Affiliation: Nankai University
Ge W, Liu Z, Sun Y, Wang T, Guo H, Chen X, et al
. Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia. Bioorg Chem. 2019;87:699-713 pubmed publisher
..On the base of these results, compound 26 might be considered as a promising candidate for further evaluation as a potential anti-AML drug. ..
Ge W, Hao X, Han F, Liu Z, Wang T, Wang M, et al
. Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents. Eur J Med Chem. 2019;166:445-469 pubmed publisher
..These findings indicate that compound 7d deserves further studies as a lead compound for ultimate discovery of effective anti-TNBC drug. ..
Ge W, Chen X, Han F, Liu Z, Wang T, Wang M, et al
. Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents. Molecules. 2018;23: pubmed publisher
..These findings indicate that compound 10b might be considered as a lead compound for exploring effective anti-HCC drugs. ..
Chen J, Li J, Wu L, Geng Y, Yu J, Chong C, et al
. Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. Eur J Med Chem. 2018;151:601-627 pubmed publisher
..More importantly, the tumor-initiating frequency was reduced by 19 folds after the treatment of 32g, which is better than that of rakicidin A (reduction of 4.7 folds). ..