Research Topics

Genomes and Genes


P P Shen


Affiliation: Nanjing University
Country: China


  1. Liu P, Li C, Zhang R, Tang Q, Wei J, Lu Y, et al. An ultrasensitive electrochemical immunosensor for procalcitonin detection based on the gold nanoparticles-enhanced tyramide signal amplification strategy. Biosens Bioelectron. 2018;126:543-550 pubmed publisher
    ..1 pg mL-1. We have successfully utilized this immunosensor to quantify the concentration of PCT in human serum samples, and the results suggest its potential use in clinical application. ..
  2. Dai H, Zhou Y, Tong C, Guo Y, Shi F, Wang Y, et al. Restoration of CD3+CD56+ cell level improves skin lesions in severe psoriasis: A pilot clinical study of adoptive immunotherapy for patients with psoriasis using autologous cytokine-induced killer cells. Cytotherapy. 2018;20:1155-1163 pubmed publisher
  3. Feng X, Weng D, Zhou F, Owen Y, Qin H, Zhao J, et al. Activation of PPAR? by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization. EBioMedicine. 2016;9:61-76 pubmed publisher
    ..Unlike rosiglitazone, apigenin does not cause significant weight gain, osteoporosis et al. Our findings identify apigenin as a modulator of PPAR? and a potential lead compound for treatment of metabolic disorders. ..
  4. Feng X, Yu W, Zhou F, Chen J, Shen P. A novel small molecule compound diaporine inhibits breast cancer cell proliferation via promoting ROS generation. Biomed Pharmacother. 2016;83:1038-1047 pubmed publisher
    ..Collectively, our results suggest that diaporine can act as an anti-cancer agent and this function is dependent on promoting high level ROS release of cancer cells. ..
  5. Bei Y, Chen J, Zhou F, Huang Y, Jiang N, Tan R, et al. BZ-26, a novel GW9662 derivate, attenuated inflammation by inhibiting the differentiation and activation of inflammatory macrophages. Biomed Pharmacother. 2016;84:730-739 pubmed publisher
    ..All our data revealed that BZ-26 modulated LPS-induced acute inflammation via inhibiting inflammatory macrophages differentiation and activation, potentially via inhibition of NF-?B signal pathway. ..
  6. Feng X, Yu W, Li X, Zhou F, Zhang W, Shen Q, et al. Apigenin, a modulator of PPAR?, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochem Pharmacol. 2017;136:136-149 pubmed publisher
    ..Therefore, our results indicate that Api ameliorates NAFLD by a novel regulating mode of Nrf2 and PPAR? in inhibiting lipid metabolism and oxidative stress abnormity. ..
  7. Lu Y, Zhang Y, Li L, Feng X, Ding S, Zheng W, et al. TAB1: a target of triptolide in macrophages. Chem Biol. 2014;21:246-56 pubmed publisher
    ..Our results suggest that TP could be a selective small-molecule inhibitor of the TAK1-TAB1 complex and that TAB1 could be a potential therapeutic target in inflammatory disease. ..
  8. Niu Z, Shi Q, Zhang W, Shu Y, Yang N, Chen B, et al. Caspase-1 cleaves PPAR? for potentiating the pro-tumor action of TAMs. Nat Commun. 2017;8:766 pubmed publisher