Yepeng Luan

Summary

Country: China

Publications

  1. ncbi request reprint The structure and main functions of aminopeptidase N
    Yepeng Luan
    Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji nan, Shandong, R P China
    Curr Med Chem 14:639-47. 2007
  2. ncbi request reprint The function of the selective inhibitors of cyclooxygenase 2
    Yepeng Luan
    Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji nan, Shandong, R P China
    Mini Rev Med Chem 6:1375-81. 2006
  3. ncbi request reprint Design, synthesis, and activity evaluation of a new 5-fluorouracil prodrug containing an Asn-Gly-Arg(NO2)COOCH3 tripeptide
    Yepeng Luan
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, Shandong, 250012, China
    Protein Pept Lett 19:1122-31. 2012
  4. ncbi request reprint Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors
    Qiang Wang
    Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji Nan, Shandong 250012, PR China
    Protein Pept Lett 17:847-53. 2010
  5. ncbi request reprint The characteristics, functions and inhibitors of three aminopeptidases belonging to the m1 family
    Yepeng Luan
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji Nan, Shandong Province, P R China
    Curr Protein Pept Sci 13:490-500. 2012
  6. ncbi request reprint LYP3, a new bestatin derivative for aminopeptidase N inhibition
    Yepeng Luan
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, 250012 Ji nan, Shandong, PR China
    Med Chem 7:32-6. 2011
  7. doi request reprint Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor
    Yepeng Luan
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Ji Nan, Shandong, PR China
    Anticancer Drugs 22:99-103. 2011

Collaborators

Detail Information

Publications7

  1. ncbi request reprint The structure and main functions of aminopeptidase N
    Yepeng Luan
    Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji nan, Shandong, R P China
    Curr Med Chem 14:639-47. 2007
    ..This review will introduce the structure and main functions of APN briefly...
  2. ncbi request reprint The function of the selective inhibitors of cyclooxygenase 2
    Yepeng Luan
    Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji nan, Shandong, R P China
    Mini Rev Med Chem 6:1375-81. 2006
    ..This review will elucidate the functions of the COX-2 inhibitors briefly and introduce some common selective inhibitors of COX-2...
  3. ncbi request reprint Design, synthesis, and activity evaluation of a new 5-fluorouracil prodrug containing an Asn-Gly-Arg(NO2)COOCH3 tripeptide
    Yepeng Luan
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, Shandong, 250012, China
    Protein Pept Lett 19:1122-31. 2012
    ..The anti-tumor activities of this new prodrug were evaluated in vivo. More significant anti-tumor effects were observed over the parent 5-fluorouracil...
  4. ncbi request reprint Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors
    Qiang Wang
    Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji Nan, Shandong 250012, PR China
    Protein Pept Lett 17:847-53. 2010
    ..Activity evaluation showed that compound C7 (IC(50) = 9.6 +/-1.3 microM) and C20 (IC(50) = 13.6 +/- 1.9 microM) were equivalent to the positive control Bestatin (IC(50) = 11.3 +/- 1.6 microM)...
  5. ncbi request reprint The characteristics, functions and inhibitors of three aminopeptidases belonging to the m1 family
    Yepeng Luan
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji Nan, Shandong Province, P R China
    Curr Protein Pept Sci 13:490-500. 2012
    ..In this review, the current situation regarding the biochemical characteristics, biological functions and inhibitors of three important members of these enzymes, aminopeptidase A, aminopeptidase N and aminopeptidase B are summarized...
  6. ncbi request reprint LYP3, a new bestatin derivative for aminopeptidase N inhibition
    Yepeng Luan
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, 250012 Ji nan, Shandong, PR China
    Med Chem 7:32-6. 2011
    ..In this work, we reformed the structure of bestatin to a new derivative LYP3 to improve the water solubility and effectiveness. The inhibitory activity of LYP3 against APN was evaluated in vitro...
  7. doi request reprint Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor
    Yepeng Luan
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Ji Nan, Shandong, PR China
    Anticancer Drugs 22:99-103. 2011
    ..We also tested the inhibitive activity of LYP2, which retained good efficacy in vitro and in vivo towards APN...