Ke Zen


Affiliation: Nanjing University
Country: China


  1. Zhang J, Li L, Li J, Liu Y, Zhang C, Zhang Y, et al. Protein tyrosine phosphatase 1B impairs diabetic wound healing through vascular endothelial growth factor receptor 2 dephosphorylation. Arterioscler Thromb Vasc Biol. 2015;35:163-74 pubmed publisher
  2. Jin F, Yang R, Wei Y, Wang D, Zhu Y, Wang X, et al. HIF-1α-induced miR-23a∼27a∼24 cluster promotes colorectal cancer progression via reprogramming metabolism. Cancer Lett. 2018;440-441:211-222 pubmed publisher
    ..Our findings reveal that the miR-23a∼27a∼24 cluster is critical regulator switching CRC metabolism from oxidative phosphorylation to glycolysis, and controlling their expression can suppress colorectal cancer progression. ..
  3. Zhao X, Zhu Y, Hu J, Jiang L, Li L, Jia S, et al. Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis. Sci Rep. 2018;8:14517 pubmed publisher
    ..In conclusion, this study demonstrates that shikonin inhibits tumor growth in mice by suppressing PKM2-mediated aerobic glycolysis. ..
  4. Wang N, Qu S, Sun W, Zeng Z, Liang H, Zhang C, et al. Direct quantification of 3' terminal 2'-O-methylation of small RNAs by RT-qPCR. RNA. 2018;: pubmed publisher
  5. Liang H, Zhang S, Fu Z, Wang Y, Wang N, Liu Y, et al. Effective detection and quantification of dietetically absorbed plant microRNAs in human plasma. J Nutr Biochem. 2015;26:505-12 pubmed publisher
    ..04% to 1.31%). Northern blotting was used to confirm the qRT-PCR results. Critical issues such as RNA extraction and internal controls were also addressed. ..
  6. Yang Z, Reeves M, Ye J, Trang P, Zhu L, Sheng J, et al. RNase P Ribozymes Inhibit the Replication of Human Cytomegalovirus by Targeting Essential Viral Capsid Proteins. Viruses. 2015;7:3345-60 pubmed publisher
  7. Zen K, Liu D, Guo Y, Wang C, Shan J, Fang M, et al. CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. PLoS ONE. 2008;3:e1826 pubmed publisher
    ..This finding offers new insights into the molecular basis of E-selectin-dependent adhesive interactions that mediate breast cancer cell transendothelial metastasis. ..
  8. Ding M, Wang C, Lu X, Zhang C, Zhou Z, Chen X, et al. Comparison of commercial exosome isolation kits for circulating exosomal microRNA profiling. Anal Bioanal Chem. 2018;410:3805-3814 pubmed publisher
    ..In this study, we compared four commonly used commercially available kits for exosomal miRNAsextraction and analyzed the advantages and weaknesses of each kit and their application to the sample ofserum and/or plasma. ..
  9. Zhang C, Liang S, Cheng S, Li W, Wang X, Zheng C, et al. Urinary miR-196a predicts disease progression in patients with chronic kidney disease. J Transl Med. 2018;16:91 pubmed publisher
    ..Prediction accuracy of ESRD was significantly improved by combining urinary miR-196a with other indicators including eGFR and proteinuria. Urinary miR-196a may serve as a biomarker for predicting CKD progression. ..

More Information


  1. Zhu D, Pan C, Sheng J, Liang H, Bian Z, Liu Y, et al. Human cytomegalovirus reprogrammes haematopoietic progenitor cells into immunosuppressive monocytes to achieve latency. Nat Microbiol. 2018;3:503-513 pubmed publisher
    ..Our findings reveal that via activating the STAT3-iNOS-NO axis, HCMV differentiates human HPCs into a longevous, immunosuppressive monocyte subset for viral latency. ..
  2. Zen K, Zhang C. Circulating microRNAs: a novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev. 2012;32:326-48 pubmed publisher
  3. Wei Y, Li M, Cui S, Wang D, Zhang C, Zen K, et al. Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes. Molecules. 2016;21: pubmed publisher
    ..These results show that shikonin inhibits the proliferation of MCF-7 cells through reducing tumor-derived exosomal miR-128. The current study suggests that shikonin suppresses MCF-7 growth by the inhibition of exosome release. ..
  4. Wang Y, Chen L, Wu Z, Wang M, Jin F, Wang N, et al. miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL. BMC Cancer. 2016;16:826 pubmed
    ..This study identified a new regulatory axis in which miR-124-3p and CBL regulate the proliferation and invasion of breast cancer cells. ..
  5. Zen K, Guo Y, Li L, Bian Z, Zhang C, Liu Y. Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood. 2011;117:4885-94 pubmed publisher
    ..By illustrating CD11b shedding by elastase, proteinase-3 and cathepsin G as a novel mechanism for PMN detachment, our study provides novel therapeutic targets for controlling inflammation. ..
  6. Liang H, Wang N, Wang Y, Wang F, Fu Z, Yan X, et al. Hepatitis B virus-human chimeric transcript HBx-LINE1 promotes hepatic injury via sequestering cellular microRNA-122. J Hepatol. 2016;64:278-291 pubmed publisher
    ..Our finding illustrates a previously uncharacterized miR-122-sequestering mechanism by which HBx-LINE1 promotes hepatic cell EMT-like changes and mouse liver injury. ..
  7. Gu H, Zhao C, Zhang T, Liang H, Wang X, Pan Y, et al. Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival. Sci Rep. 2017;7:2392 pubmed publisher
    ..In conclusion, we demonstrate a novel strategy for Salmonella evading the host immune clearance, in which Salmonella produce microRNA-like functional RNA fragments to establish a microenvironment facilitating bacterial survival. ..
  8. Ding H, Bai F, Cao H, Xu J, Fang L, Wu J, et al. PDE/cAMP/Epac/C/EBP-? signaling cascade regulates mitochondria biogenesis of tubular epithelial cells in renal fibrosis. Antioxid Redox Signal. 2017;: pubmed publisher
    ..In the present study, we investigated the role of the cAMP pathway in tubular epithelial cells mitochondrial biogenesis in the pathogenesis of renal fibrosis...
  9. Zhao C, Zhou Z, Zhang T, Liu F, Zhang C, Zen K, et al. Salmonella small RNA fragment Sal-1 facilitates bacterial survival in infected cells via suppressing iNOS induction in a microRNA manner. Sci Rep. 2017;7:16979 pubmed publisher
    ..In conclusion, our study provides new insight into the pathogenic mechanism of intracellular bacteria to modulate host innate immune response. ..
  10. Diao W, Lu L, Li S, Chen J, Zen K, Li L. MicroRNA-125b-5p modulates the inflammatory state of macrophages via targeting B7-H4. Biochem Biophys Res Commun. 2017;491:912-918 pubmed publisher
    ..Taken together, our results demonstrated for the first time that miR-125b-5p could regulate the inflammatory state of macrophages via directly targeting B7-H4. ..
  11. Jin F, Wang Y, Zhu Y, Li S, Liu Y, Chen C, et al. The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma. Sci Rep. 2017;7:3089 pubmed publisher
  12. Liang H, Yan X, Pan Y, Wang Y, Wang N, Li L, et al. MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3. Mol Cancer. 2015;14:58 pubmed publisher
    ..Our study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3. ..
  13. Zen K, Liu D, Li L, Chen C, Guo Y, Ha B, et al. The heparan sulfate proteoglycan form of epithelial CD44v3 serves as a CD11b/CD18 counter-receptor during polymorphonuclear leukocyte transepithelial migration. J Biol Chem. 2009;284:3768-76 pubmed publisher
    ..In summary, our study demonstrates for the first time that the heparan sulfate proteoglycan form of epithelial CD44v3 plays a critical role in facilitating PMN recruitment during inflammatory episodes via directly binding to CD11b/CD18. ..