Research Topics
Genomes and Genes | Chun Hua HangSummaryAffiliation: Nanjing University Country: China Publications
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Detail Information
Publications
Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in ratsChun Hua Hang
Medical College of Nanjing University, Nanjing 210002, Jiangsu Province, China
World J Gastroenterol 9:2776-81. 2003....- Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunctionChun Hua Hang
Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
World J Gastroenterol 10:875-80. 2004..To study the alterations of brain-gut peptides following traumatic brain injury (TBI) and to explore the underlying significance of these peptides in the complicated gastrointestinal dysfunction... - Expressions of intestinal NF-kappaB, TNF-alpha, and IL-6 following traumatic brain injury in ratsChun Hua Hang
Department of Neurosurgery, Clinical School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China
J Surg Res 123:188-93. 2005.... - Up-regulation of intestinal nuclear factor kappa B and intercellular adhesion molecule-1 following traumatic brain injury in ratsChun Hua Hang
Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
World J Gastroenterol 11:1149-54. 2005..The aim of current study was to investigate the temporal pattern of intestinal NF-kappaB activation and ICAM-1 expression following TBI... - Concomitant upregulation of nuclear factor-kB activity, proinflammatory cytokines and ICAM-1 in the injured brain after cortical contusion trauma in a rat modelChun Hua Hang
Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, China
Neurol India 53:312-7. 2005..However, the temporal pattern of upregulation is not well defined... - Cortical expression of nuclear factor kappaB after human brain contusionChun Hua Hang
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, P R China
Brain Res 1109:14-21. 2006..It is concluded that NF-kappaB could be highly upregulated at human contused brain and the cellular pattern of p65 and p50 expression might be closely associated with the cell functions... - Apoptosis and functional changes of dipeptide transporter (PepT1) in the rat small intestine after traumatic brain injuryChun Hua Hang
Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing, China
J Surg Res 137:53-60. 2007..However, it has not been investigated whether, and to what degree, apoptosis and alterations of absorptive function in the intestinal mucosal epithelium occur after TBI... - Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in ratsChun Hua Hang
Department of Neurosurgery, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, PR China
Brain Res 1026:23-32. 2004..It was concluded that inflammatory response and secondary brain damage occurred in the injured brain could be highly exacerbated by endotoxemia... - Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbitsMeng Liang Zhou
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
J Cereb Blood Flow Metab 27:1583-92. 2007..Our results suggest that NF-kappaB is activated in the arterial wall after SAH, which potentially leads to vasospasm development through induction of inflammatory response... - The inflammation in the gut after experimental subarachnoid hemorrhageMeng Liang Zhou
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
J Surg Res 137:103-8. 2007..This study test the hypothesis that experimental SAH could induce histopathological changes and inflammatory response associating with NF-kappaB activation pathway in the gut... - Comparison between one- and two-hemorrhage models of cerebral vasospasm in rabbitsMeng Liang Zhou
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, PR China
J Neurosci Methods 159:318-24. 2007.... - Effects of progesterone on intestinal inflammatory response, mucosa structure alterations, and apoptosis following traumatic brain injury in male ratsGang Chen
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
J Surg Res 147:92-8. 2008..However, the effects of progesterone on the inflammatory response, structure alterations, and apoptosis in the intestinal mucosa following TBI has not been investigated... 
Hemolysate-induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 expression in cultured brain microvascular endothelial cells via through ROS-dependent NF-kappaB pathwaysHua Lu
Department of Neurosurgery, Jinling Hospital, Clinical School of Nanjing University, Nanjing, China
Cell Mol Neurobiol 29:87-95. 2009..Taken together, our results indicate that hemolysate can induce inflammatory responses that increase expression of ICAM-1 and MCP-1, through ROS-dependent NF-kappaB activation in BMECs...- Influence of Nrf2 genotype on pulmonary NF-kappaB activity and inflammatory response after traumatic brain injuryWei Jin
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
Ann Clin Lab Sci 38:221-7. 2008..The results suggest that Nrf2 plays an important protective role in attenuating the pulmonary inflammatory response and NF-kappaB activation after TBI... - Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO)Gang Chen
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
Neurosci Lett 425:177-82. 2007..In conclusion, post-TBI rhEPO administration may attenuate inflammatory response in the injured rat brain, and this may be one mechanism by which rhEPO improves outcome following TBI... - Inhibition of hemolysate-induced iNOS and COX-2 expression by genistein through suppression of NF-small ka, CyrillicB activation in primary astrocytesHua Lu
Department of Neurosurgery, Jinling Hospital, and The State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, College of Life Sciences, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
J Neurol Sci 278:91-5. 2009..Therefore, we suggested that the effect of genistein-mediated inhibition of the expression hemolysate-induced iNOS and COX-2 genes is due to under the suppression of NF-small ka, CyrillicB activation in the transcriptional level... - N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhageHua Lu
Department of Neurosurgery, Jinling Hospital, Clinical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
J Clin Neurosci 16:684-8. 2009..NAC has the potential to be a novel therapeutic strategy for the treatment of SAH, and its neuroprotective effect may be partly mediated via enhancing the activity of endogenous antioxidant enzymes and inhibiting free radical generation... - Expression of Toll-like receptor 4 in the basilar artery after experimental subarachnoid hemorrhage in rabbits: a preliminary studyMeng Liang Zhou
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China
Brain Res 1173:110-6. 2007..The elevated expression of TLR4 was detected after SAH and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH... - Enhanced cortical expression of myeloid differentiation primary response protein 88 (Myd88) in patients with traumatic brain injuryWei Li
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, PR China
J Surg Res 180:133-9. 2013..However, the expression patterns of Myd88 in patients with TBI remain obscure. Hence, the aim of present study was to investigate the cortical expression of Myd88 in human contused brain... - Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of ratsJin Bing Zhao
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu Province, PR China
Neurosci Lett 498:147-52. 2011..Our results suggest that the JAK2/STAT pathway is activated in pericontusional cortex of rats, and may be involved in the neurological function recovery after TBI... - Alterations of pulmonary zinc homeostasis and cytokine production following traumatic brain injury in ratsLin Zhu
Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing, 210002, P R China
Ann Clin Lab Sci 37:356-61. 2007..The results suggest that TBI induces rapid increases of labile zinc and inflammatory mediators in lung, which may participate in the pathogenesis of acute lung injury... - Expression of intestinal myeloid differentiation primary response protein 88 (Myd88) following experimental traumatic brain injury in a mouse modelHai Ping Ling
Department of Neurosurgery, School of Medicine, Southern Medical University Guangzhou, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
J Surg Res 179:e227-34. 2013.... - Zinc as mediator of ubiquitin conjugation following traumatic brain injuryKang jian Sun
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
Brain Res 1506:132-41. 2013..All these findings indicate that alterations in Zn(2+) homeostasis may impair the protein degradation pathway and ultimately cause neuronal injury following traumatic brain injury... - The impact of microsurgical clipping and endovascular coiling on the outcome of cerebral aneurysms in patients over 60 years of ageQing Rong Zhang
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
J Clin Neurosci 19:1115-8. 2012..Our results suggest that endovascular coiling should be considered as the first-choice therapy in elderly patients with ruptured aneurysms, as it may reduce duration of both the operation and hospitalization... - Expression of myeloid differentiation primary response protein 88 (Myd88) in the cerebral cortex after experimental traumatic brain injury in ratsGuang Zhao Li
Department of Neurosurgery, School of Medicine, Southern Medical University, Jinling Hospital, Nanjing, Jiangsu Province, China
Brain Res 1396:96-104. 2011..These findings might have important implications during the administration of specific Myd88 antagonists in order to prevent or reduce inflammatory response after TBI... - Expression of monocyte chemoattractant protein-1 in the cerebral artery after experimental subarachnoid hemorrhageHua Lu
Department of Neurosurgery, Jinling Hospital, Clinical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
Brain Res 1262:73-80. 2009.... - Intraoperative indocyanine green angiography in intracranial aneurysm surgery: Microsurgical clipping and revascularizationChi Yuan Ma
Department of Neurosurery, Nanjing Jinling Hospital, Nanjing University, School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China
Clin Neurol Neurosurg 111:840-6. 2009..The goal of this report is to illustrate the use of intraoperative indocyanine green (ICG) angiography in the surgical management of intracranial aneurysms, including microsurgical clipping and revascularization... - Hemangiopericytomas in the central nervous systemWei Wu
Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Second Military Medical University, Nanjing 210002, Jiangsu Province, China
J Clin Neurosci 16:519-23. 2009..Our observations suggest that the biological behavior of hemangiopericytoma differs markedly from that of meningioma. Surgical removal and post-operative radiotherapy are thus critical for the treatment of this tumor... - Increased expression of ferritin in cerebral cortex after human traumatic brain injuryHuan Dong Liu
Department of Neurosurgery, School of Medicine, Southern Medical University Guangzhou, Jinling Hospital, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, People s Republic of China
Neurol Sci . 2012..Perl's reaction showed that most of the iron-positive cells were glia-like cells. These findings suggested that iron and ferritin might be involved in the secondary brain injury and could be therapeutic targets for patients with TBI...