijing 100083, P R China
    Biol Pharm Bull 30:1702-6. 2007
    ....
  34. pmc Promotion of Myelopoiesis in Myelosuppressed Mice by Ganoderma lucidum Polysaccharides
    Xiao Ling Zhu
    Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center Beijing, China
    Front Pharmacol 3:20. 2012
    ....
  35. ncbi request reprint Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation
    Wei Dong Li
    Department of Pharmacology, Health Science Center, Peking University, 38 Xue Yuan Road, Beijing 100083, PR China
    Int Immunopharmacol 6:1243-50. 2006
    ..These observations suggested that the inhibitory effects of DHA on TNF-alpha production may result from the block in the NF-kappaB signaling pathway upstream of IkappaB degradation...
  36. ncbi request reprint The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats
    Su min Li
    Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, 100083, Beijing, PR China
    Eur J Pharmacol 435:217-23. 2002
    ..These findings indicate that nitric oxide (NO) is involved in the rewarding properties of methamphetamine and suggest that selective nNOS inhibitors maybe useful in the management of methamphetamine abuse...
  37. pmc Antitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum
    Peng yun Wang
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center Beijing, China
    Front Pharmacol 3:135. 2012
    ..These observations suggest that the antitumor activity of Gl-BSP may be mainly related to the activation of the immune response of the host organism by the stimulation of NK cells, T cells, and macrophages...
  38. doi request reprint Sinomenine influences capacity for invasion and migration in activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, and CD147
    Yang qiong Ou
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Acta Pharmacol Sin 30:435-41. 2009
    ..Sinomenine is a pure alkaloid extracted from the Chinese medical plant Sinomenium acutum...
  39. ncbi request reprint Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism
    Qing Ping Chu
    Department of Pharmacology, Peking University, School of Basic Medical Science, 38 Xueyuan Lu, Beijing 100083, China
    Pharmacol Biochem Behav 86:693-8. 2007
    ..Significant effect was also observed with GLE on delta activity during non-REM sleep and flumazenil did not block this effect. In conclusion, GLE may be a herb having benzodiazepine-like hypnotic activity at least in part...
  40. doi request reprint Reversal effect of Ganoderma lucidum polysaccharide on multidrug resistance in K562/ADM cell line
    Wei Dong Li
    Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
    Acta Pharmacol Sin 29:620-7. 2008
    ..To investigate the reversal effect of Ganoderma lucidum polysaccharides (Gl-PS) on multidrug resistance (MDR) in the adriamycin (ADM)-resistant leukemic cell line K562/ADM...
  41. ncbi request reprint Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley
    Wing Keung Chan
    Department of Paediatrics and Adolescent Medicine, Hong Kong Jockey Club Clinical Research Center, Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
    Int Immunol 19:891-9. 2007
    ..Our study also provides a reproducible biological platform for comparing the potential therapeutic effects of different herbal-derived polysaccharides in the future...
  42. ncbi request reprint Analysis of genetic diversity in Ganoderma population with a novel molecular marker SRAP
    Shu Jing Sun
    College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, People s Republic of China
    Appl Microbiol Biotechnol 72:537-43. 2006
    ..It also suggested SRAP marker could be used in the taxonomic analysis of fungi. To our knowledge, this is the first application of SRAP marker on the systematics of Ganoderma strains within basidiomycetes...
  43. ncbi request reprint [Grasps favorable opportunity to search for truth]
    Zhi bin Lin
    Sheng Li Ke Xue Jin Zhan 36:1-5. 2005