Aihua Gu


Affiliation: Nanjing Medical University
Country: China


  1. Xu C, Liu Q, Xu J, Gu A. Quantification of Mitochondrial Genome Transcription in Male Reproductive Cells by Real-Time PCR. Methods Mol Biol. 2019;1894:171-180 pubmed publisher
    ..This study describes how to use real-time PCR to evaluate the effects of nanomaterials on mitochondrial genome transcription in male reproductive cells. ..
  2. Gu J, Zhang J, Chen Y, Wang H, Guo M, Wang L, et al. Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae (Danio rerio). Chemosphere. 2019;217:629-635 pubmed publisher
    ..0 mg/L BPS treatment. In conclusion, BPS may affect locomotor behavior and alter retinal structure in zebrafish larvae partially by increasing oxidative stress, and by suppressing the expression levels of neurodevelopment genes. ..
  3. Sun H, Liu Q, Hu H, Jiang Y, Shao W, Wang Q, et al. Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis. Cell Death Dis. 2018;9:824 pubmed publisher
    ..Our study provides evidences that BBR could be a therapeutic agent for protecting liver under cholesterol overloading via the regulation of autophagic flux. ..
  4. Xu C, Chen P, Liu W, Gu A, Wang X. Association between the XRCC1 Arg194Trp polymorphism and glioma risk: an updated meta-analysis. Asian Pac J Cancer Prev. 2014;15:7419-24 pubmed
    ..To further evaluate gene-gene and gene-environment interactions on XRCC1 polymorphisms and glioma risk, thousands of subjects and tissue-specific biochemical characterizations are required. ..
  5. Yan L, Xu C, Liu Q, Gu A, Jiang Z. Altered profile of gut microbiota after subchronic exposure to neochamaejasmin A in rats. Environ Toxicol Pharmacol. 2015;39:927-33 pubmed publisher
    ..These findings could help improve our understanding of the health effects of neochamaejasmin A and provide an example of the risk assessment of pharmaceuticals or food contaminants on the gut microbiota composition. ..
  6. Qu J, Lu C, Xu C, Chen G, Qiu L, Jiang J, et al. Perfluorooctane sulfonate-induced testicular toxicity and differential testicular expression of estrogen receptor in male mice. Environ Toxicol Pharmacol. 2016;45:150-7 pubmed publisher
    ..These results suggested that the alterations in testicular ERs expression, together with decreased proliferation and increased apoptosis of germ cells, might be involved in PFOS-induced testicular toxicity. ..
  7. Liu H, Xu C, Jiang Z, Gu A. Association of polycyclic aromatic hydrocarbons and asthma among children 6-19 years: NHANES 2001-2008 and NHANES 2011-2012. Respir Med. 2016;110:20-7 pubmed publisher
    ..This data provide epidemiological evidences that urinary PAHs are positively associated with asthma in children aged 6-19 years. However, the underlying mechanisms still need further exploration. ..
  8. Liu Q, Xu C, Ji G, Liu H, Mo Y, Tollerud D, et al. Sublethal effects of zinc oxide nanoparticles on male reproductive cells. Toxicol In Vitro. 2016;35:131-8 pubmed publisher
    ..All these contributed to the male reproductive cytotoxic effects of ZnO NPs that could be partially rescued by anti-oxidants. ..
  9. Dong Z, Ren C, Xia Y, Su D, Du T, Fan H, et al. Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. J Hematol Oncol. 2014;7:17 pubmed publisher
    ..Our data provide in vivo evidence that definitive myelopoiesis in zebrafish is critically regulated by pten via the elevation of cebpa expression. ..

More Information


  1. Shao W, Liu Q, He X, Liu H, Gu A, Jiang Z. Association between level of urinary trace heavy metals and obesity among children aged 6-19 years: NHANES 1999-2011. Environ Sci Pollut Res Int. 2017;24:11573-11581 pubmed publisher
    ..The results imply that trace heavy metals may represent critical risk factors for the development of obesity, especially in the area that the state of metal contamination is serious. ..
  2. Xu C, Jiang Z, Liu Q, Liu H, Gu A. Estrogen receptor beta mediates hepatotoxicity induced by perfluorooctane sulfonate in mouse. Environ Sci Pollut Res Int. 2017;24:13414-13423 pubmed publisher
    ..In HepG2 cells, PFOS increased ER? expression, which could be blocked by adding PHTPP (a selective antagonist of ER?). Our study thus provides new evidence that ER? mediates PFOS-induced hepatotoxicity. ..
  3. Liu Q, Shao W, Zhang C, Xu C, Wang Q, Liu H, et al. Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017;226:268-276 pubmed publisher
    ..The findings in this study draw our attention to the hazards of chronic OCPs exposure in modulating bile acid metabolism that might cause metabolic disorders and their potential to cause related diseases in human. ..
  4. Yan L, Wu S, Zhang S, Ji G, Gu A. Genetic variants in telomerase reverse transcriptase (TERT) and telomerase-associated protein 1 (TEP1) and the risk of male infertility. Gene. 2014;534:139-43 pubmed publisher
    ..243, P=0.016). In conclusion, our results give the first evidence that genetic variations of TERT rs2736100 and TEP1 rs1713449 were associated with susceptibility to male infertility. ..
  5. Gu A, Ji G, Yan L, Zhou Y. The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage. DNA Repair (Amst). 2013;12:1094-104 pubmed publisher
    ..In summary, we introduce here that ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits. ..
  6. Ji G, Yan L, Wu S, Liu J, Wang L, Zhang S, et al. Bulky DNA adducts in human sperm associated with semen parameters and sperm DNA fragmentation in infertile men: a cross-sectional study. Environ Health. 2013;12:82 pubmed publisher
    ..Our findings suggested an inverse association between sperm PAH-DNA adducts and semen quality, and provided the first epidemiologic evidence of an adverse effect of PAH-DNA adducts on sperm DNA integrity. ..
  7. Liu Q, Yan L, Xu C, Gu A, Zhao P, Jiang Z. Increased incidence of head and neck cancer in liver transplant recipients: a meta-analysis. BMC Cancer. 2014;14:776 pubmed publisher
    ..488 (95% CI: 2.379-4.598) and 4.306 (95% CI: 3.020-5.592). Liver transplant recipients are at higher risk of developing head and neck cancer than the general population. ..
  8. Zou P, Gu A, Ji G, Zhao L, Zhao P, Lu A. The TERT rs2736100 polymorphism and cancer risk: a meta-analysis based on 25 case-control studies. BMC Cancer. 2012;12:7 pubmed publisher
    ..This meta-analysis suggests that the TERT rs2736100 polymorphism may be a risk factor for cancer. Further functional studies between this polymorphism and cancer risk are warranted. ..