Xirong Guo


Affiliation: Nanjing Medical University
Country: China


  1. Pang L, You L, Ji C, Shi C, Chen L, Yang L, et al. miR-1275 inhibits adipogenesis via ELK1 and its expression decreases in obese subjects. J Mol Endocrinol. 2016;57:33-43 pubmed publisher
    ..These results suggest that miR-1275 could play a future role in the management of obesity, as a novel therapeutic target or biomarker. ..
  2. Xie K, Chen T, Zhang Y, Wen J, Cui X, You L, et al. Association of rs10830962 polymorphism with gestational diabetes mellitus risk in a Chinese population. Sci Rep. 2019;9:5357 pubmed publisher
    ..Our findings demonstrate that rs10830962 is associated with an increased risk of GDM in the Chinese population. Further functional characterization is warranted to uncover the mechanism of the genotype-phenotype association. ..
  3. Shen D, Li Y, Wang X, Wang F, Huang F, Cao Y, et al. A novel peptide suppresses adipogenic differentiation through activation of the AMPK pathway. Biochem Biophys Res Commun. 2019;: pubmed publisher
    ..These results suggest an effective role for PDBSN in suppressing adipogenesis and show potential for anti-obesity drug discovery. ..
  4. Chen L, Dai Y, Ji C, Yang L, Shi C, Xu G, et al. MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity. Mol Cell Endocrinol. 2014;393:65-74 pubmed publisher
    ..Our data indicates that miR-146b may be a new therapeutic target against human visceral obesity and metabolic dysfunction. ..
  5. Cui X, Tan J, Shi Y, Sun C, Li Y, Ji C, et al. The long non-coding RNA Gm10768 activates hepatic gluconeogenesis by sequestering microRNA-214 in mice. J Biol Chem. 2018;293:4097-4109 pubmed publisher
    ..Taken together, we identified Gm10768 as a new lncRNA activating hepatic gluconeogenesis through antagonizing miR-214 in mice. ..
  6. You L, Zhu L, Yang L, Shi C, Pang L, Zhang J, et al. Transcriptome analysis reveals the potential contribution of long noncoding RNAs to brown adipocyte differentiation. Mol Genet Genomics. 2015;290:1659-71 pubmed publisher
    ..Collectively, our findings indicated lncRNAs are involved in mouse BAT development and provide potential targets for obesity therapy. ..
  7. Wen J, Kang C, Wang J, Cui X, Hong Q, Wang X, et al. Association of maternal serum 25-hydroxyvitamin D concentrations in second and third trimester with risk of macrosomia. Sci Rep. 2018;8:6169 pubmed publisher
    ..712 for delivering infant with macrosomia. In conclusion, maternal serum 25(OH)D <50.0 nmol/L is associated with delivering a macrosomic infant, and vitamin D deficiency should be monitored in pregnant women. ..
  8. Wang X, You L, Cui X, Li Y, Wang X, Xu P, et al. Evaluation and optimization of differentiation conditions for human primary brown adipocytes. Sci Rep. 2018;8:5304 pubmed publisher
    ..Our study provides not only an optimized method for human BAC differentiation but also a cell model with good differentiation and thermogenic capacity for brown adipose research. ..
  9. Zou J, Li J, Li J, Ji C, Li Q, Guo X. Expression profile of plasma microRNAs in nonsyndromic cleft lip and their clinical significance as biomarkers. Biomed Pharmacother. 2016;82:459-66 pubmed publisher
    ..Our study demonstrated that plasma miR-16-2-3p, miR-365a-3p and miR-877-5p might become biomarkers to diagnose NSCL and dysregulation of these miRNAs might be involved in the progression of NSCL. ..

More Information


  1. Wen J, Hong Q, Wang X, Zhu L, Wu T, Xu P, et al. The effect of maternal vitamin D deficiency during pregnancy on body fat and adipogenesis in rat offspring. Sci Rep. 2018;8:365 pubmed publisher
    ..In conclusion, vitamin D deficiency during pregnancy may promote the proliferation and differentiation of pre-adipocytes, which may be associated with methylation alterations of genes, ultimately leading to offspring obesity. ..
  2. request reprint
    Cui X, You L, Li Y, Zhu L, Zhang F, Xie K, et al. A transcribed ultraconserved noncoding RNA, uc.417, serves as a negative regulator of brown adipose tissue thermogenesis. FASEB J. 2016;30:4301-4312 pubmed
    ..Cui, X., You, L., Li, Y., Zhu, L., Zhang, F., Xie, K., Cao, Y., Ji, C., Guo, X. A transcribed ultraconserved noncoding RNA, uc.417, serves as a negative regulator of brown adipose tissue thermogenesis. ..
  3. Shi C, Li N, Dong J, Wang L, Li X, Ji C, et al. Association between maternal nonresponsive feeding practice and child's eating behavior and weight status: children aged 1 to 6 years. Eur J Pediatr. 2017;176:1603-1612 pubmed publisher
    ..What is new: • The findings provide a strong evidence for the correlation between NRFR and CEB. • This finding indicates that NRFR and CEB are associated with child's unhealthy weight. ..
  4. Cui X, You L, Zhu L, Wang X, Zhou Y, Li Y, et al. Change in circulating microRNA profile of obese children indicates future risk of adult diabetes. Metabolism. 2018;78:95-105 pubmed publisher
    ..Our results provide a better understanding of the role of circulating miRNAs, particularly miR-486, miR-146b and miR-15b, in predicting the future risk of T2D in obese children. ..
  5. Chen L, Wang X, Zhu J, You L, Wang X, Cui X, et al. PID1 in adipocytes modulates whole-body glucose homeostasis. Biochim Biophys Acta Gene Regul Mech. 2018;1861:125-132 pubmed publisher
    ..Our results thus indentify PID1 as a critical regulator of glucose metabolism in adipocytes. ..
  6. Fu Y, Ji C, Chen X, Cui X, Wang X, Feng J, et al. Investigation into the antimicrobial action and mechanism of a novel endogenous peptide ?-casein 197 from human milk. AMB Express. 2017;7:119 pubmed publisher
    ..The peptide induced membrane permeabilization but did not bind to genomic DNA. Based on our findings, ?-casein 197 has potential clinical value for preventing infections of premature infants. ..