Min Chen

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi Antineutrophil cytoplasmic autoantibody-negative Pauci-immune crescentic glomerulonephritis
    Min Chen
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing 100034, P R China
    J Am Soc Nephrol 18:599-605. 2007
  2. pmc Epitope analysis of anti-myeloperoxidase antibodies in patients with ANCA-associated vasculitis
    Shen Ju Gou
    Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment Peking University, Ministry of Education, Beijing, China
    PLoS ONE 8:e60530. 2013
  3. pmc A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation
    Jian Hao
    Renal Division, Department of Medicine, Peking University, First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment Peking University, Ministry of Education, Peking Tsinghua Center for Life Sciences, Beijing, China
    PLoS ONE 8:e66305. 2013
  4. ncbi The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis
    Jian Hao
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China
    Rheumatology (Oxford) 53:300-6. 2014
  5. ncbi Clinical characteristics and outcomes of Chinese patients with cholesterol crystal embolism after coronary intervention
    Lei Meng
    Department of Cardiology, Peking University First Hospital, Beijing, PR China
    Clin Cardiol 29:503-5. 2006
  6. pmc The impact factor of rheumatology journals: an analysis of 2008 and the recent 10 years
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, 100034 Beijing, China
    Rheumatol Int 31:1611-5. 2011
  7. doi Circulating neutrophil gelatinase-associated lipocalin: a useful biomarker for assessing disease activity of ANCA-associated vasculitis
    Min Chen
    Department of Medicine, Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Rheumatology (Oxford) 48:355-8. 2009
  8. doi Severe pulmonary hemorrhage in patients with end-stage renal disease in antineutrophil cytoplasmic autoantibody-associated vasculitis
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China
    Am J Med Sci 337:411-4. 2009
  9. ncbi Follow-up of avidity and titre of anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis
    Ying Gao
    Department of Nephrology, Peking University First Hospital, Beijing, China
    Clin Endocrinol (Oxf) 66:543-7. 2007
  10. pmc Cross-reaction of anti-DNA autoantibodies with membrane proteins of human glomerular mesangial cells in sera from patients with lupus nephritis
    Hui Du
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing 100034, PR China
    Clin Exp Immunol 145:21-7. 2006

Collaborators

  • Ming Hui Zhao
  • Hai Yan Wang
  • Feng Yu
  • Peng Cheng Xu
  • Gang Liu
  • Ying Zhang
  • Jian Hao
  • Su xia Wang
  • Hong Zhang
  • Ying Gao
  • Cees G M Kallenberg
  • Huan Luo
  • Hui Du
  • Jun Zhang
  • Fei Gao
  • Fang Wang
  • Mei Wang
  • Lei Meng
  • Shen Ju Gou
  • Fu de Zhou
  • Guang qun Xing
  • Dong Yuan Chang
  • Xuna Zhao
  • Wei Lin
  • Peng Hu
  • Zhao ping Liu
  • Jun Yuan
  • Xu Jie Zhou
  • Zhao Cui
  • Xin Zheng
  • Wen Hui Ding
  • Yong Huo
  • Yan jun Gong
  • Li Bin Shi
  • Chunmei Li
  • Gang Xin
  • Xiao Na Wang
  • Zhi ying Li
  • Jicheng Lv
  • Chen Wang
  • Chen Zhang
  • Wan zhong Zou
  • Ying Li
  • Shuguang Hu
  • Yan Jin
  • Chaoliang Wei
  • Zhen Qu
  • Baoxi Wang
  • Jie E
  • Hong Ren
  • Kai Fu Tang
  • Li Tang
  • Ming Li Peng
  • Tao Su
  • Huai Dong Hu
  • Jian Wang
  • Jie Chen
  • Ying Tan
  • Min Cong
  • Li Jun Liu
  • Jie Jiang
  • Qian zhu Liu
  • Ai Hua Zhang
  • Juan Zhao
  • Chun rong Tan
  • De Shan Yu
  • Li Xia Xu
  • Xiaojie Luo
  • Kang Sheng Li
  • Cheng Zhou
  • Yun Su
  • Saying Li
  • Yihe Yang
  • Lijun Liu
  • Jing Chu Hu
  • Lu Xia Zhang
  • Zhiling Guo
  • Nan Chen
  • Cheng Liang Xiong
  • Xiao Liu
  • Caili Wang
  • Guang Qing Sun
  • Ze Song Li
  • Zhibo Wen
  • Sufang Shi
  • Shilong Lu
  • Hong Gang Li
  • Ri Na Sha
  • Wenfang Chen
  • Ya Qing Wang

Detail Information

Publications86

  1. ncbi Antineutrophil cytoplasmic autoantibody-negative Pauci-immune crescentic glomerulonephritis
    Min Chen
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing 100034, P R China
    J Am Soc Nephrol 18:599-605. 2007
    ..The renal survival was poorer in ANCA-negative patients than that in ANCA-positive ones (P < 0.05). ANCA-negative pauci-immune CrGN was not rare and might represent an independent disease entity from ANCA-positive vasculitis...
  2. pmc Epitope analysis of anti-myeloperoxidase antibodies in patients with ANCA-associated vasculitis
    Shen Ju Gou
    Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment Peking University, Ministry of Education, Beijing, China
    PLoS ONE 8:e60530. 2013
    ..The current study aimed to analyze the association between the linear epitopes of MPO-ANCA and clinicopathological features of patients with AAV...
  3. pmc A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation
    Jian Hao
    Renal Division, Department of Medicine, Peking University, First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment Peking University, Ministry of Education, Peking Tsinghua Center for Life Sciences, Beijing, China
    PLoS ONE 8:e66305. 2013
    ..The functional role of the second receptor of C5a, C5L2, remains unclear. In the current study, we investigated the role of C5L2 in C5a-primed neutrophils for ANCA-induced activation...
  4. ncbi The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis
    Jian Hao
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China
    Rheumatology (Oxford) 53:300-6. 2014
    ..19.4 (s.d. 4.66), P = 0.015; 63.2% vs. 25.8%, P = 0.002; 57.9% vs. 21.1%, P = 0.001, respectively]. Conclusion. Circulating anti-plasminogen antibodies were associated with systemic disease activity and renal disease activity of AAV. ..
  5. ncbi Clinical characteristics and outcomes of Chinese patients with cholesterol crystal embolism after coronary intervention
    Lei Meng
    Department of Cardiology, Peking University First Hospital, Beijing, PR China
    Clin Cardiol 29:503-5. 2006
    ..Cholesterol crystal embolism (CCE) is a complication of atherosclerosis. Vascular surgery, vascular angiography, and anticoagulation have been identified as inciting factors...
  6. pmc The impact factor of rheumatology journals: an analysis of 2008 and the recent 10 years
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, 100034 Beijing, China
    Rheumatol Int 31:1611-5. 2011
    ..Over the past 10 years, rheumatology journals showed a general increase in IF and rheumatology remained a leading discipline. For journals in the English language, those from Europe had an even higher increase than those from USA...
  7. doi Circulating neutrophil gelatinase-associated lipocalin: a useful biomarker for assessing disease activity of ANCA-associated vasculitis
    Min Chen
    Department of Medicine, Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Rheumatology (Oxford) 48:355-8. 2009
    ..The purpose of the current study is to investigate whether NGAL is a useful biomarker for assessing disease activity of patients with AAV...
  8. doi Severe pulmonary hemorrhage in patients with end-stage renal disease in antineutrophil cytoplasmic autoantibody-associated vasculitis
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China
    Am J Med Sci 337:411-4. 2009
    ..However, we encountered a few patients with ESRD suffering severe pulmonary hemorrhage caused by relapse of AAV. The current study presents our observation on these patients...
  9. ncbi Follow-up of avidity and titre of anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis
    Ying Gao
    Department of Nephrology, Peking University First Hospital, Beijing, China
    Clin Endocrinol (Oxf) 66:543-7. 2007
    ..The current study aimed to follow-up the avidity and titre of anti-MPO antibodies in sequential sera from patients with PTU-induced ANCA-associated systemic vasculitis (AASV)...
  10. pmc Cross-reaction of anti-DNA autoantibodies with membrane proteins of human glomerular mesangial cells in sera from patients with lupus nephritis
    Hui Du
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing 100034, PR China
    Clin Exp Immunol 145:21-7. 2006
    ..In conclusion, anti-DNA autoantibodies could cross-react directly with cell membrane proteins of human glomerular mesangial cells and might play an important role in the pathogenetic mechanism in lupus nephritis...
  11. ncbi Clinical and pathological features of renal involvement in propylthiouracil-associated ANCA-positive vasculitis
    Feng Yu
    Department of Nephrology, Peking University First Hospital, Beijing, PR China
    Am J Kidney Dis 49:607-14. 2007
    ..We present a series of Chinese patients with renal involvement in PTU-associated ANCA-positive vasculitis and describe their clinical and pathological characteristics...
  12. pmc Association of HLA genes with clinical outcomes of ANCA-associated vasculitis
    Dong Yuan Chang
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, and Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China
    Clin J Am Soc Nephrol 7:1293-9. 2012
    ..The HLA system plays a central role in the distinction between self antigens and non-self antigens. This study aimed to investigate the association between HLA genes and the outcomes of patients with ANCA-associated vasculitis (AAV)...
  13. doi Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis
    Shen Ju Gou
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China
    Kidney Int 83:129-37. 2013
    ..Thus, systemic activation of complement by the alternative pathway takes place in human AAV. Circulating Bb might be a useful biomarker in assessing disease activity of AAV...
  14. pmc p38MAPK, ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation
    Jian Hao
    Renal Division, Key Laboratory of Renal Disease, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Ministry of Health of China, Beijing, China
    PLoS ONE 7:e38317. 2012
    ..The current study further investigated the signaling pathways of C5a-mediated priming of human neutrophils for ANCA-induced neutrophil activation...
  15. ncbi Autoantibodies against glomerular mesangial cells and their target antigens in lupus nephritis
    Min Chen
    Renal Division, Institute of Nephrology, Peking University First Hospital, Beijing, P R China
    Ren Fail 27:507-13. 2005
    ..We speculated that autoantibodies against human glomerular mesangial cells might play a role in the development of lupus nephritis...
  16. doi Differential deposition of C4d and MBL in glomeruli of patients with ANCA-negative pauci-immune crescentic glomerulonephritis
    Guang qun Xing
    Renal Division, Department of Medicine, Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Peking University First Hospital, Peking University, Beijing, China
    J Clin Immunol 30:144-56. 2010
    ..This study was to investigate the evidence of complement activation in renal biopsy specimens of patients with ANCA-negative pauci-immune CrGN...
  17. doi Influence of myeloperoxidase-catalyzing reaction on the binding between myeloperoxidase and anti-myeloperoxidase antibodies
    Peng Cheng Xu
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Hum Immunol 73:364-9. 2012
    ..91 ± 0.84 vs 3.57 ± 0.84, p < 0.001, expressed as the lgT). These data demonstrated that MPO-catalyzing reaction could potentially increase the antigenicity of MPO...
  18. pmc Influence of variable domain glycosylation on anti-neutrophil cytoplasmic autoantibodies and anti-glomerular basement membrane autoantibodies
    Peng Cheng Xu
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China
    BMC Immunol 13:10. 2012
    ....
  19. ncbi Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener's granulomatosis
    Min Chen
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing 100034, PR China
    Nephrol Dial Transplant 22:139-45. 2007
    ..However, our previous study suggested that patients with MPO-ANCA positive WG were common in Chinese. This study aimed to analyse the renal histology of patients with MPO-ANCA positive WG...
  20. doi Urinary kidney injury molecule-1 in patients with IgA nephropathy is closely associated with disease severity
    Peng Cheng Xu
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Nephrol Dial Transplant 26:3229-36. 2011
    ..Urinary kidney injury molecule-1 (KIM-1) is a sensitive biomarker for proximal tubule injury. The aim of the study is to investigate the value of KIM-1 as a biomarker for assessing the renal injury in IgAN...
  21. ncbi Antineutrophil cytoplasmic autoantibodies in patients with systemic lupus erythematosus recognize a novel 69 kDa target antigen of neutrophil granules
    Min Chen
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, China
    Nephrology (Carlton) 10:491-5. 2005
    ..However, some ANCA-positive sera did not recognize either of them. The present study was to investigate the unknown target antigens of ANCA in patients with SLE and their clinical significance...
  22. doi High potential to reverse the inhibition of myeloperoxidase by ceruloplasmin of anti-myeloperoxidase autoantibodies of IgG3 subclass
    Peng Cheng Xu
    Renal Division, Department of Medicine, Peking University First Hospital, China
    Autoimmunity 45:218-25. 2012
    ..217). In conclusion, MPO-ANCA of IgG3 subclass might have stronger ability to reverse the inhibition of MPO by CP than other subclasses...
  23. doi Antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese patients
    Peng Cheng Xu
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    Clin Exp Nephrol 17:705-7. 2013
    ..Propylthiouracil is the leading cause of drug-induced AAV. The genetic background and immunological characteristics of ANCA, such as the epitope, IgG subclass and avidity, might contribute to various clinical phenotypes of AAV. ..
  24. doi Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody associated pauci-immune vasculitis
    Guang qun Xing
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China
    J Clin Immunol 29:282-91. 2009
    ..This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis...
  25. ncbi Clinical and pathological characteristics and outcomes of Chinese patients with primary anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis with immune complex deposition in kidney
    Feng Yu
    Department of Nephrology, Peking University First Hospital, Beijing, China
    Nephrology (Carlton) 12:74-80. 2007
    ..To analyse the clinical and pathological characteristics of Chinese patients with immune complex deposition in kidney in anti-neutrophil cytoplasmic antibodies (ANCA)-positive vasculitis...
  26. doi Antineutrophil cytoplasmic autoantibody-associated vasculitis in older patients
    Min Chen
    Department of Medicine, Peking University First Hospital, Beijing, China
    Medicine (Baltimore) 87:203-9. 2008
    ..Age and pulmonary infection were independent predictors of death...
  27. doi Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, Xicheng District, Beijing 100034, China
    Nat Rev Nephrol 8:476-83. 2012
    ..The duration of immunosuppressive therapy might be shorter than in primary AAV, depending on the severity of organ damage, and maintenance therapy is not always necessary...
  28. doi C-reactive protein enhances the respiratory burst of neutrophils-induced by antineutrophil cytoplasmic antibody
    Peng Cheng Xu
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China
    Mol Immunol 52:148-54. 2012
    ..So CRP can prime neutrophils and enhance the respiratory burst induced by ANCA and might be pathogenic in AAV...
  29. doi Higher DEFB4 genomic copy number in SLE and ANCA-associated small vasculitis
    Xu Jie Zhou
    Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, No 8 Xi Shi Ku Street, Xi Cheng District, Beijing 100034, China
    Rheumatology (Oxford) 51:992-5. 2012
    ..This study aims to investigate whether the DEFB4 genomic copy number variations associate with the susceptibility to these two autoimmune diseases...
  30. doi IgG subclass distribution, affinity of anti-myeloperoxidase antibodies in sera from patients with Wegener's granulomatosis and microscopic polyangiitis
    Li Jun Liu
    Renal Division, Department of Medicine Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Nephrology (Carlton) 13:629-35. 2008
    ..The aim of this study was to compare the immunological characteristics of MPO-ANCA in patients with WG and MPA...
  31. ncbi Association of circulating level of high mobility group box 1 with disease activity in antineutrophil cytoplasmic autoantibody-associated vasculitis
    Chen Wang
    Peking University First Hospital, Beijing, China
    Arthritis Care Res (Hoboken) 65:1828-34. 2013
    ..The current study aimed to investigate whether circulating HMGB-1 levels were associated with disease activity in AAV...
  32. doi ANCA-negative pauci-immune crescentic glomerulonephritis
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China
    Nat Rev Nephrol 5:313-8. 2009
    ..We also discuss the possible pathogenesis of ANCA-negative pauci-immune crescentic glomerulonephritis, paying particular attention to the mechanisms and role of neutrophil activation...
  33. ncbi Characteristics and outcome of Chinese patients with both antineutrophil cytoplasmic antibody and antiglomerular basement membrane antibodies
    Juan Zhao
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, PR China
    Nephron Clin Pract 107:c56-62. 2007
    ....
  34. doi Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma
    Peng Hu
    Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Mol Immunol 46:1654-62. 2009
    ..Together our data suggest that IL-27 and IL-23 may be two novel and attractive candidate agents to apply to cancer immunotherapy...
  35. doi Immunofixation electrophoresis was highly specific for the diagnosis of renal light-chain amyloidosis
    Fu de Zhou
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, and Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Am J Med Sci 345:18-21. 2013
    ..This study aimed to evaluate the sensitivity and specificity of serum and urine using immunofixation electrophoresis (IFE) in the diagnosis of renal AL amyloidosis in patients older than 40 years...
  36. doi Comparison of characteristics of natural autoantibodies against myeloperoxidase and anti-myeloperoxidase autoantibodies from patients with microscopic polyangiitis
    Peng Cheng Xu
    Department of Medicine, Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Rheumatology (Oxford) 50:1236-43. 2011
    ..Natural autoantibodies (NAAs) against MPO exist in normal human plasma. In the current study, the immune characteristics of MPO-NAA and MPO-ANCA were examined and compared with the aim to investigate the pathogenesis of MPO-ANCA...
  37. pmc The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients
    Huan Luo
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing 100034, China
    BMC Nephrol 12:21. 2011
    ..The present study further analyzed the association between anti-GBM disease and HLA-DQB1, -DQA1, and -DPB1 genes. Apart from this, we tried to locate the potential risk amino acid residues of anti-GBM disease...
  38. doi Detection of prostate cancer in peripheral zone: comparison of MR diffusion tensor imaging, quantitative dynamic contrast-enhanced MRI, and the two techniques combined at 3.0 T
    Chunmei Li
    Department of Radiology, Beijing Hospital of the Ministry of Health, Beijing, China
    Acta Radiol 55:239-47. 2014
    ..However, the efficacy of combined DTI and quantitative DCE-MRI in detecting prostate cancer at 3.0 T is still indeterminate...
  39. pmc Prediction of outcomes in crescentic IgA nephropathy in a multicenter cohort study
    Jicheng Lv
    Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    J Am Soc Nephrol 24:2118-25. 2013
    ..In conclusion, crescentic IgAN has a poor prognosis, and initial SCr concentration may predict kidney failure in patients with this disease. ..
  40. doi Predictors for outcomes in patients with severe ANCA-associated glomerulonephritis who were dialysis-dependent at presentation: a study of 89 cases in a single Chinese center
    Zhi ying Li
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    Semin Arthritis Rheum 42:515-21. 2013
    ..The current study investigated factors associated with restoration of renal function and early mortality in patients with severe ANCA-associated glomerulonephritis, i.e. dialysis-dependent at presentation, in a single Chinese cohort...
  41. ncbi Anti-endothelial cell antibodies in antineutrophil cytoplasmic antibodies negative pauci-immune crescentic glomerulonephritis
    Min Cong
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Nephrology (Carlton) 13:228-34. 2008
    ..The purpose of this study is to investigate the prevalence of AECA and their possible clinical significance in ANCA-negative pauci-immune CrGN...
  42. doi Involvement of protein kinase C in C5a-primed neutrophils for ANCA-mediated activation
    Jian Hao
    Renal Division, Department of Medicine, Peking University, First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment Peking University, Ministry of Education, Peking Tsinghua Center for Life Sciences, Beijing 100034, China
    Mol Immunol 54:68-73. 2013
    ..5 in untreated cells to 1071.3±81.3 after C5a treatment and decreased to 827.3±48.1 by BIS (P<0.05). Activation of PKC is an important step in the translocation of ANCA antigens and C5a-induced activation of neutrophils by ANCA...
  43. doi The renal histopathological spectrum of patients with nephrotic syndrome: an analysis of 1523 patients in a single Chinese centre
    Fu de Zhou
    Department of Medicine, Peking University First Hospital, People s Republic of China
    Nephrol Dial Transplant 26:3993-7. 2011
    ..Nephrotic syndrome is caused by a variety of glomerulopathy. The current study investigated the renal histopathological spectrum of patients with nephrotic syndrome who received a renal biopsy in our department within the last 15 years...
  44. ncbi Autoantibodies against monomeric C-reactive protein in sera from patients with lupus nephritis are associated with disease activity and renal tubulointerstitial lesions
    Ying Tan
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, and Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Hum Immunol 69:840-4. 2008
    ..276), interstitial fibrosis (r = 0.211), and chronicity index score (r = 0.243). Autoantibodies against mCRP are prevalent in patients with lupus nephritis and are associated with disease activity and renal tubulointerstitial lesions...
  45. ncbi The immunopathological spectrum of crescentic glomerulonephritis: a survey of 106 patients in a single Chinese center
    Wei Lin
    Renal Division, Department of Medicine, Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Peking University First Hospital, Peking University, Beijing, China
    Nephron Clin Pract 116:c65-74. 2010
    ..Crescentic glomerulonephritis (CrGN) is a severe form of glomerular injury. We retrospectively analyzed data from Chinese patients with CrGN in our center to characterize the immunopathological spectrum of CrGN...
  46. doi Renal neutrophils infiltration in antineutrophil cytoplasmic antibodies-negative pauci-immune crescentic glomerulonephritis
    Guang qun Xing
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    Am J Med Sci 340:474-80. 2010
    ....
  47. ncbi Neutrophil degranulation in antineutrophil cytoplasmic antibody-negative pauci-immune crescentic glomerulonephritis
    Fang Wang
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
    J Nephrol 22:491-6. 2009
    ..This study aims to investigate the evidence for neutrophil activation and degranulation at disease presentation in patients with renal biopsy-proven ANCA-negative pauci-immune CrGN...
  48. doi Follow-up of avidity and titer of anti-myeloperoxidase antibodies in sera from patients with primary ANCA-associated vasculitis
    Wei Lin
    Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Ministry of Health of China, Beijing, People s Republic of China
    Autoimmunity 42:198-202. 2009
    ..Avidity and titer of MPO-ANCA did not decreased significantly during remission in AAV, indicating the chronic repeated antigen stimulation was not removed, which might be the reason for recurrent relapses...
  49. doi Complement deposition in renal histopathology of patients with ANCA-associated pauci-immune glomerulonephritis
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China
    Nephrol Dial Transplant 24:1247-52. 2009
    ..The current study investigated the clinical and pathological significance of complement deposition in renal histopathology of patients with ANCA-associated pauci-immune glomerulonephritis...
  50. ncbi Serum B-cell activating factor in myeloperoxiase-antineutrophil cytoplasmic antibodies-associated vasculitis
    Gang Xin
    Department of Microbiology and Immunology GX, YS, K SL, Shantou University Medical College, Shantou, Guangdong, People s Republic of China Renal Division MC, m hz, Peking University First Hospital, Beijing, People s Republic of China and Department of Nephrology L XX, Guangdong General Hospital, Guangzhou, Guangdong, People s Republic of China
    Am J Med Sci 348:25-9. 2014
    ....
  51. ncbi [An analysis of multi-system involvement and renal pathology of anti-neutrophil cytoplasmic autoantibodies-related vasculitis]
    Min Chen
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing 100034, China
    Zhonghua Nei Ke Za Zhi 44:828-31. 2005
    ..To analyze the clinical and pathological characteristics of anti-neutrophil cytoplasmic autoantibodies (ANCA) associated systemic vasculitis (AASV)...
  52. doi Molecular cloning, expression and characterization of an interleukin 27 p28 homolog in pig (Sus scrofa)
    Peng Hu
    Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, The Second Affiliated Hospital, Chongqing Medical University, 74 Linjiang Road, Chongqing, China
    Vet Immunol Immunopathol 130:262-7. 2009
    ..The analysis also confirmed a cross reactivity with anti-mouse IL-27 p28 antibody. This is the first report of cloning and characterization of IL-27 p28 in pig...
  53. doi Flickering calcium microdomains signal turning of migrating cells
    Chaoliang Wei
    Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China
    Can J Physiol Pharmacol 88:105-10. 2010
    ..Furthermore, we present a new model for patterned calcium flicker activity as the mechanism for steering the turning of a migrating cell...
  54. pmc C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
    Jun Yuan
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China
    Arthritis Res Ther 14:R140. 2012
    ..In particular, C5a plays a central role. In this study, plasma and urinary levels of C5a as well as renal C5a receptors (CD88 and C5L2) expression were investigated in patients with AAV...
  55. ncbi [Anti-mesangial cell autoantibodies and their target antigens in lupus nephritis]
    Min Chen
    Renal Division, The First Hospital and Institute of Nephrology, Peking University, Beijing 100034, China
    Zhonghua Nei Ke Za Zhi 42:851-3. 2003
    ..The aim of the current study was to identify anti-MC autoantibodies in sera from patients with lupus nephritis (LN)...
  56. ncbi The target antigens of antineutrophil cytoplasmic antibodies (ANCA) induced by propylthiouracil
    Ying Gao
    Department of Nephrology, Peking University First Hospital, Beijing 100034, PR China
    Int Immunopharmacol 7:55-60. 2007
    ..The aim of the current study was to detect ANCA specificities in sera from patients with PTU-induced ANCA with and without clinical vasculitis...
  57. ncbi Non-DNA-binding antibodies in patients with lupus nephritis could recognize membrane proteins of glomerular mesangial cells
    Hui Du
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, 100034, People s Republic of China
    J Clin Immunol 26:138-44. 2006
    ..Although the target antigens might not be cell specific, the roles of these autoantibodies in the pathogenesis of lupus nephritis need further investigation...
  58. doi Normoalbuminaemia is associated with IgA nephropathy in primary glomerulopathy with nephrotic-range proteinuria in Chinese patients
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China
    Nephrol Dial Transplant 26:1247-52. 2011
    ..However, patients may have normal levels of serum albumin despite heavy proteinuria in many circumstances. This study analysed factors affecting serum levels of albumin in primary glomerulopathy patients with nephrotic-range proteinuria...
  59. doi Influence of myeloperoxidase by anti-myeloperoxidase antibodies and its association with the disease activity in microscopic polyangiitis
    Peng Cheng Xu
    Department of Medicine, Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
    Rheumatology (Oxford) 49:2068-75. 2010
    ..This study investigated potential associations between the influence of MPO-ANCA on the oxidation activity of MPO and the clinical manifestations as well as immunological characteristics of MPO-ANCA...
  60. ncbi Characteristics of Chinese patients with Wegener's granulomatosis with anti-myeloperoxidase autoantibodies
    Min Chen
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, People s Republic of China
    Kidney Int 68:2225-9. 2005
    ..However, Chinese patients with MPO-ANCA positive WG were frequently diagnosed. We now analyze the characteristics of patients with MPO-ANCA positive WG and investigate the difference between patients with MPO-ANCA and PR3-ANCA...
  61. ncbi Relapses in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis: likely to begin with the same organ as initial onset
    Min Chen
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    J Rheumatol 35:448-50. 2008
    ..In antineutrophil cytoplasmic antibody-associated vasculitis (AAV), relapses constitute a challenge despite initial good control. Our objective was to investigate whether patients with relapses shared the same initial organ involvement...
  62. ncbi Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis: a study of 121 patients in a single center
    Dong Yuan Chang
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    Nephrol Dial Transplant 27:2343-9. 2012
    ..This study aims to re-evaluate the new classification for its prognostic capacity in an independent Chinese series...
  63. ncbi Clinical and pathological features of renal amyloidosis: an analysis of 32 patients in a single Chinese centre
    Zhen Qu
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Nephrology (Carlton) 15:102-7. 2010
    ..To summarize the clinical and pathological features of renal amyloidosis in order to achieve early diagnosis...
  64. ncbi [Inhibition of oxidative activity of myeloperoxidase by anti-myeloperoxidase antibodies from patients with microscopic polyangiitis]
    Jie Chen
    Renal Division, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 40:155-9. 2008
    ....
  65. ncbi Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis
    Ai Hua Zhang
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing 100034, PR China
    Clin Immunol 122:187-93. 2007
    ..In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPO-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis...
  66. doi The association of HLA-DRB1 alleles with antineutrophil cytoplasmic antibody-associated systemic vasculitis in Chinese patients
    Huan Luo
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    Hum Immunol 72:422-5. 2011
    ..HLA-DRB1*1202 was prevalent among patients with PR3-ANCA-positive WG...
  67. doi ANCA-associated vasculitides--advances in pathogenesis and treatment
    Min Chen
    Renal Division, Peking University First Hospital, Beijing 100034, China
    Nat Rev Rheumatol 6:653-64. 2010
    ..Controlled trials in which specific immune effector cells and molecules are being therapeutically targeted have been initiated or are currently being planned...
  68. ncbi Characterization of anti-mesangial cell antibodies and their target antigens in patients with lupus nephritis
    Hui Du
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, 100034, PR China
    J Clin Immunol 25:281-7. 2005
    ..Anti-mesangial cell antibodies might play some role in the pathogenesis of lupus nephritis(LN)...
  69. ncbi [The clinical features and outcomes of immunoglobulin light-chain amyloidosis with heart involvement]
    Lei Meng
    Department of Cardiology, Peking University First Hospital, Beijing 100034, China
    Zhonghua Xin Xue Guan Bing Za Zhi 35:340-3. 2007
    ..To analyze the clinical features and outcomes of patients with immunoglobulin light-chain amyloidosis (AL) who had heart involvement...
  70. pmc The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans
    Xiao Na Wang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 9:e1003645. 2013
    ..Our findings suggest that Wt1 is important in spermatogenesis by regulating the polarity of SCs via Wnt signaling pathway and that WT1 mutation is one of the genetic causes of NOA in humans. ..
  71. ncbi Invasive pulmonary aspergillosis in patients with antineutrophil cytoplasmic antibody associated vasculitis
    Tao Su
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
    J Clin Rheumatol 15:380-2. 2009
    ..We retrospectively analyze the clinical characteristics of our patients with IPA in AAV...
  72. ncbi [Serological antibodies comparison of a hepatitis E outbreak]
    Chun rong Tan
    Department of Clinical Laboratory, Beijing Shi Ji Tan Hospital, Beijing, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 19:35-8. 2005
    ..To compare the serological characters of an outbreak of hepatitis E and evaluate sensitivity and specificity of anti-HEV E2-IgM...
  73. doi Plasma catecholamine release-inhibitory peptide catestatin in patients with essential hypertension
    Lei Meng
    Department of Cardiology, Peking University First Hospital, Beijing, People s Republic of China
    J Cardiovasc Med (Hagerstown) 12:643-7. 2011
    ..Catestatin plays an important role in the adjustment of blood pressure and cardiac function. We investigated levels of plasma catestatin in essential hypertension and the relationship between catestatin and left ventricular hypertrophy...
  74. pmc Three-dimensional turbo-spin-echo amide proton transfer MR imaging at 3-Tesla and its application to high-grade human brain tumors
    Xuna Zhao
    Philips Healthcare, Beijing, China
    Mol Imaging Biol 15:114-22. 2013
    ..In this study, we demonstrate the feasibility of applying a turbo-spin-echo (TSE)-based, three-dimensional (3D) APT sequence into routine clinical practice for patients with brain tumors...
  75. ncbi Improving the management of anemia in hemodialysis patients by implementing the continuous quality improvement program
    Min Chen
    Renal Division and Institute of Nephrology, Peking University First Hospital, Beijing, China
    Blood Purif 24:282-6. 2006
    ..The aim of this study is to improve anemia management in chronic hemodialysis patients using CQI...
  76. ncbi Effects of acupuncture therapy on abdominal fat and hepatic fat content in obese children: a magnetic resonance imaging and proton magnetic resonance spectroscopy study
    Hong Zhang
    Department of Radiology, Beijing Hospital, No 1 Dahua Road, Dongcheng, Beijing, China
    J Altern Complement Med 17:413-20. 2011
    ..The aim of this study was to use magnetic resonance imaging (MRI) together with proton magnetic resonance spectroscopy ((1)H-MRS) to study the influence of acupuncture therapy on abdominal fat and hepatic fat content in obese children...
  77. doi Measles outbreak on a college campus transmitted through internet cafés
    Yan Jin
    Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing, China
    J Infect Dis 204:S471-5. 2011
    ..During March 2008, a college in Urumqi, capital of Xinjiang Uygur Autonomous Region in China, reported a measles outbreak, amid a city-wide outbreak involving >2700 cases...
  78. doi Tacrolimus combined with corticosteroids in treatment of nephrotic idiopathic membranous nephropathy: a multicenter randomized controlled trial
    Min Chen
    Department of Nephrology, Peking University First Hospital, Beijing, China
    Am J Med Sci 339:233-8. 2010
    ..However, the effectiveness of tacrolimus versus classic regimen and its potential nephrotoxicity remain inconclusive. This study evaluated the efficacy and safety of tacrolimus plus prednisone in patients with nephrotic IMN...
  79. ncbi [Cardiovascular events in patients with chronic kidney disease]
    Lei Meng
    Department of Cardiology, Peking University First Hospital, Beijing 100034, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:53-5. 2009
    ..Cardiovascular event is common and is an important cause of death for patients with chronic kidney disease (CKD). The purpose of current study is to analyze the related risk factors of cardiovascular event in patients with CKD...
  80. ncbi [Antigens of antineutrophil cytoplasmic autoantibodies in recognizing a novel neutrophil granule antigen in lupus nephritis and its association with photosensitivity and oral ulceration]
    Min Chen
    Renal Division, The First Hospital and Institute of Nephrology, Peking University, Beijing 100034, China
    Zhonghua Nei Ke Za Zhi 41:766-8. 2002
    ..To investigate whether there are some unknown target antigens of antineutrophil cytoplasmic autoantibodies (ANCA) in patients with lupus nephritis (LN) and the prevalence and the clinical significance of these unknown target antigens...
  81. pmc Use acupuncture to treat functional constipation: study protocol for a randomized controlled trial
    Ying Li
    Chengdu University of Traditional Chinese Medicine, and First Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
    Trials 13:104. 2012
    ..Whether acupuncture is effective for patients with functional constipation is still unclear. Therefore, we report the protocol of a randomized controlled trial of using acupuncture to treat functional constipation...
  82. doi Gamma-secretase gene mutations in familial acne inversa
    Baoxi Wang
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College CAMS PUMC, Beijing, China
    Science 330:1065. 2010
    ....
  83. doi Brain natriuretic peptide rs198388 polymorphism and essential hypertension in Hunan Han people
    Min Chen
    Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:1207-13. 2010
    ..To investigate the relation between brain natriuretic peptide (BNP) rs198388 polymorphism and the susceptibility of essential hypertension in Han population of Hunan...
  84. doi Experimental evaluation of dual acceptance window weighting function for right coronary MR angiography at 3.0T
    Xuna Zhao
    Institute of Heavy Ion Physics, Beijing Key Laboratory of Medical Physics and Engineering, Physics School, Peking University, Beijing 100871, China
    Magn Reson Imaging 28:797-801. 2010
    ....
  85. ncbi [The effect of different loading doses of clopidogrel on platelet aggregation]
    Qian zhu Liu
    Department of Cardiology, Peking University First Hospital, Beijing 100034, China
    Zhonghua Nei Ke Za Zhi 46:107-10. 2007
    ..To compare the short-term efficacy and safety of high loading dose (600 mg) clopidogrel treatment with those of routine loading dose (300 mg) in patients with acute coronary syndrome and provide evidence for planning clopidogrel treatment...
  86. ncbi [Sero-epidemiological characteristics of antibody to SARS-associated coronavirus in Gansu Province]
    De Shan Yu
    Department of Acute Infectious Disease Control and Prevention, Gansu Centers for Disease Control and Prevention, Lanzhou 730000, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 18:325-7. 2004
    ..To study the levels of SARS-associated coronavirus IgG antibody of SARS patients, people who closely contacted SARS patients and normal subjects in Gansu province...