Research Topics
Genomes and GenesSpecies | Xiao Dong ZhangSummaryAffiliation: Nankai University Country: China Publications
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Detail Information
Publications
Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signallingLing Qiao
Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, PR China
Cancer Lett 269:67-77. 2008..Overexpression of Dkk-1 in Z3 cells enhanced the inhibition. Therefore, Dkk-1 secreted by Z3 cells involves the inhibition via the Wnt pathway...
Effects of hepatitis B virus X protein on the development of liver cancerXiaodong Zhang
Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, P R China
J Lab Clin Med 147:58-66. 2006..This review examines the role of HBx in the life cycle of HBV as well as the various signal transduction pathways involved in the pathogenesis of HBV-induced hepatocarcinogenesis...- Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cellsXiaodong Zhang
Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, People s Republic of China
J Lab Clin Med 145:98-104. 2005..Our data collectively demonstrate that HBX up-regulates the expression and activity of hTERT in hepatoma cells, suggesting that hTERT is associated with tumor development... - Hepatitis B virus X protein upregulates survivin expression in hepatoma tissuesXiaodong Zhang
Department of Cancer Research, Institute for Molecular Biology, Tianjin Key Laboratory of Microbial Functional Genomics, College of Life Sciences, Nankai University, Tianjin, P R China
J Med Virol 77:374-81. 2005..Collectively, these data demonstrate that HBx upregulates survivin expression in hepatoma tissues, suggesting that HBx and survivin may both be involved in carcinogenesis of HCC... - [Transformation of attached cells derived from fetal umbilical cord blood induced by conditional medium of hepatoma cells]Xiao Dong Zhang
College of Life Sciences, Nankai University, Tianjin 300071, P R China
Ai Zheng 25:1-6. 2006..This study was to explore the sensitivity of stem cells derived from fetal umbilical cord blood to carcinogenic factors... - NF-kappaB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cellsLing Qiao
Department of Biochemistry, Tianjin Key Laboratory of Mecrobial Functional Genomics, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
Acta Pharmacol Sin 29:333-40. 2008..The purpose of our study was to demonstrate the molecular mechanism of the inhibitory proliferation of hepatoma cells and breast cancer cells mediated by human mesenchymal stem cells (hMSCs)... - Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferationHang Zhang
Department of Cancer Research, Tianjin Key Laboratory of Microbial Function Genomics, Institute for Molecular Biology, Nankai University, Tianjin 300071, China
Acta Pharmacol Sin 29:473-80. 2008..To identify mutants of the hepatitis B virus (HBV) X (HBx) gene and investigate the effect of the natural mutant on liver cell proliferation... - [Screening of a sub-clone of human breast cancer cells with high metastasis potential]Li Hong Ye
College of Life Sciences, Nankai University, Tianjin 300071, China
Zhonghua Yi Xue Za Zhi 86:61-5. 2006..To screen a sub-clone of human breast cancer cell of the MCF-7 line with high metastasis potential... - Transformation of human liver L-O2 cells mediated by stable HBx transfectionWei ying Zhang
Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
Acta Pharmacol Sin 30:1153-61. 2009..To explore the mechanism of hepatocarcinogenesis associated with the hepatitis B virus X protein (HBx), we investigated the role of HBx in transformation using human liver L-O2 cells stably transfected with HBx as a model... - Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathwayWen jing Cui
Department of Biochemistry, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China
Acta Pharmacol Sin 31:725-32. 2010..To investigate whether myosin light chain kinase (MLCK) contributed to the high proliferative ability of breast cancer cells... - Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cellsFeng Ze Wang
Departments of Biochemistry, Tianjin Key Laboratory of Microbial Functional Genomics, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China
Acta Pharmacol Sin 29:83-9. 2008..To investigate the mechanism of promoting proliferation by HBXIP, the effect of HBXIP on human TERT (hTERT) was investigated in human mesenchymal stem cells (hMSC)... - Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signalingXiao Lei Zhou
Department of Biochemistry, Institute for Molecular Biology, Nankai University, Tianjin, China
Acta Pharmacol Sin 31:202-10. 2010..To investigate the role of DKK-1/Wnt/beta-catenin signaling in high proliferation of LM-MCF-7 breast cancer cells, a sub-clone of MCF-7 cell line... - A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenaseQi Wang
Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, China
Acta Pharmacol Sin 31:367-74. 2010..In this study, we further investigated the mechanism of increased hepatoma cell growth that was mediated by HBxDelta127... - A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenaseXuan Zhang
Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
Acta Pharmacol Sin 31:593-600. 2010..To explore a novel function of a mutant of the hepatitis B virus X protein (HBx Delta 127) in the promotion of hepatoma cell migration... - Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cellsFeng Ze Wang
Departments of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China
Acta Pharmacol Sin 28:431-8. 2007..To investigate the effect of Hepatitis B X-interacting protein (HBXIP) on cell proliferation... - Gene expression profiles of human liver cells mediated by hepatitis B virus X proteinWei ying Zhang
Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China
Acta Pharmacol Sin 30:424-34. 2009..To demonstrate the gene expression profiles mediated by hepatitis B virus X protein (HBx), we characterized the molecular features of pathogenesis associated with HBx in a human liver cell model... 
Anti-hepatitis B virus X protein in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBVHang Zhang
Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China
J Biomed Biotechnol 2009:289068. 2009..01), suggesting that anti-HBx in sera is a marker of HBV replication rather than a protective antibody. Thus, our findings reveal that circulating anti-HBx in sera is one of the markers of development of LC and HCC mediated by HBV...- Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2Guang Yao Kong
Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, Nankai University, Tianjin 300071, China
Acta Pharmacol Sin 32:1173-80. 2011..To investigate the mechanism underlying the increase of hepatoma cell proliferation by hepatitis B virus X protein (HBx)... - A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cellsNan Hu
Department of Biochemistry, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
Acta Pharmacol Sin 32:921-9. 2011..To investigate the endogenous signaling pathways associated with high proliferation potential of breast cancer cells... - Size-dependent in vivo toxicity of PEG-coated gold nanoparticlesXiao Dong Zhang
Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, People s Republic of China
Int J Nanomedicine 6:2071-81. 2011..Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of 5, 10, 30, and 60 nm PEG-coated gold nanoparticles in mice... - [Prospective non-randomized study of chemotherapy combined with radiotherapy versus chemotherapy alone in patients with metastatic or relapsed esophageal squamous cell carcinoma]Xiao Dong Zhang
Department of Gastrointestinal Medicine, Clinical Cancer Institute, Beijing Cancer Hospital, Peking University, Beijing 100036, China
Zhonghua Zhong Liu Za Zhi 29:474-7. 2007.... - Early enteral and parenteral nutritional support in patients with cirrhotic portal hypertension after pericardial devascularizationKe Zhang
Department of Hepatobiliary Surgery, The 302nd Hospital of PLA, Beijing 100039, China
Hepatobiliary Pancreat Dis Int 4:55-9. 2005.... - Expression of novel isoforms of the CIC-1 chloride channel in astrocytic glial cells in vitroXiao Dong Zhang
Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan
Glia 47:46-57. 2004..The present study showed that astrocytic glial cells express multiple isoforms of the ClC-1 chloride channel, which has been thought to be expressed almost exclusively in the skeletal muscle...