Jian Qun Chen

Summary

Affiliation: Nanjing University
Country: China

Publications

  1. pmc Important role of indels in somatic mutations of human cancer genes
    Haiwang Yang
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    BMC Med Genet 11:128. 2010
  2. doi request reprint Unique evolutionary pattern of numbers of gramineous NBS-LRR genes
    Jing Li
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
    Mol Genet Genomics 283:427-38. 2010
  3. doi request reprint Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes
    Dacheng Tian
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    Nature 455:105-8. 2008
  4. pmc Highly asymmetric rice genomes
    Jing Ding
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing, China
    BMC Genomics 8:154. 2007
  5. ncbi request reprint Genetic variation of NBS-LRR class resistance genes in rice lines
    Sihai Yang
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    Theor Appl Genet 116:165-77. 2008
  6. doi request reprint Codon usage bias and determining forces in green plant mitochondrial genomes
    Bin Wang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    J Integr Plant Biol 53:324-34. 2011
  7. doi request reprint Increased complexity of gene structure and base composition in vertebrates
    Ying Wu
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, China
    J Genet Genomics 38:297-305. 2011
  8. ncbi request reprint Unique pattern of R-gene variation within populations in Arabidopsis
    Jing Ding
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    Mol Genet Genomics 277:619-29. 2007
  9. doi request reprint Relative evolutionary rates of NBS-encoding genes revealed by soybean segmental duplication
    Xiaohui Zhang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Mol Genet Genomics 285:79-90. 2011
  10. doi request reprint Complex mutation and weak selection together determined the codon usage bias in bryophyte mitochondrial genomes
    Bin Wang
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    J Integr Plant Biol 52:1100-8. 2010

Collaborators

Detail Information

Publications16

  1. pmc Important role of indels in somatic mutations of human cancer genes
    Haiwang Yang
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    BMC Med Genet 11:128. 2010
    ..More and more cancer related genes are found to have accumulated somatic mutations. However, little has been reported about mutational patterns of insertions/deletions (indels) in these genes...
  2. doi request reprint Unique evolutionary pattern of numbers of gramineous NBS-LRR genes
    Jing Li
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
    Mol Genet Genomics 283:427-38. 2010
    ..In addition, the small proportion of conserved NBSs suggests that the loss of NBSs may be a general tendency in grass species...
  3. doi request reprint Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes
    Dacheng Tian
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    Nature 455:105-8. 2008
    ..The consistency of these patterns within and between species suggests that indel-associated substitution is a general mutational mechanism...
  4. pmc Highly asymmetric rice genomes
    Jing Ding
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing, China
    BMC Genomics 8:154. 2007
    ..var. 93-11 provide an opportunity to systematically investigate the extent of the gene repertoire polymorphism, even though the genomic data of 93-11 derived from whole-short-gun sequencing is not yet as complete as that of Nipponbare...
  5. ncbi request reprint Genetic variation of NBS-LRR class resistance genes in rice lines
    Sihai Yang
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    Theor Appl Genet 116:165-77. 2008
    ..Our results also suggested that R-genes were under strong selection, which shaped R-gene variation patterns...
  6. doi request reprint Codon usage bias and determining forces in green plant mitochondrial genomes
    Bin Wang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    J Integr Plant Biol 53:324-34. 2011
    ..Such differences, together with previous reports based on the chloroplast data, suggests that after plants colonized the land, their codon usages in organellar genomes are more reluctant to be shaped by selection force...
  7. doi request reprint Increased complexity of gene structure and base composition in vertebrates
    Ying Wu
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, China
    J Genet Genomics 38:297-305. 2011
    ....
  8. ncbi request reprint Unique pattern of R-gene variation within populations in Arabidopsis
    Jing Ding
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    Mol Genet Genomics 277:619-29. 2007
    ..Consequently, the shared-polymorphism became recyclable for new R-genes, as the corresponding avirulence re-emerges in pathogen populations...
  9. doi request reprint Relative evolutionary rates of NBS-encoding genes revealed by soybean segmental duplication
    Xiaohui Zhang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Mol Genet Genomics 285:79-90. 2011
    ..It is important to determine the exact relative evolutionary rates of TNL, non-TNL, and non-NBS genes in order to understand how fast the host plant can adjust its response to rapidly evolving pathogens in a coevolutionary context...
  10. doi request reprint Complex mutation and weak selection together determined the codon usage bias in bryophyte mitochondrial genomes
    Bin Wang
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, China
    J Integr Plant Biol 52:1100-8. 2010
    ..In summary, complex mutation and weak selection together determined the codon usages in bryophyte mitochondrial genomes...
  11. pmc Optimal codon identities in bacteria: implications from the conflicting results of two different methods
    Bin Wang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu Province, China
    PLoS ONE 6:e22714. 2011
    ..For all above reasons, we conclude that real optimal codons actually do not track the genomic GC content, and correlation method is misleading in identifying optimal codons and better be avoided...
  12. doi request reprint Recent duplications dominate NBS-encoding gene expansion in two woody species
    Sihai Yang
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing, China
    Mol Genet Genomics 280:187-98. 2008
    ..Non-TIR-NBS-encoding genes were poly- or paraphyletic, i.e. genes from three or more plant species were nested in different clades, suggesting different evolutionary patterns between these two gene types...
  13. pmc Patterns of exon-intron architecture variation of genes in eukaryotic genomes
    Liucun Zhu
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing 210093, PR China
    BMC Genomics 10:47. 2009
    ..Several studies have investigated the variations of intron length, GC content, ordinal position in a gene and divergence. However, there is little study about the structural variation of exons and introns...
  14. ncbi request reprint [A genome-wide analysis of P450 gene family in waterflea (Daphnia pulex)]
    Yun Hua Zhang
    School of Life Science, Nanjing University, Nanjing 210093
    Fen Zi Xi Bao Sheng Wu Xue Bao 42:53-60. 2009
    ..5% of genes in which positive selections were detected. Moreover, twenty motifs were identified, there in to, 5 motifs existed in over 90% of P450 genes...
  15. ncbi request reprint [Monitoring of pollen-mediated gene flow from transgenic Bt cotton]
    Chang Yong Wang
    School of Life Sciences, Nanjing University, Nanjing 210093, China
    Ying Yong Sheng Tai Xue Bao 18:801-6. 2007
    ..01), and FGF generally tended to decrease with increasing distance from the Bt cotton plot, with a frequency of 2.0% at the farthest distance of 25 m...
  16. doi request reprint Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria
    Jian Qun Chen
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing, China
    Mol Biol Evol 26:1523-31. 2009
    ..Indels, therefore, may play a nontrivial role in controlling differences in genetic variation and divergence across functional regions of a genome...