Hui Xu

Summary

Affiliation: Northwest A and F University
Country: China

Publications

  1. ncbi request reprint Combinatorial synthesis of benzimidazole-azo-phenol derivatives as antifungal agents
    Yazhen Ke
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Comb Chem High Throughput Screen 17:89-95. 2014
  2. ncbi request reprint Progress of bis(heteroaryl)piperazines (BHAPs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) against human immunodeficiency virus type 1 (HIV-1)
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, P R China
    Mini Rev Med Chem 10:62-72. 2010
  3. ncbi request reprint Antifungal activities of some indole derivatives
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, PR China
    Z Naturforsch C 65:437-9. 2010
  4. ncbi request reprint Developments of indoles as anti-HIV-1 inhibitors
    Hui Xu
    Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, P R China
    Curr Pharm Des 15:2120-48. 2009
  5. doi request reprint Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Bioorg Med Chem Lett 20:7274-7. 2010
  6. doi request reprint Natural products-based insecticidal agents 9. Design, semisynthesis and insecticidal activity of 28-acyloxy derivatives of toosendanin against Mythimna separata Walker in vivo
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 21:1974-7. 2011
  7. doi request reprint Semisynthesis and quantitative structure-activity relationship (QSAR) study of novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin as insecticidal agents
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Life Sciences, Northwest A and F University, Yangling 712100, Shannxi Province, People s Republic of China
    J Agric Food Chem 57:7919-23. 2009
  8. doi request reprint Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 21:5177-80. 2011
  9. doi request reprint Antifungal agents. Part 3: synthesis and antifungal activities of 3-acylindole analogs against phytopathogenic fungi in vitro
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Chem Biol Drug Des 78:864-8. 2011
  10. doi request reprint Unexpectedly convenient and stereoselective synthesis of 4α-acyloxy-2-chloropodophyllotoxins in the presence of BF₃ ·Et₂O
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 21:4008-12. 2011

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Combinatorial synthesis of benzimidazole-azo-phenol derivatives as antifungal agents
    Yazhen Ke
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Comb Chem High Throughput Screen 17:89-95. 2014
    ..The EC50 values of V-5 against F. graminearum, A. solani, V. mali, B. cinerea, and C. lunata were 0.09, 0.08, 0.06, 0.07, and 0.11 μmol/mL, respectively. ..
  2. ncbi request reprint Progress of bis(heteroaryl)piperazines (BHAPs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) against human immunodeficiency virus type 1 (HIV-1)
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, P R China
    Mini Rev Med Chem 10:62-72. 2010
    ..It will pave the way for the design and development of BHAPs as anti-HIV-1 agents in AIDS chemotherapy in the future...
  3. ncbi request reprint Antifungal activities of some indole derivatives
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, PR China
    Z Naturforsch C 65:437-9. 2010
    ..Especially compounds 2, 5, 8, and 9 exhibited broad-spectrum antifungal activities against the above-mentioned seven phytopathogenic fungi, and showed more potent activities than hymexazole, a commercial agricultural fungicide...
  4. ncbi request reprint Developments of indoles as anti-HIV-1 inhibitors
    Hui Xu
    Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, P R China
    Curr Pharm Des 15:2120-48. 2009
    ..It will pave the way for the design of indole derivatives as anti-HIV-1 drugs in the future...
  5. doi request reprint Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Bioorg Med Chem Lett 20:7274-7. 2010
    ..Preliminary structure-activity relationships study demonstrated that introduction of electron-donating substituents R(1) and R(2), and the proper length of substituent R(3) were usually very important for their antifungal activities...
  6. doi request reprint Natural products-based insecticidal agents 9. Design, semisynthesis and insecticidal activity of 28-acyloxy derivatives of toosendanin against Mythimna separata Walker in vivo
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 21:1974-7. 2011
    ..In general, it indicated that the butanoyloxy or phenylacryloyloxy moiety at the 28-position of toosendanin was essential for the insecticidal activity...
  7. doi request reprint Semisynthesis and quantitative structure-activity relationship (QSAR) study of novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin as insecticidal agents
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Life Sciences, Northwest A and F University, Yangling 712100, Shannxi Province, People s Republic of China
    J Agric Food Chem 57:7919-23. 2009
    ..The quantitative structure-activity relationships (QSAR) of compounds 4a-4o showed that the relative number of benzene rings and final heat of formation were very important descriptors to their insecticidal activity...
  8. doi request reprint Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 21:5177-80. 2011
    ....
  9. doi request reprint Antifungal agents. Part 3: synthesis and antifungal activities of 3-acylindole analogs against phytopathogenic fungi in vitro
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Chem Biol Drug Des 78:864-8. 2011
    ....
  10. doi request reprint Unexpectedly convenient and stereoselective synthesis of 4α-acyloxy-2-chloropodophyllotoxins in the presence of BF₃ ·Et₂O
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 21:4008-12. 2011
    ..Meanwhile, the insecticidal activity of compounds 5a-u was preliminarily evaluated against the pre-third-instar larvae of Mythimna separata Walker in vivo at the concentration of 1mg/mL...
  11. doi request reprint Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, XiNong Road 22, Northwest A and F University, Yangling 712100, China
    Eur J Med Chem 46:1919-25. 2011
    ....
  12. ncbi request reprint Antifungal activity of some diaryl ethers
    Hui Xu
    Lab of Pharmaceutical Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Chem Pharm Bull (Tokyo) 55:1755-7. 2007
    ..graminearum, F. oxysporum f. sp. vasinfectum and F. oxysporum f. sp. cucumarinum. Meantime, some structure-activity relationships were also observed...
  13. ncbi request reprint Synthesis and antifungal activities of some 2,6-bis-(un)substituted phenoxymethylpyridines
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, PR China
    Z Naturforsch C 65:433-6. 2010
    ..sp. vasinfectum. Among all derivatives, compound 3a exhibited a broad-spectrum antifungal activity against the five phytopathogenic fungi...
  14. doi request reprint Natural products-based insecticidal agents 4. Semisynthesis and insecticidal activity of novel esters of 2-chloropodophyllotoxin against Mythimna separata Walker in vivo
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Life Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 19:5415-8. 2009
    ....
  15. ncbi request reprint One-pot N-arylation of indoles directly from N-arylsulfonylindoles via consecutive deprotection and S(N)Ar Reactions with activated Aryl halides
    Hui Xu
    Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Chem Pharm Bull (Tokyo) 57:321-3. 2009
    ..This tandem reaction affords an efficient and convenient preparation of N-arylindoles that benefit from prior indoles protection by arylsulfonyl group, and can shorten a reaction sequence and improve synthetic efficiency...
  16. ncbi request reprint Synthesis of dibenzofurans directly from aryl halides and ortho-bromophenols via one-pot consecutive SNAr and intramolecular palladium-catalyzed aryl-aryl coupling reactions
    Hui Xu
    Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Chem Pharm Bull (Tokyo) 56:1496-8. 2008
    ..The desired dibenzofurans were obtained in 32-99% isolated yields...
  17. ncbi request reprint A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007
    Hui Xu
    Laboratory of Pharmaceutical Synthesis, College of Science, Northwest A and F University, Yangling 712100, P R China
    Curr Med Chem 16:327-49. 2009
    ..Therefore, this review presents up-to-date coverage of podophyllotoxin in regard to hemisynthesis, biosynthesis, biological activities, mode of action and structure-activity relationship...
  18. doi request reprint Synthesis of diaryl-azo derivatives as potential antifungal agents
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 20:4193-5. 2010
    ..It seemed that 4-((un)substituted phenylazo)-phenol and 4-((un)substituted phenylazo)-3-methylphenol might be considered as new lead structures for further design of agricultural fungicides...
  19. ncbi request reprint Synthesis and HIV-1 integrase inhibition activity of some N-arylindoles
    Hui Xu
    Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Chem Pharm Bull (Tokyo) 56:720-2. 2008
    ..88 microg/ml and TI value of 24.61. Meantime, some structure-activity relationships were also observed and will provide a new lead for design and discovery of more potent N-arylindoles as HIV-1 integrase inhibitors...
  20. doi request reprint Natural products-based insecticidal agents 7. Semisynthesis and insecticidal activity of novel 4alpha-alkyloxy-2-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Bioorg Med Chem Lett 20:5009-12. 2010
    ....
  21. doi request reprint Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 20:4503-6. 2010
    ..The structure-activity relationships demonstrated that trans-lactone, 4beta-substitution, 2beta-chlorine substitution, and 4'-methoxy group were the important structural properties of podophyllotoxins for good insecticidal activity...
  22. doi request reprint An efficient and practical synthesis of mandelic acid by combination of complex phase transfer catalyst and ultrasonic irradiation
    Hui Xu
    Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A and F University, Yangling, Shaanxi Province 712100, PR China
    Ultrason Sonochem 15:930-2. 2008
    ..The main advantages of this present method are that the reaction time is much shorter and the yield is higher than those of the classical method. p-Methoxymandelic acid was also obtained in a 84% yield under the same reaction conditions...
  23. doi request reprint Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 20:2500-2. 2010
    ..Especially 5a exhibited the most potent insecticidal activity compared with toosendanin, a commercial insecticide derived from Melia azedarach...
  24. ncbi request reprint C(aryl)-O bond formation from aryl methanesulfonates via consecutive deprotection and S(N)Ar reactions with aryl halides in an ionic liquid
    Hui Xu
    College of Science, Northwest A and F University, Yangling 712100, PR China
    Molecules 12:861-7. 2007
    ..The procedure involves consecutive deprotection of aryl methane-sulfonates and a nucleophilic aromatic substitution (S(N)Ar) with activated aryl halides...
  25. doi request reprint Antifungal agents. Part 4: Synthesis and antifungal activities of novel indole[1,2-c]-1,2,4-benzotriazine derivatives against phytopathogenic fungi in vitro
    Hui Xu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, XiNong Road 22, Yangling, Shaanxi 712100, China
    Eur J Med Chem 46:364-9. 2011
    ..It clearly demonstrated that introduction of appropriate substituents on the indolyl ring of indole[1,2-c]-1,2,4-benzotriazine (5a) would lead to the more potent derivatives...
  26. ncbi request reprint Microwave-assisted combinatorial synthesis of 2-alkyl-2-(N-arylsulfonylindol- 3-yl)-3-N-Acyl-5-Aryl-1,3,4-oxadiazolines as anti-HIV-1 agents
    Zhi Ping Che
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Comb Chem High Throughput Screen 16:400-7. 2013
    ..5 equiv.). Moreover, two compounds exhibited the promising anti-HIV-1 activity when evaluated for their inhibitory activity against HIV-1 replication in acutely infected C8166 cells...
  27. ncbi request reprint Anti human immunodeficiency virus-1 (HIV-1) agents 3. synthesis and in vitro anti-HIV-1 activity of some N-arylsulfonylindoles
    Ling Ling Fan
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Chem Pharm Bull (Tokyo) 57:797-800. 2009
    ..26 and 0.74 microg/ml, and TI values of 543.78 and >270.27, respectively...
  28. doi request reprint Synthesis and quantitative structure-activity relationship (QSAR) study of novel 4-acyloxypodophyllotoxin derivatives modified in the A and C rings as insecticidal agents
    Shuzhen He
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, Shannxi Province, People s Republic of China
    J Agric Food Chem 61:618-25. 2013
    ..Among them, two important ones are BEHm2 and Mor14v. This study will pave the way for further design, structural modification, and development of podophyllotoxin derivatives as insecticidal agents...
  29. ncbi request reprint Anti HIV-1 agents 6. Synthesis and anti-HIV-1 activity of indolyl glyoxamides
    Yi Wang
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, PR China
    Med Chem 8:831-3. 2012
    ..83 and 4.35 µg/mL, and TI values of >27.15 and 49.45, respectively. It demonstrated that introduction of the substituent R(3) as the halogen atom and the position of R(3) were generally important to their activity...
  30. doi request reprint Fluorescence 'on-off-on' chemosensor for sequential recognition of Fe(3+) and Hg(2+) in water based on tetraphenylethylene motif
    Yuanyuan Yan
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shannxi Province, PR China
    Bioorg Med Chem 21:508-13. 2013
    ..The selectivity of this complex for Hg(2+) over other heavy and transition metal ions is excellent, and its sensitivity for Hg(2+) is at 2 ppb in water...
  31. doi request reprint Synthesis and quantitative structure-activity relationship (QSAR) study of novel isoxazoline and oxime derivatives of podophyllotoxin as insecticidal agents
    Yi Wang
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest Agriculture and Forestry A and F University, Yangling 712100, Shannxi, People s Republic of China
    J Agric Food Chem 60:8435-43. 2012
    ..For this model, the standard deviation error in prediction (SDEP) is 0.0592, the correlation coefficient (R(2)) is 0.861, and the leave-one-out cross-validation correlation coefficient (Q(2)loo) is 0.797. ..
  32. doi request reprint Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents
    Yong Guo
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, China
    Bioorg Med Chem Lett 22:5384-7. 2012
    ..Especially compounds 6d and 7a displayed the most pronounced insecticidal activity compared with toosendanin, a commercial botanical insecticide derived from Melia azedarach...
  33. ncbi request reprint Synthesis and antifungal activities of 2-(N-arylsulfonylindol-3-yl)-3-aryl-1,3-thiazinan-4-ones
    Huan Qu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, PR China
    Z Naturforsch C 68:77-81. 2013
    ..sp. vasinfectum, Alternaria brassicae, Valsa mali, Alternaria alternata, and Pyricularia oryzae. Among all derivatives, especially compound 4j exhibited a potential antifungal activity against four phytopathogenic fungi...
  34. doi request reprint Phenanthroimidazole-based thiobenzamide as an effective sensor for highly selective detection of mercury(II)
    Yong Guo
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, 712100 Yangling, Shaanxi Province, China
    Bioorg Med Chem Lett 23:3382-4. 2013
    ..57-9.12...
  35. doi request reprint Anti HIV-1 agents 5: synthesis and anti-HIV-1 activity of some N-arylsulfonyl-3-acetylindoles in vitro
    Jun Qiang Ran
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Bioorg Med Chem Lett 20:3534-6. 2010
    ..36 and 0.13 microg/mL, and TI values of >555.55 and 791.85, respectively. It demonstrated that introduction of the acetyl group at the 3-position of N-arylsulfonyl-6-methylindoles could generally lead to the more potent analogs...
  36. ncbi request reprint Anti human immunodeficiency virus type 1 (HIV-1) agents 4. Discovery of 5,5'-(p-phenylenebisazo)-8-hydroxyquinoline sulfonates as new HIV-1 inhibitors in vitro
    Xi Wen Zeng
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Chem Pharm Bull (Tokyo) 58:976-9. 2010
    ..59 and 4.01 microg/ml, and therapeutic index (TI) values of 31.77 and 24.51, respectively...
  37. doi request reprint Synthesis and insecticidal activity of some novel fraxinellone-based esters
    Yong Guo
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shannxi Province, People s Republic of China
    J Agric Food Chem 60:7016-21. 2012
    ..This will pave the way for further design, structural modification, and development of fraxinellone as an insecticidal agent...
  38. ncbi request reprint Combinatorial synthesis of a series of alkyl/alkenylacyloxy derivatives at the C-28 position of toosendanin as insecticidal agents
    Junliang Zhang
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, PR China
    Comb Chem High Throughput Screen 16:394-9. 2013
    ..It suggested that for the n-alkyloyloxy series derivatives, the proper length of the side chain R at the C-28 position of toosendanin was very important for their insecticidal activity...
  39. doi request reprint Synthesis and quantitative structure-activity relationship (QSAR) study of novel N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives as nematicidal agents
    Zhiping Che
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shaanxi Province, People s Republic of China
    J Agric Food Chem 61:5696-705. 2013
    ..774 and 3.412, respectively. This study will pave the way for future design, structural modification, and development of indole derivatives as nematicidal agents...
  40. ncbi request reprint Anti human immunodeficiency virus-1 (HIV-1) agents 1. Discovery of benzyl phenyl ethers as new HIV-1 inhibitors in vitro
    Hui Ling Dai
    Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A and F University, Yangling, China
    Chem Pharm Bull (Tokyo) 57:84-6. 2009
    ..96 microg/ml and therapeutic index value of 18.32. The preliminary structure-activity relationships of these benzyl phenyl ethers were also described...
  41. doi request reprint Synthesis of benzopyrano[4,3-b](N-arylsulfonyl)indoles and benzopyrano[3,4-b](N-arylsulfonyl)indoles via intramolecular palladium-catalyzed aryl-aryl coupling reaction
    Ling Ling Fan
    College of Sciences, Northwest A and F University, Yangling, People s Republic of China
    Mol Divers 16:415-21. 2012
    ....
  42. doi request reprint Synthesis and insecticidal activity of new deoxypodophyllotoxin-based phenazine analogues against Mythimna separata Walker
    Juanjuan Wang
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shannxi Province, People s Republic of China
    J Agric Food Chem 61:6336-43. 2013
    ..This will pave the way for further design, structural modification, and development of deoxypodophyllotoxin-based derivatives as insecticidal agents...
  43. doi request reprint Structure and antimicrobial activities of benzoyl phenyl-thiosemicarbazone-chitosans
    Zhimei Zhong
    College of Science, Inner Mongolia Agricultural University, Huhhot 010018, China
    Int J Biol Macromol 50:1169-74. 2012
    ..74%. These results indicate that the derivatives have potential ability used as antibacterial reagent in agricultural field...
  44. doi request reprint Synthesis of 4β-acyloxypodophyllotoxin analogs modified in the C and E rings as insecticidal agents against Mythimna separata Walker
    Xiaoyan Zhi
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shaanxi Province, China
    Bioorg Med Chem Lett 24:765-72. 2014
    ..3%. To alkylacyloxy series, the proper length of the side chain at the C-4 position of Ia-g, IIa-g and IIIa-g was important for their insecticidal activity. ..
  45. doi request reprint Semisynthesis and insecticidal activity of some fraxinellone derivatives modified in the B ring
    Yong Guo
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shaanxi Province, People s Republic of China
    J Agric Food Chem 61:11937-44. 2013
    ....
  46. doi request reprint Semisynthesis and quantitative structure-activity relationship (QSAR) study of some cholesterol-based hydrazone derivatives as insecticidal agents
    Chun Yang
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shaanxi Province, People s Republic of China
    Bioorg Med Chem Lett 23:4806-12. 2013
    ..Among them, two important ones are the Mor06u and RDF085v. ..
  47. doi request reprint Synthesis of novel 4α-(acyloxy)-2'(2',6')-(di)halogenopodophyllotoxin derivatives as insecticidal agents
    Zhiping Che
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shaanxi Province, People s Republic of China
    J Agric Food Chem 61:8148-55. 2013
    ..This will pave the way for further design, structural modification, and development of podophyllotoxin derivatives as insecticidal agents. ..
  48. doi request reprint A novel diagnostic platform based on multiplex ligase detection-PCR and microarray for simultaneous detection of swine viruses
    Yonghou Jiang
    College of Life Sciences, Zhejiang Sci Tech University, 2nd Street, Hangzhou 310018, China
    J Virol Methods 178:171-8. 2011
    ..The results demonstrate that this novel assay is a specific, sensitive, and multiplex diagnostic method for detection of multiple pathogens and can also be adapted easily for diagnostic purposes...
  49. doi request reprint Natural-product-based insecticidal agents 14. Semisynthesis and insecticidal activity of new piperine-based hydrazone derivatives against Mythimna separata Walker in vivo
    Huan Qu
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, PR China
    Bioorg Med Chem Lett 23:5552-7. 2013
    ..It suggested that introduction of the substituents at the C-2 position on the phenyl ring of the hydrazone derivatives was important for their insecticidal activity...
  50. doi request reprint PCR-RFLP analysis of the diversity of phytate-degrading bacteria in the Tibetan Plateau
    Yu Zhi Miao
    College of Life Sciences, Sichuan Normal University, Chengdu 610101, P R China
    Can J Microbiol 59:245-51. 2013
    ..Moreover, extreme harsh soils are logically the best soils in which to find some strains of phytate-degrading bacteria for exploiting in the fields of biotechnology and industry...
  51. doi request reprint A water-soluble 1,8-naphthalimide-based 'turn on' fluorescent chemosensor for selective and sensitive recognition of mercury ion in water
    Huiling Dai
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shannxi Province, China
    Bioorg Med Chem Lett 21:5141-4. 2011
    ..An increase in the fluorescent intensity at 562 nm was due to the formation of a 1:1 1-Hg(2+) inclusion complex...
  52. doi request reprint Modifying thermostability of appA from Escherichia coli
    Weihua Zhu
    Microbiology and Metabolic Engineering Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610064, Sichuan, People s Republic of China
    Curr Microbiol 61:267-73. 2010
    ..coli by high throughput screening with a fluorescence substrate is a fast, simple, and effective method. The mutant I408L obtained in this study could be used for the large-scale commercial production of phytase...
  53. doi request reprint Expression of food-grade phytase in Lactococcus lactis from optimized conditions in milk broth
    Yuzhi Miao
    College of Life Sciences, Sichuan Normal University, Chengdu 610101, PR China
    J Biosci Bioeng 116:34-8. 2013
    ..23 U/mL. The results of this study may be used in the dairy fermentation industry for the development of functional, healthy yogurts and other fermented dairy foods that provide both active phytase and viable probiotics to the consumer...
  54. doi request reprint Insight into dihalogenation of E-ring of podophyllotoxins, and their acyloxyation derivatives at the C4 position as insecticidal agents
    Zhiping Che
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100, Shaanxi Province, China College of Forestry, Henan University of Science and Technology, Luoyang 471003, Henan Province, China
    Bioorg Med Chem Lett 23:5592-8. 2013
    ..The insecticidal activity of 2'(2',6')-(di)halogen-substituted podophyllotoxin derivatives were evaluated with Mythimna separata Walker. ..
  55. doi request reprint Alkalophilic adaptation of XynB endoxylanase from Aspergillus niger via rational design of pKa of catalytic residues
    Hui Xu
    Microbiology and Metabolic Engineering Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610064, PR China
    J Biosci Bioeng 115:618-22. 2013
    ..It indicated that Glu175 may convert into a nucleophile residue and Glu84 into an acid/base residue...
  56. ncbi request reprint A Selective and Sensitive "Turn-on" Fluorescent Chemosensor for Recognition of Hg(2+) Ions in Water
    Huiling Dai
    Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A and F University, Yangling 712100 P R China, Fax 86 29 87091952
    Chemistry 18:11188-91. 2012
    ....
  57. doi request reprint Synthesis and antifungal activity of carabrone derivatives
    Jun Tao Feng
    Research and Development Center of Biorational Pesticide, College of Plant Protection, Northwest A and F University, Yangling, China
    Molecules 15:6485-92. 2010
    ..Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity...
  58. ncbi request reprint Overview of naphthalimide analogs as anticancer agents
    Min Lv
    College of Plnt Protection, Northwest A and F University, Yangling 712100, P R China
    Curr Med Chem 16:4797-813. 2009
    ..It will pave the way for the design and development of naphthalimide analogs as anticancer agents...
  59. ncbi request reprint The combinatorial synthesis of bioactive quinoxalines, quinoxalinones and quinoxalinols
    Min Lv
    College of Plant Protection, Northwest A and F University, Yangling 712100, P R China
    Comb Chem High Throughput Screen 13:293-301. 2010
    ....
  60. doi request reprint Autohydrolysis of bamboo (Dendrocalamus giganteus Munro) culm for the production of xylo-oligosaccharides
    Xiao Xiao
    Northwest A and F University, 712100 Yangling, China
    Bioresour Technol 138:63-70. 2013
    ..The result demonstrated that the yield of xylo-oligosaccharides obtained by autohydrolysis depends on the reaction temperature and time...
  61. doi request reprint The influence of the different inductivity of acetyl phenyl-thiosemicarbazone-chitosan on antimicrobial activities
    Zhimei Zhong
    College of Sciences, Inner Mongolia Agricultural University, Huhhot, China
    Int J Biol Macromol 48:713-9. 2011
    ..10%. The bioactivities of the derivatives have relationship with the grafted groups with different inductivity...
  62. doi request reprint Cloning, expression, and characterization of xylose reductase with higher activity from Candida tropicalis
    Feiwei Zhang
    College of Life Sciences, Sichuan University, Chengdu 610064, P R China
    J Microbiol 47:351-7. 2009
    ..63 g/L cell mass, 93.67 g/L xylitol, and 2.34 g/L x h xylitol productivity. This XR coupled with its dual coenzyme specificity, high activity, and catalytic efficiency proved its utility in in vitro xylitol production...
  63. doi request reprint Detection and genotyping of porcine circovirus in naturally infected pigs by oligo-microarray
    Yonghou Jiang
    College of Life Sciences, Zhejiang Sci Tech University, Hangzhou, PR China
    Res Vet Sci 89:133-9. 2010
    ..Our results indicated that the oligonucleotide array is useful for the identification and discrimination of PCV from clinical isolates and specimens in a clinical laboratory...
  64. ncbi request reprint Recent advances in semisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: an update (2008-2010)
    M Lv
    Laboratory of Pharmaceutical, Design and Synthesis, Northwest A and F University, Yangling 712100, PR China
    Mini Rev Med Chem 11:901-9. 2011
    ....
  65. ncbi request reprint Dipyridodiazepinone analogs as human immunodeficiency virus type 1-specific non-nucleoside reverse transcriptase inhibitors: an overview
    M Lv
    College of Plant Protection, Northwest A and F University, Yangling 712100, PR China
    Curr Med Chem 17:1874-98. 2010
    ..It will pave the way for the design and development of novel dipyridodiazepinone analogs as NNRTIs in AIDS chemotherapy in the future...
  66. ncbi request reprint CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin
    Hui Xu
    Pharmazeutische Biologie, Pharmazeutisches Institut, Eberhard Karls Universitat Tubingen, 72076 Tubingen, Germany
    Microbiology 149:2183-91. 2003
    ..Furthermore, they indicate that the C-methylation at position 5 of the pyrrole moiety occurs after the attachment of pyrrole-2-carboxylic acid unit to the deoxysugar moiety...
  67. ncbi request reprint Shock tube study of dissociation and relaxation in 1,1-difluoroethane and vinyl fluoride
    Hui Xu
    Department of Chemical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA
    Phys Chem Chem Phys 9:4164-76. 2007
    ..These large energy-transfer parameters now seem routine in these large fluorinated species. It is perhaps a surprising result for which there is as yet no explanation...
  68. ncbi request reprint Development of a novel ultrasound-assisted headspace liquid-phase microextraction and its application to the analysis of chlorophenols in real aqueous samples
    Hui Xu
    Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
    J Chromatogr A 1167:1-8. 2007
    ..The method is very suitable for the analysis of trace volatile and semivolatile pollutants in real aqueous sample...
  69. ncbi request reprint Fluoride-induced oxidative stress of osteoblasts and protective effects of baicalein against fluoride toxicity
    Xiang Qun Jin
    College of Chemistry Jilin University, Changchun 130012, People s Republic of China
    Biol Trace Elem Res 116:81-9. 2007
    ..The protective role of baicalein is obvious as an inhibitor of lipid peroxidation against the damage induced by the high concentration of fluoride...
  70. ncbi request reprint Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking
    Chunquan Sheng
    School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People s Republic of China
    J Med Chem 49:2512-25. 2006
    ..In vitro antifungal assay revealed that the antifungal activities of these novel azoles were greatly improved, which confirmed the reliability of the model from molecular modeling...
  71. pmc Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A
    Hui Xu
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331 3507, USA
    J Nat Prod 71:1233-6. 2008
    ..Site-directed mutagenesis of the DTG motif of ValG to DCD altered its preferences for metal ion binding, but did not seem to affect its substrate specificity...
  72. ncbi request reprint Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and function
    Wei Liu
    Department of Pathology, University of Alabama at Birmingham, Alabama 35294, USA
    J Biol Chem 279:54759-69. 2004
    ....
  73. ncbi request reprint Rapid, simultaneous determination of headspace oxygen and moisture in pharmaceutical packages using muGC
    Hui Xu
    Pharmaceutical Research and Development, Merck Research Laboratories, Merck and Co Inc, West Point, PA 19486, USA
    J Pharm Biomed Anal 38:225-31. 2005
    ..03% to be accurately quantified. The subject method was applied to measure the headspace oxygen and moisture in pharmaceutical blister packaging and glass vials...
  74. ncbi request reprint Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity
    Qingli Shi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York 10605, USA
    J Biol Chem 280:10888-96. 2005
    ..These results suggest that in addition to its essential role in metabolism, the E2k component of KGDHC may have other novel roles...
  75. ncbi request reprint Peptide mediated formation of hierarchically organized solution and solid state polymer nanostructures
    Harm Anton Klok
    Ecole Polytechnique Federale de Lausanne EPFL, Institut des materiaux, Laboratoire des Polymères, Bâtiment MX D, Lausanne, Switzerland
    Faraday Discuss 128:29-41. 2005
    ....
  76. ncbi request reprint New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN
    Hui Xu
    Pharmazeutische Biologie, Pharmazeutisches Institut, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany
    Chem Biol 11:655-62. 2004
    ..The results give further insight into the structure-activity relationships of aminocoumarin antibiotics...
  77. ncbi request reprint Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory
    Ming Gao Zhao
    Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, 220 Han Dan Road, Shanghai 200433, China
    Neuron 47:859-72. 2005
    ..Our results demonstrate that the NR2B subunit of the NMDA receptor in the prefrontal cortex is critically involved in both LTP and contextual memory...
  78. ncbi request reprint Structure and dynamics of self-assembled poly(ethylene glycol) based coiled-coil nano-objects
    Guido W Vandermeulen
    Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
    Chemphyschem 5:488-94. 2004
    ....
  79. ncbi request reprint [Oxygen-limited autotrophic nitrification and denitrification--a novel technology for biological nitrogen removal]
    Dan Zhang
    Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
    Ying Yong Sheng Tai Xue Bao 14:2333-6. 2003
    ..It has become one of the most prosperous and practicable biological nitrogen removal technologies. The recent research of OLAND was reviewed, and its microbial mechanism as well as its applicable prospect was remarked in this paper...
  80. ncbi request reprint Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats
    Hui Xu
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, Mich 48824, USA
    Hypertension 43:329-34. 2004
    ..It is concluded that depressor responses and decreases in HR and RSNA caused by acute tempol treatment are caused by direct sympathetic nerve activity inhibition that is not accompanied by SOD-mimetic action in the aorta or vena cava...
  81. ncbi request reprint Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring
    Caren L Freel Meyers
    Department of Biological Chemistry, and Molecular Pharmacology, LHRRB 309, Harvard Medical School, Boston, MA 02115, USA
    Angew Chem Int Ed Engl 43:67-70. 2004
  82. ncbi request reprint A general model for biosorption of Cd2+, Cu2+ and Zn2+ by aerobic granules
    Yu Liu
    Environmental Engineering Research Centre, School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    J Biotechnol 102:233-9. 2003
    ..7, 59.6 and 164.5 mgg(-1), respectively. These values may imply that aerobic granules are effective biosorbent for the removal of Cd(2+), Cu(2+) and Zn(2+) from industrial wastewater...
  83. ncbi request reprint Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies
    Gang Wei
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Control Release 83:65-74. 2002
    ..However, no further improvement in the ocular retention was observed when adding HA-Na into the thermosetting gel due to the substantially decreased gel strength...
  84. ncbi request reprint Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats
    Hui Xu
    Department of Pharmacology and Toxicology and the Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Heart Circ Physiol 283:H885-92. 2002
    ..There is an additional interaction between NO and tempol that contributes to depressor responses in DOCA-salt rats...
  85. pmc Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A
    Linquan Bai
    Laboratory of Microbial Metabolism and School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200030, China
    Chem Biol 13:387-97. 2006
    ..The role of valG in the glycosylation of validoxylamine to VAL-A was demonstrated in vitro by enzymatic assay...
  86. ncbi request reprint Short-term plasticity at primary afferent synapse in rat spinal dorsal horn and its biological function
    Ye hong Wan
    Institute of Neuroscience, Shanghai Jiaotong University, Shanghai, PR China
    Neurosignals 15:74-90. 2006
    ....
  87. ncbi request reprint Dynamic changes in microbial activity and community structure during biodegradation of petroleum compounds: a laboratory experiment
    Hui Li
    Key Laboratory of Terrestrial Ecological Processes, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
    J Environ Sci (China) 19:1003-13. 2007
    ..Based on the results described in this paper, the soil function in Shenfu irrigation area was disturbed to some extent...
  88. ncbi request reprint Noncovalently supported heterogeneous chiral amine catalysts for asymmetric direct aldol and Michael addition reactions
    Sanzhong Luo
    Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry and Graduate School, Chinese Academy of Sciences, Beijing, 100080, China
    Chemistry 14:1273-81. 2008
    ..Significantly, the deactivated catalysts could be regenerated following an acidic washing/amine recharging procedure...
  89. ncbi request reprint Preparation, characterization and photocatalytic properties of Cu-loaded BiVO(4)
    Hui Xu
    School of the Environment, Jiangsu University, Zhenjiang, PR China
    J Hazard Mater 153:877-84. 2008
    ..An efficient N-demethylation of MB using Cu-BiVO(4) catalyst (5 at.% Cu content) calcined at 300 degrees C was also observed...
  90. ncbi request reprint Analysis and optimization of nonequilibrium capillary electrophoresis of alpha-fetoprotein isoforms
    Rajiv Bharadwaj
    Microfluidics Group, Caliper Life Sciences, Mountain View, California 94043, USA
    Anal Chem 80:129-34. 2008
    ..This study provides insight into the physics of affinity-based separations and can be extended to describe and optimize other nonequilibrium CE systems...
  91. ncbi request reprint Determining the mechanical response of particle-laden fluid interfaces using surface pressure isotherms and bulk pressure measurements of droplets
    Cecile Monteux
    UPMC ESPCI CNRS UMR7615, 10 rue Vauquelin, 75005, Paris, France
    Phys Chem Chem Phys 9:6344-50. 2007
    ..Moreover we find that the compressibility in the jammed state does not depend on the particle size...
  92. doi request reprint Highly enantioselective direct syn- and anti-aldol reactions of dihydroxyacetones catalyzed by chiral primary amine catalysts
    Sanzhong Luo
    Beijing National Laboratory for Molecular Sciences BNLMS, Center for Chemical Biology, Institute of Chemistry and Graduate School, Chinese Academy of Sciences, Beijing 100080, China
    Org Lett 10:653-6. 2008
    ..This type of organocatalysts functionally mimics all four DHA aldolases, namely L-fuculose-1-phosphate aldolase, D-tagatose-1,6-diphosphate aldolase, D-fructose-1,6-diphosphate aldolase, and L-rhamnulose-1-phosphate aldolase...
  93. doi request reprint Combinatorial synthesis of functionalized chiral and doubly chiral ionic liquids and their applications as asymmetric covalent/non-covalent bifunctional organocatalysts
    Long Zhang
    Department of Chemistry and State key Laboratory of Elemento organic Chemistry, Nankai University, Tianjin, 300071, China
    Org Biomol Chem 6:567-76. 2008
    ..The resultant bis-functionalized CILs showed significantly improved stereoselectivity over the mono-functionalized parent CILs...
  94. doi request reprint Indole alkoloids from Nauclea officinalis with weak antimalarial activity
    Jingyong Sun
    School of Pharmacy, Shandong University, Jinan 250012, People s Republic of China
    Phytochemistry 69:1405-10. 2008
    ..In vitro activity screening of the above seven compounds showed weak to moderate inhibitory activity against Plasmodium falciparum...
  95. doi request reprint Asymmetric direct aldol reactions of pyruvic derivatives
    Sanzhong Luo
    Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry and Graduate School, Chinese Academy of Sciences, Beijing, China
    Org Lett 10:1775-8. 2008
    ....
  96. ncbi request reprint Pluronic F127-g-poly(acrylic acid) copolymers as in situ gelling vehicle for ophthalmic drug delivery system
    Wen di Ma
    Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning, PC 110016, People s Republic of China
    Int J Pharm 350:247-56. 2008
    ..Pluronic-g-PAA copolymer can be a promising in situ gelling vehicle for ophthalmic drug delivery system...
  97. ncbi request reprint Development of an improved liquid phase microextraction technique and its application in the analysis of flumetsulam and its two analogous herbicides in soil
    Hui Xu
    Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Center for Analysis and Testing, Central China Normal University, Wuhan 430079, People s Republic of China
    J Agric Food Chem 55:9351-6. 2007
    ..The novel, simple, rapid, sensitive technique is very suitable for extraction of apolar and medium polar analyte in complex environmental samples...
  98. ncbi request reprint Temperature-responsive, Pluronic-g-poly(acrylic acid) copolymers in situ gels for ophthalmic drug delivery: rheology, in vitro drug release, and in vivo resident property
    Wen di Ma
    Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, China
    Drug Dev Ind Pharm 34:258-66. 2008
    ..The results showed that the Pluronic-g-PAA copolymer can be a promising in situ gelling vehicle for ophthalmic drug delivery...
  99. ncbi request reprint Evaluation of hydroperoxides in common pharmaceutical excipients
    Walter R Wasylaschuk
    Pharmaceutical Analysis Chemistry, Merck Research Laboratories, Merck and Co, Inc, P O Box 4, WP78 210, West Point, PA 19486, USA
    J Pharm Sci 96:106-16. 2007
    ..Defining critical HPO limits for excipients should be driven by the chemistry of a specific drug substance or product and can only be defined within this context...
  100. ncbi request reprint Evolution of pyrrolidine-type asymmetric organocatalysts by "click" chemistry
    Sanzhong Luo
    Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Science, Beijing, 100080 China
    J Org Chem 71:9244-7. 2006
    ..The clicked organocatalysts were evaluated in asymmetric Michael addition of ketones to nitroolefins, showing good catalytic activity and stereoselectivity (up to 100% yield, syn:anti = 99:1, 96% ee)...
  101. ncbi request reprint In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model
    Hui Xu
    Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100083, P R China
    Acad Radiol 13:1532-7. 2006
    ..We used a 1.5-T MR scanner to investigate in vivo hydrogen 1 ((1)H) MRS to evaluate metabolic changes in the hepatocarcinogenesis experimental rat model...