Bo Liu

Summary

Country: China

Publications

  1. pmc Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer
    B Liu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
    Cell Death Dis 4:e892. 2013
  2. pmc Autophagic pathways as new targets for cancer drug development
    Bo Liu
    West China Hospital, Sichuan University, Chengdu, China
    Acta Pharmacol Sin 31:1154-64. 2010
  3. doi request reprint Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways
    Bo Liu
    School of Life Sciences and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610064, China
    Biochimie 92:1934-8. 2010
  4. ncbi request reprint Induction of apoptosis by Concanavalin A and its molecular mechanisms in cancer cells
    Bo Liu
    School of Life Sciences, Sichuan University, Chengdu, Sichuan, China
    Autophagy 5:432-3. 2009
  5. doi request reprint Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway
    Bo Liu
    College of Life Sciences, State Key Laboratory of Oral Diseases, Sichuan University, Wuhou District, Chengdu 610064, China
    Cancer Lett 275:54-60. 2009
  6. doi request reprint In silico analysis of molecular mechanisms of Galanthus nivalis agglutinin-related lectin-induced cancer cell death from carbohydrate-binding motif evolution hypothesis
    Qi Jia Yu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School and School of Life Sciences, Sichuan University, Chengdu 610064, China
    Appl Biochem Biotechnol 165:1037-46. 2011
  7. doi request reprint A novel sialic acid-specific lectin from Phaseolus coccineus seeds with potent antineoplastic and antifungal activities
    Jing Chen
    College of Life Sciences, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610064, China
    Phytomedicine 16:352-60. 2009
  8. ncbi request reprint Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells
    Bo Liu
    School of Life Sciences, Sichuan University, Chengdu 610064, China
    Biochim Biophys Acta 1790:840-4. 2009
  9. doi request reprint A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells
    Zhen Liu
    College of Life Sciences, Sichuan University, Chengdu 610064, China
    Phytomedicine 15:867-75. 2008
  10. ncbi request reprint Network-based identification of novel connections among apoptotic signaling pathways in cancer
    Nan Wang
    School of Life Sciences and The State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610064, China
    Appl Biochem Biotechnol 167:621-31. 2012

Collaborators

Detail Information

Publications64

  1. pmc Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer
    B Liu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
    Cell Death Dis 4:e892. 2013
    ....
  2. pmc Autophagic pathways as new targets for cancer drug development
    Bo Liu
    West China Hospital, Sichuan University, Chengdu, China
    Acta Pharmacol Sin 31:1154-64. 2010
    ..A better understanding of the relationship between autophagy and cancer would ultimately allow us to harness autophagic pathways as new targets for drug discovery in cancer therapeutics...
  3. doi request reprint Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways
    Bo Liu
    School of Life Sciences and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610064, China
    Biochimie 92:1934-8. 2010
    ..Taken together, these results demonstrate that PCL induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways...
  4. ncbi request reprint Induction of apoptosis by Concanavalin A and its molecular mechanisms in cancer cells
    Bo Liu
    School of Life Sciences, Sichuan University, Chengdu, Sichuan, China
    Autophagy 5:432-3. 2009
    ..More importantly, we report for the first time that Con A can induce human melanoma A375 cell death in a caspase-dependent manner as well as via a mitochondrial apoptotic pathway...
  5. doi request reprint Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway
    Bo Liu
    College of Life Sciences, State Key Laboratory of Oral Diseases, Sichuan University, Wuhou District, Chengdu 610064, China
    Cancer Lett 275:54-60. 2009
    ..Moreover, we confirmed that the ROS-p38-p53 pathway was involved in PCL-induced autophagy. In conclusion, these results indicate that PCL induces apoptosis and autophagy via a mitochondrial-mediated ROS-p38-p53 pathway...
  6. doi request reprint In silico analysis of molecular mechanisms of Galanthus nivalis agglutinin-related lectin-induced cancer cell death from carbohydrate-binding motif evolution hypothesis
    Qi Jia Yu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School and School of Life Sciences, Sichuan University, Chengdu 610064, China
    Appl Biochem Biotechnol 165:1037-46. 2011
    ..nivalis agglutinin-related lectins induce cancer cell death...
  7. doi request reprint A novel sialic acid-specific lectin from Phaseolus coccineus seeds with potent antineoplastic and antifungal activities
    Jing Chen
    College of Life Sciences, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610064, China
    Phytomedicine 16:352-60. 2009
    ....
  8. ncbi request reprint Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells
    Bo Liu
    School of Life Sciences, Sichuan University, Chengdu 610064, China
    Biochim Biophys Acta 1790:840-4. 2009
    ....
  9. doi request reprint A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells
    Zhen Liu
    College of Life Sciences, Sichuan University, Chengdu 610064, China
    Phytomedicine 15:867-75. 2008
    ..Also, bioinformatics analyses showed that this lectin is speculated to bind a certain mannose-containing receptor on cancer cell surface thereby initiating downstream caspase cascade...
  10. ncbi request reprint Network-based identification of novel connections among apoptotic signaling pathways in cancer
    Nan Wang
    School of Life Sciences and The State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610064, China
    Appl Biochem Biotechnol 167:621-31. 2012
    ....
  11. doi request reprint Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways
    Shu Ya Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Biochem Biophys Res Commun 406:497-500. 2011
    ..In conclusion, these findings may provide a new perspective of Polygonatum cyrtonema lectin (PCL) as a potential anti-tumor drug targeting PCD pathways for future cancer therapeutics...
  12. ncbi request reprint Concanavalin A, from an old protein to novel candidate anti-neoplastic drug
    Chun Yang Li
    School of Life Sciences, Sichuan University, Chengdu 610064, China
    Curr Mol Pharmacol 3:123-8. 2010
    ..In conclusion, these findings may shed light on the complicated molecular mechanisms of ConA-induced cancer cell death, thereby opening a new perspective for plant lectins as potential anti-neoplastic drugs in future cancer therapeutics...
  13. doi request reprint Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells
    Bo Liu
    College of Life Sciences, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
    Arch Biochem Biophys 482:1-6. 2009
    ..Also, we demonstrate firstly that ConA induces A375 cell death in a caspase-dependent manner as well as through a mitochondrial apoptotic pathway...
  14. ncbi request reprint Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells
    Bo Liu
    College of Life Sciences, Sichuan University, Chengdu, Sichuan, China
    Autophagy 5:253-5. 2009
    ..In conclusion, these findings indicate that PCL induces both apoptosis and autophagy in cancer cells through a mitochondria-mediated ROS-p38-p53 pathway...
  15. doi request reprint Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities
    Bo Liu
    College of Life Sciences and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610064, China
    Phytomedicine 16:601-8. 2009
    ..Furthermore, our results demonstrate that these lectins induce apoptosis in MCF-7 cells via a caspase-dependent pathway...
  16. doi request reprint Plant lectins: targeting programmed cell death pathways as antitumor agents
    Lei Lei Fu
    School of Life Sciences and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Biochem Cell Biol 43:1442-9. 2011
    ..And, this research may, in turn, ultimately help cancer biologists and clinicians to exploit lectins as potential novel antitumor drugs in the future...
  17. ncbi request reprint Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites
    Bo Liu
    College of Life Sciences, Sichuan University, Chengdu, China
    BMB Rep 41:369-75. 2008
    ..g., hemagglutinating and mitogenic activity assays, fluorescence and Circular Dichrosim (CD) spectroscopy) to profoundly identify the role of some key amino acids in the structure-function relationship of PCL...
  18. pmc Targeting autophagic pathways for cancer drug discovery
    Bo Liu
    School of Life Sciences, Sichuan University, Chengdu, People s Republic of China
    Chin J Cancer 32:113-20. 2013
    ..This review discusses the current status of targeting autophagic pathways as a potential cancer therapy...
  19. doi request reprint Plant lectins: potential antineoplastic drugs from bench to clinic
    Bo Liu
    School of Life Sciences, Sichuan University, Chengdu 610064, China
    Cancer Lett 287:1-12. 2010
    ..In conclusion, these inspiring findings would open a new perspective for plant lectins as potential antineoplastic drugs from bench to clinic...
  20. ncbi request reprint Unraveling the complexity of hepatitis B virus: from molecular understanding to therapeutic strategy in 50 years
    Bo Liu
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Int J Biochem Cell Biol 45:1987-96. 2013
    ..Together, the data in this 50-year review may provide new clues to elucidate molecular mechanisms of HBV pathogenesis and shed new light on the future HBV therapies. ..
  21. doi request reprint Bioinspired total synthesis of bolivianine: a Diels-Alder/intramolecular hetero-Diels-Alder cascade approach
    Changchun Yuan
    Key Laboratory of Green Chemistry and Technology of the Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China
    J Am Chem Soc 135:9291-4. 2013
    ..The synthetic efforts validate our modified biogenetic hypothesis and allow us to confirm the absolute configuration of bolivianine. ..
  22. doi request reprint Synthesis of a series of novel chiral Lewis base catalysts and their application in promoting asymmetric hydrosilylation of β-enamino esters
    Xing Chen
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610041 China
    Org Biomol Chem 11:3089-93. 2013
    ..It is noteworthy that several cyclic substrates were hydrosilylated under the optimal conditions to give the cyclic β-amino esters with high yields, good diastereoselectivities as well as good ee values...
  23. doi request reprint Beclin-1: autophagic regulator and therapeutic target in cancer
    Lei Lei Fu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
    Int J Biochem Cell Biol 45:921-4. 2013
    ..Here, we summarize that Beclin-1 serves not only as a key autophagic regulator with its specific interactors, but as a potential therapeutic target in cancer...
  24. doi request reprint Core signaling pathways of survival/death in autophagy-related cancer networks
    Shu Ya Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
    Int J Biochem Cell Biol 43:1263-6. 2011
    ..Therefore, a better understanding of the relationships between autophagy and cancer may ultimately allow cancer biologists and clinicians to harness core autophagic pathways for the discovery of potential novel drug targets...
  25. ncbi request reprint [Dynamic characteristics of forest landscape in Chengdu City in last 20 years]
    Lin Gu
    Sichuan Academy of Forestry, Chengdu 610081, China
    Ying Yong Sheng Tai Xue Bao 21:1081-9. 2010
    ....
  26. ncbi request reprint [Value of 16-slice spiral CT in the diagnosis of tumor-like bronchial tuberculosis]
    Ying Zhang
    Department of Radiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1943-5. 2010
    ..To evaluate the value of 16-slice multi-detector CT (MDCT) in the diagnosis of tumor-like bronchial tuberculosis...
  27. ncbi request reprint [Study on the enhanced luminescence of GdTaO4:Eu3+ phosphors by Li+ codopant]
    Shang yi Fu
    Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, Department of Bohr Solid Physics, Tongji University, Shanghai 200092, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:2317-20. 2010
    ..Gd(0.92-x)Li(x)TaO4:Eu0.08(3+) has not only quite a good crystallinity but also less Gd2O3 and Ta2O5 hetero phases when x = 0.06 or 0.10. Therefore, their luminescence intensities can be improved evidently...
  28. ncbi request reprint Clinical and radiographic results of cervical artificial disc arthroplasty: over three years follow-up cohort study
    Wei Tian
    Department of Spine Surgery, Beijing Jishuitan Hospital, Fourth Clinical Medical College of Peking University, Beijing 100035, China
    Chin Med J (Engl) 123:2969-73. 2010
    ..The clinical and radiographic effects of cervical disc arthroplasty in short term have been ascertained. The aim of this study is to research the data of mid-term results...
  29. ncbi request reprint [Study of pedicle screw placement assisted by intraoperative three-dimensional navigation in lumbar vertebrae with axial rotation]
    Wei Tian
    Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China
    Zhonghua Wai Ke Za Zhi 48:838-41. 2010
    ....
  30. ncbi request reprint [Modification and luminescence properties of transparent Lu2SiO5 : Ce3+ thin-film phosphors]
    Yang Yang Fan
    Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology, Department of Physics, Tongji University, Shanghai 200092, China
    Guang Pu Xue Yu Guang Pu Fen Xi 31:344-8. 2011
    ..The luminescence properties of the film were studied. Their performances were good, which implied that the film would have promising applications in high-spatial-resolution X-ray imaging and flat panel display devices...
  31. ncbi request reprint [Biology and phenology of Xanthoceras sorbifolia in Wudan area]
    Li Ping Ma
    Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
    Ying Yong Sheng Tai Xue Bao 19:2583-7. 2008
    ..17. The individuals of X. sorbifolia had definite differences in their phenology, which was disadvantageous to the cross pollination among the individuals, and the enhancement of pollination rate...
  32. doi request reprint Exploring the relationship between vegetation spectra and eco-geo-environmental conditions in karst region, Southwest China
    Yuemin Yue
    Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China
    Environ Monit Assess 160:157-68. 2010
    ..Employing a combination of spectral and spatial analysis, it is anticipated that hyperspectral imagery can be used in interpreting or mapping eco-geo-environmental conditions covered with vegetation in karst region...
  33. doi request reprint Feasibility of a two-stage biological aerated filter for depth processing of electroplating-wastewater
    Bo Liu
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Engineering Center of Water Treatment and Water Environmental Remediation, Ministry of Education, Nanjing University, Nanjing, PR China
    Bioresour Technol 100:3891-6. 2009
    ..46%, respectively. The effluent steadily reached the wastewater reuse standard. Compared to the traditional BAF, the period before backwashing of the T-SBAF could be extended to 10days, and the recovery time was considerably shortened...
  34. ncbi request reprint [Effect of ethanol on sulfate reduction and methanogenesis]
    Qi Wang
    Engineering Center of Water Treatment and Environment Remediation, Ministry of Education, National Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China
    Huan Jing Ke Xue 30:924-9. 2009
    ..But higher recycle ratio (r = 20) made substrate gradient too little and SO4(2-) reduction efficiency reduced, while lower recycle ratio (r = 5) made sludge bed shrunken and COD removal efficiency reduced...
  35. doi request reprint Effect of processing conditions on sonochemical synthesis of nanosized copper aluminate powders
    Weizhong Lv
    College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen, PR China
    Ultrason Sonochem 17:344-51. 2010
    ....
  36. ncbi request reprint [Preventive effects of pueraria on presbycusis in rats]
    Wangyan Chen
    Department of Otorhinolaryngology, Chinese and Western Medicine Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23:703-5. 2009
    ..To investigate the preventive effects of Pueraria on presbycusis in rats...
  37. doi request reprint Enhanced degradation of 4-nitrophenol by microwave assisted Fe/EDTA process
    Bo Liu
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, PR China
    J Hazard Mater 176:213-9. 2010
    ..237 to 0.635 after reaction for 18 min, indicating that the biodegradability of wastewater was greatly improved by Fe/EDTA/MW system and would benefit to further treatment by biochemical methods...
  38. ncbi request reprint [The unique Entner-Doudoroff (ED) glycolysis pathway of glucose in archaea--a review]
    Tianming Liu
    College of Food and Biongineering, Shandong Institute of Light Industry, Jinan 250353, China
    Wei Sheng Wu Xue Bao 48:1126-31. 2008
    ..We reviewed recent advances in the ED glycolytic pathway of archaeon concerning enzymes, regulation and energy transformation. The potentials of glycolysis pathway in archaea were also discussed...
  39. ncbi request reprint [A quantitative study of the relationship between levels of liver fibrosis markers in sera and fibrosis stages of liver tissues of patients with chronic hepatic diseases]
    Xian jun Ding
    Department of Infectious Diseases, People s Hospital of Zhoushan, Zhoushan 316000, China
    Zhonghua Gan Zang Bing Za Zhi 13:911-4. 2005
    ..To study the quantitative relationship between the levels of serum liver fibrosis markers and fibrosis stages of liver tissues in patients with chronic hepatic diseases...
  40. doi request reprint Sonochemical synthesis of cobalt aluminate nanoparticles under various preparation parameters
    Weizhong Lv
    College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060, PR China
    Ultrason Sonochem 17:793-801. 2010
    ..The apparent activation energy (E) and the pre-exponential constant (A) were 304.26 kJ/mol and 6.441 x 10(14)s(-1), respectively. Specific surface area was investigated by means of Brunauer Emmett Teller (BET) surface area measurements...
  41. ncbi request reprint [A fMRI observation on different cererbral regions activated by acupuncture of Shenmen (HT 7) and Yanglao (SI 6)]
    Shang jie Chen
    Department of Rehabilitation, Baoan People s Hospital, Shenzhen 518101, China
    Zhen Ci Yan Jiu 33:267-71. 2008
    ..To observe the influence of acupuncture of Shenmen (HT 7) and Yanglao (SI 6) on neuro-images in different cerebral regions in volunteer subjects...
  42. ncbi request reprint [Harmful elements removal from Polygonum multiflorum by supercritical CO2 extraction]
    Zhen Wen
    College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060, China
    Zhong Yao Cai 31:1567-71. 2008
    ..To remove harmful elements as copper, lead and arsenic from Polygonum multiflorum, a Chinese traditional medicine, by supercritical carbon dioxide extraction...
  43. ncbi request reprint Asymmetric total synthesis of onoseriolide, bolivianine, and isobolivianine
    Biao Du
    Key Laboratory of Green Chemistry and Technology of the Ministry of Education Institution, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064 China, Fax 86 28 8541 3712
    Chemistry 20:2613-22. 2014
    ..The biosynthetic mechanism and the excellent regio- and endo selectivities in the cascade are well supported by theoretical chemistry based on the DFT calculations. ..
  44. doi request reprint Deconvoluting the role of reactive oxygen species and autophagy in human diseases
    Xin Wen
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Free Radic Biol Med 65:402-10. 2013
    ....
  45. ncbi request reprint Palladium-catalyzed direct arylation of N-heteroarenes with arylsulfonyl hydrazides
    Bo Liu
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, Chengdu, P R China
    Chemistry 18:10830-3. 2012
    ..The method offers a straightforward approach to a variety of aryl-heteroaryl compounds...
  46. doi request reprint Palladium-catalyzed desulfitative C-H arylation of heteroarenes with sodium sulfinates
    Bo Liu
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China
    Chemistry 17:13415-9. 2011
  47. doi request reprint MicroRNA-modulated autophagic signaling networks in cancer
    Lei Lei Fu
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, School of Life Sciences, Sichuan University, Chengdu 610041, China
    Int J Biochem Cell Biol 44:733-6. 2012
    ....
  48. ncbi request reprint Gold-catalyzed synthesis of nitrogen-containing heterocycles from epsilon-N-protected propargylic esters
    Jianfeng Huang
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China
    Org Biomol Chem 8:2697-9. 2010
    ..A mild and efficient gold-catalyzed tandem cyclization to piperidinyl enol esters has been developed with facilely available epsilon-N-Boc-protected propargylic esters...
  49. doi request reprint Targeting apoptotic and autophagic pathways for cancer therapeutics
    Jun Jie Liu
    Sichuan University, Chengdu, China
    Cancer Lett 300:105-14. 2011
    ..In summary, these findings may ultimately allow biologists to harness apoptotic and autophagic pathways as novel targets for cancer therapeutics...
  50. doi request reprint Mitochondrial ROS generation for regulation of autophagic pathways in cancer
    Zi Yue Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
    Biochem Biophys Res Commun 414:5-8. 2011
    ..Therefore, a better understanding of the intricate relationships between mitochondrial ROS and autophagy may ultimately allow cancer biologists to harness mitochondrial ROS-mediated autophagic pathways for cancer drug discovery...
  51. ncbi request reprint Hyperthermia-conditioned OECs serum-free-conditioned medium induce NSC differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity
    Lei Wang
    1 Department of Neurosurgery, the Second Affiliated Hospital of Hunan Normal University PLA 163 Hospital, Changsha, People s Republic of China 2 Key Laboratory of Protein Chemistry and Developmental Biology of Education Committee, College of Life Sciences, Hunan Normal University, Changsha, People s Republic of China 3 Address correspondence to Ming Lu, M D, Department of Neurosurgery, the Second Affiliated Hospital of Hunan Normal University PLA 163 Hospital, Changsha 410003, People s Republic of China Ping Chen, Ph D, Key Laboratory of Protein Chemistry and Developmental Biology of Education Committee, College of Life Sciences, Hunan Normal University, Changsha 410081, P R China
    Transplantation 97:1225-32. 2014
    ..In the present study, we investigated the effects of hyperthermia-conditioned OEC-conditioned medium (OCM) on induction of NSCs into nerve cells...
  52. ncbi request reprint Preparation and characterization of a novel recombinant human parathyroid hormone (1-34) analog (Gly1-Gln26-rhPTH(1-34)) with enhanced biological activity
    Xiao Chao Xu
    College of Life Sciences, Sichuan University, Chengdu, China
    Protein Pept Lett 15:854-60. 2008
    ..95-30.54% and 1.98-23.32%, compared to control-vehicle group (OVX, P<0.001) and sham- operated group (SHAM, P<0.01), respectively...
  53. doi request reprint An integrated proteomics and bioinformatics analyses of hepatitis B virus X interacting proteins and identification of a novel interactor apoA-I
    Tao Zhang
    The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China
    J Proteomics 84:92-105. 2013
    ....
  54. ncbi request reprint Discovery of a full-color-tunable fluorescent core framework through direct C-H (hetero)arylation of N-heterocycles
    Bo Liu
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P R China
    Chemistry 18:1599-603. 2012
  55. doi request reprint Asymmetric total synthesis of ent-heliespirones A & C
    Chong Huang
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China
    Chem Commun (Camb) 46:5280-2. 2010
    ..This synthetic strategy features a highly diastereoselective palladium-catalyzed Michael addition to form 3,5-trans lactone and a final biomimetic intramolecular oxa-spirocyclization...
  56. doi request reprint Cytotoxicity and apoptosis induction of weisiensin B isolated from Rabdosia weisiensis C.Y. Wu in human hepatoma cells
    Lan Ding
    College of Life Sciences, Northwest Normal University, Lanzhou, China
    J Asian Nat Prod Res 10:1055-62. 2008
    ..The results demonstrated that a significant fraction of weisiensin B-treated cells died by an apoptotic pathway in BEL-7402 cells...
  57. doi request reprint Total synthesis of (±)-chloranthalactone A
    Guizhou Yue
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
    Org Lett 13:5406-8. 2011
    ..A total synthesis of (±)-chloranthalactone A was completed. It features substrate-controlled epoxidation of ketone and highly diastereoselective intramolecular cyclopropanation to construct the cis, trans-3/5/6 tricyclic skeleton...
  58. ncbi request reprint Construction of the cyclophane core of the hirsutellones via a RCM strategy
    Mingzheng Huang
    Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
    Org Lett 12:2504-7. 2010
    ..Construction of the highly strained [10]-paracyclophane core of the hirsutellones has been completed via an effective RCM strategy...
  59. doi request reprint LSD1 is required for chromosome segregation during mitosis
    Shuang Lv
    Laboratory of Cancer Biology, College of Life Sciences, Capital Normal University, 105 Xi San Huan Road N, Beijing, China
    Eur J Cell Biol 89:557-63. 2010
    ..Our results suggest that LSD1 plays a role in chromosomal segregation during mitosis partially through transcriptional regulation of BUBR1 and MAD2...
  60. doi request reprint Release of hydrophobic anticancer drug from a newly designed self-assembling peptide
    Min Wu
    West China Hospital Nanomedicine Laboratory and Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, 610041, P R China
    Mol Biosyst 7:2040-7. 2011
    ..The results described herein provide further incentives for basic studies on self-assembling peptide-based delivery of hydrophobic anticancer drugs...
  61. ncbi request reprint [Clinical effectiveness and safety of sanchi tong shu capsule in the treatment of aural vertigo: a multi-center randomized controlled clinical trial]
    Juan Meng
    Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26:295-9. 2012
    ..To evaluate the clinical effectiveness and safety of Sanchi Tong Shu capsule in the treatment of common aural vertigo...
  62. ncbi request reprint The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling
    Hang zi Chen
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Gut 61:714-24. 2012
    ..The orphan nuclear receptor TR3 plays important roles in proliferation and apoptosis. In this study, we investigated how TR3 suppresses intestinal tumorigenesis by regulating Wnt signalling...
  63. ncbi request reprint Regulation of the orphan receptor TR3 nuclear functions by c-Jun N terminal kinase phosphorylation
    Bo Liu
    Department of Biomedical Sciences, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian, China
    Endocrinology 148:34-44. 2007
    ..Taken together, our findings revealed a novel cross talk between TR3 and JNK signal pathway and shed light on the mechanism of JNK phosphorylation-dependent regulation on TR3 nuclear functions...
  64. pmc p53 mediates the negative regulation of MDM2 by orphan receptor TR3
    Bi Xing Zhao
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian, China
    EMBO J 25:5703-15. 2006
    ....