Yue Chen


Affiliation: Nankai University
Country: China


  1. Ge W, Liu Z, Sun Y, Wang T, Guo H, Chen X, et al. Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia. Bioorg Chem. 2019;87:699-713 pubmed publisher
    ..On the base of these results, compound 26 might be considered as a promising candidate for further evaluation as a potential anti-AML drug. ..
  2. Ge W, Hao X, Han F, Liu Z, Wang T, Wang M, et al. Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents. Eur J Med Chem. 2019;166:445-469 pubmed publisher
    ..These findings indicate that compound 7d deserves further studies as a lead compound for ultimate discovery of effective anti-TNBC drug. ..
  3. Ge W, Chen X, Han F, Liu Z, Wang T, Wang M, et al. Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents. Molecules. 2018;23: pubmed publisher
    ..These findings indicate that compound 10b might be considered as a lead compound for exploring effective anti-HCC drugs. ..
  4. Ye B, Jiang P, Zhang T, Sun Y, Hao X, Cui Y, et al. Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin. Mar Drugs. 2018;16: pubmed publisher
    ..3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment. ..
  5. Chen J, Li J, Wu L, Geng Y, Yu J, Chong C, et al. Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. Eur J Med Chem. 2018;151:601-627 pubmed publisher
    ..More importantly, the tumor-initiating frequency was reduced by 19 folds after the treatment of 32g, which is better than that of rakicidin A (reduction of 4.7 folds). ..
  6. Ding Y, Gao X, Long J, Kuang B, Chen Y, Zhang Q. Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. Bioorg Med Chem Lett. 2016;26:1165-8 pubmed publisher
    ..Further study suggested that DDL induced apoptosis mainly through the up-regulation of apoptosis related protein Bax, followed by the cleavage of caspase-3, caspase-9, and PARP. ..
  7. Li Y, Wang J, Pan C, Meng F, Chu X, Ding Y, et al. Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib. Bioorg Med Chem Lett. 2016;26:1419-27 pubmed publisher
    ..These findings suggest that these compounds are able to inhibit leukemia stem-like cells. ..
  8. Shi Y, Dai D, Li J, Dong Y, Jiang Y, Li H, et al. Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines. Molecules. 2016;21:514 pubmed publisher
    ..SFN, 3d and 14c significantly induced the activation of caspase-3, and reduced the ALDH⁺ subpopulation in the SUM159 cell line, while the marketed drug doxrubicin(DOX) increased the ALDH⁺ subpopulation. ..
  9. Li H, He D, Zhao X, Sun T, Zhang Q, Bai C, et al. Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells. Bioorg Med Chem Lett. 2018;28:700-706 pubmed publisher
    ..8.98 μM). Compounds 15a and 24a also inhibited colony formation in MCF-7 cells and inhibited cell migration in the cell wound scratch assay in B16BL6 cells. Moreover, hydroxyl compounds 15a and 24a had low toxicity in vivo. ..

More Information


  1. Jiang Y, Li H, Li X, Lu J, Zhang Q, Bai C, et al. Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis. Bioorg Med Chem Lett. 2018;28:737-741 pubmed publisher
    ..Compound 8b also did not cause appreciable toxicity in mice after 5 weeks at a daily dose of 200 mg/kg. ..
  2. Tian Y, Xu X, Ding Y, Hao X, Bai Y, Tang Y, et al. Synthesis and biological evaluation of nannocystin analogues toward understanding the binding role of the (2R,3S)-Epoxide in nannocystin A. Eur J Med Chem. 2018;150:626-632 pubmed publisher
    ..Our results showed that the (2R,3S)-epoxide of nannocystin A is mainly responsible for controlling the macrocyclic conformation, rather than binding directly to the target. ..
  3. Yang Z, Kuang B, Kang N, Ding Y, Ge W, Lian L, et al. Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives. Eur J Med Chem. 2017;127:296-304 pubmed publisher
    ..3 ?M) comparing with its high anti-AML activity. The selectivity indexes for AML cells KG1a and HL-60 were 30.8 and 11.2, respectively. Preliminary study revealed that compound 6j could induce apoptosis of KG1a cells. ..