Jiang Gu

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi request reprint H5N1 infection of the respiratory tract and beyond: a molecular pathology study
    Jiang Gu
    Infectious Disease Centre, Peking University, Beijing, China
    Lancet 370:1137-45. 2007
  2. pmc Multiple organ infection and the pathogenesis of SARS
    Jiang Gu
    Department of Pathology, Peking University, Beijing, China 100083
    J Exp Med 202:415-24. 2005
  3. pmc Correlation of immunoglobulin G expression and histological subtype and stage in breast cancer
    Baokai Yang
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University Health Science Center, Beijing, China
    PLoS ONE 8:e58706. 2013
  4. doi request reprint IgG gene expression and its possible significance in prostate cancers
    Yuxuan Liu
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    Prostate 72:690-701. 2012
  5. pmc Expression and distribution of cystic fibrosis transmembrane conductance regulator in neurons of the human brain
    Yong Guo
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University Health Science Center, Beijing, China
    J Histochem Cytochem 57:1113-20. 2009
  6. doi request reprint Expression and distribution of cystic fibrosis transmembrane conductance regulator in neurons of the spinal cord
    Yong Guo
    Department of Pathology, Peking University Health Science Center, Beijing, China
    J Neurosci Res 87:3611-9. 2009
  7. doi request reprint Expression and distribution of immunoglobulin G and its receptors in an immune privileged site: the eye
    Na Niu
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
    Cell Mol Life Sci 68:2481-92. 2011
  8. doi request reprint Neutrophils may be a vehicle for viral replication and dissemination in human H5N1 avian influenza
    Yingying Zhao
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    Clin Infect Dis 47:1575-8. 2008
  9. pmc Immunoglobulin g (IgG) expression in human umbilical cord endothelial cells
    Yingying Zhao
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    J Histochem Cytochem 59:474-88. 2011
  10. ncbi request reprint The spleen as a target in severe acute respiratory syndrome
    Jun Zhan
    Department of Histology and Embryology, Peking University Health Science Center, Beijing, China
    FASEB J 20:2321-8. 2006

Collaborators

Detail Information

Publications42

  1. ncbi request reprint H5N1 infection of the respiratory tract and beyond: a molecular pathology study
    Jiang Gu
    Infectious Disease Centre, Peking University, Beijing, China
    Lancet 370:1137-45. 2007
    ..Previous studies have shown that the human infection with avian influenza H5N1 could also target organs apart from the lungs...
  2. pmc Multiple organ infection and the pathogenesis of SARS
    Jiang Gu
    Department of Pathology, Peking University, Beijing, China 100083
    J Exp Med 202:415-24. 2005
    ..A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features...
  3. pmc Correlation of immunoglobulin G expression and histological subtype and stage in breast cancer
    Baokai Yang
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University Health Science Center, Beijing, China
    PLoS ONE 8:e58706. 2013
    ..However, the association of breast cancer derived IgG with genesis and development of the disease has not yet been established...
  4. doi request reprint IgG gene expression and its possible significance in prostate cancers
    Yuxuan Liu
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    Prostate 72:690-701. 2012
    ..Recently, accumulating evidence indicates that cancer cells, as well as some normal cells can secret IgG. This study was designed to evaluate IgG gene expression and its possible significance in PCa tissue samples and cell lines...
  5. pmc Expression and distribution of cystic fibrosis transmembrane conductance regulator in neurons of the human brain
    Yong Guo
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University Health Science Center, Beijing, China
    J Histochem Cytochem 57:1113-20. 2009
    ..The presence of CFTR in central neurons not only provides a possible explanation for the neural symptoms observed in CF patients, but also may lead to a better understanding of the functions of CFTR in the human brain...
  6. doi request reprint Expression and distribution of cystic fibrosis transmembrane conductance regulator in neurons of the spinal cord
    Yong Guo
    Department of Pathology, Peking University Health Science Center, Beijing, China
    J Neurosci Res 87:3611-9. 2009
    ..Its mutation causes cystic fibrosis. Our finding of abundant CFTR in the spinal cord suggests that this molecule may be significant in the normal function and pathology of the spinal cord...
  7. doi request reprint Expression and distribution of immunoglobulin G and its receptors in an immune privileged site: the eye
    Na Niu
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
    Cell Mol Life Sci 68:2481-92. 2011
    ....
  8. doi request reprint Neutrophils may be a vehicle for viral replication and dissemination in human H5N1 avian influenza
    Yingying Zhao
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    Clin Infect Dis 47:1575-8. 2008
    ..Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza...
  9. pmc Immunoglobulin g (IgG) expression in human umbilical cord endothelial cells
    Yingying Zhao
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    J Histochem Cytochem 59:474-88. 2011
    ..These results indicate that umbilical endothelial cells are capable of synthesizing IgG with properties similar to those of immune cells and that they may play additional roles besides lining the vessels and transporting IgG...
  10. ncbi request reprint The spleen as a target in severe acute respiratory syndrome
    Jun Zhan
    Department of Histology and Embryology, Peking University Health Science Center, Beijing, China
    FASEB J 20:2321-8. 2006
    ..On average, CD68+ macrophages were increased in size by 2.21-fold. We hypothesize that the collapse of the splenic immune system plays a key role in the clinical outcome of these patients...
  11. doi request reprint Expression and distribution of immunoglobulin G and its receptors in the human nervous system
    Na Niu
    Department of Pathology, Weifang Medical University, Weifang, Shandong Province 261042, China Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
    Int J Biochem Cell Biol 43:556-63. 2011
    ..Given the widespread expression of IgG and its receptors, IgG most likely has an important biological function in the nervous system and might be classified as an immune mediator involved in neuro-immune crosstalk...
  12. ncbi request reprint [Lung pathology and pathogenesis of severe acute respiratory syndrome: a report of six full autopsies]
    Fei Pei
    Department of Pathology, Peking University Health Science Center, Beijing, China
    Zhonghua Bing Li Xue Za Zhi 34:656-60. 2005
    ..The SARS-associated coronavirus (SARS-CoV) has been identified as the causal agent, but the pathology and pathogenesis are still not quite clear...
  13. ncbi request reprint Orchitis: a complication of severe acute respiratory syndrome (SARS)
    Jian Xu
    Department of Anatomy, School of Basic Medical Sciences, Peking University, Beijing 100083, China
    Biol Reprod 74:410-6. 2006
    ..Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients...
  14. ncbi request reprint Biosafety level 3 laboratory for autopsies of patients with severe acute respiratory syndrome: principles, practices, and prospects
    Ling Li
    Department of Pathology, Health Science Center, School of Basic Medical Sciences, Peking University, Beijing, China
    Clin Infect Dis 41:815-21. 2005
    ..The highly infectious nature of SARS coronavirus (SARS-CoV) compelled our pathologists to consider biosafety issues in the autopsy room and for tissue processing procedures...
  15. pmc CD117-positive cells of the heart: progenitor cells or mast cells?
    Yan Zhou
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    J Histochem Cytochem 58:309-16. 2010
    ..These results strongly suggest that the newly reported CD117(+)/CD45(dim/moderate) putative cardiac progenitor cells are mast cells. The significance of this observation in stem cell research of the heart is discussed...
  16. ncbi request reprint A feasibility study of virtual slides in surgical pathology in China
    Xinxia Li
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University Health Science Center, Beijing, 100083, China
    Hum Pathol 38:1842-8. 2007
    ..These results showed that this newly designed virtual microscope system have an acceptable diagnostic accuracy that is of practical value and may be suitable for application in China...
  17. ncbi request reprint An assessment of World Health Organization criteria for severe acute respiratory syndrome in patients with cancer
    Jin Gu
    Department of Surgical Oncology, School of Oncology, Peking University, Beijing, People s Republic of China
    Cancer 100:1374-8. 2004
    ....
  18. ncbi request reprint All-trans-retinoic acid induces cell growth arrest in a human medulloblastoma cell line
    Qing Chang
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University Health Science Center, 38 Xueyuan Road, Beijing, 100083, China
    J Neurooncol 84:263-7. 2007
    ..In conclusion, we have provided evidence for the first time that RA may induce cell cycle arrest in vitro in DAOY MB cells via inhibition of CyclinD1 or C-myc...
  19. doi request reprint Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)
    Lan Wei
    Department of Anatomy, Histology and Embryology, Health Science Center, Beijing University, Beijing, China
    Biochem Cell Biol 88:723-30. 2010
    ..It appears that changes in these endocrine cells and their hormones are affected by the severity of this new infectious disease...
  20. ncbi request reprint Autophagy induced by suberoylanilide hydroxamic acid in Hela S3 cells involves inhibition of protein kinase B and up-regulation of Beclin 1
    Qi Cao
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China
    Int J Biochem Cell Biol 40:272-83. 2008
    ....
  21. doi request reprint Cystic fibrosis transmembrane conductance regulator expression in human spinal and sympathetic ganglia
    Na Niu
    Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China
    Lab Invest 89:636-44. 2009
    ..Moreover, CFTR in ganglia may be associated with pathophysiological changes seen in cystic fibrosis...
  22. ncbi request reprint Quantitative morphometry by image analysis of normal, hyperplastic and cancerous ductal breasts
    Jie Gao
    Department of Pathology, School of Basic Medical Science, Peking University Health Science Center, Beijing, China
    Anal Quant Cytol Histol 31:255-61. 2009
    ....
  23. doi request reprint Off-Target Effects of c-MET Inhibitors on Thyroid Cancer Cells
    Yan Zhou
    Corresponding Authors Yan Zhou, Department of Pathology, School of Basic Medical Sciences, Peking Beijing University, Beijing, China
    Mol Cancer Ther 13:134-43. 2014
    ..Mol Cancer Ther; 13(1); 134-43. ©2013 AACR. ..
  24. doi request reprint Comparative Virus Replication and Host Innate Responses in Human Cells Infected with Three Prevalent Clades (2.3.4, 2.3.2, and 7) of Highly Pathogenic Avian Influenza H5N1 Viruses
    Honglei Sun
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
    J Virol 88:725-9. 2014
    ..3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4-infected macrophages caused the most severe cellular damage and strongest proinflammatory response. ..
  25. ncbi request reprint Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases
    Xueying Shi
    Department of Pathology, Peking University Health Science Center, Beijing, China
    Am J Gastroenterol 100:169-76. 2005
    ..Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease...
  26. doi request reprint Expression of cystic fibrosis transmembrane conductance regulator in ganglion cells of the hearts
    Peng Pan
    Department of Pathology, School of Basic Medical Sciences, Beijing University Health Science Center, Beijing, China
    Neurosci Lett 441:35-8. 2008
    ....
  27. ncbi request reprint [Gene detection of severe acute respiratory syndrome-related coronavirus]
    Bing Quan Wu
    Department of Pathology, Health Science Center, Peking University, Beijing 100083, China
    Zhonghua Bing Li Xue Za Zhi 32:212-4. 2003
    ..To develop a newly real-time RT-polymerase chain reaction assay for severe acute respiratory syndrome (SARS) related coronavirus in human whole blood...
  28. ncbi request reprint Immunoglobulin G expression in carcinomas and cancer cell lines
    Zhengshan Chen
    Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Rd, Haidian District, Beijing 100083, China
    FASEB J 21:2931-8. 2007
    ..These data suggest that cancer cells are capable of producing IgG. Because of its potential biological and clinical significance, this phenomenon warrants further investigation...
  29. ncbi request reprint SARS infection among health care workers in Beijing, China
    Liuyi Li
    JAMA 290:2662-3. 2003
  30. ncbi request reprint [Analysis of medical workers suffered from SARS]
    Liuyi Li
    Department of Infection Management, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 35:51-4. 2003
    ..To investigate the prevalence of SARS infection in medical workers and the efficacy of isolation precautions in the hospital...
  31. ncbi request reprint Acute immunodeficiency, multiple organ injury, and the pathogenesis of SARS
    Jiang Gu
    Appl Immunohistochem Mol Morphol 11:281-2. 2003
  32. pmc Molecular pathology in the lungs of severe acute respiratory syndrome patients
    Juxiang Ye
    Department of Pathology, Dean, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Rd, Beijing 100083, China
    Am J Pathol 170:538-45. 2007
    ..For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. In addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in SARS...
  33. ncbi request reprint [Pathologic study of circulating blood leukocytes in severe acute respiratory syndrome]
    Yan Feng Zhong
    Department of Pathology, Peking University Health Science Center, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 83:2137-41. 2003
    ..To study the pathologic characteristics and pathogenesis of circulating blood leucocytes infected by severe acute respiratory syndrome associated coronavirus (SARS CoV or SCV) in SARS patients...
  34. ncbi request reprint Pathogenetic mechanisms of severe acute respiratory syndrome
    Yong Guo
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University, 38 Xueyuan Road, 100083 Beijing, China
    Virus Res 133:4-12. 2008
    ..The implications of the proposed pathogenesis for prevention, diagnosis and therapy of the disease are discussed...
  35. ncbi request reprint [Expression of SARS-CoV in various types of cells in lung tissues]
    Yuan Lu
    Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100083, China
    Beijing Da Xue Xue Bao 37:453-7. 2005
    ..To investigate the cell types infected by severe acute respiratory syndrome-associated coronavirus (SARS-CoV) in lung tissues and explore the mechanism of lung injury in SARS...
  36. ncbi request reprint Development of a molecular screening test for hereditary hearing loss and genetic susceptibility to aminoglycoside toxicity for Chinese population
    Xi Yu He
    Department of Medical Genetics, College of Medicine, University of South Alabama, Mobile 36688, USA
    Beijing Da Xue Xue Bao 37:51-4. 2005
    ..Two common mutations, the 235delC in GJB2 gene and the mutation A1555G in mitochondrial DNA, are included in the newly developed screening panel for Chinese population...
  37. ncbi request reprint [Pathology and immunohistochemistry of thyroid in severe acute respiratory syndrome]
    Shen Sun
    Department of Histology and Embryology, Peking University Health Science Center, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 85:667-70. 2005
    ..To study the pathological characteristics of thyroid gland and the changes on hormone content of thyroid cells in severe acute respiratory syndrome (SARS) patients...
  38. ncbi request reprint Pathology of the thyroid in severe acute respiratory syndrome
    Lan Wei
    Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking Beijing University, 100083 Beijing, China
    Hum Pathol 38:95-102. 2007
    ..Apoptosis may play a role in the pathogenesis of SARS associated coronavirus infection in the thyroid gland...
  39. pmc Pathology, molecular biology, and pathogenesis of avian influenza A (H5N1) infection in humans
    Christine Korteweg
    Department of Pathology, School of Basic Medical Sciences, Infectious Disease Center, Peking Beijing University, 38 Xueyuan Rd, Beijing, China 100083
    Am J Pathol 172:1155-70. 2008
    ..A comprehensive appreciation of H5N1 influenza pathogenetic mechanisms should aid in the design of effective strategies for prevention, diagnosis, and treatment of this emerging disease...
  40. ncbi request reprint Assessment of diagnostic accuracy and feasibility of dynamic telepathology in China
    Xinxia Li
    Department of Pathology, Peking University Health Science Center, Beijing 100083, China
    Hum Pathol 39:236-42. 2008
    ....
  41. ncbi request reprint Avian influenza receptor expression in H5N1-infected and noninfected human tissues
    Lu Yao
    Department of Pathology, School of Basic Medical Sciences, Peking Beijing University, 38 Xueyuan Rd, 100083 Beijing, China
    FASEB J 22:733-40. 2008
    ..Finally, the relative lack of AIV-Rs in the upper airway may be a one of the factors preventing efficient human-to-human transmission of H5N1 influenza...
  42. pmc Pathology and pathogenesis of severe acute respiratory syndrome
    Jiang Gu
    Professor and Chairman, Department of Pathology, Dean, School of Medical Sciences, Director, Infectious Disease Center, Peking Beijing University, 38 Xueyuan Rd, 100083 Beijing, China
    Am J Pathol 170:1136-47. 2007
    ..It seems that both abnormal immune responses and injury to immune cells may be key factors in the pathogenesis of this new disease...