Genomes and Genes


Yuan Sun


Affiliation: National Key Laboratory of Veterinary Biotechnology
Country: China


  1. Wang Y, Yuan J, Cong X, Qin H, Wang C, Li Y, et al. Generation and Efficacy Evaluation of a Recombinant Pseudorabies Virus Variant Expressing the E2 Protein of Classical Swine Fever Virus in Pigs. Clin Vaccine Immunol. 2015;22:1121-9 pubmed publisher
    ..The data indicate that rPRVTJ-delgE/gI-E2 is a promising candidate bivalent vaccine against PRV and CSFV coinfections. ..
  2. Li L, Yu J, Zhang Y, Yang Q, Li Y, Zhang L, et al. Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway. J Virol. 2017;91: pubmed publisher
    ..This work will be beneficial to the development of novel anti-CSFV strategies by targeting pOASL. ..
  3. Luo Y, Li N, Cong X, Wang C, Du M, Li L, et al. Pathogenicity and genomic characterization of a pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China. Vet Microbiol. 2014;174:107-15 pubmed publisher
    ..Taken together, the TJ strain is a highly pathogenic PRV variant with unique molecular signatures. Further studies are needed to explore the relevance of the sequence differences to the virulence alteration of the PRV variant. ..
  4. Luo Y, Li L, Austermann Busch S, Dong M, Xu J, Shao L, et al. Enhanced expression of the Erns protein of classical swine fever virus in yeast and its application in an indirect enzyme-linked immunosorbent assay for antibody differentiation of infected from vaccinated animals. J Virol Methods. 2015;222:22-7 pubmed publisher
    ..4%) compared with PrioCHECK CSFV E(rns) (59.6%). Taken together, the yE(rns)-based iELISA is specific and sensitive, representing a promising DIVA test for E2-based marker vaccines against CSF. ..
  5. Wang Y, Xia S, Lei J, Cong X, Xiang G, Luo Y, et al. Dose-dependent pathogenicity of a pseudorabies virus variant in pigs inoculated via intranasal route. Vet Immunol Immunopathol. 2015;168:147-52 pubmed publisher
  6. Cong X, Lei J, Xia S, Wang Y, Li Y, Li S, et al. Pathogenicity and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant in susceptible animals. Vet Microbiol. 2016;182:170-7 pubmed publisher
    ..In conclusion, rPRVTJ-delgE/gI/TK has the potential to be developed as a vaccine for controlling the currently prevalent PR in China. ..
  7. Xia S, Du M, Lei J, Liu Y, Wang Y, Ji S, et al. Piglets with maternally derived antibodies from sows immunized with rAdV-SFV-E2 were completely protected against lethal CSFV challenge. Vet Microbiol. 2016;190:38-42 pubmed publisher
    ..These results indicate that MDAs from the sow immunized with rAdV-SFV-E2 are able to confer full passive immunity to newborn piglets. ..
  8. Lei J, Xia S, Wang Y, Du M, Xiang G, Cong X, et al. Safety and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the E2 protein of classical swine fever virus in pigs. Immunol Lett. 2016;174:63-71 pubmed publisher
    ..These findings suggest that rPRVTJ-delgE/gI/TK-E2 is a promising bivalent DIVA vaccine candidate against CSFV and PRV coinfections. ..
  9. Xia S, Lei J, Du M, Wang Y, Cong X, Xiang G, et al. Enhanced protective immunity of the chimeric vector-based vaccine rAdV-SFV-E2 against classical swine fever in pigs by a Salmonella bacterial ghost adjuvant. Vet Res. 2016;47:64 pubmed publisher
    ..The data indicate that BG are a promising adjuvant to enhance the efficacy of rAdV-SFV-E2 and possibly other vaccines. ..

More Information


  1. Xia S, Xiang G, Lei J, Du M, Wang Y, Zhou M, et al. Efficacy of the marker vaccine rAdV-SFV-E2 against classical swine fever in the presence of maternally derived antibodies to rAdV-SFV-E2 or C-strain. Vet Microbiol. 2016;196:50-54 pubmed publisher
    ..These findings demonstrate that the MDAs to either rAdV-SFV-E2 or C-strain do not interfere with the efficacy of rAdV-SFV-E2, which highlights the great potential of the vaccine for control and eradication of CSF. ..
  2. Luo Y, Ji S, Lei J, Xiang G, Liu Y, Gao Y, et al. Efficacy evaluation of the C-strain-based vaccines against the subgenotype 2.1d classical swine fever virus emerging in China. Vet Microbiol. 2017;201:154-161 pubmed publisher
    ..1d CSFV emerging in China. Further investigation is needed to comprehensively assess the efficacy of C-strain of different doses against the subgenotype 2.1d CSFV. ..