Affiliation: Nankai University
Wang Y, Yang B, Zhai Y, Yin Z, Sun Y, Rao Z. Peptidyl aldehyde NK-1.8k suppresses enterovirus 71 and enterovirus 68 infection by targeting protease 3C. Antimicrob Agents Chemother. 2015;59:2636-46 pubmed publisher
..The combination of NK-1.8k and an EV71 RNA-dependent RNA polymerase inhibitor or entry inhibitor exhibited a strong synergistic anti-EV71 effect. Our findings suggest that NK-1.8k could potentially be developed for anti-EV therapy. ..
Guo Y, Wang Y, Cao L, Wang P, Qing J, Zheng Q, et al
. A Conserved Inhibitory Mechanism of a Lycorine Derivative against Enterovirus and Hepatitis C Virus. Antimicrob Agents Chemother. 2016;60:913-24 pubmed publisher
..We also documented the significant synergistic anti-EV71 and anti-HCV effects of 1-acetyllycorine with reported inhibitors, supporting potential combination therapy for the treatment of EV71 and HCV infections. ..
Wang P, Yuan H, Zhang X, Li Y, Shang L, Yin Z. Novel lycorine derivatives as anticancer agents: synthesis and in vitro biological evaluation. Molecules. 2014;19:2469-80 pubmed publisher
..The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed. ..
Shang L, Wang Y, Qing J, Shu B, Cao L, Lou Z, et al
. An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation. Antiviral Res. 2014;112:47-58 pubmed publisher
..A significant synergistic anti-EV71 effect of NITD008 with rupintrivir (AG7088) (a protease inhibitor) was documented, supporting the potential combination therapy of NITD008 with other inhibitors for the treatment of EV71 infections. ..
Han Z, Liang X, Ren X, Shang L, Yin Z. A 3,7-Dihydroxyphenoxazine-based Fluorescent Probe for Selective Detection of Intracellular Hydrogen Peroxide. Chem Asian J. 2016;11:818-22 pubmed publisher
..Importantly, NBCD enabled the visualization of epidermal growth factor (EGF)-stimulated H2O2 generation inside the cells. ..
Zeng D, Ma Y, Zhang R, Nie Q, Cui Z, Wang Y, et al
. Synthesis and structure-activity relationship of Î±-keto amides as enterovirus 71 3C protease inhibitors. Bioorg Med Chem Lett. 2016;26:1762-6 pubmed publisher
..32Â±0.26Î¼M, 1.88Â±0.35Î¼M and 1.52Â±0.31Î¼M, respectively) and favorable CC50 values (CC50>100Î¼M). Î±-Keto amide may represent a good choice as a warhead for EV71 3C(pro) inhibitor. ..
Han Z, Liang X, Wang Y, Qing J, Cao L, Shang L, et al
. The discovery of indole derivatives as novel hepatitis C virus inhibitors. Eur J Med Chem. 2016;116:147-155 pubmed publisher
..72 ± 0.09 ?M) with the highest selectivity index (SI > 69.44). In addition, the mechanism of action study of NINS derivatives demonstrated that NINS derivatives interfere with the early step (viral entry) of the HCV life cycle. ..
Zhai Y, Ma Y, Ma F, Nie Q, Ren X, Wang Y, et al
. Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors. Eur J Med Chem. 2016;124:559-573 pubmed publisher
..Structure and relationship study led to the discovery of aldehyde 5x (IC50 = 0.10 ± 0.02 ?M, EC50 = 0.11 ± 0.07 ?M), which exhibited the most potent 3Cpro inhibitory and antiviral activity. ..
Wang M, Ma P, Xi X, Liu L, Wen Y, Liu K, et al
. Online solid phase extraction and liquid chromatography-mass spectrometric determination of nucleoside drugs in plasma. Talanta. 2016;161:278-287 pubmed publisher
..The method was tested in plasma samples from some patients and showed good performance. ..