Ling Chen


Affiliation: Nanjing Medical University
Country: China


  1. Zhou L, Yin J, Wang C, Liao J, Liu G, Chen L. Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPAR?. Hum Mol Genet. 2014;23:4094-102 pubmed publisher
    ..Collectively, these results indicate that neuronal seipin deficiency causing reduced PPAR? levels leads to affective disorders in male mice that are rescued by E2-increased PPAR? expression. ..
  2. Li G, Zhou L, Zhu Y, Wang C, Sha S, Xian X, et al. Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ. Dis Model Mech. 2015;8:1615-24 pubmed publisher
  3. Zhou L, Chen T, Li G, Wu C, Wang C, Li L, et al. Activation of PPARγ Ameliorates Spatial Cognitive Deficits through Restoring Expression of AMPA Receptors in Seipin Knock-Out Mice. J Neurosci. 2016;36:1242-53 pubmed publisher
    ..The PPARγ agonist rosiglitazone can ameliorate spatial cognitive deficits and rescue the LTP induction in seipin knock-out mice by restoring AMPA receptor expression and ERK-CREB activities. ..
  4. Chang H, Di T, Wang Y, Zeng X, Li G, Wan Q, et al. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiol Dis. 2019;127:350-361 pubmed publisher
  5. Hua X, Xiong J, Zhang Y, Cao X, Sun P, Wu J, et al. Exposure of pregnant mice to triclosan causes hyperphagic obesity of offspring via the hypermethylation of proopiomelanocortin promoter. Arch Toxicol. 2019;93:547-558 pubmed publisher
  6. Liu D, Chi T, Ji X, Liu P, Qi X, Zhu L, et al. Sigma-1 receptor activation alleviates blood-brain barrier dysfunction in vascular dementia mice. Exp Neurol. 2018;308:90-99 pubmed publisher
  7. Zhou R, Chen F, Feng X, Zhou L, Li Y, Chen L. Perinatal exposure to low-dose of bisphenol A causes anxiety-like alteration in adrenal axis regulation and behaviors of rat offspring: a potential role for metabotropic glutamate 2/3 receptors. J Psychiatr Res. 2015;64:121-9 pubmed publisher
    ..mGlu2/3 receptor may serve as a novel biomarker and potential therapeutic target for anxiety disorders associated with adverse early-life agents including perinatal BPA exposure. ..
  8. Sha S, Hong J, Qu W, Lu Z, Li L, Yu W, et al. Sex-related neurogenesis decrease in hippocampal dentate gyrus with depressive-like behaviors in sigma-1 receptor knockout mice. Eur Neuropsychopharmacol. 2015;25:1275-86 pubmed publisher
    ..These results indicate that the σ1R deficiency impairs neurogenesis leading to a depressive-like phenotype, which is alleviated by the neuroprotection of E2. ..
  9. Wang Y, Chen T, Yuan Z, Zhang Y, Zhang B, Zhao L, et al. Ras inhibitor S-trans, trans-farnesylthiosalicylic acid enhances spatial memory and hippocampal long-term potentiation via up-regulation of NMDA receptor. Neuropharmacology. 2018;139:257-267 pubmed publisher
    ..The results indicate that the Ras inhibition by FTS can enhance NMDAr-dependent LTP by increasing Src activity to promote NMDAr GluN2A/GluN2B phosphorylation, which then leads to spatial memory potentiation. ..

More Information


  1. Wang L, Hong J, Wu Y, Liu G, Yu W, Chen L. Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of ?-synuclein and neuroinflammation. Cell Death Dis. 2018;9:440 pubmed publisher
  2. Feng X, Wang X, Cao X, Xia Y, Zhou R, Chen L. Chronic Exposure of Female Mice to an Environmental Level of Perfluorooctane Sulfonate Suppresses Estrogen Synthesis Through Reduced Histone H3K14 Acetylation of the StAR Promoter Leading to Deficits in Follicular Development and Ovulation. Toxicol Sci. 2015;148:368-79 pubmed publisher
    ..The present study provides evidence that the chronic exposure to the low-dose of PFOS through selectively reducing histone acetylation of StAR suppresses the biosynthesis of E2 to impair the follicular development and ovulation. ..
  3. Yin J, Sha S, Chen T, Wang C, Hong J, Jie P, et al. Sigma-1 (σ₁) receptor deficiency reduces β-amyloid(25-35)-induced hippocampal neuronal cell death and cognitive deficits through suppressing phosphorylation of the NMDA receptor NR2B. Neuropharmacology. 2015;89:215-24 pubmed publisher
    ..These results indicate that the σ1R deficiency can reduce Aβ(25-35)-induced neuronal cell death and cognitive deficits through suppressing Aβ(25-35)-enhanced NR2B phosphorylation. ..
  4. Wang C, Chen T, Li G, Zhou L, Sha S, Chen L. Simvastatin prevents β-amyloid(25-35)-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate. Neuropharmacology. 2015;97:122-32 pubmed publisher
    ..The results indicate that the SV-treatment in Aβ25-35-mice via reduction of FPP can protect neurogenesis through α7nAChR-cascading PI3K-Akt and increasing BDNF, which may improve spatial cognitive function. ..
  5. Zhao L, Chen T, Wang C, Li G, Zhi W, Yin J, et al. Atorvastatin in improvement of cognitive impairments caused by amyloid β in mice: involvement of inflammatory reaction. BMC Neurol. 2016;16:18 pubmed publisher
    ..These protective functions of ATV involved the pathway of reducing farnesyl pyrophosphate (FPP). ..
  6. Feng X, Cao X, Zhao S, Wang X, Hua X, Chen L, et al. Exposure of Pregnant Mice to Perfluorobutanesulfonate Causes Hypothyroxinemia and Developmental Abnormalities in Female Offspring. Toxicol Sci. 2017;155:409-419 pubmed publisher
    ..These results indicate that prenatal PFBS exposure (?200?mg/kg/day) causes permanent hypothyroxinemia accompanied by deficits in perinatal growth, pubertal onset, and reproductive organ development in female mice. ..
  7. Zhang B, Wang L, Chen T, Hong J, Sha S, Wang J, et al. Sigma-1 receptor deficiency reduces GABAergic inhibition in the basolateral amygdala leading to LTD impairment and depressive-like behaviors. Neuropharmacology. 2017;116:387-398 pubmed publisher
  8. Zhang Z, Hong J, Zhang S, Zhang T, Sha S, Yang R, et al. Postpartum estrogen withdrawal impairs hippocampal neurogenesis and causes depression- and anxiety-like behaviors in mice. Psychoneuroendocrinology. 2016;66:138-49 pubmed publisher
    ..Collectively, these results indicate that postpartum estrogen withdrawal impairs hippocampal neurogenesis in mice that show depression- and anxiety-like behaviors. ..
  9. Chen T, Wang C, Sha S, Zhou L, Chen L, Chen L. Simvastatin Enhances Spatial Memory and Long-Term Potentiation in Hippocampal CA1 via Upregulation of α7 Nicotinic Acetylcholine Receptor. Mol Neurobiol. 2016;53:4060-4072 pubmed publisher
    ..The findings indicate that the administration of SV through reducing FPP increases α7nAChR expression and α7nAChR-related Akt and ERK2 phosphorylation, leading to LTP enhancement and spatial cognitive potentiation. ..
  10. Hong J, Chen F, Wang X, Bai Y, Zhou R, Li Y, et al. Exposure of preimplantation embryos to low-dose bisphenol A impairs testes development and suppresses histone acetylation of StAR promoter to reduce production of testosterone in mice. Mol Cell Endocrinol. 2016;427:101-11 pubmed publisher
    ..These results provide evidence that exposure to BPA in preimplantation embryo retards the development of testes by reducing histone acetylation of the StAR promoter to disrupt the testicular testosterone synthesis. ..
  11. Chen T, Zhang B, Li G, Chen L, Chen L. Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons. Neuropharmacology. 2016;107:411-421 pubmed publisher
  12. Qian Y, Yin J, Hong J, Li G, Zhang B, Liu G, et al. Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse. J Neuroinflammation. 2016;13:145 pubmed publisher
  13. Zhang S, Hong J, Zhang T, Wu J, Chen L. Activation of Sigma-1 Receptor Alleviates Postpartum Estrogen Withdrawal-Induced "Depression" Through Restoring Hippocampal nNOS-NO-CREB Activities in Mice. Mol Neurobiol. 2017;54:3017-3030 pubmed publisher
    ..The findings indicate that the activation of ?1R can alleviate postpartum "depression" through increasing nNOS-NO-CREB activities. ..
  14. Xu Q, Ji X, Chi T, Liu P, Jin G, Chen L, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017;376:166-175 pubmed publisher
    ..The activation of σ1r improves the impairment of learning and memory in the ischemia/reperfusion model, and the expression of BDNF, which may have been achieved through the NR2A-CaMKIV-TORC1 pathway. ..
  15. Yang R, Zhang B, Chen T, Zhang S, Chen L. Postpartum estrogen withdrawal impairs GABAergic inhibition and LTD induction in basolateral amygdala complex via down-regulation of GPR30. Eur Neuropsychopharmacol. 2017;27:759-772 pubmed publisher
    ..The results indicate that postpartum E2 withdrawal causes dysfunction of GABAAR-mediated inhibition in the BLA through reducing GPR30 expression, which impairs LTD induction and causes anxiety-like behaviors. ..
  16. Hong J, Wang L, Zhang T, Zhang B, Chen L. Sigma-1 receptor knockout increases ?-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra. Neurobiol Aging. 2017;59:171-183 pubmed publisher
    ..The results indicate that the ?1R deficiency through enhanced aggregation and phosphorylation of ?Syn causes the loss of dopaminergic neurons leading to the decline of motor coordination. ..
  17. Zhang Y, Lv X, Bai Y, Zhu X, Wu X, Chao J, et al. Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression. J Neuroinflammation. 2015;12:29 pubmed publisher
    ..Understanding the regulation of σ-1R expression could provide insights into the development of potential therapeutic strategies for astrocyte activation induced by methamphetamine. ..
  18. Sha S, Xu J, Lu Z, Hong J, Qu W, Zhou J, et al. Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation. Mol Neurobiol. 2016;53:355-368 pubmed publisher
    ..The results suggest that the JWA deficiency through cascading FAK-PI3K-Akt-mTOR pathway increases the newborn neurons and enhances the LTP induction in hippocampal DG, which leads to the spatial cognitive potentiation. ..