Ji Sheng Han

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi request reprint Acupuncture and endorphins
    Ji Sheng Han
    Neuroscience Research Institute, Peking University and Key Laboratory of Neuroscience Peking University, Ministry of Education, 38 Xue Yuan Road, Beijing 100083, PR China
    Neurosci Lett 361:258-61. 2004
  2. doi request reprint Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine
    Jisheng Han
    Neuroscience Research Institute, Peking University, Beijing 100191, China
    Front Med 5:141-50. 2011
  3. doi request reprint Acupuncture research is part of my life
    Ji Sheng Han
    Neuroscience Research Institute, Peking University, Beijing, China
    Pain Med 10:611-8. 2009
  4. ncbi request reprint Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated
    Xiang Dang Shi
    Neuroscience Research Institute, Key Laboratory for Neuroscience, Peking University, The Ministry of Education, 38 Xueyuan Road, Beijing 100083, PR China
    Brain Res Mol Brain Res 130:124-33. 2004
  5. doi request reprint Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation
    Shan Jing Geng
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100191, PR China
    Exp Neurol 222:256-66. 2010
  6. ncbi request reprint The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats
    Yao Ying Ma
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, 38 Xueyuan Road, Beijing 100083, PR China
    Exp Neurol 200:343-55. 2006
  7. ncbi request reprint Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons
    Feng Qiao Li
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, People s Republic of China
    Exp Neurol 179:28-37. 2003
  8. ncbi request reprint Differential modulation of nociceptive neural responses in medial and lateral pain pathways by peripheral electrical stimulation: a multichannel recording study
    Jin Yan Wang
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, PR China
    Brain Res 1014:197-208. 2004
  9. ncbi request reprint Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy
    Xi Bin Liang
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    Brain Res Mol Brain Res 108:51-9. 2002
  10. ncbi request reprint Parallel pain processing in freely moving rats revealed by distributed neuron recording
    Jin Yan Wang
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 100083, Beijing, PR China
    Brain Res 992:263-71. 2003

Collaborators

Detail Information

Publications91

  1. ncbi request reprint Acupuncture and endorphins
    Ji Sheng Han
    Neuroscience Research Institute, Peking University and Key Laboratory of Neuroscience Peking University, Ministry of Education, 38 Xue Yuan Road, Beijing 100083, PR China
    Neurosci Lett 361:258-61. 2004
    ..This finding has been verified in clinical studies in patients with various kinds of chronic pain including low back pain and diabetic neuropathic pain...
  2. doi request reprint Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine
    Jisheng Han
    Neuroscience Research Institute, Peking University, Beijing 100191, China
    Front Med 5:141-50. 2011
    ..This article reviews the past, present, and foreseeable future regarding the use of acupuncture-related technique for the treatment of opiate addiction from the perspective of translational medicine...
  3. doi request reprint Acupuncture research is part of my life
    Ji Sheng Han
    Neuroscience Research Institute, Peking University, Beijing, China
    Pain Med 10:611-8. 2009
    ..This article describes my decision as a young medical graduate to devote my life to research on acupuncture and pain medicine; it has since been my life's journey-one full of challenges and happiness, pitfalls and achievements...
  4. ncbi request reprint Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated
    Xiang Dang Shi
    Neuroscience Research Institute, Key Laboratory for Neuroscience, Peking University, The Ministry of Education, 38 Xueyuan Road, Beijing 100083, PR China
    Brain Res Mol Brain Res 130:124-33. 2004
    ..These findings suggest that enkephalin and dynorphin in NAc may play important roles in the mechanisms underlying the inhibitory effect of PES on the expression and reinstatement of morphine-induced CPP in rats...
  5. doi request reprint Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation
    Shan Jing Geng
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100191, PR China
    Exp Neurol 222:256-66. 2010
    ..These data suggested that the BDNF/TrkB-mediated signaling pathway in the spinal cord was involved in the development of nerve injury-induced neuropathic pain through the activation of dorsal horn NMDA-2B receptors...
  6. ncbi request reprint The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats
    Yao Ying Ma
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, 38 Xueyuan Road, Beijing 100083, PR China
    Exp Neurol 200:343-55. 2006
    ..Taking together, these findings suggested that NR2B containing NMDA receptor may be more involved with morphine reward rather than natural rewards, and that antagonism of NR2B may have a potential for the treatment of morphine abuse...
  7. ncbi request reprint Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons
    Feng Qiao Li
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, People s Republic of China
    Exp Neurol 179:28-37. 2003
    ..The underlying mechanism may be relevant to its neurotrophic effect and its efficacy in stimulating the expression of BDNF...
  8. ncbi request reprint Differential modulation of nociceptive neural responses in medial and lateral pain pathways by peripheral electrical stimulation: a multichannel recording study
    Jin Yan Wang
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, PR China
    Brain Res 1014:197-208. 2004
    ....
  9. ncbi request reprint Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy
    Xi Bin Liang
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    Brain Res Mol Brain Res 108:51-9. 2002
    ..Activation of endogenous neurotrophins by EA may be involved in the regeneration of the injured dopaminergic neurons, which may underlie the effectiveness of EA in the treatment of PD...
  10. ncbi request reprint Parallel pain processing in freely moving rats revealed by distributed neuron recording
    Jin Yan Wang
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 100083, Beijing, PR China
    Brain Res 992:263-71. 2003
    ..The results provide an initial demonstration of distributed activity patterns within different pain systems in awake and freely moving rats, hence, providing confirmation of the existence of the dual pain pathways...
  11. doi request reprint Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation
    Feng Yu Liu
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100191, PR China
    Brain Res 1330:45-60. 2010
    ....
  12. ncbi request reprint NMDA receptor in nucleus accumbens is implicated in morphine withdrawal in rats
    Dong Ji
    Neuroscience Research Institute, Peking University, Key Laboratory for Neuroscience, Beijing, PR China
    Neurochem Res 29:2113-20. 2004
    ..These results indicate that the NMDA receptor antagonist ketamine has the ability to suppress morphine withdrawal syndrome in experimental settings without motor interference, and NAc could be the critical CNS site mediating such effect...
  13. ncbi request reprint Electroacupuncture suppresses expression of gastric ghrelin and hypothalamic NPY in chronic food restricted rats
    Nan Tian
    Neuroscience Research Institute, Peking University, Beijing 100083, PR China
    Peptides 27:2313-20. 2006
    ..A reduction in the orexigenic peptides ghrelin and NPY may be involved in the underlying mechanism...
  14. ncbi request reprint Ketamine enhances the efficacy to and delays the development of tolerance to electroacupuncture-induced antinociception in rats
    Cheng Huang
    Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience, The Ministry of Education, 38 Xueyuan Road, Beijing 100083, China
    Neurosci Lett 375:138-42. 2005
    ....
  15. ncbi request reprint Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats
    Hao Luo
    Neuroscience Research Institute, Peking University, Ministry of Education, 38 Xueyuan Road, Beijing 100083, PR China
    Neuroreport 15:655-8. 2004
    ..A shift of VRI expression from small to medium DRG neurons over the observation period was seen. These results suggest that VR1 could play an important role in the early stage, but not the late stage, of CFA inflammatory nociception...
  16. ncbi request reprint A comparison between spontaneous electroencephalographic activities induced by morphine and morphine-related environment in rats
    Yan fang Zuo
    Neuroscience Research Institute, Peking University, Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 10083, P R China
    Brain Res 1136:88-101. 2007
    ..These results indicate that the central mechanisms underlying the motivation of morphine-induced place preference may be somehow different from those underlying the reward effects produced by acute morphine administration...
  17. ncbi request reprint Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception
    Yun Wang
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, Key Laboratory of Neuroscience Peking University, Minister of Education, 38 Xueyuan Road, Beijing 100083, PR China
    Exp Neurol 192:156-62. 2005
    ..We conclude that the more potent anti-nociceptive effect induced by 2/100 Hz EAS, as compared with that of (2 + 100) Hz EAS, was due, at least partly, to the synergistic interaction of endomorphin-2 and dynorphin in rat spinal cord...
  18. ncbi request reprint Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats
    Jin Huang
    Neuroscience Research Institute, Peking University Health Science Center, Beijing, China
    Exp Neurol 200:124-34. 2006
    ..These results indicate that the changes of activity pattern in forebrain networks may underlie the emerging and subsiding of central sensitization-induced pain behavior in the second phase of formalin test...
  19. ncbi request reprint Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain
    Cheng Huang
    Neuroscience Research Institute, Peking University, Key Laboratory of Neurosciene, Ministry of Education, Beijing, PR China
    Brain Res Bull 63:99-103. 2004
    ..In conclusion, the present results indicate that a single or repetitive EA could reduce mechanical hyperalgesia, but not thermal hyperalgesia, in CFA-inflammatory pain rats, and the opioid system might be involved in these effects...
  20. doi request reprint Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens
    Jing Liang
    Neuroscience Research Institute, Department of Neurobiology, School of Basic Medical Sciences, Peking University, China
    Neuropharmacology 58:233-40. 2010
    ..These findings support the possibility of using 2 Hz EA for the treatment of opiate addiction...
  21. ncbi request reprint NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement
    Yao Ying Ma
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, 38 Xueyuan Road, Beijing 100083, PR China
    Exp Neurol 203:309-19. 2007
    ..These results indicate that the NR2B-containing NMDA receptors in the NAc and the dorsal hippocampus play a significant role in mediating the reinstatement of rewarding responses to morphine...
  22. ncbi request reprint Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects: a functional magnetic resonance imaging study
    Wei Ting Zhang
    Neuroscience Research Institute, Peking University, 38 Xue Yuan Rd, Beijing 100083, China
    Brain Res 982:168-78. 2003
    ....
  23. ncbi request reprint Brain opioid-receptors are involved in mediating peripheral electric stimulation-induced inhibition of morphine conditioned place preference in rats
    Xiang Dang Shi
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Brain Res 981:23-9. 2003
    ..05-0.01). These results indicate that the anti-craving effects induced by repeated PES of 100 Hz is mediated by the activation of supra-segmental delta- and kappa-opioid receptors in the central nervous system...
  24. ncbi request reprint Evidence from brain imaging with fMRI supporting functional specificity of acupoints in humans
    Wei Ting Zhang
    Neuroscience Research Institute, Peking University, 38 Xue Yuan Rd, Beijing 100083, China
    Neurosci Lett 354:50-3. 2004
    ..Thus, stimulation of acupoints in the same spinal segments induced distinct though overlapped cerebral response patterns, which indicated the existence of acupoint specificity...
  25. ncbi request reprint Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist
    Ying Wang
    Neuroscience Research Institute and Department of Neurobiology, Key Laboratory for Neuroscience, Peking University, 38 Xueyuan Rd, Beijing 100083, PR China
    Exp Neurol 202:313-23. 2006
    ....
  26. ncbi request reprint Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor and NMDA receptor implicated
    Rui Qing Sun
    Neuroscience Research Institute and Key Laboratory of Neuroscience, Ministry of Education, Peking University, Beijing 100083, PR China
    Exp Neurol 187:23-9. 2004
    ..This increase could be reversed by repetitive 2 Hz PES. These results suggest that PES can relieve neuropathic pain, and that mu-opioid receptors and NMDA receptors are involved in the effect of PES...
  27. ncbi request reprint Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats
    Ji Huan Chen
    Neuroscience Research Institute, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, PR China
    Exp Neurol 194:550-6. 2005
    ....
  28. doi request reprint Peripheral electrical stimulation-induced suppression of morphine-induced CCP in rats: a role for dopamine in the nucleus accumbens
    Yao Ying Ma
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    Brain Res 1212:63-70. 2008
    ..Our results suggest that MLDS seems to play important roles in the mechanisms underlying PES's suppression of the rewarding effect of drug-associated environmental cues in the rat...
  29. pmc Peripheral electrical stimulation reversed the cell size reduction and increased BDNF level in the ventral tegmental area in chronic morphine-treated rats
    Ning Ning Chu
    Neuroscience Research Institute, The Ministry of Education and Ministry of Public Health, Peking University, Beijing 100083, PR China
    Brain Res 1182:90-8. 2007
    ..Activation of endogenous BDNF by PES may play a role in the recovery of the injured dopaminergic neurons in the morphine addictive rats...
  30. ncbi request reprint Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain
    Guo Gang Xing
    Department of Neurobiology, Key Laboratory for Neuroscience of the Ministry of Education and Public Health, Peking University, 38 Xue Yuan Road, Beijing 100083, People s Republic of China
    Exp Neurol 208:323-32. 2007
    ..LTD of synaptic strength in the spinal dorsal horn in SNL rats may contribute to the long-lasting analgesic effects of EA at 2 Hz...
  31. ncbi request reprint Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement
    Cheng Huang
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Brain Res 945:20-5. 2002
    ..In conclusion, EA induces reliable, strain-dependent analgesia in mice. The naloxone-reversibility of EA, a measure of whether it is opioid or non-opioid mediated, is dependent upon intensity and frequency...
  32. ncbi request reprint Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats
    Feng Yu Liu
    Neuroscience Research Institute and Department of Neurobiology, Peking University, Key Laboratory for Neuroscience, Ministry of Education, Beijing, People s Republic of China
    J Pharmacol Exp Ther 321:1046-53. 2007
    ....
  33. doi request reprint Behavioral and electrophysiological evidence for the differential functions of TRPV1 at early and late stages of chronic inflammatory nociception in rats
    Hao Luo
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Neurochem Res 33:2151-8. 2008
    ..These results provide new evidence for the functional significance of TRPV1 at the early stage, but not the late stage, in the rat model of CFA-induced inflammatory pain...
  34. ncbi request reprint [Protective effect of tripchlorolide on dopaminergic neurons in partially lesioned rat model of Parkinson's disease]
    Xiao Xin Cheng
    Neuroscience Research Institute, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 37:339-42. 2002
    ..To study whether the immunosuppressant tripchlorolide (T4) exerts neuroprotective effect on dopaminergic neurons...
  35. ncbi request reprint Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain
    Ying Zhang
    Neuroscience Research Institute, Department of Neurobiology, The Key Laboratory for Neuroscience, The Ministry of Education, Peking University Health Science Center, Beijing, 100083, P R China
    Neurochem Res 32:1592-9. 2007
    ..These studies suggest that DREAM might have other roles in pain modulation in the spinal cord in addition to its well-known role as a transcriptional repressor...
  36. ncbi request reprint Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation
    Qian Sun
    Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience, Ministry of Education, Beijing 100083, China
    Exp Neurol 191:128-36. 2005
    ..These findings suggest that ectopic discharges may be crucial in the triggering of neuropathic pain in the early stage, but their importance become more limited over time...
  37. ncbi request reprint Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain
    Cheng Huang
    Key Laboratory of Neuroscience, Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    Neurosci Lett 368:327-31. 2004
    ..p. injection of naloxone (2.0 mg/kg). These results suggested that ketamine potentiate the anti-allodynic of EA in rats with spinal nerve ligation, and endogenous opioid system is likely to be involved in this process...
  38. ncbi request reprint Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain
    Qian Sun
    Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience, Ministry of Education, 38 Xueyuan Road, Beijing 100083, China
    Brain Res 1032:63-9. 2005
    ..These results indicate that I(h) might play a role in the generation of various forms of ectopic discharges in the injured DRG neurons and may thus be a possible target for neuropathic pain treatment...
  39. doi request reprint Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model
    Qin Zheng
    Neuroscience Research Institute and Department of Neurobiology, Peking University, Beijing, PR China
    Pain 154:434-48. 2013
    ..Thus, suppression of KCNQ/M channels in primary DRG neurons plays a crucial role in the development of bone cancer pain...
  40. ncbi request reprint The Neuroscience Research Institute at Peking University: a place for the solution of pain and drug abuse
    Albert C H Yu
    Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100083, China
    Cell Mol Neurobiol 28:13-9. 2008
    ..The institute is simultaneously investigating both theoretical and clinical studies. Acupuncture remains the core of research, while pain and drug abuse form the two disciplines...
  41. ncbi request reprint Peripheral electric stimulation attenuates the expression of cocaine-induced place preference in rats
    Yan Hua Ren
    Neuroscience Research Institute, Beijing University, 38 Xueyuan Road, 100083, Beijing, PR China
    Brain Res 957:129-35. 2002
    ..These results suggest that PES could inhibits cocaine-induced CPP in a frequency-dependent manner. This effect is probably mediated by an endogenous kappa-opioid mechanism...
  42. ncbi request reprint Coding of peripheral electrical stimulation frequency in thalamocortical pathways
    He Yang
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100083, PR China
    Exp Neurol 196:138-52. 2005
    ..These properties, in turn, may facilitate or inhibit their responses when stimulation with specific frequency information arrives...
  43. ncbi request reprint [Current status in drug addiction and addiction memory research]
    Hao Ran Wang
    Neuroscience Research Institute, Peking University, Beijing 100083
    Sheng Li Ke Xue Jin Zhan 34:202-6. 2003
    ..Addiction is closely related to the disorder of associate learning that depends on dopamine. Hippocampus may play a key role in addiction. At last, we put forward the future directions for research...
  44. ncbi request reprint Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies
    Ji Sheng Han
    Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing 100083, China
    Trends Neurosci 26:17-22. 2003
  45. doi request reprint Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference
    Xiu Fang Lv
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, Beijing 100191, PR China
    Behav Brain Res 223:182-91. 2011
    ..1 protein expression in the NAc shell is only critical for the context-induced retrieval of memory. As a result, Arc/Arg3.1 may be a potential therapeutic target for the prevention of drug abuse or the relapse of drug use...
  46. doi request reprint Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat
    Yu Qiu Jiang
    Neuroscience Research Institute, Peking University, Beijing 100083, China
    Pain 137:495-506. 2008
    ..These results suggest that axonal HCN channel accumulation plays an important role in ectopic discharges from injured spinal nerves and contributes to the development of mechanical allodynia in neuropathic pain rats...
  47. ncbi request reprint Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice
    Cheng Huang
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Neurosci Lett 350:93-6. 2003
    ..0 ng. NST (5.0 ng) partly reversed chronic tolerance to EA. These results suggest that NST in the brain might play roles in EA-induced antinociceptive effect and the development of chronic tolerance to EA in mice...
  48. ncbi request reprint Effects of lesions of various brain areas on drug priming or footshock-induced reactivation of extinguished conditioned place preference
    Bin Wang
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xueyuan Road, 100083, Beijing, China
    Brain Res 950:1-9. 2002
    ..These results suggest that, while both drug priming and footshock stress are effective in reactivating drug-seeking behavior, they might work through different neurochemical mechanisms and anatomical pathways...
  49. ncbi request reprint Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats
    Jin Yan Wang
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Synapse 61:335-42. 2007
    ..On basis of the above findings, we propose that nociceptive responses are modulated by corticothalamic feedback during nociceptive transmission, which may be tight in the lateral pathway, while loose in the medial pathway...
  50. ncbi request reprint Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats
    De Run Tian
    Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing 100083, PR China
    Peptides 25:2147-53. 2004
    ..Failure of hypothalamic anorexigenic peptides CART and alpha-MSH to increase their content in response to HIF diet may play a key role for overly high energy consumption, resulting in obesity...
  51. ncbi request reprint Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation
    Feng Qiao Li
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    J Neuroimmunol 148:24-31. 2004
    ..Our data suggests that triptolide may protect dopaminergic neurons from LPS-induced injury and its efficiency in inhibiting microglia activation may underlie the mechanism...
  52. doi request reprint Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue
    - Fei-Wang
    Neuroscience Research Institute, Peking University, Beijing 100083, PR China
    Peptides 35:23-30. 2012
    ....
  53. doi request reprint Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats
    - Fei Wang
    Neuroscience Research Institute, Peking University, Beijing 100083, PR China
    Peptides 32:2394-9. 2011
    ..We concluded that EA treatment at ST36/SP6 acted through ARH to significantly inhibit food intake and body weight gain when fed a high-fat diet and that the stimulation of α-MSH expression and release might be involved in the mechanism...
  54. pmc The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant
    Lu Yu
    Neuroscience Research Institute, School of Basic Medical Sciences, Peking University, Beijing, PR China
    Mol Pain 4:61. 2008
    ..Chronic inflammatory nociception of rats was produced by intraplantar injection of complete Freund's adjuvant (CFA) and data was collected until day 28 following injection...
  55. ncbi request reprint [Capsaicin and its receptor--vanilloid receptor]
    Hao Luo
    Neuroscience Research Institute, Department of Neurobiology, Peking University, Beijing 100083
    Sheng Li Ke Xue Jin Zhan 34:11-5. 2003
    ..Mice lacking the VR1 gene have deficits in thermal- or inflammation-induced hyperalgesia, which confirms the involvement of this channel in pain sensation, especially the sensation of heat-evoked pain...
  56. ncbi request reprint Nociceptive responses of anterior cingulate cortical ensembles in behaving rats
    Jin Yan Wang
    Neuroscience Research Institute and Department of Neurobiology, Peking University School of Basic Medical Sciences, Beijing 100083, China
    Beijing Da Xue Xue Bao 36:47-51. 2004
    ..To confirm the role of anterior cingulated cortices (ACC) in the coding of pain affect by exploring the neural ensemble coding pattern within the anterior cingulate cortex in behaving rats with a multichannel recording technique...
  57. ncbi request reprint Electroacupuncture facilitates recovery of male sexual behavior in morphine withdrawal rats
    Guo hong Cui
    Neuroscience Research Institute, Peking University and Department of Neurobiology, Peking University Health Science Center, Beijing, China
    Neurochem Res 29:397-401. 2004
    ..The effect of EA on sexual behavior may involve both neuronal and hormonal pathways...
  58. ncbi request reprint The possible involvement of endogenous ligands for mu-, delta- and kappa-opioid receptors in modulating morphine-induced CPP expression in rats
    Jing Liang
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, 38 Xueyuan Road, Beijing 100083, PR China
    Peptides 27:3307-14. 2006
    ..The results suggest that the release of endogenous mu-, delta- and kappa-opioid agonists in the NAc shell may play a role for EA suppression of opiate addiction...
  59. ncbi request reprint Distribution of beacon immunoreactivity in the rat brain
    Fei Wang
    Neuroscience Research Institute and Department of Neurobiology, Peking University, Key Laboratory of Neuroscience, Ministry of Education and Ministry of Health, 38 Xueyuan Road, Beijing 100083, PR China
    Peptides 27:165-71. 2006
    ..The topographical distribution of beacon-IR in the brain suggests multiple biological activities for beacon in addition to its proposed roles in modulating feeding behaviors and pituitary hormone release...
  60. doi request reprint Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats
    Min Liu
    Neuroscience Research Institute, Peking University, Beijing, PR China Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, PR China
    Pain 154:1551-68. 2013
    ..Pharmacological blockade of P2X3 receptors or knockdown of VILIP-1 in DRGs would be used as innovative strategies for the treatment of bone cancer pain. ..
  61. pmc Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain
    Qin Zheng
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100191, People s Republic of China
    Mol Pain 8:24. 2012
    ....
  62. ncbi request reprint Decreased dynorphin A (1-17) in the spinal cord of spastic rats after the compressive injury
    Hong Wei Dong
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Beijing 100083, China
    Brain Res Bull 67:189-95. 2005
    ..Our data supported the note that the reduction of endogenous dynorphin A (1-17) might play an important role in the pathogenesis of spinally induced muscle spasticity and the replenishment of its shortage might relieve the spasticity...
  63. ncbi request reprint Suppression of cue-induced heroin craving and cue-reactivity by single-trial transcutaneous electrical nerve stimulation at 2 Hz
    Fei Zhong
    Neuroscience Research Institute, Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China
    Addict Biol 11:184-9. 2006
    ..These results indicate that the craving induced by a heroin-related cue can be immediately and significantly suppressed, and the cardiovascular activation totally abolished by a single-trial 2 Hz TENS for 30 minutes...
  64. ncbi request reprint [Acupuncture for the treatment of drug addiction]
    Cai Lian Cui
    Neuroscience Research Institute, Peking University, Beijing, China
    Sheng Li Ke Xue Jin Zhan 39:325-30. 2008
    ..In this review, the efficacy of acupuncture and related techniques for the treatment of drug dependence in experimental settings and clinical practice will be reviewed, and the possible mechanisms underlying this effect be discussed...
  65. pmc Electroacupuncture of 2 hz has a rewarding effect: evidence from a conditioned place preference study in rats
    Wei Xia
    Department of Neurobiology, Neuroscience Research Institute, School of Basic Medical Sciences, Peking University, Key Lab for Neuroscience of the Ministry of Education and Key Lab for Neuroscience, Ministry of Public Health, 38 Xueyuan Road, Beijing 100191, China
    Evid Based Complement Alternat Med 2011:730514. 2011
    ..1 mg kg(-1), i.p.), respectively. TempspacetempspaceIt is concluded that 2 Hz EA is capable of inducing CPP in the rat via the activation of the endogenous opioid-, cannabinoid- and dopamine-systems...
  66. ncbi request reprint Dynamic processing of nociception in cortical network in conscious rats: a laser-evoked field potential study
    Zhi Mei Qiao
    Neuroscience Research Institute, Peking University, Beijing, China
    Cell Mol Neurobiol 28:671-87. 2008
    ..4) Characterization of the spatio-temporal responses to noxious laser stimulation may be a valuable model for the study of pain mechanisms and for the assessment of analgesia...
  67. doi request reprint Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain
    Xiao Xiu Qu
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100191, PR China
    Exp Neurol 215:298-307. 2009
    ..Therefore, the spinal cord NMDA-2B receptor is likely to be a target for clinical pain therapy...
  68. ncbi request reprint [Enhanced-real time PCR: a highly sensitive method for SARS-coronavirus detection]
    Chang Hai Yu
    Neuroscience Research Institue, Peking University, Beijing 100083, China
    Beijing Da Xue Xue Bao 38:211-3. 2006
    ..The increased sensitivity of the assay would have major benefits in screening suspected SARS patients rapidly and efficiently and may help control the spread of SARS and other infectious diseases during future outbreak...
  69. ncbi request reprint Glial cell line-derived neurotrophic factor protects astrocytes from staurosporine- and ischemia- induced apoptosis
    Albert Cheung Hoi Yu
    Neuroscience Research Institute, Peking University, Beijing, China
    J Neurosci Res 85:3457-64. 2007
    ..Moreover, GDNF reduced caspase-3 activity but not that of caspase-1 in cultured astrocytes after ischemia treatment. Thus, GDNF protects astrocytes from apoptosis by inhibiting the activation of caspase-3...
  70. pmc Electroacupuncture treatment normalized sleep disturbance in morphine withdrawal rats
    Yi Jing Li
    Neuroscience Research Institute, Department of Neurobiology, School of Basic Medical Sciences, Peking University, Key Lab for Neuroscience, the Ministry of Education and Key Lab for Neuroscience, The Ministry of Public Health, Beijing 10019 1, China
    Evid Based Complement Alternat Med 2011:361054. 2011
    ..Both 2 and 100 Hz EA produced a significant increase in NREM sleep, REM sleep and total sleep time. It was suggested that EA could be a potential treatment for sleep disturbance during morphine withdrawal...
  71. doi request reprint Transcutaneous electrical acupoint stimulation in children with autism and its impact on plasma levels of arginine-vasopressin and oxytocin: a prospective single-blinded controlled study
    Rong Zhang
    Neuroscience Research Institute, Peking University, Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory for Neuroscience, Ministry of Education, Beijing, PR China
    Res Dev Disabil 33:1136-46. 2012
    ..Changes in plasma levels of AVP and possibly OXT may be involved in mediating the therapeutic effect of TEAS...
  72. ncbi request reprint [Prospective study of Han's acupoint nerve stimulator for preventing relapse of detoxified heroin addicts]
    Jun Fang
    Neuroscience Research Institute, Peking University, Bejing, China
    Zhonghua Yi Xue Za Zhi 90:1472-6. 2010
    ..To assess the efficacy of transcutaneous electrical acupoint stimulation (TEAS) in preventing the relapse of detoxified heroin users in a period of 12 months...
  73. ncbi request reprint Electroacupuncture analgesia is enhanced in transgenic nociceptin/orphanin FQ knock-out mice
    You Wan
    Peking University Neuroscience Research Institute, Beijing 100191, China
    Beijing Da Xue Xue Bao 41:376-9. 2009
    ..Transgenic OFQ knock-out mice provide us a useful tool to investigate the role of endogenous OFQ in EA analgesia. The present study aims to investigate the role of OFQ in the EA-induced analgesia with OFQ knock-out mice...
  74. pmc Damage of splenic T lymphocyte proliferation and differentiation and its normalization by electroacupuncture in morphine-dependent mice mode
    Hong yu Li
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100191, China
    Evid Based Complement Alternat Med 2011:424092. 2011
    ..These findings indicated that chronic morphine exposure-induced immune dysfunction in mice could be normalized by 2 Hz EA...
  75. doi request reprint Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats
    Yi Li
    Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and of Health, Peking University, 38 Xueyuan Road, Beijing 100083, People s Republic of China
    Neurochem Res 33:2070-7. 2008
    ....
  76. ncbi request reprint Neuroscience in China. Introduction
    Ji Sheng Han
    Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100083, China
    Cell Mol Neurobiol 28:5-7. 2008
    ..This assay tries to analyze the historical and contemporary background underlying the current status...
  77. doi request reprint Global trends and performances of acupuncture research
    Ji Sheng Han
    Neuroscience Research Institute, Peking University, Beijing 100191, People s Republic of China
    Neurosci Biobehav Rev 35:680-7. 2011
    ..Among the acupuncture research, pain control has been the most prevalent direction of study, and brain imaging is attracting the most recent attention...
  78. ncbi request reprint Hyperpolarization-activated, cyclic nucleotide-gated cation channels: roles in the differential electrophysiological properties of rat primary afferent neurons
    Huiyin Tu
    Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience Peking University, Ministry of Education, Beijing, Peoples Republic of China
    J Neurosci Res 76:713-22. 2004
    ..These results suggest that the different HCN channels in the three types of DRG neurons might contribute to their differential electrophysiological properties...
  79. ncbi request reprint [Progress in the basic research on neurobiological mechanisms of cancer pain]
    Ying Zhang
    Neuroscience Research Institute, Peking University, Beijing
    Sheng Li Ke Xue Jin Zhan 35:224-8. 2004
    ..Here we summarized the study progress of cancer pain animal models, neurochemical mechanisms and drugs for treatment of cancer pain from recent literatures...
  80. pmc Modulation of brain electroencephalography oscillations by electroacupuncture in a rat model of postincisional pain
    Jing Wang
    Neuroscience Research Institute, Peking University, Beijing 100191, China
    Evid Based Complement Alternat Med 2013:160357. 2013
    ....
  81. doi request reprint Dose- and time-dependent, context-induced elevation of dopamine and its metabolites in the nucleus accumbens of morphine-induced CPP rats
    Yao Ying Ma
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education, 38 Xueyuan Road, Beijing 100083, PR China
    Behav Brain Res 204:192-9. 2009
    ..e., in the home cage). These results suggest that that the long-lasting elevation of DA and its metabolites in the NAc is attributable mainly to drug-associated context, rather than the residual effect of morphine...
  82. doi request reprint Electroacupuncture in the treatment of obesity
    Fei Wang
    Neuroscience Research Institute, Peking University, Beijing 100083, People s Republic of China
    Neurochem Res 33:2023-7. 2008
    ..Results obtained in this laboratory in recent five years will be summarized in some detail...
  83. ncbi request reprint The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis
    Hui Li Li
    Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience PKU, Ministry of Education and Department of Neurobiology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    FEBS Lett 580:1723-8. 2006
    ..Thus maintenance of high NDAP levels may cause apoptosis. The different regulations of NDAP expression by neurotrophins indicate that the expression of NDAP might be a checkpoint for apoptosis during neuronal development...
  84. ncbi request reprint Modulation of cold pain in human brain by electric acupoint stimulation: evidence from fMRI
    Wei Ting Zhang
    Department of Neurobiology, Peking University, Beijing, China
    Neuroreport 14:1591-6. 2003
    ..We suggest that EAS may induce an analgesic effect via modulation of both the sensory and the emotional aspect of pain processing...
  85. doi request reprint Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area
    Ling Hu
    Neuroscience Research Institute, Peking University, China
    Addict Biol 14:431-7. 2009
    ..Our findings suggest that 100 Hz EA is a potential therapy for the treatment of opiate addiction by normalizing the activity of VTA DA neurons...
  86. ncbi request reprint Adenovirus-mediated delivery of GDNF ameliorates corticospinal neuronal atrophy and motor function deficits in rats with spinal cord injury
    Xiao Qing Tang
    Neuroscience Research Institute, Department of Neurobiology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, PR China
    Neuroreport 15:425-9. 2004
    ..These results demonstrated that adenovirus-mediated delivery of GDNF could prevent the retrograde atrophy of corticospinal motoneurons and improve the motor function in rats with spinal cord injury...
  87. ncbi request reprint Involvement of ionotropic glutamate receptors in low frequency electroacupuncture analgesia in rats
    Byung Tae Choi
    Department of Anatomy, College of Oriental Medicine, Research Institute of Oriental Medicine, Dong Eui University, Busan 614 052, Korea
    Neurosci Lett 377:185-8. 2005
    ..These results suggest that ionotropic glutamate receptors may be involved in the induction of 2 Hz EA analgesia...
  88. ncbi request reprint CCK(B) receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice
    Cheng Huang
    Department of Physiology, Gannan Medical University, 1 Yixueyuan Road, Ganzhou 341000, PR China
    Brain Res Bull 71:447-51. 2007
    ..The results opened a way for further investigation of the function of CCK-8 in pain modulation using inbred strains of mice...
  89. ncbi request reprint TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues
    Jeanette Cheng
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 13:BR163-7. 2007
    ..An extremely promising method for treatment of low to moderate levels of chronic pain in humans is transcutaneous electrical nerve stimulation (TENS)...
  90. ncbi request reprint Up-regulation of the expression of cocaine and amphetamine-regulated transcript peptide by electroacupuncture in the arcuate nucleus of diet-induced obese rats
    De Run Tian
    Department of Anatomy, Tianjin Medical University, China
    Neurosci Lett 383:17-21. 2005
    ..The results suggest that EA can up-regulate the expression of CART peptide to approach normal level, resulting in an inhibition of food intake and a reduction of body weight in DIO rats...
  91. ncbi request reprint Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats
    Xi Bin Liang
    Department of Neurology, Johns Hopkins University, School of Medicine, USA
    Neuroreport 14:1177-81. 2003
    ....