Wu B, Liu Y, Liu F, Deng Q, Wang J, Han R, et al. The antinociceptive effects and molecular mechanisms of ghrelin(1-7)-NH2 at the supraspinal level in acute pain in mice. Brain Res Bull. 2018;: pubmed publisher
..Furthermore, ghrelin(1-7)-NH2 as the active fragment of ghrelin may be a promising peptide for developing new analgesic drugs. ..
Liu F, Zhang M, Zeng P, Liu W, Wang J, Yang B, et al. Study on the molecular mechanism of antinociception induced by ghrelin in acute pain in mice. Peptides. 2016;83:1-7 pubmed publisher
..The results suggested that i.c.v. injection of ghrelin initially activated the GHS-R1Î±, which in turn increased the release of endogenous PENK to activation of OPRD to produce antinociception. ..