Quan Zhang

Summary

Affiliation: Nankai University
Country: China

Publications

  1. Ge W, Liu Z, Sun Y, Wang T, Guo H, Chen X, et al. Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia. Bioorg Chem. 2019;87:699-713 pubmed publisher
    ..On the base of these results, compound 26 might be considered as a promising candidate for further evaluation as a potential anti-AML drug. ..
  2. Ge W, Hao X, Han F, Liu Z, Wang T, Wang M, et al. Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents. Eur J Med Chem. 2019;166:445-469 pubmed publisher
    ..These findings indicate that compound 7d deserves further studies as a lead compound for ultimate discovery of effective anti-TNBC drug. ..
  3. Ding Y, Pan W, Xu J, Wang T, Chen T, Liu Z, et al. Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells. Bioorg Chem. 2019;86:363-367 pubmed publisher
  4. Ge W, Chen X, Han F, Liu Z, Wang T, Wang M, et al. Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents. Molecules. 2018;23: pubmed publisher
    ..These findings indicate that compound 10b might be considered as a lead compound for exploring effective anti-HCC drugs. ..
  5. Chen J, Li J, Wu L, Geng Y, Yu J, Chong C, et al. Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. Eur J Med Chem. 2018;151:601-627 pubmed publisher
    ..More importantly, the tumor-initiating frequency was reduced by 19 folds after the treatment of 32g, which is better than that of rakicidin A (reduction of 4.7 folds). ..
  6. Ding Y, Guo H, Ge W, Chen X, Li S, Wang M, et al. Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. Eur J Med Chem. 2018;156:216-229 pubmed publisher
    ..The preliminary molecular mechanism of 6e was also investigated. On the base of these results, compound 6e might be considered as a promising candidate for further evaluation as a potential anti-cancer drug. ..
  7. Shi Y, Dai D, Li J, Dong Y, Jiang Y, Li H, et al. Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines. Molecules. 2016;21:514 pubmed publisher
    ..SFN, 3d and 14c significantly induced the activation of caspase-3, and reduced the ALDH⁺ subpopulation in the SUM159 cell line, while the marketed drug doxrubicin(DOX) increased the ALDH⁺ subpopulation. ..