Research Topics

Genomes and Genes


Wei Wu


Affiliation: Nanjing Medical University
Country: China


  1. Tang Q, Pan F, Yang J, Fu Z, Lu Y, Wu X, et al. Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: a case-control study. Clin Epigenetics. 2018;10:134 pubmed publisher
    ..We conclude that abnormalities of DMR within imprinted genes may be associated with idiopathic male infertility. Disruption in methylation pattern of the three imprinted genes does not occur in high-risk genotypes of DNMTs. ..
  2. Guo D, Jiang H, Chen Y, Yang J, Fu Z, Li J, et al. Elevated microRNA-141-3p in placenta of non-diabetic macrosomia regulate trophoblast proliferation. EBioMedicine. 2018;38:154-161 pubmed publisher
    ..However, no significant difference was found in early pregnancy of C57BL/6J mice treated with miR-141-3p agomir. miR-141-3p could stimulate placental cell proliferation to participate in the occurrence and development of NDFMS. ..
  3. Hu W, Chen M, Wu W, Lu J, Zhao D, Pan F, et al. Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites. Environ Int. 2016;91:188-95 pubmed publisher
    ..05, 95% CI=4.78-60.20, P=2.34×10(-5)). Most metabolites identified were involved in the tricarboxylic acid cycle. In conclusion, it is a novel study of the interaction on male infertility from the aspect of metabolomics. ..
  4. Yuan B, Gu H, Xu B, Tang Q, Wu W, Ji X, et al. Effects of Gold Nanorods on Imprinted Genes Expression in TM-4 Sertoli Cells. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..Our study suggested that aberrant expression of imprinted genes might be an underlying mechanism for the GNRs-induced reproductive toxicity in TM-4 Sertoli cells. ..
  5. Wu W, Lu J, Tang Q, Zhang S, Yuan B, Li J, et al. GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects. Sci Rep. 2013;3:2258 pubmed publisher
    ..Further studies of GSTM1 and GSTT1 with their biological functions are needed to understand the role of these genes in the development of male infertility. ..
  6. Tang Q, Chen Y, Wu W, Ding H, Xia Y, Chen D, et al. Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. Sci Rep. 2017;7:11219 pubmed publisher
    ..These results suggested that variants in different DNMT genes have different relationships with idiopathic male infertility, and Chinese men carrying these variants have an increased or decreased risk of abnormal semen parameters. ..