Gang Hu

Summary

Affiliation: Nanjing Medical University
Country: China

Publications

  1. Gao G, Li F, Hu Y, Yan R, Liu B, Liu X, et al. Glycemic variation in uncontrolled Graves' disease patients with normal glucose metabolism: Assessment by continuous glucose monitoring. Endocrine. 2018;: pubmed publisher
    ..Uncontrolled GD patients with normal glucose metabolism had a greater GV, and the FT4 level may contributed to the increased GV. ..
  2. Lv Y, Hu R, Jing M, Zhao T, Wu N, Song R, et al. Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type, but not in dopamine D3 receptor knockout mice. Acta Pharmacol Sin. 2018;: pubmed publisher
  3. Zhang Q, Li C, Zhang T, Ge Y, Han X, Sun S, et al. Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD. Mol Cell Neurosci. 2018;92:164-176 pubmed publisher
    ..Our findings suggest that Kir6.2 plays a crucial role in the pathogenesis of PD and regulating Kir6.2/K-ATP channel may be a promising strategy for PD treatment. ..
  4. Wang L, Zhai Y, Xu L, Qiao C, Sun X, Ding J, et al. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Exp Neurol. 2014;251:22-9 pubmed publisher
    ..Our study indicates that metabolic inflammation exacerbates DA neuronal degeneration in the progress of PD, which will provide a novel insight into the etiology of PD. ..
  5. Chen M, Zou W, Chen M, Cao L, Ding J, Xiao W, et al. Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway. Eur J Pharmacol. 2018;833:221-229 pubmed publisher
  6. Zhu J, Hu Z, Han X, Wang D, Jiang Q, Ding J, et al. Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3. Cell Death Differ. 2018;25:2037-2049 pubmed publisher
    ..Collectively, our study illustrates that astrocytic Drd2 inhibits NLRP3 inflammasome activation through a β-arrestin2-dependent mechanism, and provides a new strategy for treatment of PD. ..
  7. Qiao C, Zhang Q, Jiang Q, Zhang T, Chen M, Fan Y, et al. Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson's disease. J Neuroinflammation. 2018;15:193 pubmed publisher
    ..This study gives us an insight into the direct linkage between liver inflammation and DA neuron damage in the pathogenesis of PD and provides the potential target of NLRP3 for developing novel drugs for PD therapy. ..
  8. Li X, Ding X, Wu R, Chen L, Gao J, Hu G, et al. A behavioral mechanistic investigation of the role of 5-HT1A receptors in the mediation of rat maternal behavior. Pharmacol Biochem Behav. 2018;169:16-26 pubmed publisher
    ..More work is needed to further delineate the psychological and neuronal mechanisms underlying the maternal disruptive effect of 5-HT1A receptor activation. ..
  9. Du R, Sun H, Hu Z, Lu M, Ding J, Hu G. Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson's disease. Cell Death Dis. 2018;9:404 pubmed publisher
    ..Collectively, our findings reveal that Kir6.1/K-ATP channel modulates microglia phenotypes transition via inhibition of p38 MAPK-NF-κB signaling pathway and Kir6.1/K-ATP channel may be a promising therapeutic target for PD. ..

More Information

Publications25

  1. Zhou Y, Zhu J, Lv Y, Song C, Ding J, Xiao M, et al. Kir6.2 Deficiency Promotes Mesencephalic Neural Precursor Cell Differentiation via Regulating miR-133b/GDNF in a Parkinson's Disease Mouse Model. Mol Neurobiol. 2018;55:8550-8562 pubmed publisher
    ..2 deficiency. Collectively, we clarify for the first time that Kir6.2/K-ATP channel functions as a novel endogenous negative regulator of NPC differentiation, and provide a promising neuroprotective target for PD therapeutics. ..
  2. Lu M, Su C, Qiao C, Bian Y, Ding J, Hu G. Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson's Disease via Autophagy and Mitochondrial ROS Clearance. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
  3. Qiao C, Zhang L, Sun X, Ding J, Lu M, Hu G. Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease. Mol Neurobiol. 2017;54:4292-4302 pubmed publisher
    ..These findings will shed new insight into the potential of caspase-1 as a target for PD therapy. ..
  4. Sun H, Liang R, Yang B, Zhou Y, Liu M, Fang F, et al. Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson's disease. Neuroscience. 2016;317:65-75 pubmed publisher
    ..Our data provide the first evidence that AQP4 modulates astrocyte-to-microglia communication in neuroinflammation, although its effect on astrocyte inflammatory activation remains to be explored. ..
  5. Song N, Fang Y, Sun X, Jiang Q, Song C, Chen M, et al. Salmeterol, agonist of β2-aderenergic receptor, prevents systemic inflammation via inhibiting NLRP3 inflammasome. Biochem Pharmacol. 2018;150:245-255 pubmed publisher
    ..These results provide new ideas for the future treatment of systemic inflammation and other inflammatory diseases. ..
  6. Du R, Tan J, Sun X, Lu M, Ding J, Hu G. Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
  7. Shan H, Bian Y, Shu Z, Zhang L, Zhu J, Ding J, et al. Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. Neuropharmacology. 2016;107:68-78 pubmed publisher
  8. Ding X, Li X, Shu Q, Wu R, Hu G, Li M. Time-dependent sensitization of antipsychotic effect in adolescent male and female rats. Behav Brain Res. 2017;328:186-194 pubmed publisher
    ..g. specific drugs, drug doses), individual (e.g. male versus female) and environmental (e.g. specific behavioral models) factors play a role in the modulation of the strength of antipsychotic sensitization and tolerance. ..
  9. Zhang Y, Zhang Y, Bai Y, Chao J, Hu G, Chen X, et al. Involvement of PUMA in pericyte migration induced by methamphetamine. Exp Cell Res. 2017;356:28-39 pubmed publisher
    ..Thus, targeted studies of PUMA could provide insights to facilitate the development of a potential therapeutic approach for alleviation of methamphetamine-induced pericyte migration. ..
  10. Hua J, Yin N, Yang B, Zhang J, Ding J, Fan Y, et al. Ginkgolide B and bilobalide ameliorate neural cell apoptosis in ?-synuclein aggregates. Biomed Pharmacother. 2017;96:792-797 pubmed publisher
    ..Together, we firstly find that aggregated ?-Syn induced cell apoptosis and GB and BB may attenuate aggregated ?-Syn-induced cell apoptosis, which gives us an insight into the novel therapy for PD in future. ..
  11. Du R, Wu F, Lu M, Shu X, Ding J, Wu G, et al. Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression. Redox Biol. 2016;9:178-187 pubmed publisher
    ..Collectively, our findings reveal that UCP2 regulates inflammation responses in astrocytes and plays an important role in the pathogenesis of depression and that UCP2 may be a promising therapeutic target for depression. ..
  12. Zhang Q, Cheng H, Rong R, Yang H, Ji Q, Li Q, et al. The Effect of PSD-93 Deficiency on the Expression of Early Inflammatory Cytokines Induced by Ischemic Brain Injury. Cell Biochem Biophys. 2015;73:695-700 pubmed publisher
    ..PSD-93 knockout may play a neuroprotective role by mediating the early release of inflammatory cytokines induced by cerebral ischemia. ..
  13. Zhou Y, Lu M, Du R, Qiao C, Jiang C, Zhang K, et al. MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease. Mol Neurodegener. 2016;11:28 pubmed publisher
    ..These findings will give us an insight into the potential of miR-7 and NLRP3 inflammasome in terms of opening up novel therapeutic avenues for PD. ..
  14. request reprint
    Fan Z, Lu M, Qiao C, Zhou Y, Ding J, Hu G. MicroRNA-7 Enhances Subventricular Zone Neurogenesis by Inhibiting NLRP3/Caspase-1 Axis in Adult Neural Stem Cells. Mol Neurobiol. 2016;53:7057-7069 pubmed
    ..Our study provides a direct link between NLRP3 inflammasome activation and α-syn-impaired neurogenesis in the pathogenesis of α-synucleinopathies. ..
  15. Fan Y, Kong H, Ye X, Ding J, Hu G. ATP-sensitive potassium channels: uncovering novel targets for treating depression. Brain Struct Funct. 2016;221:3111-22 pubmed publisher
    ..2(-/-) mice. Collectively, our findings demonstrate that K-ATP channels are involved in the pathogenesis of depression and may be a promising target for the therapy of depression. ..
  16. Du R, Dai T, Cao W, Lu M, Ding J, Hu G. Kir6.2-containing ATP-sensitive K(+) channel is required for cardioprotection of resveratrol in mice. Cardiovasc Diabetol. 2014;13:35 pubmed publisher
    ..Our study demonstrates that resveratrol exerts cardioprotective effects through AMPK -Kir6.2/K-ATP signal pathway and Kir6.2-containing K-ATP channel is required for cardioprotection of resveratrol. ..