Xiao Han

Summary

Affiliation: Nanjing Medical University
Country: China

Publications

  1. Huang Q, You W, Li Y, Sun Y, Zhou Y, Zhang Y, et al. Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival. Diabetes. 2018;67:2280-2292 pubmed publisher
    ..Our work demonstrates a novel mechanism of glucolipotoxicity-induced β-cell failure mediated through miR-299-5p downregulation. ..
  2. Li K, Qiu C, Sun P, Liu D, Wu T, Wang K, et al. Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles. Cell Rep. 2019;26:2998-3010.e5 pubmed publisher
    ..Our study identifies Ets1 as an enhancer of FoxO1 acetylation and a repressor of hepatic gluconeogenesis in response to hormonal signals. ..
  3. Wang K, Liu D, Zhang Y, Chang X, Xu R, Pang J, et al. SAD-A, a downstream mediator of GLP-1 signaling, promotes the phosphorylation of Bad S155 to regulate in vitro β-cell functions. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..This phosphorylation might therefore be involved in the GLP-1-linked protection against β-cell dysfunction and apoptosis. ..
  4. Cao D, Jiang C, Wan C, Zhang M, Zhang Q, Zhao M, et al. Upregulation of MiR-126 Delays the Senescence of Human Glomerular Mesangial Cells Induced by High Glucose via Telomere-p53-p21-Rb Signaling Pathway. Curr Med Sci. 2018;38:758-764 pubmed publisher
    ..The results may serve as a new strategy for the treatment of DKD. ..
  5. Xu B, Chen M, Ji X, Yao M, Mao Z, Zhou K, et al. Metabolomic profiles reveal key metabolic changes in heat stress-treated mouse Sertoli cells. Toxicol In Vitro. 2015;29:1745-52 pubmed publisher
  6. Wang H, Wang X, Zhu Y, Chen F, Sun Y, Han X. Increased androgen levels in rats impair glucose-stimulated insulin secretion through disruption of pancreatic beta cell mitochondrial function. J Steroid Biochem Mol Biol. 2015;154:254-66 pubmed publisher
    ..This work has significance for hyperandrogenic women with PCOS: excess activation of the androgen receptor by androgens may provoke beta cell dysfunction via mitochondrial dysfunction. ..
  7. Chen F, Sha M, Wang Y, Wu T, Shan W, Liu J, et al. Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models. Diabetologia. 2016;59:316-24 pubmed publisher
    ..Our observations suggest that Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes. ..
  8. Gao F, Zhang X, Zhou L, Zhou S, Zheng Y, Yu J, et al. Type 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery. Metabolism. 2016;65:78-88 pubmed publisher
    ..Our investigation establishes a model for a focused study of bile acids in the context of bariatric surgery that may contribute to the identification of therapeutics for T2DM. ..
  9. Li Y, Zhang T, Huang Q, Sun Y, Chang X, Zhang H, et al. Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise. Endocrine. 2016;54:383-395 pubmed
    ..Our findings explore the broader role of p53 in regulating pancreatic beta-cell demise in the presence of GS and may provide a therapeutic target for the treatment and prevention of diabetes. ..

More Information

Publications15

  1. Zhang Y, Chang M, Yang X, Han X. In silico investigation of agonist activity of a structurally diverse set of drugs to hPXR using HM-BSM and HM-PNN. J Huazhong Univ Sci Technolog Med Sci. 2016;36:463-468 pubmed publisher
    ..882, q LOO (2) =0.856, q EXT (2) =0.655). The developed models indicated that molecular aromatic and electric property, molecular weight and complexity may govern agonist activity of a structurally diverse set of drugs to hPXR. ..
  2. Zhang Y, Mei H, Shan W, Shi L, Chang X, Zhu Y, et al. Lentinan protects pancreatic ? cells from STZ-induced damage. J Cell Mol Med. 2016;20:1803-12 pubmed publisher
  3. Zhang Y, Mei H, Chang X, Chen F, Zhu Y, Han X. Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155. J Mol Cell Biol. 2016;8:505-517 pubmed
    ..Our study reveals a novel mechanism through which obesity induces an imbalance in the M1-to-M2 macrophage ratio in adipose tissue, thus causing chronic inflammation and local insulin resistance. ..
  4. Zhan S, Wu Y, Sun P, Lin H, Zhu Y, Han X. Decrease in Circulating Fatty Acids Is Associated with Islet Dysfunction in Chronically Sleep-Restricted Rats. Int J Mol Sci. 2016;17: pubmed
    ..This study provides a new perspective on the relationship between insufficient sleep and lipid/glucose metabolism, which offers insights into the role of stressful challenges in a healthy lifestyle. ..
  5. Chen F, Zhu Y, Tang X, Sun Y, Jia W, Sun Y, et al. Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic ?-cells dysfunction. Endocrinology. 2011;152:1779-88 pubmed publisher
    ..Inhibition of FoxA2 can effectively protect ?-cells against DEX-induced dysfunction. ..
  6. Chen S, Li X, Liu L, Liu C, Han X. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. FASEB J. 2018;32:1139-1153 pubmed publisher
    ..Chen, S., Li, X., Liu, L., Liu, C., Han, X. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. ..