Luqing Shang

Summary

Affiliation: Nankai University
Country: China

Publications

  1. Qiao D, Shen T, Zhu M, Liang X, Zhang L, Yin Z, et al. A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H2S and various thiol species in solution and in live cells. Chem Commun (Camb). 2018;54:13252-13255 pubmed publisher
  2. Fu S, Nie Q, Ma Y, Song P, Ren X, Luo C, et al. Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease. Chem Commun (Camb). 2018;54:2890-2893 pubmed publisher
    ..Furthermore, based on 12c and 12f, we have obtained reversible inhibitors 17c and 17f. These results demonstrated that TGSOF is a useful strategy for identifying suitable fragments in developing leads in drug discovery. ..
  3. Zeng D, Ma Y, Zhang R, Nie Q, Cui Z, Wang Y, et al. Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors. Bioorg Med Chem Lett. 2016;26:1762-6 pubmed publisher
    ..32±0.26μM, 1.88±0.35μM and 1.52±0.31μM, respectively) and favorable CC50 values (CC50>100μM). α-Keto amide may represent a good choice as a warhead for EV71 3C(pro) inhibitor. ..
  4. Han Z, Liang X, Ren X, Shang L, Yin Z. A 3,7-Dihydroxyphenoxazine-based Fluorescent Probe for Selective Detection of Intracellular Hydrogen Peroxide. Chem Asian J. 2016;11:818-22 pubmed publisher
    ..Importantly, NBCD enabled the visualization of epidermal growth factor (EGF)-stimulated H2O2 generation inside the cells. ..
  5. Han Z, Liang X, Wang Y, Qing J, Cao L, Shang L, et al. The discovery of indole derivatives as novel hepatitis C virus inhibitors. Eur J Med Chem. 2016;116:147-155 pubmed publisher
    ..72 ± 0.09 ?M) with the highest selectivity index (SI > 69.44). In addition, the mechanism of action study of NINS derivatives demonstrated that NINS derivatives interfere with the early step (viral entry) of the HCV life cycle. ..
  6. Zhai Y, Ma Y, Ma F, Nie Q, Ren X, Wang Y, et al. Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors. Eur J Med Chem. 2016;124:559-573 pubmed publisher
    ..Structure and relationship study led to the discovery of aldehyde 5x (IC50 = 0.10 ± 0.02 ?M, EC50 = 0.11 ± 0.07 ?M), which exhibited the most potent 3Cpro inhibitory and antiviral activity. ..
  7. Wang Y, Cao L, Zhai Y, Ma J, Nie Q, Li T, et al. Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k. Antiviral Res. 2017;141:91-100 pubmed publisher
    ..The combination of NK-1.9k and EV71 polymerase or entry inhibitors produced strong synergistic antiviral effects. Collectively, our findings suggest our compounds can potentially be developed as drugs for the treatment of HFMD. ..