Affiliation: Nankai University
Ge W, Liu Z, Sun Y, Wang T, Guo H, Chen X, et al
. Design and synthesis of parthenolide-SAHA hybrids for intervention of drug-resistant acute myeloid leukemia. Bioorg Chem. 2019;87:699-713 pubmed publisher
..On the base of these results, compound 26 might be considered as a promising candidate for further evaluation as a potential anti-AML drug. ..
Ge W, Hao X, Han F, Liu Z, Wang T, Wang M, et al
. Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents. Eur J Med Chem. 2019;166:445-469 pubmed publisher
..These findings indicate that compound 7d deserves further studies as a lead compound for ultimate discovery of effective anti-TNBC drug. ..
Ge W, Chen X, Han F, Liu Z, Wang T, Wang M, et al
. Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents. Molecules. 2018;23: pubmed publisher
..These findings indicate that compound 10b might be considered as a lead compound for exploring effective anti-HCC drugs. ..
Ye B, Jiang P, Zhang T, Sun Y, Hao X, Cui Y, et al
. Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin. Mar Drugs. 2018;16: pubmed publisher
..3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment. ..
Chen J, Li J, Wu L, Geng Y, Yu J, Chong C, et al
. Syntheses and anti-pancreatic cancer activities of rakicidin A analogues. Eur J Med Chem. 2018;151:601-627 pubmed publisher
..More importantly, the tumor-initiating frequency was reduced by 19 folds after the treatment of 32g, which is better than that of rakicidin A (reduction of 4.7 folds). ..
Ding Y, Gao X, Long J, Kuang B, Chen Y, Zhang Q. Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells. Bioorg Med Chem Lett. 2016;26:1165-8 pubmed publisher
..Further study suggested that DDL induced apoptosis mainly through the up-regulation of apoptosis related protein Bax, followed by the cleavage of caspase-3, caspase-9, and PARP. ..
Li Y, Wang J, Pan C, Meng F, Chu X, Ding Y, et al
. Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib. Bioorg Med Chem Lett. 2016;26:1419-27 pubmed publisher
..These findings suggest that these compounds are able to inhibit leukemia stem-like cells. ..
Shi Y, Dai D, Li J, Dong Y, Jiang Y, Li H, et al
. Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines. Molecules. 2016;21:514 pubmed publisher
..SFN, 3d and 14c significantly induced the activation of caspase-3, and reduced the ALDH⁺ subpopulation in the SUM159 cell line, while the marketed drug doxrubicin(DOX) increased the ALDH⁺ subpopulation. ..
Li H, He D, Zhao X, Sun T, Zhang Q, Bai C, et al
. Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells. Bioorg Med Chem Lett. 2018;28:700-706 pubmed publisher
..8.98 μM). Compounds 15a and 24a also inhibited colony formation in MCF-7 cells and inhibited cell migration in the cell wound scratch assay in B16BL6 cells. Moreover, hydroxyl compounds 15a and 24a had low toxicity in vivo. ..