Ling Lu


Affiliation: Nanjing Normal University
Country: China


  1. Wei H, Yue S, Zhang S, Lu L. Lipid-Lowering Effect of the Pleurotus eryngii (King Oyster Mushroom) Polysaccharide from Solid-State Fermentation on Both Macrophage-Derived Foam Cells and Zebrafish Models. Polymers (Basel). 2018;10: pubmed publisher
    ..Our findings suggest that the P. eryngii polysaccharide from solid-state fermentation (PESF) can be used as a valuable lipid-lowering food additive or raw materials for producing lipid-lowering drugs. ..
  2. Li X, Li Y, Wang R, Wang Q, Lu L. Toxoflavin Produced by Burkholderia gladioli from Lycoris aurea Is a New Broad-Spectrum Fungicide. Appl Environ Microbiol. 2019;85: pubmed publisher
    ..fumigatus Consequently, our findings provide a promising approach to abundantly produce toxoflavin, which has novel broad-spectrum antifungal activity, especially against those currently problematic drug-resistant isolates. ..
  3. Cai Z, Du W, Liu L, Pan D, Lu L. Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation. mSphere. 2019;4: pubmed publisher
    ..nidulans, indicating that species-specific machinery exists for Cu acquisition in Aspergillus. ..
  4. Chen J, Yong Y, Xia X, Wang Z, Liang Y, Zhang S, et al. The excreted polysaccharide of Pleurotus eryngii inhibits the foam-cell formation via down-regulation of CD36. Carbohydr Polym. 2014;112:16-23 pubmed publisher
    ..Expression analysis suggests that EP is able to cause the down-regulation of the scavenger receptor-CD36 on both transcription and protein levels. Most importantly, EP can be obtained by fermentation in a mass-production. ..
  5. Zhang C, Meng X, Gu H, Ma Z, Lu L. Predicted Glycerol 3-Phosphate Dehydrogenase Homologs and the Glycerol Kinase GlcA Coordinately Adapt to Various Carbon Sources and Osmotic Stress in Aspergillus fumigatus. G3 (Bethesda). 2018;8:2291-2299 pubmed publisher
    ..Therefore, the findings of this study elucidate how saprophytic filamentous fungi have developed pathways distinct from those of budding yeasts to adapt to varied carbon sources and survive environmental stresses. ..
  6. Zhong G, Jiang P, Qiao W, Zhang Y, Wei W, Lu L. Protein phosphatase 2A (PP2A) regulatory subunits ParA and PabA orchestrate septation and conidiation and are essential for PP2A activity in Aspergillus nidulans. Eukaryot Cell. 2014;13:1494-506 pubmed publisher
    ..Thus, our findings support the previously unrealized evidence that the B-family subunits of PP2A have comprehensive functions as partners of heterotrimeric enzyme complexes of PP2A, both spatially and temporally, in A. nidulans. ..
  7. Liu F, Pu L, Zheng Q, Zhang Y, Gao R, Xu X, et al. Calcium signaling mediates antifungal activity of triazole drugs in the Aspergilli. Fungal Genet Biol. 2015;81:182-90 pubmed publisher
    ..Thus, our study provides potential clues that specific inhibitors of calcium signaling could be clinically useful adjuncts to conventional azole antifungals in the Aspergilli. ..
  8. Lu L, Sirish P, Zhang Z, Woltz R, Li N, Timofeyev V, et al. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem. 2015;290:4663-76 pubmed publisher
    ..Utilizing a Cav1.3 null mutant mouse model, we demonstrate that ablation of Cav1.3 results in a decrease in the protein expression of myosin light chain 2, which interacts and increases the membrane localization of SK2 channels. ..
  9. Cai Z, Chai Y, Zhang C, Qiao W, Sang H, Lu L. The Gβ-like protein CpcB is required for hyphal growth, conidiophore morphology and pathogenicity in Aspergillus fumigatus. Fungal Genet Biol. 2015;81:120-31 pubmed publisher

More Information


  1. Zhang C, Meng X, Wei X, Lu L. Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus. Fungal Genet Biol. 2016;86:47-57 pubmed publisher
    ..Moreover, we found that MMEJ-mediated CRISPR-Cas9 mutagenesis is independent of the ku80 pathway, indicating that this system can function as a powerful and versatile genome-editing tool in clinical Aspergillus isolates. ..
  2. Song J, Zhai P, Zhang Y, Zhang C, Sang H, Han G, et al. The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. MBio. 2016;7:e01919-15 pubmed publisher
  3. Song J, Liu X, Zhai P, Huang J, Lu L. A putative mitochondrial calcium uniporter in A. fumigatus contributes to mitochondrial Ca(2+) homeostasis and stress responses. Fungal Genet Biol. 2016;94:15-22 pubmed publisher
  4. Song J, Zhai P, Lu L. Damage resistance protein (Dap) contributes to azole resistance in a sterol-regulatory-element-binding protein SrbA-dependent way. Appl Microbiol Biotechnol. 2017;101:3729-3741 pubmed publisher
    ..Thus, our findings demonstrate that Dap proteins indirectly sense azole stress and link the function of the azole stress-regulator SrbA with the role of Daps in azole susceptibility. ..
  5. Cai Z, Du W, Zeng Q, Long N, Dai C, Lu L. Cu-sensing transcription factor Mac1 coordinates with the Ctr transporter family to regulate Cu acquisition and virulence in Aspergillus fumigatus. Fungal Genet Biol. 2017;107:31-43 pubmed publisher
  6. Long N, Xu X, Zeng Q, Sang H, Lu L. Erg4A and Erg4B Are Required for Conidiation and Azole Resistance via Regulation of Ergosterol Biosynthesis in Aspergillus fumigatus. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..Therefore, our finding indicates that inhibition of Erg4A and Erg4B might be an effective approach for alleviating A. fumigatus infection. ..
  7. Lu L, Timofeyev V, Li N, Rafizadeh S, Singapuri A, Harris T, et al. Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). Proc Natl Acad Sci U S A. 2009;106:18402-7 pubmed publisher
    ..The importance of our findings may transcend the area of K(+) channels, given that similar cytoskeletal interaction and anchoring may be critical for the membrane localization of other ion channels in neurons and other excitable cells. ..
  8. Jiang H, Liu F, Zhang S, Lu L. Putative PmrA and PmcA are important for normal growth, morphogenesis and cell wall integrity, but not for viability in Aspergillus nidulans. Microbiology. 2014;160:2387-95 pubmed publisher
    ..Thus, our findings suggest AnPmrA and AnPmcA might play important roles in growth, morphogenesis and cell wall integrity in A. nidulans in a different way from that in yeasts. ..
  9. Zhang C, Lu L. Precise and Efficient In-Frame Integration of an Exogenous GFP Tag in Aspergillus fumigatus by a CRISPR System. Methods Mol Biol. 2017;1625:249-258 pubmed publisher
    ..fumigatus. According to the detectable proportional fluorescence intensity, it is possible to in vivo track the A. fumigatus infection and to assess the fungal burden in relative organs. ..
  10. Wei X, Chen P, Gao R, Li Y, Zhang A, Liu F, et al. Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..In addition, our study suggests that genome-wide sequencing combined with alignment comparison analysis is an efficient approach to identify the contribution of single nucleotide polymorphism (SNP) diversity to drug resistance. ..