Lin Liu


Affiliation: Nankai University
Country: China


  1. Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, et al. Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2015;112:E5936-43 pubmed publisher
    ..Together, in contrast to the prevailing view, Erk signaling is required for telomere maintenance, genomic stability, and self-renewal of mouse ESCs. ..
  2. request reprint
    Yin Y, Wang H, Liu K, Wang F, Ye X, Liu M, et al. Knockdown of H19 enhances differentiation capacity to epidermis of parthenogenetic embryonic stem cells. Curr Mol Med. 2014;14:737-48 pubmed
  3. Mao J, Liu L. Generation of iPS Cells from Granulosa Cells. Methods Mol Biol. 2016;1357:451-64 pubmed publisher
    ..Here, we describe generation of mouse and pig iPS cells from granulosa cells with high efficiency. ..
  4. Fu H, Tian C, Ye X, Sheng X, Wang H, Liu Y, et al. Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells. Stem Cell Reports. 2018;11:70-87 pubmed publisher
    ..Taken together, telomere rejuvenation links to reprogramming and pluripotency of CiPSCs. Crotonylation facilitates telomere maintenance and enhances chemically induced reprogramming to pluripotency. ..
  5. Guo R, Ye X, Yang J, Zhou Z, Tian C, Wang H, et al. Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells. Nat Commun. 2018;9:2620 pubmed publisher
    ..These data suggest the important role of feeders in maintaining telomeres for long-term stable self-renewal and developmental pluripotency of mESCs. ..
  6. Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, et al. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014;29:7-19 pubmed publisher
    ..Mechanistically, Rif1 interacts and stabilizes H3K9 methylation complex. Thus, Rif1 regulates telomere length homeostasis of ESCs by mediating heterochromatic silencing. ..
  7. Sung L, Chang W, Zhang Q, Liu C, Liou J, Chang C, et al. Telomere elongation and naive pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer. Cell Rep. 2014;9:1603-9 pubmed publisher
    ..These data suggest that SCNT could offer a powerful tool to reprogram telomeres and to discover the factors for robust restoration of telomeres and pluripotency of telomerase haplo-insufficient somatic cells. ..
  8. Yang J, Guo R, Wang H, Ye X, Zhou Z, Dan J, et al. Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs. Cell Rep. 2016;15:1809-21 pubmed publisher
    ..Together, Tet enzymes play important roles in telomere maintenance and chromosomal stability of ESCs by modulating sub-telomeric methylation levels. ..
  9. Liu L. Linking Telomere Regulation to Stem Cell Pluripotency. Trends Genet. 2017;33:16-33 pubmed publisher
    ..Here, I discuss the link between telomere elongation and homeostasis to the acquisition and maintenance of stem cell pluripotency, and their regulatory mechanisms by epigenetic modifications. ..

More Information


  1. Mao J, Zhang Q, Deng W, Wang H, Liu K, Fu H, et al. Epigenetic Modifiers Facilitate Induction and Pluripotency of Porcine iPSCs. Stem Cell Reports. 2017;8:11-20 pubmed publisher
    ..piPSCs induced by Tet1+OSKM followed by conversion with HDACi show high pluripotency. Together, epigenetic modifiers enhance generation of piPSCs and reduce their reliance on exogenous genes. ..
  2. Zeng M, Sheng X, Keefe D, Liu L. Reconstitution of ovarian function following transplantation of primordial germ cells. Sci Rep. 2017;7:1427 pubmed publisher
    ..Methods for maintaining self-renewal and expansion in vivo of PGCs and controlling follicle activation will be essential for continuing maintenance of the functional reconstructed ovaries. ..
  3. Wang H, Zhang K, Liu Y, Fu Y, Gao S, Gong P, et al. Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biol. 2017;15:114 pubmed publisher
    ..Single cell analysis of telomeres and RNA-sequencing can be exploited to further understand the molecular mechanisms of telomere heterogeneity. ..