Jun Lu


Country: China


  1. Wu D, Wen X, Han X, Wang S, Wang Y, Shen M, et al. Role of Circular RNA DLEU2 in Human Acute Myeloid Leukemia. Mol Cell Biol. 2018;38: pubmed publisher
    ..miR-496 antagonized the effects of PRKACB on MOLM-13 cell proliferation and apoptosis. Collectively, circRNA-DLEU2 accelerated human AML by suppressing miR-496 and promoting PRKACB expression. ..
  2. Wu D, Wen X, Han X, Wang S, Wang Y, Shen M, et al. Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9. Mol Ther Nucleic Acids. 2019;16:229-245 pubmed publisher
  3. Wu D, Wang Y, Fan S, Zhang Z, Shan Q, Lu J, et al. High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity. Eur J Med Chem. 2019;164:252-262 pubmed publisher
    ..In addition, 4 decreased the ECAR and lactate formation, increased OCR and ROS level in NCIH1975 cancer cell, which could be used as a promising modulator to reprogram the glucose metabolic pathways in NCIH1975 cancer cells. ..
  4. Wu D, Wang S, Wen X, Han X, Wang Y, Shen M, et al. LncRNA SNHG15 acts as a ceRNA to regulate YAP1-Hippo signaling pathway by sponging miR-200a-3p in papillary thyroid carcinoma. Cell Death Dis. 2018;9:947 pubmed publisher
    ..In summary, our findings demonstrated that SNHG15 serves as a competitively endogenous RNA (ceRNA) to regulate YAP1-Hippo signaling pathway by sponging miR-200a-3p in papillary thyroid carcinoma. ..
  5. Yuan Z, Zhao L, Zhang Y, Li S, Pan B, Hua L, et al. Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes. J Neurooncol. 2018;140:249-260 pubmed publisher
    ..This study shows that GOLPH3 has great potential as a target for the gene therapy of glioma and is of great value in precise medical applications. ..
  6. Han X, Wen X, Wang Y, Wang S, Shen M, Zhang Z, et al. Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia. Mol Med. 2018;24:18 pubmed publisher
    ..The key findings of the present study demonstrated that CREB1 gene silencing results in aggravated VD that occurs as a result of inhibiting the PKA-CREB signaling pathway, thus exasperating cognitive dysfunction. ..
  7. Wu D, Hong X, Wang L, Cui X, Lu J, Chen G, et al. MicroRNA-17 inhibition overcomes chemoresistance and suppresses epithelial-mesenchymal transition through a DEDD-dependent mechanism in gastric cancer. Int J Biochem Cell Biol. 2018;102:59-70 pubmed publisher
    ..From the short review above, the key findings emerge that inhibition of miR-17 may have tumor suppressive effects on GC and enhance its chemosensitivity by promoting DEDD, highlighting a novel target for GC therapy. ..
  8. Li N, Li M, Hong W, Shao J, Xu H, Shimano H, et al. Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2881-2889 pubmed publisher
    ..Therefore, our data have identified a previously unrecognized role for Brg1 in hepatic lipid metabolism by portraying Brg1 as an essential epigenetic co-factor for SREBP1c. ..
  9. Zhuang J, Wang S, Shan Q, Zhang Z, Li M, Zheng G, et al. Adeno-associated virus vector-mediated expression of DJ-1 attenuates learning and memory deficits in 2, 2´, 4, 4´-tetrabromodiphenyl ether (BDE-47)-treated mice. J Hazard Mater. 2018;347:390-402 pubmed publisher
    ..Taken together, our results demonstrate that DJ-1 plays a pivotal role in BDE-47-induced neurotoxic effects and learning and memory deficits. ..

More Information


  1. Lu H, Jin P, Tang Y, Fan S, Zhang Z, Wang F, et al. microRNA-136 inhibits proliferation and promotes apoptosis and radiosensitivity of cervical carcinoma through the NF-κB pathway by targeting E2F1. Life Sci. 2018;199:167-178 pubmed publisher
    ..Based on our results, miR-136 inhibits proliferation, while acting to promote apoptosis and radiosensitivity in cervical carcinoma by targeting E2F1 through the NF-κB signaling pathway, resulting in improved prognoses. ..
  2. Jin X, Wang S, Shen M, Wen X, Han X, Wu J, et al. Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. Brain Res Bull. 2017;134:236-245 pubmed publisher
    ..Our results indicated that the rehabilitation training can inhibit the apoptosis of nerve cells as well as promote the recovery of both neural Rehabilitation training in rats with IS. ..
  3. Wang Y, Shen M, Wang S, Wen X, Han X, Zhang Z, et al. Inhibition of the TGF-?1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model. Life Sci. 2017;189:106-113 pubmed publisher
    ..Our findings suggested that up-regulation of TGF-?1 inhibited the TGF-?1/Smad signaling pathway acting to alleviate OA, thus highlighting the potential of the TGF-?1/Smad signaling pathway as a therapeutic target for treatment of OA. ..
  4. Cai Q, Tang Y, Fan S, Zhang Z, Li H, Huang S, et al. In vivo effects of dexmedetomidine on immune function and tumor growth in rats with ovarian cancer through inhibiting the p38MAPK/NF-?B signaling pathway. Biomed Pharmacother. 2017;95:1830-1837 pubmed publisher
    ..The findings of the study suggest that a particular dosage of DEX may act to enhance the immune function of rats with OC by inhibiting the p38MAPK/NF-?B signaling pathway. ..
  5. Li M, Hong W, Hao C, Li L, Wu D, Shen A, et al. SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice. FASEB J. 2018;32:500-511 pubmed publisher
    ..Li, M., Hong, W., Hao, C., Li, L., Wu, D., Shen, A., Lu, J., Zheng, Y., Li, P., Xu, Y. SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice. ..
  6. Shan Q, Zheng G, Zhu A, Cao L, Lu J, Wu D, et al. Epigenetic modification of miR-10a regulates renal damage by targeting CREB1 in type 2 diabetes mellitus. Toxicol Appl Pharmacol. 2016;306:134-43 pubmed publisher
    ..Collectively, these results elucidate that HDAC3/miR-10a/CREB1 serves as a new mechanism underlying kidney injury, providing potential therapeutic targets in type 2 diabetes. ..
  7. Zhuang J, Wen X, Zhang Y, Shan Q, Zhang Z, Zheng G, et al. TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice. Brain Behav Immun. 2017;65:99-110 pubmed publisher
  8. Jin P, Lu H, Tang Y, Fan S, Zhang Z, Wang Y, et al. The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells. Biomed Pharmacother. 2017;96:1324-1334 pubmed publisher
    ..The observations and findings of the study suggested that the silencing of DNA-PKcs inhibits the proliferation, migration and invasion, while acting to promote cell apoptosis in MG-63 cells and osteosarcoma growth in nude mice. ..
  9. Shen M, Wang S, Wen X, Han X, Wang Y, Zhou X, et al. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury. Biomed Pharmacother. 2017;95:885-893 pubmed publisher
    ..The data shows that Dex exerts a neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with TBI. ..
  10. Wang X, Zhang Z, Zheng G, Wang A, Sun C, Qin S, et al. The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated with Restoration of NAD⁺ Levels and Attenuation of NLRP3 Inflammasome Activation in High-Fat-Diet-Treated Mice. Molecules. 2017;22: pubmed publisher
    ..In summary, PSPC protected against HFD-induced hepatic inflammation by boosting NAD⁺ level to inhibit NLRP3 inflammasome activation. ..
  11. Zhang Z, Wang X, Zheng G, Shan Q, Lu J, Fan S, et al. Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in High-Fat Diet-Treated Mice. Int J Mol Sci. 2016;18: pubmed publisher
  12. Hong X, Wu D, Lu J, Zheng Y, Tu W, Yan J. Lipoprotein (a) as a Predictor of Early Stroke Recurrence in Acute Ischemic Stroke. Mol Neurobiol. 2018;55:718-726 pubmed publisher
    ..704-0.859; P < 0.01). Our findings suggest that elevated serum Lp(a) levels can predict the risk of early stroke recurrence in patients with first-ever ischemic stroke. Further research is needed to replicate these findings. ..