Gao Y, Liu C, Wan G, Wang X, Cheng X, Ou Y. Phycocyanin prevents methylglyoxal-induced mitochondrial-dependent apoptosis in INS-1 cells by Nrf2. Food Funct. 2016;7:1129-37 pubmed publisher
..Altogether, these results demonstrated that PC prevented mitochondrial-dependent apoptosis in MG-induced INS-1 cells and the effect was associated with Nrf2 activation. ..
Ou Y, Lin L, Yang X, Pan Q, Cheng X. Antidiabetic potential of phycocyanin: effects on KKAy mice. Pharm Biol. 2013;51:539-44 pubmed publisher
..Therefore, PC may have a potential clinical utility in combating type-2 diabetes. ..
Ou Y, Yuan Z, Li K, Yang X. Phycocyanin may suppress D-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways. Toxicol Lett. 2012;215:25-30 pubmed publisher
Gao Y, Liao G, Xiang C, Yang X, Cheng X, Ou Y. Effects of phycocyanin on INS-1 pancreatic Î²-cell mediated by PI3K/Akt/FoxO1 signaling pathway. Int J Biol Macromol. 2016;83:185-94 pubmed publisher
..In conclusion, PC was capable to protect INS-1 pancreatic Î²-cell against MG-induced cell dysfunction through modulating PI3K/Akt pathway and the downstream FoxO1. ..
Ou Y, Ren Z, Wang J, Yang X. Phycocyanin ameliorates alloxan-induced diabetes mellitus in mice: Involved in insulin signaling pathway and GK expression. Chem Biol Interact. 2016;247:49-54 pubmed publisher
..The results suggest that phycocyanin ameliorates alloxan-induced diabetes mellitus in mice by activating insulin signaling pathway and GK expression in pancreas and liver in diabetic mice. ..
Zhu L, Zhang F, Yang L, Ge Y, Wei Q, Ou Y. EPSAH, an exopolysaccharide from Aphanothece halophytica GR02, improves both cellular and humoral immunity as a novel polysaccharide adjuvant. Chin J Nat Med. 2016;14:541-8 pubmed publisher
..These results indicated that EPSAH had a strong potential to increase both cellular and humoral immune responses, particularly promoting the development of Th1 polarization. ..
Ou Y, Liao G, Yuan Z, Wu W. Protective effect of recombinant hirudin variant III against galactose-mediated rat lens epithelial cell damage. Curr Eye Res. 2012;37:187-94 pubmed publisher
..In addition, rHV3 may be able to inhibit apoptosis of lens epithelial cells through the mitochondrial pathways of apoptosis by regulating Bcl-2 and Bax expression. ..