Jing Liu

Summary

Country: China

Publications

  1. pmc β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis
    Jing Liu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, PR China
    BMC Cancer 11:183. 2011
  2. doi c-Src expression is predictive of poor prognosis in breast cancer patients with bone metastasis, but not in patients with visceral metastasis
    Lingyun Zhang
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China
    APMIS 120:549-57. 2012
  3. doi Receptor activator for nuclear factor κ B expression predicts poor prognosis in breast cancer patients with bone metastasis but not in patients with visceral metastasis
    Lingyun Zhang
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China
    J Clin Pathol 65:36-40. 2012
  4. doi Proteasome inhibitor bortezomib (PS-341) enhances RANKL-induced MDA-MB-231 breast cancer cell migration
    Lingyun Zhang
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, PR China
    Mol Med Rep 5:580-4. 2012
  5. doi TRAIL-activated EGFR by Cbl-b-regulated EGFR redistribution in lipid rafts antagonises TRAIL-induced apoptosis in gastric cancer cells
    Ling Xu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China
    Eur J Cancer 48:3288-99. 2012
  6. doi Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals
    Shun Chao Yan
    Department of Medical Oncology, The First Hospital, China Medical University, Heping District, Shenyang, Liaoning Province, China
    Acta Oncol 50:693-9. 2011
  7. doi Epirubicin enhances TRAIL-induced apoptosis in gastric cancer cells by promoting death receptor clustering in lipid rafts
    Ling Xu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, P R China
    Mol Med Rep 4:407-11. 2011
  8. pmc Protective autophagy antagonizes oxaliplatin-induced apoptosis in gastric cancer cells
    Ling Xu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P R China
    Chin J Cancer 30:490-6. 2011
  9. doi Cbl-b-dependent degradation of FLIP(L) is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells
    Guodong Zhang
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China
    FEBS Lett 586:3104-10. 2012
  10. doi Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells
    Jing Liu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, P R China
    Mol Med Report 3:491-6. 2010

Collaborators

Detail Information

Publications21

  1. pmc β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis
    Jing Liu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, PR China
    BMC Cancer 11:183. 2011
    ..The mechanism by which β-elemene kills cells remains unclear. The aim of the present study is to investigate the anti-tumor effect of β-elemene on human gastric cancer cells and the molecular mechanism involved...
  2. doi c-Src expression is predictive of poor prognosis in breast cancer patients with bone metastasis, but not in patients with visceral metastasis
    Lingyun Zhang
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China
    APMIS 120:549-57. 2012
    ..Our findings demonstrate that c-Src expression is a potential independent predictor of poor prognosis in breast cancer patients with bone metastasis...
  3. doi Receptor activator for nuclear factor κ B expression predicts poor prognosis in breast cancer patients with bone metastasis but not in patients with visceral metastasis
    Lingyun Zhang
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China
    J Clin Pathol 65:36-40. 2012
    ..The present study was aimed to evaluate the effect of RANK on prognosis in breast cancer patients with bone metastasis and patients with visceral metastasis...
  4. doi Proteasome inhibitor bortezomib (PS-341) enhances RANKL-induced MDA-MB-231 breast cancer cell migration
    Lingyun Zhang
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, PR China
    Mol Med Rep 5:580-4. 2012
    ..Our results for the first time support the theory that PS-341 treatment may be unsuitable for RANK-positive breast cancer patients...
  5. doi TRAIL-activated EGFR by Cbl-b-regulated EGFR redistribution in lipid rafts antagonises TRAIL-induced apoptosis in gastric cancer cells
    Ling Xu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China
    Eur J Cancer 48:3288-99. 2012
    ..The contribution of DISC formation and the inhibition of EGFR signal triggered in lipid rafts are both essential for increasing the sensitivity of gastric cancer cells to TRAIL...
  6. doi Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals
    Shun Chao Yan
    Department of Medical Oncology, The First Hospital, China Medical University, Heping District, Shenyang, Liaoning Province, China
    Acta Oncol 50:693-9. 2011
    ..However, the molecular mechanisms of this effect are not well understood. In the present study, we investigated the roles of c-Src, ERK, AKT and c-Cbl ubiquitin ligases during TAM-induced apoptosis of MCF-7 cells...
  7. doi Epirubicin enhances TRAIL-induced apoptosis in gastric cancer cells by promoting death receptor clustering in lipid rafts
    Ling Xu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, P R China
    Mol Med Rep 4:407-11. 2011
    ..05). Our data demonstrate that epirubicin enhanced TRAIL-induced apoptosis in gastric cancer MGC803 cells, at least partially, through death receptor redistribution in the lipid rafts...
  8. pmc Protective autophagy antagonizes oxaliplatin-induced apoptosis in gastric cancer cells
    Ling Xu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P R China
    Chin J Cancer 30:490-6. 2011
    ..In conclusion, oxaliplatin-induced protective autophagy partially prevents apoptosis in gastric cancer MGC803 cells. The combination of autophagy inhibitor and oxaliplatin may be a new therapeutic option for gastric cancer...
  9. doi Cbl-b-dependent degradation of FLIP(L) is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells
    Guodong Zhang
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China
    FEBS Lett 586:3104-10. 2012
    ..Our findings lead to a better understanding of the mechanism of action of ATO, and suggest that a novel signaling pathway is required for ATO-induced autophagy in K562 and MGC803 cells...
  10. doi Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells
    Jing Liu
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, P R China
    Mol Med Report 3:491-6. 2010
    ..Our data demonstrated that the activation of PI3K/Akt and NF-κB by TRAIL is responsible for resistance to TRAIL in human gastric cancer cells. Blockage of survival signals significantly enhances the apoptosis induced by TRAIL...
  11. pmc Cbl-b enhances sensitivity to 5-fluorouracil via EGFR- and mitochondria-mediated pathways in gastric cancer cells
    Dan Feng
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China
    Int J Mol Sci 14:24399-411. 2013
    ..These results suggest that Cbl-b enhances sensitivity to 5-FU via EGFR- and mitochondria-mediated pathways in gastric cancer cells. ..
  12. ncbi Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation
    Xiujuan Qu
    Department of Medical Oncology, The First Hospital of China Medical University, No 155, North Nanjing Street, Heping District, 110001 Shenyang, China
    Mol Cell Biochem 340:107-14. 2010
    ..The consistent results were also showed in the process of Ara-c treatment. These observations indicate that Cbl-b promotes RBL-2H3 apoptosis induced by VP-16 or Ara-c, probably through inhibition of Akt and activation of ERK...
  13. ncbi Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells
    Ling Xu
    Department of Medical Oncology, The First Hospital of China Medical University, Heping, Shenyang 110001, P R China
    Oncol Rep 32:318-24. 2014
    ..These data suggest that Src activates EGFR through the interaction of both Src-EGFR and Src-caveolin-1, and then antagonizes TRAIL-induced apoptosis in gastric cancer cells...
  14. doi Trastuzumab and oxaliplatin exhibit a synergistic antitumor effect in HER2-postive gastric cancer cells
    Xiaodi Ding
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China
    Anticancer Drugs 25:315-22. 2014
    ..Our study provides preclinical evidence for the optimization of this combination regimen in the treatment of HER2-positive gastric cancer patients. ..
  15. doi β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells
    Jing Liu
    Department of Medical Oncology, The First Hospital, China Medical University, Shenyang, China
    J Pharm Pharmacol 64:146-53. 2012
    ..In this study, the antitumour effect of β-elemene on human non-small-cell lung cancer (NSCLC) A549 cells and the mechanism involved have been investigated...
  16. doi Bortezomib synergizes TRAIL-induced apoptosis in gastric cancer cells
    Jing Liu
    Department of Medical Oncology, The First Hospital of China Medical University, 110001 Shenyang, People s Republic of China
    Dig Dis Sci 55:3361-8. 2010
    ..The combination of TRAIL and bortezomib might be an effective regimen for the treatment of advanced gastric cancer...
  17. pmc Cetuximab-induced MET activation acts as a novel resistance mechanism in colon cancer cells
    Na Song
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China
    Int J Mol Sci 15:5838-51. 2014
    ..These results implicate alternative targeting of MET or SRC as rational strategies for reversing cetuximab resistance in colon cancer. ..
  18. ncbi Infection with respiratory syncytial virus influences FasL-mediated apoptosis of pulmonary γδ T cells in a murine model of allergen sensitization
    Sheng Zeng
    Department of Immunology, School of Basic Medical Science, China Medical University, Shenyang, PR China
    J Asthma 51:360-5. 2014
    ..Respiratory syncytial virus (RSV) infection can decrease the number of Th2-type γδ T cells. However, the underlying mechanisms remain unknown...
  19. doi Transcriptomic analysis of peripheral blood mononuclear cells in rapid progressors in early HIV infection identifies a signature closely correlated with disease progression
    Zi Ning Zhang
    Key Laboratory of AIDS Immunology of Ministry of Health, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China
    Clin Chem 59:1175-86. 2013
    ..Identification of biomarkers distinguishing rapid progressors (RPs) vs chronic progressors (CPs) is critical for early clinical intervention and could provide novel strategies to facilitate vaccine design and immune therapy...
  20. doi Associations of HLA class I antigen specificities and haplotypes with disease progression in HIV-1-infected Hans in Northern China
    Hui Zhang
    Key Laboratory of AIDS Immunology of the Ministry of Health, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, China
    Hum Immunol 74:1636-42. 2013
    ..730, 0.246 and 0.445, respectively). These findings suggest that the host's genetics make important contributions to HIV viral control and may help to develop peptide-based vaccines for this population...
  21. pmc Immunological and virological benefits resulted from short-course treatment during primary HIV infection: a meta-analysis
    Jingjing Chen
    Key Laboratory of AIDS Immunology of Ministry of Health, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China
    PLoS ONE 8:e82461. 2013
    ..And to investigate whether treatment initiation time, treatment duration and follow-up time after treatment interruption would affect these post-treatment immunovirological outcomes...