Ting Jun Fan
Affiliation: Ocean University of China
Fan W, Sui Y, Fan T. Proparacaine induces cytotoxicity and mitochondria-dependent apoptosis in corneal stromal cells both in vitro and in vivo. Toxicol Res (Camb). 2016;5:1434-1444 pubmed publisher
..These results suggest that PPC above 1/32 of its clinical dosage has remarkable cytotoxicity to corneal stromal cells, which is achieved by inducing death receptor-mediated mitochondria-dependent apoptosis of HCS cells. ..
Diao J, Pang X, Qiu Y, Miao Y, Yu M, Fan T. Construction of a human corneal stromal equivalent with non-transfected human corneal stromal cells and acellular porcine corneal stromata. Exp Eye Res. 2015;132:216-24 pubmed publisher
..The constructed TE-HCS has promising potentials in regenerative medicine and treatment of diseases caused by corneal stromal disorders. ..
Fan T, Zhao J, Ma X, Xu X, Zhao W, Xu B. Establishment of a continuous untransfected human corneal endothelial cell line and its biocompatibility to denuded amniotic membrane. Mol Vis. 2011;17:469-80 pubmed
..The cell line, with excellent biocompatibility to dAM, might be used for in vitro reconstruction of HCE and provides a promising method for the treatment of diseases caused by corneal endothelial disorders. ..
Fan T, Zhao J, Hu X, Ma X, Zhang W, Yang C. Therapeutic efficiency of tissue-engineered human corneal endothelium transplants on rabbit primary corneal endotheliopathy. J Zhejiang Univ Sci B. 2011;12:492-8 pubmed publisher
..The TE-HCE functions normally as an endothelial barrier and pump and promises to be an equivalent of HCE for clinical therapy of human PCEP. ..
Xu B, Zhao J, Jing Z, Zhang Y, Shi Y, Fan T. Role of hemoglobin from blood clam Scapharca kagoshimensis beyond oxygen transport. Fish Shellfish Immunol. 2015;44:248-56 pubmed publisher
Tian C, Wen Q, Fan T. Cytotoxicity of atropine to human corneal epithelial cells by inducing cell cycle arrest and mitochondrion-dependent apoptosis. Exp Toxicol Pathol. 2015;67:517-24 pubmed publisher
..Taken together, our results suggest that atropine has remarkable cytotoxicity to HCEP cells by inducing cell cycle arrest and death receptor-mediated mitochondrion-dependent apoptosis. ..
Shan M, Fan T. Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway. Toxicol In Vitro. 2016;35:36-42 pubmed publisher
Zhao J, Qiu Y, Tian C, Fan T. The cytotoxic and pro-apoptotic effects of phenylephrine on corneal stromal cells via a mitochondrion-dependent pathway both in vitro and in vivo. Exp Toxicol Pathol. 2016;68:409-17 pubmed publisher
Xu B, Zhang Y, Jing Z, Fan T. Molecular characteristics of hemoglobins in blood clam and their immune responses to bacterial infection. Int J Biol Macromol. 2017;99:375-383 pubmed publisher