Ting Ting Wang
Affiliation: Nanjing University
Lv M, Xu Y, Tang R, Ren J, Shen S, Chen Y, et al
. miR141-CXCL1-CXCR2 signaling-induced Treg recruitment regulates metastases and survival of non-small cell lung cancer. Mol Cancer Ther. 2014;13:3152-62 pubmed publisher
..Mechanistically, decreased expressions of miR141, associated with the survival of patients with NSCLC with MPE, resulted in the increased production of CXCL1 and recruitment of Tregs to promote immune escape of tumor. ..
Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, et al
. The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells. Immunity. 2018;49:504-514.e4 pubmed publisher
..The frequency of MDSCs in tumor tissues of colon cancer patients correlated positively with fungal burden, pointing to the relevance of this regulatory axis in human disease. ..
Tang R, Shen S, Zhao X, Nie Y, Xu Y, Ren J, et al
. Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer. Stem Cell Res Ther. 2015;6:71 pubmed publisher
..These results proved that MSCs could migrate to colon tissues and induce the differentiation of Treg cells via Smad2 as so to inhibit the colitis and suppress the development of CAC. ..
Shi T, Ma Y, Yu L, Jiang J, Shen S, Hou Y, et al
. Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints. Int J Mol Sci. 2018;19: pubmed publisher
..Finally, predictions are made for future personalized cancer immunotherapy based on different checkpoint modulations. ..
Ren J, Ding L, Xu Q, Shi G, Li X, Li X, et al
. LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway. Sci Rep. 2017;7:749 pubmed publisher
..Taken together, these observations imply that LF-MF suppressed lung cancer via inhibiting cell iron metabolism, stabilizing p53 protein and activation P53- miR-34a-E2F1/E2F3 pathway. ..
Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, et al
. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. Sci Rep. 2017;7:11776 pubmed publisher
..Taken together, this study proved that LF-MFs can inhibit lung cancers through miR-486 induced autophagic cell death, which suggest a clinical application of LF-MFs in cancer treatment. ..