Ting Jun Fan


Affiliation: Ocean University of China
Country: China


  1. Fan W, Sui Y, Fan T. Proparacaine induces cytotoxicity and mitochondria-dependent apoptosis in corneal stromal cells both in vitro and in vivo. Toxicol Res (Camb). 2016;5:1434-1444 pubmed publisher
    ..These results suggest that PPC above 1/32 of its clinical dosage has remarkable cytotoxicity to corneal stromal cells, which is achieved by inducing death receptor-mediated mitochondria-dependent apoptosis of HCS cells. ..
  2. Diao J, Pang X, Qiu Y, Miao Y, Yu M, Fan T. Construction of a human corneal stromal equivalent with non-transfected human corneal stromal cells and acellular porcine corneal stromata. Exp Eye Res. 2015;132:216-24 pubmed publisher
    ..The constructed TE-HCS has promising potentials in regenerative medicine and treatment of diseases caused by corneal stromal disorders. ..
  3. Fan T, Zhao J, Ma X, Xu X, Zhao W, Xu B. Establishment of a continuous untransfected human corneal endothelial cell line and its biocompatibility to denuded amniotic membrane. Mol Vis. 2011;17:469-80 pubmed
    ..The cell line, with excellent biocompatibility to dAM, might be used for in vitro reconstruction of HCE and provides a promising method for the treatment of diseases caused by corneal endothelial disorders. ..
  4. Fan T, Zhao J, Hu X, Ma X, Zhang W, Yang C. Therapeutic efficiency of tissue-engineered human corneal endothelium transplants on rabbit primary corneal endotheliopathy. J Zhejiang Univ Sci B. 2011;12:492-8 pubmed publisher
    ..The TE-HCE functions normally as an endothelial barrier and pump and promises to be an equivalent of HCE for clinical therapy of human PCEP. ..
  5. Xu B, Zhao J, Jing Z, Zhang Y, Shi Y, Fan T. Role of hemoglobin from blood clam Scapharca kagoshimensis beyond oxygen transport. Fish Shellfish Immunol. 2015;44:248-56 pubmed publisher
  6. Tian C, Wen Q, Fan T. Cytotoxicity of atropine to human corneal epithelial cells by inducing cell cycle arrest and mitochondrion-dependent apoptosis. Exp Toxicol Pathol. 2015;67:517-24 pubmed publisher
    ..Taken together, our results suggest that atropine has remarkable cytotoxicity to HCEP cells by inducing cell cycle arrest and death receptor-mediated mitochondrion-dependent apoptosis. ..
  7. Shan M, Fan T. Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway. Toxicol In Vitro. 2016;35:36-42 pubmed publisher
  8. Zhao J, Qiu Y, Tian C, Fan T. The cytotoxic and pro-apoptotic effects of phenylephrine on corneal stromal cells via a mitochondrion-dependent pathway both in vitro and in vivo. Exp Toxicol Pathol. 2016;68:409-17 pubmed publisher
  9. Xu B, Zhang Y, Jing Z, Fan T. Molecular characteristics of hemoglobins in blood clam and their immune responses to bacterial infection. Int J Biol Macromol. 2017;99:375-383 pubmed publisher

More Information


  1. Fan T, Wang D, Zhao J, Wang J, Fu Y, Guo R. Establishment and characterization of a novel untransfected corneal endothelial cell line from New Zealand white rabbits. Mol Vis. 2009;15:1070-8 pubmed
    ..To establish and characterize a novel untransfected corneal endothelial cell line from New Zealand white rabbits (NRCE cell line) for studies on corneal endothelial cells...
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    Fan T, Wang J, Yuan W, Zhong Q, Shi Y, Cong R. Purification and characterization of hatching enzyme from brine shrimp Artemia salina. Acta Biochim Biophys Sin (Shanghai). 2010;42:165-71 pubmed
    ..Besides of these, AHE was also sensitive to EDTA and Zn21. Combined with the results that the EDTA-pre-treated HE activity could be perfectly recovered by Zn21, it is indicated that AHE might be also a kind of Zn-metalloprotease...
  3. Wen Q, Fan T, Tian C. Cytotoxicity of atropine to human corneal endothelial cells by inducing mitochondrion-dependent apoptosis. Exp Biol Med (Maywood). 2016;241:1457-65 pubmed publisher
    ..Our findings provide new insights into the cytotoxicity and apoptosis-inducing effect of atropine which should be used with great caution in eye clinic. ..