Ya Yi Hou


Affiliation: Nanjing University
Country: China


  1. Ji J, Dou H, Li X, Song Y, Li X, Li E, et al. Novel benzenediamine derivative FC99 ameliorates zymosan-induced arthritis by inhibiting RORγt expression and Th17 cell differentiation. Acta Biochim Biophys Sin (Shanghai). 2014;46:829-36 pubmed publisher
    ..Our findings suggest that FC99 may be a potential therapeutic candidate for the treatment of RA and other inflammatory disorders. ..
  2. Ding L, Ren J, Zhang D, Li Y, Huang X, Ji J, et al. The TLR3 Agonist Inhibit Drug Efflux and Sequentially Consolidates Low-Dose Cisplatin-Based Chemoimmunotherapy while Reducing Side Effects. Mol Cancer Ther. 2017;16:1068-1079 pubmed publisher
    ..i>Mol Cancer Ther; 16(6); 1068-79. ©2017 AACR. ..
  3. Li D, Shi G, Wang J, Zhang D, Pan Y, Dou H, et al. Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells. Arthritis Res Ther. 2019;21:105 pubmed publisher
  4. Shi G, Li D, Li X, Ren J, Xu J, Ding L, et al. mTOR inhibitor INK128 attenuates systemic lupus erythematosus by regulating inflammation-induced CD11b+Gr1+ cells. Biochim Biophys Acta Mol Basis Dis. 2019;1865:1-13 pubmed publisher
    ..We also provide evidence for the first time that INK128, a second generation mTOR inhibitor, has a good therapeutic action on lupus development by regulating CD11b+Gr1+ cells. ..
  5. Qi J, Li D, Shi G, Zhang X, Pan Y, Dou H, et al. Myeloid-derived suppressor cells exacerbate Sjögren's syndrome by inhibiting Th2 immune responses. Mol Immunol. 2018;101:251-258 pubmed publisher
    ..Mechanistically, MDSCs down-regulated the percentages of Th2 cells in NOD mice and SS patients. In summary, our findings suggested that MDSCs exacerbated Sjögren's syndrome by inhibiting Th2 cells. ..
  6. Tang R, Shen S, Zhao X, Nie Y, Xu Y, Ren J, et al. Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer. Stem Cell Res Ther. 2015;6:71 pubmed publisher
    ..These results proved that MSCs could migrate to colon tissues and induce the differentiation of Treg cells via Smad2 as so to inhibit the colitis and suppress the development of CAC. ..
  7. Shi T, Ma Y, Yu L, Jiang J, Shen S, Hou Y, et al. Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints. Int J Mol Sci. 2018;19: pubmed publisher
    ..Finally, predictions are made for future personalized cancer immunotherapy based on different checkpoint modulations. ..
  8. Zhao G, Zhou X, Fang T, Hou Y, Hu Y. Hyaluronic acid promotes the expression of progesterone receptor membrane component 1 via epigenetic silencing of miR-139-5p in human and rat granulosa cells. Biol Reprod. 2014;91:116 pubmed publisher
    ..Taken together, we report an unrecognized mechanism of HA in the promotion of PGRMC1 expression, suggesting that HA may be a potential molecule for the prevention and treatment of POI. ..
  9. Dong G, Fan H, Yang Y, Zhao G, You M, Wang T, et al. 17β-Estradiol enhances the activation of IFN-α signaling in B cells by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p that target IKKε. Biochim Biophys Acta. 2015;1852:1585-98 pubmed publisher
    ..Our findings may provide a new perspective for understanding the mechanism underlying the gender difference in the prevalence of SLE. ..

More Information


  1. Song Y, Liu X, Yue H, Ji J, Dou H, Hou Y. Anti-inflammatory effects of benzenediamine derivate FC-98 on sepsis injury in mice via suppression of JNK, NF-κB and IRF3 signaling pathways. Mol Immunol. 2015;67:183-92 pubmed publisher
    ..These results suggest that FC-98 could be a promising therapeutic agent for inflammatory diseases. ..
  2. Dong G, You M, Fan H, Ji J, Ding L, Li P, et al. 17β-estradiol contributes to the accumulation of myeloid-derived suppressor cells in blood by promoting TNF-α secretion. Acta Biochim Biophys Sin (Shanghai). 2015;47:620-9 pubmed publisher
    ..Our findings provide a new insight into the mechanism of gender difference in the prevalence of inflammation and autoimmune diseases. ..
  3. Ji J, Xu J, Li F, Li X, Gong W, Song Y, et al. A benzenediamine derivate FC-99 attenuates lupus nephritis in MRL/lpr mice via inhibiting myeloid dendritic cell-secreted BAFF. Acta Biochim Biophys Sin (Shanghai). 2016;48:411-9 pubmed publisher
    ..These data indicate that FC-99 attenuates lupus nephritis in MRL/lpr mice via inhibiting DC-secreted BAFF, suggesting that FC-99 may be a potential therapeutic candidate for the treatment of SLE. ..
  4. Ji J, Xu J, Zhao S, Liu F, Qi J, Song Y, et al. Myeloid-derived suppressor cells contribute to systemic lupus erythaematosus by regulating differentiation of Th17 cells and Tregs. Clin Sci (Lond). 2016;130:1453-67 pubmed publisher
  5. Yang L, Dou H, Song Y, Hou Y. Benzenediamine analog FC-99 inhibits TLR2 and TLR4 signaling in peritoneal macrophage in vitro. Life Sci. 2016;144:129-37 pubmed publisher
    ..FC-99 improved the condition of DSS-induced mouse colitis by inhibiting the activation of TLR2 and TLR4 signaling pathways in macrophage. These results suggest that FC-99 may be developed as a new therapeutic drug for IBD. ..
  6. Ji J, Fan H, Li F, Li X, Dong G, Gong W, et al. A benzenediamine derivative fc-99 attenuates lupus-like syndrome in MRL/lpr mice related to suppression of pDC activation. Immunol Lett. 2015;168:355-65 pubmed publisher
    ..This study suggests that FC-99 may be a potential therapeutic candidate for the treatment of SLE. ..
  7. Ding L, Dong G, Zhang D, Ni Y, Hou Y. The regional function of cGAS/STING signal in multiple organs: One of culprit behind systemic lupus erythematosus?. Med Hypotheses. 2015;85:846-9 pubmed publisher
    ..Given this, we propose a hypothesis that the cGAS-STING pathway in multiple organs function versatile and can facilitate overall disease progression of SLE though impertinent cytosolic self-DNA sensing. ..
  8. Liu D, You M, Xu Y, Li F, Zhang D, Li X, et al. Inhibition of curcumin on myeloid-derived suppressor cells is requisite for controlling lung cancer. Int Immunopharmacol. 2016;39:265-272 pubmed publisher
    ..And curcumin reduces the level of IL-6 in tumor-bearing mice to impair the expansion and function of MDSCs. These results suggest that inhibition of MDSCs in tumor is requisite for controlling lung cancer. ..
  9. Zhou J, Miao H, Li X, Hu Y, Sun H, Hou Y. Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt. Inflamm Res. 2017;66:177-185 pubmed publisher
    ..Curcumin inhibited the expression of proinflammatory factors and macrophage infiltration in placenta and ameliorated LPS-induced adverse pregnancy outcomes in mice by inhibiting inflammation via upregulation of phosphorylated Akt. ..
  10. Hu E, Ding L, Miao H, Liu F, Liu D, Dou H, et al. MiR-30a attenuates immunosuppressive functions of IL-1β-elicited mesenchymal stem cells via targeting TAB3. FEBS Lett. 2015;589:3899-907 pubmed publisher
    ..Moreover, the over-expression of miR-30a also impaired MSCs' anti-inflammatory effects on macrophages. These data demonstrated that miR-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE. ..
  11. Fan H, Zhao G, Ren D, Liu F, Dong G, Hou Y. Gender differences of B cell signature related to estrogen-induced IFI44L/BAFF in systemic lupus erythematosus. Immunol Lett. 2017;181:71-78 pubmed publisher
    ..Therefore, we conclude that the diagnosis and treatment of these immune-related diseases should consider the baseline gender-related differences. ..
  12. Gao S, Gong Y, Ji J, Yuan L, Han L, Guo Y, et al. A new benzenediamine derivative modulates Toll-like receptors-induced myeloid dendritic cells activation and ameliorates lupus-like syndrome in MRLlpr/lpr mice. Eur J Pharmacol. 2017;803:94-102 pubmed publisher
    ..These results indicate that FC-99 modulates TLR-induced activation of mDCs and ameliorates lupus-like syndrome in MRLlpr/lpr mice. This effect is closely associated with the inhibition of I?B-? and upregulation of TNFAIP3. ..
  13. Zhang D, Ding L, Li Y, Ren J, Shi G, Wang Y, et al. Midkine derived from cancer-associated fibroblasts promotes cisplatin-resistance via up-regulation of the expression of lncRNA ANRIL in tumour cells. Sci Rep. 2017;7:16231 pubmed publisher
    ..In conclusion, we firstly describe that CAFs in the TME contribute to the high level of MK in tumours and that CAF-derived MK can promote cisplatin resistance via the elevated expression of lncRNA ANRIL. ..
  14. Nie Y, Du L, Mou Y, Xu Z, Weng L, Du Y, et al. Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation. BMC Cancer. 2013;13:582 pubmed publisher
    ..This suggests that the inhibition may be attributed to modulation of LF-MF on immune function and LF-MF may be a potential therapy for treatment of melanoma. ..
  15. Ren J, Ding L, Xu Q, Shi G, Li X, Li X, et al. LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway. Sci Rep. 2017;7:749 pubmed publisher
    ..Taken together, these observations imply that LF-MF suppressed lung cancer via inhibiting cell iron metabolism, stabilizing p53 protein and activation P53- miR-34a-E2F1/E2F3 pathway. ..
  16. Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, et al. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. Sci Rep. 2017;7:11776 pubmed publisher
    ..Taken together, this study proved that LF-MFs can inhibit lung cancers through miR-486 induced autophagic cell death, which suggest a clinical application of LF-MFs in cancer treatment. ..
  17. Liang D, Xiao Feng H, Guan Jun D, Er Ling H, Sheng C, Ting Ting W, et al. Activated STING enhances Tregs infiltration in the HPV-related carcinogenesis of tongue squamous cells via the c-jun/CCL22 signal. Biochim Biophys Acta. 2015;1852:2494-503 pubmed publisher
    ..Therefore, our findings provided distinct insight into the side effects of activated STING in HPV-related carcinogenesis. ..
  18. Chen S, Zhao G, Miao H, Tang R, Song Y, Hu Y, et al. MicroRNA-494 inhibits the growth and angiogenesis-regulating potential of mesenchymal stem cells. FEBS Lett. 2015;589:710-7 pubmed publisher
    ..Taken together, we report an unrecognized mechanism of miR-494 affecting dMSC proliferation and function in the pathology of PE. ..
  19. Lu K, Li W, Liu X, Sun M, Zhang M, Wu W, et al. Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression. BMC Cancer. 2013;13:461 pubmed publisher
    ..Thus, MEG3 may represent a new marker of poor prognosis and is a potential therapeutic target for NSCLC intervention. ..