Jinyi Liu


Country: China


  1. Han F, Zhang M, Liu W, Sun L, Hao X, Yin L, et al. SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients. Respir Res. 2018;19:241 pubmed publisher
    ..This study highlights a special role and prognostic value of SOX30 in ADC, providing a novel therapeutic target for particular subtype NSCLC patients. ..
  2. Hao X, Han F, Zhang N, Chen H, Jiang X, Yin L, et al. TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer. Cell Death Differ. 2018;: pubmed publisher
    ..Overall, these findings uncover a role for the p53 inactivator TC2N in regulating the proliferation and apoptosis of lung cancer cells. Our present study provides novel insights into the mechanism of tumorigenesis in lung cancer. ..
  3. Zhang X, Liu W, Yang H, Tan L, Ao L, Liu J, et al. Inhibition of PPARα attenuates vimentin phosphorylation on Ser-83 and collapse of vimentin filaments during exposure of rat Sertoli cells in vitro to DBP. Reprod Toxicol. 2014;50:11-8 pubmed publisher
  4. Ou Y, Chen P, Zhou Z, Li C, Liu J, Tajima K, et al. Associations between variants on ADIPOQ and ADIPOR1 with colorectal cancer risk: a Chinese case-control study and updated meta-analysis. BMC Med Genet. 2014;15:137 pubmed publisher
    ..These data suggested that variant rs1342387 on ADIPOR1 may be a novel CRC susceptibility factor. ..
  5. Hao X, Han F, Ma B, Zhang N, Chen H, Jiang X, et al. SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma. J Exp Clin Cancer Res. 2018;37:111 pubmed publisher
    ..This study provides novel insights on the regulatory mechanism of desmosomal genes in lung adenocarcinoma. ..
  6. Chen H, Zhao J, Li Y, He L, Huang Y, Shu W, et al. Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. Toxicol Lett. 2018;289:42-53 pubmed publisher
    ..Our study suggested that characteristic gene alterations regulated by DNA methylation and miRNA could play an important role in environmental MC-LR induced hepatic carcinogenesis. ..
  7. Jiang X, Zhang N, Yin L, Zhang W, Han F, Liu W, et al. A commercial Roundup® formulation induced male germ cell apoptosis by promoting the expression of XAF1 in adult mice. Toxicol Lett. 2018;296:163-172 pubmed publisher
    ..The present study suggested that Roundup® exposure has potential negative implications on male reproductive health in mammals. ..
  8. Jiang X, Yin L, Zhang N, Han F, Liu W, Zhang X, et al. Bisphenol A induced male germ cell apoptosis via IFN?-XAF1-XIAP pathway in adult mice. Toxicol Appl Pharmacol. 2018;355:247-256 pubmed publisher
    ..Together, these data indicated that BPA triggers male germ cell apoptosis in mice via the IFN?-XAF1-XIAP pathway, which may contribute to BPA-induced testis toxicity. ..
  9. Zhang G, Liu K, Ling X, Wang Z, Zou P, Wang X, et al. DBP-induced endoplasmic reticulum stress in male germ cells causes autophagy, which has a cytoprotective role against apoptosis in vitro and in vivo. Toxicol Lett. 2016;245:86-98 pubmed publisher
    ..These findings provide novel clues regarding the molecular events involved in DBP-induced germ cell apoptosis. ..

More Information


  1. Yin L, Dai Y, Jiang X, Liu Y, Chen H, Han F, et al. Role of DNA methylation in bisphenol A exposed mouse spermatocyte. Environ Toxicol Pharmacol. 2016;48:265-271 pubmed publisher
    ..These findings indicate that BPA had toxicity in spermatocytes, and DNA methylation may play a vital role in the regulation of BPA-triggered spermatocyte toxicity. ..
  2. Yin L, Dai Y, Cui Z, Jiang X, Liu W, Han F, et al. The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2?/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity. Toxicol Appl Pharmacol. 2017;314:98-108 pubmed publisher
    ..Taken together, these data suggested that the ROS regulated PERK/EIF2?/chop pathway played a vital role in BPA-induced male reproductive toxicity. ..
  3. Jiang X, Chen H, Cui Z, Yin L, Zhang W, Liu W, et al. Low-dose and combined effects of oral exposure to bisphenol A and diethylstilbestrol on the male reproductive system in adult Sprague-Dawley rats. Environ Toxicol Pharmacol. 2016;43:94-102 pubmed publisher
    ..These findings indicate that ER stress is important in BPA/DES-induced damage in rat testes. Low-dose and combined exposure to BPA and DES may have toxic effects on male fertility in the adult population. ..
  4. Han F, Liu W, Shi X, Yang J, Zhang X, Li Z, et al. SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of ?-Catenin in Lung Cancer. EBioMedicine. 2018;31:253-266 pubmed publisher
    ..Altogether, these results highlight an important role and mechanism of SOX30 in lung cancer metastasis, providing a potential therapeutic target for anti-metastasis. ..
  5. Liu W, Liu J, Ao L, Zhou Z, Zhou Y, Cui Z, et al. Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Toxicol Lett. 2009;189:5-13 pubmed publisher
    ..These results suggest that DNA methylation alterations are an early event in tumorigenesis and play an important role during MCA/DEN-induced multistep rat lung carcinogenesis. ..
  6. Yang J, Han F, Liu W, Chen H, Hao X, Jiang X, et al. ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/?-catenin pathway. J Exp Clin Cancer Res. 2017;36:170 pubmed publisher
    ..We reveal for the first time that ALX4 acts as a novel functional tumor suppressor inactivated by DNA methylation and is an independent prognostic factor in breast cancer. ..