Youfei Guan

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi request reprint Nuclear receptors link gender dimorphism of renal disease progression
    Y Guan
    Department of Physiology and Pathophysiology, Peking Beijing University Health Science Center, Beijing, China
    Kidney Int 70:1889-90. 2006
  2. pmc Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting
    Youfei Guan
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 117:2496-505. 2007
  3. ncbi request reprint Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney
    Andre Schneider
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1205-13. 2004
  4. pmc AMPK potentiates hypertonicity-induced apoptosis by suppressing NFκB/COX-2 in medullary interstitial cells
    Qifei Han
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    J Am Soc Nephrol 22:1897-911. 2011
  5. doi request reprint Induction of MIF expression by oxidized LDL via activation of NF-kappaB in vascular smooth muscle cells
    Lihong Chen
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Atherosclerosis 207:428-33. 2009
  6. ncbi request reprint Expression of mouse membrane-associated prostaglandin E2 synthase-2 (mPGES-2) along the urogenital tract
    Guangrui Yang
    Department of Physiology and Pathophysiology, Health Science Center, Peking University, Beijing 100083, China
    Biochim Biophys Acta 1761:1459-68. 2006
  7. ncbi request reprint Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet
    Dae Ryong Cha
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 2372, USA
    Am J Nephrol 27:479-82. 2007
  8. doi request reprint Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway
    Jing Li
    Department of Physiology and Pathophysiology, Beijing, China
    Hepatology 53:1906-16. 2011
  9. doi request reprint Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release
    Xiao Yan Dai
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
    Kidney Int 83:1042-51. 2013
  10. doi request reprint Klotho is a target gene of PPAR-gamma
    Hong Zhang
    Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China
    Kidney Int 74:732-9. 2008

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Nuclear receptors link gender dimorphism of renal disease progression
    Y Guan
    Department of Physiology and Pathophysiology, Peking Beijing University Health Science Center, Beijing, China
    Kidney Int 70:1889-90. 2006
    ..Lu and colleagues provide evidence that the signaling pathways of the nuclear receptors ERalpha, AR and PPARalpha are associated with gender differences in CKD progression...
  2. pmc Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting
    Youfei Guan
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 117:2496-505. 2007
    ..Similarly, the pressor response to EP1-selective agonists sulprostone and 17-phenyltrinor PGE2 were blunted by SC51322 and in EP1-null mice. These data support the possibility of targeting the EP1 receptor for antihypertensive therapy...
  3. ncbi request reprint Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney
    Andre Schneider
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1205-13. 2004
    ..The present studies were aimed at determining the intrarenal localization of mPGES-1 and whether it is coexpressed with COX-1 or COX-2...
  4. pmc AMPK potentiates hypertonicity-induced apoptosis by suppressing NFκB/COX-2 in medullary interstitial cells
    Qifei Han
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    J Am Soc Nephrol 22:1897-911. 2011
    ..Furthermore, this study raises safety concerns for the development of AMPK activators as anti-diabetic drugs, especially for patients prone to dehydration...
  5. doi request reprint Induction of MIF expression by oxidized LDL via activation of NF-kappaB in vascular smooth muscle cells
    Lihong Chen
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Atherosclerosis 207:428-33. 2009
    ..Taken together, our results revealed that MIF expression can be induced by oxLDL in VSMCs via a NF-kappaB dependent manner, which may contribute to the pathogenesis of atherosclerosis...
  6. ncbi request reprint Expression of mouse membrane-associated prostaglandin E2 synthase-2 (mPGES-2) along the urogenital tract
    Guangrui Yang
    Department of Physiology and Pathophysiology, Health Science Center, Peking University, Beijing 100083, China
    Biochim Biophys Acta 1761:1459-68. 2006
    ..This expression pattern is consistent with an important role for mPGES-2-mediated PGE(2) in urogenital function...
  7. ncbi request reprint Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet
    Dae Ryong Cha
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 2372, USA
    Am J Nephrol 27:479-82. 2007
    ..The aim of this study was to evaluate the potential role of PPARalpha in insulin resistance in aging mice induced by a high-fat diet...
  8. doi request reprint Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway
    Jing Li
    Department of Physiology and Pathophysiology, Beijing, China
    Hepatology 53:1906-16. 2011
    ..Moreover, FOXO1 overexpression increased PANDER expression in cultured hepatocytes and mouse livers...
  9. doi request reprint Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release
    Xiao Yan Dai
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
    Kidney Int 83:1042-51. 2013
    ..Therapeutic agents influencing the autophagic response may be of benefit to treat aging or disease-related vascular calcification and osteoporosis...
  10. doi request reprint Klotho is a target gene of PPAR-gamma
    Hong Zhang
    Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China
    Kidney Int 74:732-9. 2008
    ..These results demonstrate that klotho is a target gene of PPAR-gamma...
  11. ncbi request reprint Peroxisome proliferator activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice
    Dae Ryong Cha
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Diabetes 56:2036-45. 2007
    ..These findings support the utility of dual PPARalpha/gamma agonists in treating type 2 diabetes and diabetic nephropathy...
  12. doi request reprint Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury
    Yunfeng Zhou
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Kidney Int 79:1302-11. 2011
    ..Thus, PPAR-α deficiency exacerbates DOX-related renal injury, in part, due to increased podocyte apoptosis...
  13. doi request reprint Thyroid hormone-responsive SPOT 14 homolog promotes hepatic lipogenesis, and its expression is regulated by liver X receptor α through a sterol regulatory element-binding protein 1c-dependent mechanism in mice
    Jing Wu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Cardiovascular Science of the Ministry of Education, Beijing, China
    Hepatology 58:617-28. 2013
    ..Conclusion: Thrsp is a lipogenic gene in the liver that is induced by the LXR agonist through an LXR-α-mediated, SREBP-1c-dependent mechanism. Therefore, Thrsp may represent a potential therapeutic target for the treatment of NAFLD...
  14. pmc Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs
    Xuefen Xie
    Department of Physiology and Pathophysiology, Peking University, Health Sciences Center, Beijing 100083, China
    Mol Endocrinol 23:434-43. 2009
    ..These findings also provide new insights into diabetes-associated complications such as fatty liver disease...
  15. pmc Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake
    Geyang Xu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China
    Endocrinology 150:3637-44. 2009
    ..mTOR is therefore a gastric fuel sensor whose activity is linked to the regulation of energy intake through ghrelin...
  16. ncbi request reprint Laminar shear stress regulates liver X receptor in vascular endothelial cells
    Minjia Zhu
    Department of Physiology and Pathophysiology, Peking University, Health Sciences Center, Beijing, China 100083
    Arterioscler Thromb Vasc Biol 28:527-33. 2008
    ..The liver X receptors (LXRs) regulate a set of genes involved in lipid metabolism and reverse cholesterol transport. We investigated the mechanism by which shear stress regulates LXR in vascular endothelial cells (ECs)...
  17. pmc Regulation of gastric hormones by systemic rapamycin
    Geyang Xu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
    Peptides 31:2185-92. 2010
    ..05), but had no effect on somatostatin production (165.2±25.07 pg/ml vs. 178.9±29.14 pg/ml, p=0.73). Gastric mTOR is a gastric sensor whose activity is linked to the differential regulation of gastric hormone production and release...
  18. doi request reprint Role of PPARgamma in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential
    Jichun Yang
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China
    Clin Sci (Lond) 116:17-26. 2009
    ..In this review, we summarize and discuss recent findings regarding the renoprotective effects of PPARgamma in Type 2 diabetes and the potential underlying mechanisms...
  19. doi request reprint FAM3A is a target gene of peroxisome proliferator-activated receptor gamma
    Yanlan Zhou
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Biochim Biophys Acta 1830:4160-70. 2013
    ..To date, the biological function of FAM3A, the first member of FAM3 gene family, remains unknown. We aimed to investigate whether the expression of FAM3A in liver cells is regulated by peroxisome proliferator-activated receptors (PPARs)...
  20. doi request reprint Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
    Xiaomei Qin
    Institute of Cardiovascular Science and Key Laboratory of Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing, China
    Hepatology 48:432-41. 2008
    ..Furthermore, overexpression of PPARdelta by intravenous infection with the PPARdelta adenovirus induced the expression of Insig-1, suppressed SREBP-1 activation, and, consequently, ameliorated hepatic steatosis in obese db/db mice...
  21. pmc Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor response via decreasing arterial contractility
    Lihong Chen
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Haidian District, Beijing, China
    Arterioscler Thromb Vasc Biol 32:3024-32. 2012
    ..The present studies aimed at elucidating the role of prostaglandin E(2) receptor subtype 3 (E-prostanoid [EP] 3) in regulating blood pressure...
  22. pmc Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats
    Yunfeng Zhou
    Department of Physiology and Pathophysiology, Peking University Health Science Center, 38 Xueyuan Rd, Beijing, China
    Am J Physiol Renal Physiol 295:F662-71. 2008
    ..Activation of SREBP-1 transcription factor may represent an underlying molecular mechanism of hyperlipidemia in NS...
  23. pmc Prostaglandin E2 promotes endothelial differentiation from bone marrow-derived cells through AMPK activation
    Zhenjiu Zhu
    Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    PLoS ONE 6:e23554. 2011
    ..Therefore, by promoting the differentiation and migration of BMCs, PGE2 reinforced their neovascularization by binding to the receptor of EP4 in an AMPK-dependent manner. PGE2 may have clinical value in ischemic heart disease...
  24. ncbi request reprint Liver X receptor-alpha mediates cholesterol efflux in glomerular mesangial cells
    Jing Wu
    Division of Nephrology, S 3223 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 287:F886-95. 2004
    ..These data suggest that LXRalpha may be a potential therapeutic target for treating lipid-related renal glomerular disease...
  25. ncbi request reprint Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption
    Youfei Guan
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, 21st Avenue South at Garland Avenue, Nashville, Tennessee 37232, USA
    Nat Med 11:861-6. 2005
    ..These studies identify Scnn1g as a PPARgamma target gene in the collecting duct. Activation of this pathway mediates fluid retention associated with TZDs, and suggests amiloride might provide a specific therapy...
  26. pmc Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression
    Gexin Zhao
    Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Science, School of Basic Medical Science, Peking University Health Science Center, Ministry of Education, Beijing, PR China
    Kidney Int 82:34-44. 2012
    ..Thus, TNF-activated NF-κB promotes inflammation-accelerated vascular calcification by inhibiting ankylosis protein homolog expression and consequent pyrophosphate secretion...
  27. doi request reprint Role of pancreatic-derived factor in type 2 diabetes: evidence from pancreatic β cells and liver
    Chunjiong Wang
    Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Science, Peking University Health Science Center, Beijing, China
    Nutr Rev 70:100-6. 2012
    ..In summary, PANDER plays an important role in the progression of type 2 diabetes by negatively regulating islet β-cell function and insulin sensitivity in the liver...
  28. pmc A maladaptive role for EP4 receptors in podocytes
    Erin M Stitt-Cavanagh
    Kidney Research Centre, Division of Nephrology, Department of Medicine, Ottawa Hospital, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    J Am Soc Nephrol 21:1678-90. 2010
    ..05). These findings suggest that prostaglandin E(2), acting via EP4 receptors contributes to podocyte injury and compromises the glomerular filtration barrier...
  29. pmc Activating transcription factor 4 regulates osteoclast differentiation in mice
    Huiling Cao
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Clin Invest 120:2755-66. 2010
    ..These results demonstrate that ATF4 plays a direct role in regulating OCL differentiation and suggest that it may be a therapeutic target for treating bone diseases associated with increased OCL activity...
  30. ncbi request reprint Genomic structure and genitourinary expression of mouse cytosolic prostaglandin E(2) synthase gene
    Yahua Zhang
    Division of Nephrology, S 3223 MCN, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Biochim Biophys Acta 1634:15-23. 2003
    ..In urinary bladder, cPGES expression was restricted to the transitional epithelial cells. This expression pattern is consistent with an important role for cPGES-mediated PGE(2) in urogenital tissue function...
  31. ncbi request reprint Generation of a conditional allele of the mouse prostaglandin EP4 receptor
    Andre Schneider
    Division of Nephrology and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Genesis 40:7-14. 2004
    ..The EP4(flox) mouse should provide a useful reagent with which to examine the physiologic roles of the EP4 receptor...
  32. ncbi request reprint Effect of deletion of the prostaglandin EP4 receptor on stimulation of calcium release from cultured mouse calvariae: impaired responsiveness in heterozygotes
    Peili Zhan
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Prostaglandins Other Lipid Mediat 78:19-26. 2005
    ..These results suggest that the EP4 receptor may be rate limiting not only for PGE2 stimulated resorption but also for resorption stimulated by other agonists, like PTH that induce PGE2 production...
  33. ncbi request reprint Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule
    Yahua Zhang
    Division of Nephrology, S 3223 MCN, Vanderbilt Univ Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 290:F1065-73. 2006
    ..Taken together, these data suggest LXR activation of SCD1 expression may play an important role in regulating lipid metabolism and cell function in renal proximal straight tubules...
  34. doi request reprint Targeted disruption of the prostaglandin E2 E-prostanoid 2 receptor exacerbates vascular neointimal formation in mice
    Sen Zhu
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 31:1739-47. 2011
    ..The PGE(2) receptor E-prostanoid 2 (EP2) is involved in the proliferation and migration of various cell types. We aimed to determine the role of EP2 in the pathogenesis of neointimal formation after vascular injury...
  35. doi request reprint PPARγ as a therapeutic target in diabetic nephropathy and other renal diseases
    Jichun Yang
    Department of Physiology and Pathophysiology, Peking Beijing University Diabetes Center, Key Laboratory of Molecular Cardiovascular Sciences, Peking Beijing University Health Science Center, Beijing, China
    Curr Opin Nephrol Hypertens 21:97-105. 2012
    ..The current review aims to summarize and discuss recent findings evaluating the protective effects of PPARγ against kidney diseases with a focus on diabetic nephropathy. We will also delineate the potential underlying mechanisms...
  36. pmc Modulation of ghrelin O-acyltransferase expression in pancreatic islets
    Wenjiao An
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Cell Physiol Biochem 26:707-16. 2010
    ..Although ghrelin is mainly secreted from gastric X/A like endocrine cells, it is also expressed in pancreatic islet cells and regulates insulin secretion. In this study, we examined the expression and regulation of GOAT in pancreas...
  37. doi request reprint Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes
    Dongjuan Zhang
    Dept of Physiology and Pathophysiology, Peking University Health Science Ctr, Haidian District, Beijing, China
    Am J Physiol Endocrinol Metab 300:E287-95. 2011
    ..Enhanced ketone body production in the diabetic kidney may represent a novel mechanism involved in the pathogenesis of DN...
  38. pmc Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel
    Kiyoshi Nakagawa
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Clin Invest 116:1696-702. 2006
    ..It is expected that these results could lead to new strategies for the early diagnosis and clinical management of this devastating disease...
  39. pmc Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage
    Qian Wang
    Dept of Physiology and Pathophysiology, Peking Univ Health Science Center, Beijing, China
    Am J Physiol Renal Physiol 304:F168-76. 2013
    ....
  40. ncbi request reprint Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract
    Osamu Saito
    Division of Nephrology, Department of Medicine, Vanderbilt University Veterans Affairs Medical Center, Nashville, Tennessee 37212, USA
    Am J Physiol Renal Physiol 284:F1164-70. 2003
    ..Intrarenal expression of the FP receptor in the DCT and CCD suggests an important role for the FP receptor regulating water and solute transport in these segments of the nephron...
  41. pmc Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells
    Janos Peti-Peterdi
    Department of Medicine, University of Alabama at Birmingham, Alabama, USA
    J Clin Invest 112:76-82. 2003
    ....
  42. pmc PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
    Jichun Yang
    Department of Physiology and Pathophysiology, Peking Beijing University Diabetes Center, Peking Beijing University Health Science Center, Beijing 100083, China
    PPAR Res 2008:723243. 2008
    ..In this review, we summarize recent findings elucidating the role of PPARs in female reproduction, with particular focus on evidence from gene knockout and transgenic animal model study...
  43. pmc Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
    Jichun Yang
    Department of Physiology and Pathophysiology, Peking University Diabetes Center, Peking University Health Science Center, Beijing, China
    Nutr Rev 68:270-9. 2010
    ..In vivo, leucine administration improves glycemic control in humans and rodents with type 2 diabetes. This review summarizes and discusses the recent findings regarding the effects of leucine metabolism on pancreatic beta-cell function...
  44. doi request reprint Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes
    Rui Wang
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Biochem J 430:245-54. 2010
    ..Taken together, these results suggest that SREBP-1c directly mediates the effect of insulin on Cidea in hepatocytes and that Cidea, at least in part, mediates SREBP-1c-dependent lipid accumulation...
  45. pmc Distinct roles for basal and induced COX-2 in podocyte injury
    Huifang Cheng
    Division of Nephrology, Vanderbilt University School of Medicine and Nashville Veterans Affairs Hospital, Nashville, TN 37232, USA
    J Am Soc Nephrol 20:1953-62. 2009
    ..These results suggest that basal COX-2 may be important for podocyte survival, but overexpression of podocyte COX-2 increases susceptibility to podocyte injury, which is mediated, in part, by activation of the thromboxane receptor...
  46. ncbi request reprint Targeted gene disruption of the prostaglandin E2 EP2 receptor
    Richard M Breyer
    Departments of Medicine Division of Nephrology, Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Adv Exp Med Biol 507:321-6. 2002
  47. doi request reprint Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis
    Aijun Qiao
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Hepatology 54:509-21. 2011
    ..Finally, the overexpression of PNPLA3 in mouse liver increased the serum triglyceride level and impaired glucose tolerance; in contrast, the knockdown of PNPLA3 in db/db mouse liver improved glucose tolerance...
  48. pmc Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts
    Xiaoyan Zhang
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Cell Biochem 105:885-95. 2008
    ..Taken together, these results for the first time demonstrate that ATF4 is a critical regulator of proliferation and survival in BMSCs and osteoblasts in vitro and in vivo...
  49. ncbi request reprint PPAR-gamma agonists and diabetic nephropathy
    Yahua Zhang
    Division of Nephrology and Hypertension, S 3223 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Curr Diab Rep 5:470-5. 2005
    ..This review summarizes the recently emerging evidence suggesting that peroxisome proliferator-activated receptor-gamma agonists may prove to be effective therapeutic agents in the treatment of diabetic renal complications...
  50. pmc Silencing of Long Noncoding RNA AK139328 Attenuates Ischemia/Reperfusion Injury in Mouse Livers
    Zhenzhen Chen
    Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing, China MOE Key Laboratory of Molecular Cardiovascular Science, Peking University, Beijing, China
    PLoS ONE 8:e80817. 2013
    ..LncRNA AK139328 might be a novel target for diagnosis and treatment of liver surgery or transplantation. ..
  51. doi request reprint Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome
    Xinwang Chen
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
    J Mol Endocrinol 50:R21-37. 2013
    ..PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome...
  52. ncbi request reprint Peroxisome proliferator-activated receptors and renal diseases
    Jing Wu
    Department of Physiology and Pathophysiology, Peking Beijing University Diabetes Center, Key Laboratory of Molecular Cardiovascular Science, Peking Beijing University Health Science Center, Beijing, China
    Front Biosci (Landmark Ed) 14:995-1009. 2009
    ..In this review, we summarize the role of the three identified PPAR isoforms, PPARa, -d, and -?, in renal physiology and discuss the renoprotective effects of PPAR ligands in various kidney diseases...
  53. ncbi request reprint Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells
    Yanbo Fan
    Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Science, Peking University Health Science Center, Beijing 100083, China
    Arterioscler Thromb Vasc Biol 28:315-21. 2008
    ..The role of peroxisome proliferator-activated receptor-delta (PPAR-delta) in endothelial activation remains poorly understood. In this study, we investigated the anti-inflammatory effect of PPAR-delta and the mechanism involved...
  54. doi request reprint The mechanisms linking adiposopathy to type 2 diabetes
    Jichun Yang
    Department of Physiology and Pathophysiology, Peking University Diabetes Center, Peking University Health Science Center, Beijing, 100191, China
    Front Med 7:433-44. 2013
    ..The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes. ..
  55. doi request reprint Family with sequence similarity 3 gene family and nonalcoholic fatty liver disease
    Jichun Yang
    Department of Physiology and Pathophysiology, Peking University Diabetes Center, Beijing, China
    J Gastroenterol Hepatol 28:105-11. 2013
    ..In this brief review, we discussed the latest findings regarding the role of FAM3 gene family members, in particular FAM3B, in the pathogenesis of NAFLD...
  56. pmc Physiological effects of superoxide dismutase on altered visual function of retinal ganglion cells in db/db mice
    Chunxia Xiao
    Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing, China
    PLoS ONE 7:e30343. 2012
    ....
  57. pmc Fenofibrate inhibited the differentiation of T helper 17 cells in vitro
    Zhou Zhou
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China
    PPAR Res 2012:145654. 2012
    ..Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases...
  58. pmc Cloning and expression of the rabbit prostaglandin EP2 receptor
    Youfei Guan
    Division of Nephrolgy, Veterans Administration Medical Center, and Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    BMC Pharmacol 2:14. 2002
    ..Evidence supports an important role for the EP2 receptor in regulating fertility, vascular tone and renal function...
  59. doi request reprint Mitochondrial reactive oxygen species promote p65 nuclear translocation mediating high-phosphate-induced vascular calcification in vitro and in vivo
    Ming Ming Zhao
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University Health Science Center, Beijing, People s Republic of China
    Kidney Int 79:1071-9. 2011
    ..Thus, mitochondrial ROS-mediated p65 nuclear translocation is involved in phosphate-induced VC...
  60. doi request reprint Effects of an isopropanolic-aqueous black cohosh extract on central body temperature of ovariectomized rats
    Xiaoyan Ma
    Department of Gynecology, The First Hospital of Peking University, Beijing, China
    J Ethnopharmacol 138:156-61. 2011
    ..Black cohosh (Cimicifuga racemosa) is widely used in menopause symptoms strategy...
  61. doi request reprint Endometrial abnormality in women with polycystic ovary syndrome
    Kewei Shang
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Reprod Sci 19:674-83. 2012
    ..Here we review the features of the endometrial abnormalities in women with PCOS. The ability to improve the endometrial functions is of potential therapeutic targets to increase reproductive outcome of women with PCOS...
  62. ncbi request reprint Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 53:336-46. 2004
    ..Inhibition of PAI-1 might provide a novel anti-obesity and anti-insulin resistance treatment...
  63. ncbi request reprint Anti-inflammatory effect of PPARgamma in cultured human mesangial cells
    Zuying Xiong
    Renal Division of First Hospital and Institute of Nephrology, Peking University, Beijing, China
    Ren Fail 26:497-505. 2004
    ..Our data suggest that PPARgamma plays an important role in mesangial cells responding to inflammatory stress. PPARgamma may prove to be a pharmacological target in glomerulonephritis...
  64. pmc Cytokines in the Progression of Pancreatic β-Cell Dysfunction
    Chunjiong Wang
    Department of Physiology and Pathophysiology, Peking University Diabetes Center, Peking University Health Science Center, Beijing 100191, China
    Int J Endocrinol 2010:515136. 2010
    ..The imbalance in deleterious and protective cytokines plays pivotal roles in the development and progression of pancreatic β-cell dysfunction under insulin-resistant conditions...
  65. ncbi request reprint Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease
    Y Guan
    Division of Nephrology, and Department of Molecular Physiology, Veterans Administration Medical Center, and Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    Kidney Int 60:14-30. 2001
    ..The availability of PPAR-selective agonists and antagonists may provide a new approach to modulate the renal response to diseases including glomerulonephritis, glomerulosclerosis and diabetic nephropathy...
  66. ncbi request reprint PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice
    C W Park
    Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Kidney Int 69:1511-7. 2006
    ..The activation of PPARalpha by fenofibrate in mesangial cells may partially contribute to its renal protection. Thus, fenofibrate may serve as a therapeutic agent for type II diabetes and diabetic nephropathy...
  67. ncbi request reprint Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice
    Andre Schneider
    Universitätsklinikum Eppendorf, 20246 Hamburg, Germany
    Am J Physiol Renal Physiol 284:F411-7. 2003
    ..The Mx1Cre transgene should prove a useful reagent to achieve temporally regulated recombination in endothelial, glomerular, and distal renal epithelia in mice...
  68. doi request reprint PPARs and the kidney in metabolic syndrome
    Xiongzhong Ruan
    Center for Nephrology, University College of London, London, United Kingdom
    Am J Physiol Renal Physiol 294:F1032-47. 2008
    ..This review focuses on current knowledge of the role of PPARs in MetS and discusses the potential therapeutic utility of PPAR modulators in the treatment of kidney diseases associated with MetS...
  69. ncbi request reprint Increased severity of renal impairment in nephritic mice lacking the EP1 receptor
    Sherine Rahal
    Kidney Research Centre, Molecular Medicine Program, Ottawa Health Research Institute, Division of Nephrology, Ottawa Hospital and University of Ottawa, 451 Smyth Road, Rm 1317, Ottawa, Ontario K1H 8M5, Canada
    Can J Physiol Pharmacol 84:877-85. 2006
    ..Taken together, the increased renal impairment seen in NTS EP1-/- mice suggests that the EP1 subtype plays a compensatory role in the context of acute nephritis...
  70. ncbi request reprint Urine concentrating defect in prostaglandin EP1-deficient mice
    Chris R J Kennedy
    Department of Medicine, Ottawa Hospital, Ontario, Canada
    Am J Physiol Renal Physiol 292:F868-75. 2007
    ..These data suggest that PGE(2) modulates urine concentration by acting at EP(1) receptors, not in the collecting duct, but within the hypothalamus to promote AVP synthesis in response to acute WD...
  71. ncbi request reprint Effects of different PPARgamma-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis
    Ulf Panzer
    Zentrum fur Innere Medizin, Medizinische Klinik IV, University of Hamburg, Hamburg, Germany
    Kidney Int 62:455-64. 2002
    ..We evaluated the effects of different forms of PPARgamma activators in a model of experimental glomerulonephritis (GN) in rats...
  72. ncbi request reprint Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha
    Cheol Whee Park
    Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, 62, Yoido Dong, Youngdeungpo ku, Seoul, Korea 150 713
    Diabetes 55:885-93. 2006
    ..PPARalpha agonists may serve as useful therapeutic agents for type 1 diabetic nephropathy...
  73. ncbi request reprint Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct
    Richard L Hébert
    Departments of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 280:35028-37. 2005
    ..In contrast to the Ca(2+) signal transduced by other FP receptors, this renal FP receptor signals via a PT-sensitive mechanism that is not coupled to cell Ca(2+)...