Jiang Lin

Summary

Country: China

Publications

  1. Wang Y, Zhang T, Yang D, Yao D, Yang L, Zhou J, et al. Reduced miR-215 expression predicts poor prognosis in patients with acute myeloid leukemia. Jpn J Clin Oncol. 2016;46:350-6 pubmed publisher
    ..Our study demonstrates that reduced microRNA-215 expression is a common event and is associated with poor clinical outcome in acute myeloid leukemia. ..
  2. Xu Z, Ma J, Zhou J, Wen X, Yao D, Zhang W, et al. Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia. J Transl Med. 2019;17:102 pubmed publisher
    ..PCDH17 gene was silenced by DNA methylation in AML. Low PCDH17 expression is associated with distinct clinical and biological features and improves risk stratification in patients with AML. ..
  3. Xu Z, Tang C, Zhou J, Ma J, Wen X, Deng Z, et al. SOX7 methylation is an independent prognostic factor in myelodysplastic syndromes. Pathol Res Pract. 2019;215:322-328 pubmed publisher
    ..Our findings demonstrated that SOX7 methylation conferred adverse prognosis in MDS patients and was associated with leukemia progression. ..
  4. Zhou J, Wang Y, Zhang T, Yang D, Yao D, Guo H, et al. Epigenetic inactivation of DLX4 is associated with disease progression in chronic myeloid leukemia. Biochem Biophys Res Commun. 2015;463:1250-6 pubmed publisher
    ..001). Our study indicated that hypermethylation of DLX4 correlated with disease progression of CML. Moreover, DLX4 expression was regulated by its methylation in CML. ..
  5. Zhang T, Qian Z, Wen X, Zhou J, Li X, Xu Z, et al. Lower expression of bone marrow miR-122 is an independent risk factor for overall survival in cytogenetically normal acute myeloid leukemia. Pathol Res Pract. 2018;214:896-901 pubmed publisher
    ..062 and 0.049, respectively). Our findings indicated that lower expression of BM miR-122 acted as an independent risk factor for OS in CN-AML. ..
  6. Zhou J, Zhang L, Zhang T, Gu Y, Wu D, Zhang W, et al. Dysregulation of miR-200s clusters as potential prognostic biomarkers in acute myeloid leukemia. J Transl Med. 2018;16:135 pubmed publisher
    ..Expression of miR-200a/200b/429 cluster was frequently down-regulated in AML, and low expression of miR-429 as an independent risk factor for CR, whereas low expression of miR-200b as an independent prognostic biomarker for OS. ..
  7. Zhou J, Zhang T, Wang Y, Yang D, Yang L, Ma J, et al. DLX4 hypermethylation is a prognostically adverse indicator in de novo acute myeloid leukemia. Tumour Biol. 2016;37:8951-60 pubmed publisher
    ..Our study indicates that DLX4 hypermethylation is negatively associated with DLX7 expression and predicts poor clinical outcome in de novo AML patients. ..
  8. Yang J, Yao D, Ma J, Yang L, Guo H, Wen X, et al. The prognostic implication of SRSF2 mutations in Chinese patients with acute myeloid leukemia. Tumour Biol. 2016;37:10107-14 pubmed publisher
    ..These results suggest that SRSF2 mutation occurs at a low frequency in aged AML patients and might not be associated with adverse prognosis in Chinese AML patients. ..
  9. Yao X, Zhou J, Yang J, Zhang W, Ma J, Wen X, et al. SETBP1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. Pathol Res Pract. 2018;214:706-712 pubmed publisher
    ..We established a rapid, inexpensive, high-throughput and sensitive method to screen SETBP1 mutations. SETBP1 mutations were a rare molecular event in AML and MDS patients. ..

More Information

Publications12

  1. Zhang Y, Yao D, Zhu X, Zhou J, Ma J, Yang J, et al. DNMT3A intragenic hypomethylation is associated with adverse prognosis in acute myeloid leukemia. Leuk Res. 2015;39:1041-7 pubmed publisher
    ..25 months, P=0.011). Multivariate analysis confirmed the independent adverse impact of DNMT3A hypomethylation in CN-AML. Our data suggest that DNMT3A DMR2 hypomethylation is a negative prognostic hallmark in CN-AML. ..
  2. Zhang T, Guo H, Zhou J, Li X, Zhang W, Ma J, et al. Bone marrow miR-10a overexpression is associated with genetic events but not affects clinical outcome in acute myeloid leukemia. Pathol Res Pract. 2018;214:169-173 pubmed publisher
    ..BM miR-10 overexpression is associated with genetic events but not affects clinical outcome in AML. ..
  3. Zhang Z, Lian X, Yao D, He P, Ma J, Xu Z, et al. Reduced intensity conditioning of allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia in patients older than 50 years of age: a systematic review and meta-analysis. J Cancer Res Clin Oncol. 2017;143:1853-1864 pubmed publisher
    ..05). RIC-alloHSCT is a feasible treatment option for the patients older than 50 year of age with MDS and AML. Advanced diseases status and higher diseases risk may be the poor factors for prognosis. ..