Chun Hua Hang

Summary

Affiliation: Nanjing University
Country: China

Publications

  1. ncbi request reprint Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats
    Chun Hua Hang
    Medical College of Nanjing University, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 9:2776-81. 2003
  2. ncbi request reprint Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing, China
    J Surg Res 137:53-60. 2007
  3. ncbi request reprint Cortical expression of nuclear factor kappaB after human brain contusion
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, P R China
    Brain Res 1109:14-21. 2006
  4. ncbi request reprint Concomitant upregulation of nuclear factor-kB activity, proinflammatory cytokines and ICAM-1 in the injured brain after cortical contusion trauma in a rat model
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, China
    Neurol India 53:312-7. 2005
  5. ncbi request reprint Up-regulation of intestinal nuclear factor kappa B and intercellular adhesion molecule-1 following traumatic brain injury in rats
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 11:1149-54. 2005
  6. ncbi request reprint Expressions of intestinal NF-kappaB, TNF-alpha, and IL-6 following traumatic brain injury in rats
    Chun Hua Hang
    Department of Neurosurgery, Clinical School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China
    J Surg Res 123:188-93. 2005
  7. ncbi request reprint Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 10:875-80. 2004
  8. ncbi request reprint Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in rats
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, PR China
    Brain Res 1026:23-32. 2004
  9. ncbi request reprint Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits
    Meng Liang Zhou
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Cereb Blood Flow Metab 27:1583-92. 2007
  10. ncbi request reprint The inflammation in the gut after experimental subarachnoid hemorrhage
    Meng Liang Zhou
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Surg Res 137:103-8. 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats
    Chun Hua Hang
    Medical College of Nanjing University, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 9:2776-81. 2003
    ....
  2. ncbi request reprint Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injury
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing, China
    J Surg Res 137:53-60. 2007
    ..However, it has not been investigated whether, and to what degree, apoptosis and alterations of absorptive function in the intestinal mucosal epithelium occur after TBI...
  3. ncbi request reprint Cortical expression of nuclear factor kappaB after human brain contusion
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, P R China
    Brain Res 1109:14-21. 2006
    ..It is concluded that NF-kappaB could be highly upregulated at human contused brain and the cellular pattern of p65 and p50 expression might be closely associated with the cell functions...
  4. ncbi request reprint Concomitant upregulation of nuclear factor-kB activity, proinflammatory cytokines and ICAM-1 in the injured brain after cortical contusion trauma in a rat model
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, China
    Neurol India 53:312-7. 2005
    ..However, the temporal pattern of upregulation is not well defined...
  5. ncbi request reprint Up-regulation of intestinal nuclear factor kappa B and intercellular adhesion molecule-1 following traumatic brain injury in rats
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 11:1149-54. 2005
    ..The aim of current study was to investigate the temporal pattern of intestinal NF-kappaB activation and ICAM-1 expression following TBI...
  6. ncbi request reprint Expressions of intestinal NF-kappaB, TNF-alpha, and IL-6 following traumatic brain injury in rats
    Chun Hua Hang
    Department of Neurosurgery, Clinical School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China
    J Surg Res 123:188-93. 2005
    ....
  7. ncbi request reprint Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 10:875-80. 2004
    ..To study the alterations of brain-gut peptides following traumatic brain injury (TBI) and to explore the underlying significance of these peptides in the complicated gastrointestinal dysfunction...
  8. ncbi request reprint Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in rats
    Chun Hua Hang
    Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, PR China
    Brain Res 1026:23-32. 2004
    ..It was concluded that inflammatory response and secondary brain damage occurred in the injured brain could be highly exacerbated by endotoxemia...
  9. ncbi request reprint Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits
    Meng Liang Zhou
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Cereb Blood Flow Metab 27:1583-92. 2007
    ..Our results suggest that NF-kappaB is activated in the arterial wall after SAH, which potentially leads to vasospasm development through induction of inflammatory response...
  10. ncbi request reprint The inflammation in the gut after experimental subarachnoid hemorrhage
    Meng Liang Zhou
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Surg Res 137:103-8. 2007
    ..This study test the hypothesis that experimental SAH could induce histopathological changes and inflammatory response associating with NF-kappaB activation pathway in the gut...
  11. doi request reprint Recombinant high-mobility group box 1 protein (HMGB-1) promotes myeloid differentiation primary response protein 88 (Myd88) upregulation in mouse primary cortical neurons
    Wei Li
    Department of Neurosurgery, School of Medicine, Jinling Hospital, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu, People s Republic of China
    Neurol Sci 34:847-53. 2013
    ....
  12. ncbi request reprint Expression of Toll-like receptor 4 in the basilar artery after experimental subarachnoid hemorrhage in rabbits: a preliminary study
    Meng Liang Zhou
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    Brain Res 1173:110-6. 2007
    ..The elevated expression of TLR4 was detected after SAH and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH...
  13. ncbi request reprint Comparison between one- and two-hemorrhage models of cerebral vasospasm in rabbits
    Meng Liang Zhou
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, PR China
    J Neurosci Methods 159:318-24. 2007
    ....
  14. ncbi request reprint Influence of Nrf2 genotype on pulmonary NF-kappaB activity and inflammatory response after traumatic brain injury
    Wei Jin
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
    Ann Clin Lab Sci 38:221-7. 2008
    ..The results suggest that Nrf2 plays an important protective role in attenuating the pulmonary inflammatory response and NF-kappaB activation after TBI...
  15. doi request reprint Hemolysate-induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 expression in cultured brain microvascular endothelial cells via through ROS-dependent NF-kappaB pathways
    Hua Lu
    Department of Neurosurgery, Jinling Hospital, Clinical School of Nanjing University, Nanjing, China
    Cell Mol Neurobiol 29:87-95. 2009
    ..Taken together, our results indicate that hemolysate can induce inflammatory responses that increase expression of ICAM-1 and MCP-1, through ROS-dependent NF-kappaB activation in BMECs...
  16. ncbi request reprint Effects of progesterone on intestinal inflammatory response, mucosa structure alterations, and apoptosis following traumatic brain injury in male rats
    Gang Chen
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Surg Res 147:92-8. 2008
    ..However, the effects of progesterone on the inflammatory response, structure alterations, and apoptosis in the intestinal mucosa following TBI has not been investigated...
  17. doi request reprint Zinc as mediator of ubiquitin conjugation following traumatic brain injury
    Kang jian Sun
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    Brain Res 1506:132-41. 2013
    ..All these findings indicate that alterations in Zn(2+) homeostasis may impair the protein degradation pathway and ultimately cause neuronal injury following traumatic brain injury...
  18. ncbi request reprint Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO)
    Gang Chen
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
    Neurosci Lett 425:177-82. 2007
    ..In conclusion, post-TBI rhEPO administration may attenuate inflammatory response in the injured rat brain, and this may be one mechanism by which rhEPO improves outcome following TBI...
  19. doi request reprint Expression of the NLRP3 inflammasome in cerebral cortex after traumatic brain injury in a rat model
    Huan Dong Liu
    Department of Neurosurgery, School of Medicine, Jinling Hospital, Southern Medical University Guangzhou, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, People s Republic of China
    Neurochem Res 38:2072-83. 2013
    ..These results suggested that NLRP3-inflammasome might play an important role in the inflammation induced by TBI and could be a target for TBI therapy...
  20. doi request reprint Inhibition of hemolysate-induced iNOS and COX-2 expression by genistein through suppression of NF-small ka, CyrillicB activation in primary astrocytes
    Hua Lu
    Department of Neurosurgery, Jinling Hospital, and The State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, College of Life Sciences, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
    J Neurol Sci 278:91-5. 2009
    ..Therefore, we suggested that the effect of genistein-mediated inhibition of the expression hemolysate-induced iNOS and COX-2 genes is due to under the suppression of NF-small ka, CyrillicB activation in the transcriptional level...
  21. doi request reprint N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhage
    Hua Lu
    Department of Neurosurgery, Jinling Hospital, Clinical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
    J Clin Neurosci 16:684-8. 2009
    ..NAC has the potential to be a novel therapeutic strategy for the treatment of SAH, and its neuroprotective effect may be partly mediated via enhancing the activity of endogenous antioxidant enzymes and inhibiting free radical generation...
  22. doi request reprint Enhanced cortical expression of myeloid differentiation primary response protein 88 (Myd88) in patients with traumatic brain injury
    Wei Li
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, PR China
    J Surg Res 180:133-9. 2013
    ..However, the expression patterns of Myd88 in patients with TBI remain obscure. Hence, the aim of present study was to investigate the cortical expression of Myd88 in human contused brain...
  23. doi request reprint Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats
    Jin Bing Zhao
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu Province, PR China
    Neurosci Lett 498:147-52. 2011
    ..Our results suggest that the JAK2/STAT pathway is activated in pericontusional cortex of rats, and may be involved in the neurological function recovery after TBI...
  24. doi request reprint Biphasic activation of nuclear factor kappa B and expression of p65 and c-Rel after traumatic brain injury in rats
    Yang Chun Hu
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, People s Republic of China
    Inflamm Res 63:109-15. 2014
    ..Hence, the current study was designed to detect the time course of NF-κB activation and expression of NF-κB p65 and c-Rel subunits around the contused cortex following TBI...
  25. ncbi request reprint Alterations of pulmonary zinc homeostasis and cytokine production following traumatic brain injury in rats
    Lin Zhu
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing, 210002, P R China
    Ann Clin Lab Sci 37:356-61. 2007
    ..The results suggest that TBI induces rapid increases of labile zinc and inflammatory mediators in lung, which may participate in the pathogenesis of acute lung injury...
  26. doi request reprint Expression and cell distribution of receptor for advanced glycation end-products in the rat cortex following experimental subarachnoid hemorrhage
    Hua Li
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    Brain Res 1543:315-23. 2014
    ....
  27. doi request reprint Glycyrrhizic acid confers neuroprotection after subarachnoid hemorrhage via inhibition of high mobility group box-1 protein: a hypothesis for novel therapy of subarachnoid hemorrhage
    Qing Sun
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, PR China
    Med Hypotheses 81:681-5. 2013
    ..GA might be a new novel therapy of SAH for better outcomes. ..
  28. doi request reprint Expression of intestinal CD40 after experimental traumatic brain injury in rats
    Yang Chun Hu
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, People s Republic of China Department of Neurosurgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou Province, People s Republic of China
    J Surg Res 184:1022-7. 2013
    ..Hence, we designed the current study to explore the intestinal expression pattern of CD40 after TBI in rats. We hypothesized that CD40 could mediate inflammation and ultimately contribute to acute intestinal mucosal injury after TBI...
  29. doi request reprint Expression of intestinal myeloid differentiation primary response protein 88 (Myd88) following experimental traumatic brain injury in a mouse model
    Hai Ping Ling
    Department of Neurosurgery, School of Medicine, Southern Medical University Guangzhou, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
    J Surg Res 179:e227-34. 2013
    ....
  30. doi request reprint The impact of microsurgical clipping and endovascular coiling on the outcome of cerebral aneurysms in patients over 60 years of age
    Qing Rong Zhang
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Clin Neurosci 19:1115-8. 2012
    ..Our results suggest that endovascular coiling should be considered as the first-choice therapy in elderly patients with ruptured aneurysms, as it may reduce duration of both the operation and hospitalization...
  31. doi request reprint Expression of myeloid differentiation primary response protein 88 (Myd88) in the cerebral cortex after experimental traumatic brain injury in rats
    Guang Zhao Li
    Department of Neurosurgery, School of Medicine, Southern Medical University, Jinling Hospital, Nanjing, Jiangsu Province, China
    Brain Res 1396:96-104. 2011
    ..These findings might have important implications during the administration of specific Myd88 antagonists in order to prevent or reduce inflammatory response after TBI...
  32. doi request reprint Intraoperative indocyanine green angiography in intracranial aneurysm surgery: Microsurgical clipping and revascularization
    Chi Yuan Ma
    Department of Neurosurery, Nanjing Jinling Hospital, Nanjing University, School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China
    Clin Neurol Neurosurg 111:840-6. 2009
    ..The goal of this report is to illustrate the use of intraoperative indocyanine green (ICG) angiography in the surgical management of intracranial aneurysms, including microsurgical clipping and revascularization...
  33. doi request reprint Expression of monocyte chemoattractant protein-1 in the cerebral artery after experimental subarachnoid hemorrhage
    Hua Lu
    Department of Neurosurgery, Jinling Hospital, Clinical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
    Brain Res 1262:73-80. 2009
    ....
  34. doi request reprint Hemangiopericytomas in the central nervous system
    Wei Wu
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Second Military Medical University, Nanjing 210002, Jiangsu Province, China
    J Clin Neurosci 16:519-23. 2009
    ..Our observations suggest that the biological behavior of hemangiopericytoma differs markedly from that of meningioma. Surgical removal and post-operative radiotherapy are thus critical for the treatment of this tumor...
  35. doi request reprint Expression and cell distribution of myeloid differentiation primary response protein 88 in the cerebral cortex following experimental subarachnoid hemorrhage in rats: a pilot study
    Qing Sun
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    Brain Res 1520:134-44. 2013
    ..These results might have important implications during the administration of specific MyD88 antagonists in order to prevent or reduce inflammatory response following SAH...
  36. doi request reprint Increased expression of ferritin in cerebral cortex after human traumatic brain injury
    Huan Dong Liu
    Department of Neurosurgery, School of Medicine, Southern Medical University Guangzhou, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, People s Republic of China
    Neurol Sci 34:1173-80. 2013
    ..Perl's reaction showed that most of the iron-positive cells were glia-like cells. These findings suggested that iron and ferritin might be involved in the secondary brain injury and could be therapeutic targets for patients with TBI...