Dewen Tong


Affiliation: Northwest A and F University
Country: China


  1. Du Q, Wu X, Wang T, Yang X, Wang Z, Niu Y, et al. Porcine Circovirus Type 2 Suppresses IL-12p40 Induction via Capsid/gC1qR-Mediated MicroRNAs and Signalings. J Immunol. 2018;201:533-547 pubmed publisher
  2. Ma X, Zhao X, Zhang Z, Guo J, Guan L, Li J, et al. Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-κB pathway in porcine intestinal epithelial cell line. BMC Genomics. 2018;19:747 pubmed publisher
    ..The data revealed that differentially expressed mRNAs and ncRNAs were primarily enriched in inflammation-related pathways and ssc_circ_009380 promoted activation of NF-κB pathway by binding miR-22 during TGEV-induced inflammation. ..
  3. Zhao X, Song X, Bai X, Tan Z, Ma X, Guo J, et al. microRNA-222 Attenuates Mitochondrial Dysfunction During Transmissible Gastroenteritis Virus Infection. Mol Cell Proteomics. 2019;18:51-64 pubmed publisher
    ..Together, our data establish a significant role of miR-222 in regulating mitochondrial dysfunction in response to TGEV infection. ..
  4. Fan Y, Song X, Gao Y, Chen Y, Ma L, Zhang W, et al. Preparation and optimization of ophiopogon polysaccharide liposome and its activity on Kupffer cells. Int J Pharm. 2014;477:421-30 pubmed publisher
    ..813 μg mL(-1). These results indicated that the immune-enhancing activity of OP was significantly improved after encapsulated with liposome. Therefore, liposome would be expected to exploit into a new-type preparation of OP. ..
  5. Fan Y, Ma X, Zhang J, Ma L, Gao Y, Zhang W, et al. Ophiopogon polysaccharide liposome can enhance the non-specific and specific immune response in chickens. Carbohydr Polym. 2015;119:219-27 pubmed publisher
    ..Moreover, its efficacy was significantly better than ophiopogon polysaccharide (OP). These results indicated that the immune-enhancing activity of OP was significantly improved after encapsulated with liposome. ..
  6. Fan Y, Ren M, Hou W, Guo C, Tong D, Ma L, et al. The activation of Epimedium polysaccharide-propolis flavone liposome on Kupffer cells. Carbohydr Polym. 2015;133:613-23 pubmed publisher
    ..These results suggested that EPL could activate KCs and possessed the stronger immunomodulatory effect, which provided the theoretical basis for further studying the mechanism of EPL on improving the immune response. ..
  7. Chang L, Lu Z, Li D, Zhang L, Wang Z, Du Q, et al. Melamine causes testicular toxicity by destroying blood-testis barrier in piglets. Toxicol Lett. 2018;296:114-124 pubmed publisher
    ..In conclusion, MA exposure gives rise to testicular toxicity in male piglets through destroying BTB integrity. ..
  8. Zhang Q, Xu Y, Chang R, Tong D, Xu X. Transmissible gastroenteritis virus N protein causes endoplasmic reticulum stress, up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell. Res Vet Sci. 2018;119:109-115 pubmed publisher
    ..These results provide a better understanding of the functions and structural mechanisms of TGEV N protein. ..
  9. Zhang H, Huang Y, Wang L, Yu T, Wang Z, Chang L, et al. Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology. 2016;85:1446-56 pubmed publisher
    ..The immortalized PTCs maintained its original characteristics and can be used as a model cells line to study the pathologic changes of porcine placental trophoblast in viruses infectious diseases. ..

More Information


  1. Zhao X, Xiang H, Bai X, Fei N, Huang Y, Song X, et al. Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation. Virol J. 2016;13:26 pubmed publisher
    ..All these results suggest that PPV-induced ROS accumulation mediates apoptosis in ST cells, which provided theoretical basis for the molecular pathogenesis of PPV infection. ..
  2. Xu D, Du Q, Han C, Wang Z, Zhang X, Wang T, et al. p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Vet Res. 2016;47:120 pubmed
    ..Taken together, this study demonstrates that PCV2 infection induces S phase accumulation to favor viral replication in host cells through activation of the p53 pathway. ..
  3. Zhang W, Wang Z, Zhang L, Zhang Z, Chen J, Chen W, et al. Melatonin stimulates the secretion of progesterone along with the expression of cholesterol side-chain cleavage enzyme (P450scc) and steroidogenic acute regulatory protein (StAR) in corpus luteum of pregnant sows. Theriogenology. 2018;108:297-305 pubmed publisher
    ..The data support the presence of MT1 and MT2 in porcine CL and a regulatory role for melatonin in luteal function through MT1 and MT2-mediated signal transduction pathways. ..
  4. Zhang W, Zhang Z, Chen J, Tong D. Ghrelin is expressed in the pregnant mammary glands of dairy goats and promotes the cell proliferation of mammary epithelial cells. Gen Comp Endocrinol. 2018;260:115-124 pubmed publisher
  5. Li D, Du Q, Wu B, Li J, Chang L, Zhao X, et al. Immunogenicity of adenovirus vaccines expressing the PCV2 capsid protein in pigs. Vaccine. 2017;35:4722-4729 pubmed publisher
  6. Zhang L, Huang Y, Wang Z, Luo X, Zhang H, Du Q, et al. Establishment and characterization of a telomerase immortalized porcine luteal cells. Theriogenology. 2017;94:105-113 pubmed publisher
    ..In summary, we developed an immortalized porcine luteal cell line which maintained its originally morphological, biological and functional characteristics. ..
  7. Zhao X, Bai X, Guan L, Li J, Song X, Ma X, et al. microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro. Mol Cell Proteomics. 2018;17:190-204 pubmed publisher
    ..The data indicate that miR-4331 aggravates TGEV-induced mitochondrial damage by repressing expression of RB1, promoting IL1RAP, and activating p38 MAPK pathway. ..
  8. request reprint
    Tong D, Mu P, Dong Q, Zhao B, Liu W, Zhao J, et al. Immunological evaluation of SW-HSA conjugate on goats. Colloids Surf B Biointerfaces. 2007;58:61-7 pubmed
    ..01) in the immune poisoning groups than that in the poisoning control group, and there was no significant difference (p>0.01) between the two immune poisoning groups within the poisoning experiment...
  9. Zhang H, Huang Y, Du Q, Luo X, Zhang L, Zhao X, et al. Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochem Biophys Res Commun. 2015;456:649-55 pubmed publisher
    ..This study may contribute to shed light on the molecular pathogenesis of PPV infection. ..
  10. Ding L, Huang Y, Du Q, Dong F, Zhao X, Zhang W, et al. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochem Biophys Res Commun. 2014;445:497-503 pubmed publisher
    ..Taken together, these results demonstrated that TGEV N protein might play an important role in TGEV infection-induced p53 activation and cell cycle arrest at the S and G2/M phases and apoptosis occurrence. ..