Ren Y, Zhang H, Pan B, Yan C. A Kazal-type serine proteinase inhibitor from Cyclina sinensis is involved in immune response and signal pathway initiation. Fish Shellfish Immunol. 2015;47:110-6 pubmed publisher
..anguillarum in vitro. Hence, we propose that CsKPI plays an important role in the innate immunity and mediates TLR2 and MyD88-dependent pathway initiation in C. sinensis. ..
Ren Y, Pan H, Pan B, Bu W. Identification and functional characterization of three TLR signaling pathway genes in Cyclina sinensis. Fish Shellfish Immunol. 2016;50:150-9 pubmed publisher
..01) after injection with CsMyD88 RNAi. These findings might be valuable for understanding the innate immune signaling pathways of C. sinensis and enabling future studies on host-pathogen interactions. ..
Gao S, Ren Y, Zhang H, Pan B, Gao H. Identification and expression analysis of I?B and NF-?B genes from Cyclina sinensis. Fish Shellfish Immunol. 2016;56:427-435 pubmed publisher
..These results collectively indicated that the NF-?B signaling pathway, including CsI?B and CsNF-?B genes, might be involved in early innate immune responses and may be regulated by a MyD88-dependent signaling pathway in C. sinensis. ..
Ren Y, Pan H, Yang Y, Pan B, Bu W. Molecular cloning, characterization and functional analysis of a heat shock protein 70 gene in Cyclina sinensis. Fish Shellfish Immunol. 2016;58:663-668 pubmed publisher
..01). The results indicated that CsHSP70 could play an important role in mediating the environmental stress and immune responses, and regulating TLR signaling pathway in C. sinensis. ..
Ren Y, Ding D, Pan B, Bu W. The TLR13-MyD88-NF-?B signalling pathway of Cyclina sinensis plays vital roles in innate immune responses. Fish Shellfish Immunol. 2017;70:720-730 pubmed publisher
..sinensis. These findings collectively lay the foundation for studying the functional characterization of internal signalling factors and establishing a regulatory network for the TLR signalling pathway in molluscs. ..