Xiao Dong Zhang

Summary

Affiliation: Nankai University
Country: China

Publications

  1. ncbi request reprint Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling
    Ling Qiao
    Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, PR China
    Cancer Lett 269:67-77. 2008
  2. ncbi request reprint Effects of hepatitis B virus X protein on the development of liver cancer
    Xiaodong Zhang
    Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, P R China
    J Lab Clin Med 147:58-66. 2006
  3. ncbi request reprint Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP
    Weiying Zhang
    State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, P, R, China
    Mol Cancer 13:128. 2014
  4. pmc Anti-hepatitis B virus X protein in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV
    Hang Zhang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China
    J Biomed Biotechnol 2009:289068. 2009
  5. pmc Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model
    Guangyao Kong
    Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People s Republic of China
    PLoS ONE 6:e19518. 2011
  6. pmc Hepatitis B virus X protein drives multiple cross-talk cascade loops involving NF-κB, 5-LOX, OPN and Capn4 to promote cell migration
    Xuan Zhang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People s Republic of China
    PLoS ONE 7:e31458. 2012
  7. ncbi request reprint Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells
    Xiaodong Zhang
    Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, People s Republic of China
    J Lab Clin Med 145:98-104. 2005
  8. ncbi request reprint [Transformation of attached cells derived from fetal umbilical cord blood induced by conditional medium of hepatoma cells]
    Xiao Dong Zhang
    College of Life Sciences, Nankai University, Tianjin 300071, P R China
    Ai Zheng 25:1-6. 2006
  9. ncbi request reprint Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues
    Xiaodong Zhang
    Department of Cancer Research, Institute for Molecular Biology, Tianjin Key Laboratory of Microbial Functional Genomics, College of Life Sciences, Nankai University, Tianjin, P R China
    J Med Virol 77:374-81. 2005
  10. doi request reprint Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation
    Hang Zhang
    Department of Cancer Research, Tianjin Key Laboratory of Microbial Function Genomics, Institute for Molecular Biology, Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 29:473-80. 2008

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling
    Ling Qiao
    Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, PR China
    Cancer Lett 269:67-77. 2008
    ..Overexpression of Dkk-1 in Z3 cells enhanced the inhibition. Therefore, Dkk-1 secreted by Z3 cells involves the inhibition via the Wnt pathway...
  2. ncbi request reprint Effects of hepatitis B virus X protein on the development of liver cancer
    Xiaodong Zhang
    Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, P R China
    J Lab Clin Med 147:58-66. 2006
    ..This review examines the role of HBx in the life cycle of HBV as well as the various signal transduction pathways involved in the pathogenesis of HBV-induced hepatocarcinogenesis...
  3. ncbi request reprint Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP
    Weiying Zhang
    State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, P, R, China
    Mol Cancer 13:128. 2014
    ..The oncopreotein hepatitis B X-interacting protein (HBXIP), a target of miR-520b, is involved in the development of cancer. In this study, we focus on the investigation of hepatocarcinogenesis mediated by HBx...
  4. pmc Anti-hepatitis B virus X protein in sera is one of the markers of development of liver cirrhosis and liver cancer mediated by HBV
    Hang Zhang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China
    J Biomed Biotechnol 2009:289068. 2009
    ..01), suggesting that anti-HBx in sera is a marker of HBV replication rather than a protective antibody. Thus, our findings reveal that circulating anti-HBx in sera is one of the markers of development of LC and HCC mediated by HBV...
  5. pmc Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model
    Guangyao Kong
    Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People s Republic of China
    PLoS ONE 6:e19518. 2011
    ..Thus, we conclude that miR-29a is involved in the regulation of migration of hepatoma cells mediated by HBx through PTEN in cell culture model...
  6. pmc Hepatitis B virus X protein drives multiple cross-talk cascade loops involving NF-κB, 5-LOX, OPN and Capn4 to promote cell migration
    Xuan Zhang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, People s Republic of China
    PLoS ONE 7:e31458. 2012
    ..Thus, we conclude that HBx drives multiple cross-talk cascade loops involving NF-κB, 5-LOX, OPN and Capn4 to promote cell migration. This finding provides new insight into the mechanism involving the promotion of cell migration by HBx...
  7. ncbi request reprint Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells
    Xiaodong Zhang
    Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, People s Republic of China
    J Lab Clin Med 145:98-104. 2005
    ..Our data collectively demonstrate that HBX up-regulates the expression and activity of hTERT in hepatoma cells, suggesting that hTERT is associated with tumor development...
  8. ncbi request reprint [Transformation of attached cells derived from fetal umbilical cord blood induced by conditional medium of hepatoma cells]
    Xiao Dong Zhang
    College of Life Sciences, Nankai University, Tianjin 300071, P R China
    Ai Zheng 25:1-6. 2006
    ..This study was to explore the sensitivity of stem cells derived from fetal umbilical cord blood to carcinogenic factors...
  9. ncbi request reprint Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues
    Xiaodong Zhang
    Department of Cancer Research, Institute for Molecular Biology, Tianjin Key Laboratory of Microbial Functional Genomics, College of Life Sciences, Nankai University, Tianjin, P R China
    J Med Virol 77:374-81. 2005
    ..Collectively, these data demonstrate that HBx upregulates survivin expression in hepatoma tissues, suggesting that HBx and survivin may both be involved in carcinogenesis of HCC...
  10. doi request reprint Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation
    Hang Zhang
    Department of Cancer Research, Tianjin Key Laboratory of Microbial Function Genomics, Institute for Molecular Biology, Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 29:473-80. 2008
    ..To identify mutants of the hepatitis B virus (HBV) X (HBx) gene and investigate the effect of the natural mutant on liver cell proliferation...
  11. doi request reprint NF-kappaB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cells
    Ling Qiao
    Department of Biochemistry, Tianjin Key Laboratory of Mecrobial Functional Genomics, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 29:333-40. 2008
    ..The purpose of our study was to demonstrate the molecular mechanism of the inhibitory proliferation of hepatoma cells and breast cancer cells mediated by human mesenchymal stem cells (hMSCs)...
  12. doi request reprint A mutant of hepatitis B virus X protein (HBx Delta 127) enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase
    Xuan Zhang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 31:593-600. 2010
    ..To explore a novel function of a mutant of the hepatitis B virus X protein (HBx Delta 127) in the promotion of hepatoma cell migration...
  13. doi request reprint A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase
    Qi Wang
    Department of Cancer Research, Institute for Molecular Biology, Nankai University, Tianjin, China
    Acta Pharmacol Sin 31:367-74. 2010
    ..In this study, we further investigated the mechanism of increased hepatoma cell growth that was mediated by HBxDelta127...
  14. doi request reprint Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling
    Xiao Lei Zhou
    Department of Biochemistry, Institute for Molecular Biology, Nankai University, Tianjin, China
    Acta Pharmacol Sin 31:202-10. 2010
    ..To investigate the role of DKK-1/Wnt/beta-catenin signaling in high proliferation of LM-MCF-7 breast cancer cells, a sub-clone of MCF-7 cell line...
  15. ncbi request reprint Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells
    Feng Ze Wang
    Departments of Biochemistry, Tianjin Key Laboratory of Microbial Functional Genomics, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China
    Acta Pharmacol Sin 29:83-9. 2008
    ..To investigate the mechanism of promoting proliferation by HBXIP, the effect of HBXIP on human TERT (hTERT) was investigated in human mesenchymal stem cells (hMSC)...
  16. ncbi request reprint Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway
    Wen jing Cui
    Department of Biochemistry, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China
    Acta Pharmacol Sin 31:725-32. 2010
    ..To investigate whether myosin light chain kinase (MLCK) contributed to the high proliferative ability of breast cancer cells...
  17. ncbi request reprint Transformation of human liver L-O2 cells mediated by stable HBx transfection
    Wei ying Zhang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 30:1153-61. 2009
    ..To explore the mechanism of hepatocarcinogenesis associated with the hepatitis B virus X protein (HBx), we investigated the role of HBx in transformation using human liver L-O2 cells stably transfected with HBx as a model...
  18. ncbi request reprint Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells
    Feng Ze Wang
    Departments of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 28:431-8. 2007
    ..To investigate the effect of Hepatitis B X-interacting protein (HBXIP) on cell proliferation...
  19. ncbi request reprint [Screening of a sub-clone of human breast cancer cells with high metastasis potential]
    Li Hong Ye
    College of Life Sciences, Nankai University, Tianjin 300071, China
    Zhonghua Yi Xue Za Zhi 86:61-5. 2006
    ..To screen a sub-clone of human breast cancer cell of the MCF-7 line with high metastasis potential...
  20. ncbi request reprint Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications
    Xiao Dong Zhang
    Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People s Republic of China
    Int J Nanomedicine 9:2069-72. 2014
    ..We propose that small hydrodynamic sized nanoclusters can achieve both nontoxic and therapeutic clinical features. ..
  21. pmc Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice
    Jie Chen
    Tianjin Key Laboratory of Molecular Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Nankai District, Tianjin, People s Republic of China
    Int J Nanomedicine 8:2409-19. 2013
    ..These findings indicated that sex differences may be one of the important elements for in vivo toxicity of gold nanoparticles. ..
  22. doi request reprint Gene expression profiles of human liver cells mediated by hepatitis B virus X protein
    Wei ying Zhang
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China
    Acta Pharmacol Sin 30:424-34. 2009
    ..To demonstrate the gene expression profiles mediated by hepatitis B virus X protein (HBx), we characterized the molecular features of pathogenesis associated with HBx in a human liver cell model...
  23. doi request reprint Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2
    Guang Yao Kong
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology of Ministry of Education, Institute for Molecular Biology, Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 32:1173-80. 2011
    ..To investigate the mechanism underlying the increase of hepatoma cell proliferation by hepatitis B virus X protein (HBx)...
  24. ncbi request reprint Enhanced tumor accumulation of sub-2 nm gold nanoclusters for cancer radiation therapy
    Xiao Dong Zhang
    Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China
    Adv Healthc Mater 3:133-41. 2014
    ..After the treatment, the small-sized GSH-Au25 NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au25 NCs in the body...
  25. doi request reprint A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells
    Nan Hu
    Department of Biochemistry, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
    Acta Pharmacol Sin 32:921-9. 2011
    ..To investigate the endogenous signaling pathways associated with high proliferation potential of breast cancer cells...
  26. ncbi request reprint Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ
    Shang Ze Li
    College of Life Sciences, Wuhan University, Wuhan 430072, China
    Biochim Biophys Acta 1843:1365-72. 2014
    ..Our results indicate that NLK functions as a pivotal negative regulator in TNFα-induced activation of NF-κB via disrupting the interaction of TAK1 with IKKβ. ..
  27. ncbi request reprint TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3
    Ming ming Hu
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Proc Natl Acad Sci U S A 111:1509-14. 2014
    ..Our findings reveal a previously undiscovered mechanism by which cells keep the inflammatory response in check to avoid excessive harmful immune response triggered by TNFα and IL-1β. ..
  28. pmc Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
    Xiao Dong Zhang
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, People s Republic of China
    Int J Nanomedicine 6:2071-81. 2011
    ..Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of 5, 10, 30, and 60 nm PEG-coated gold nanoparticles in mice...
  29. ncbi request reprint [Prospective non-randomized study of chemotherapy combined with radiotherapy versus chemotherapy alone in patients with metastatic or relapsed esophageal squamous cell carcinoma]
    Xiao Dong Zhang
    Department of Gastrointestinal Medicine, Clinical Cancer Institute, Beijing Cancer Hospital, Peking University, Beijing 100036, China
    Zhonghua Zhong Liu Za Zhi 29:474-7. 2007
    ....
  30. ncbi request reprint Early enteral and parenteral nutritional support in patients with cirrhotic portal hypertension after pericardial devascularization
    Ke Zhang
    Department of Hepatobiliary Surgery, The 302nd Hospital of PLA, Beijing 100039, China
    Hepatobiliary Pancreat Dis Int 4:55-9. 2005
    ....
  31. ncbi request reprint Expression of novel isoforms of the CIC-1 chloride channel in astrocytic glial cells in vitro
    Xiao Dong Zhang
    Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Glia 47:46-57. 2004
    ..The present study showed that astrocytic glial cells express multiple isoforms of the ClC-1 chloride channel, which has been thought to be expressed almost exclusively in the skeletal muscle...