Affiliation: Northeast Normal University
Qi W, Wang R, Chen H, Wang X, Xiao T, Boldogh I, et al
. BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51. J Cell Sci. 2015;128:317-30 pubmed publisher
..Our present study provides a mechanistic insight into how BRG1, which is known to be involved in chromatin remodelling, plays a substantial role in the homologous recombination repair pathway in mammalian cells. ..
Wang R, Bi J, Ampah K, Ba X, Liu W, Zeng X. Lipid rafts control human melanoma cell migration by regulating focal adhesion disassembly. Biochim Biophys Acta. 2013;1833:3195-3205 pubmed publisher
..Taken together, these observations provide a new mechanism to further explain how lipid rafts regulate the migration of melanoma cell and suggest that lipid rafts may be novel and attractive targets for cancer therapy. ..
Ba X, Aguilera Aguirre L, Rashid Q, Bacsi A, Radak Z, Sur S, et al
. The role of 8-oxoguanine DNA glycosylase-1 in inflammation. Int J Mol Sci. 2014;15:16975-97 pubmed publisher
Ke Y, Wang K, Xu H, Wang C, Zhang J, Zeng X, et al
. The establishment of methods for free PAR generation and PAR reader detection. Mol Cell Probes. 2018;39:57-60 pubmed publisher
Wang R, Hao W, Pan L, Boldogh I, Ba X. The roles of base excision repair enzyme OGG1 in gene expression. Cell Mol Life Sci. 2018;75:3741-3750 pubmed publisher
..The present review discusses how cells exploit damaged guanine base(s) and the authentic repair protein to orchestrate a profile of various transcriptomes in redox-regulated biological processes. ..
Batnasan E, Wang R, Wen J, Ke Y, Li X, Bohio A, et al
. 17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha. Toxicol Lett. 2015;232:1-9 pubmed publisher
..The present study provided us insight into how to apply hormone therapy in intervention of parthanatos-implicated ischemic and degenerative diseases. ..
Wang R, Li C, Qiao P, Xue Y, Zheng X, Chen H, et al
. OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos. Cell Death Dis. 2018;9:628 pubmed publisher
..These results suggested that OGG1 guards genome integrity through either lesion repair or elimination of cells with malignant potential, to maintain the homeostasis of the host, which might depend on the magnitude of guanine oxidation. ..
Pan L, Zhu B, Hao W, Zeng X, Vlahopoulos S, Hazra T, et al
. Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor ?B-driven Gene Expression. J Biol Chem. 2016;291:25553-25566 pubmed
..These results are the first to document a novel paradigm wherein the DNA repair protein OGG1 bound to its substrate is coupled to DNA occupancy of NF-?B and functions in epigenetic regulation of gene expression. ..
Ba X, Boldogh I. 8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions. Redox Biol. 2018;14:669-678 pubmed publisher
..Deviations/variations from this artful coordination may be the etiological links between guanine oxidation and various cellular pathologies and diseases during ageing processes. ..