Xing Jie Liang

Summary

Country: China

Publications

  1. doi request reprint Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis
    Jie Meng
    Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, 100190, China
    Nanoscale 3:4713-9. 2011
  2. doi request reprint Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation
    Anil Kumar
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, no 11, First North Road, Beijing100190, PR China
    Nanoscale 5:8307-25. 2013
  3. pmc SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
    Xing Jie Liang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Cancer Res 6:1499-506. 2008
  4. pmc Biopharmaceutics and therapeutic potential of engineered nanomaterials
    Xing Jie Liang
    Laboratory of Nanobiomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanosciences and Technology of China, Beijing 100190, P R China
    Curr Drug Metab 9:697-709. 2008
  5. pmc Circumventing tumor resistance to chemotherapy by nanotechnology
    Xing Jie Liang
    Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, China
    Methods Mol Biol 596:467-88. 2010
  6. pmc Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis
    Xing Jie Liang
    Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    Proc Natl Acad Sci U S A 107:7449-54. 2010
  7. ncbi request reprint Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo
    Jinfeng Xing
    Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China
    Mini Rev Med Chem 10:126-37. 2010
  8. ncbi request reprint Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells
    Xing Jie Liang
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 1A 09, 37 Convent Drive, Bethesda, MD 20892 4254, USA
    Exp Cell Res 293:283-91. 2004
  9. ncbi request reprint Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines
    Xing Jie Liang
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4254, USA
    Cancer Res 63:5909-16. 2003
  10. ncbi request reprint Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance
    Xing Jie Liang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda 20892 4256, Maryland, USA
    Anticancer Res 25:4113-22. 2005

Collaborators

Detail Information

Publications59

  1. doi request reprint Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis
    Jie Meng
    Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, 100190, China
    Nanoscale 3:4713-9. 2011
    ..Their possible anti-tumor mechanisms were also discussed. The present study may provide new insight into the mechanism of action of these nanoparticles...
  2. doi request reprint Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation
    Anil Kumar
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, no 11, First North Road, Beijing100190, PR China
    Nanoscale 5:8307-25. 2013
    ..We also emphasize the environmental and health prospects of nanomaterials for human health care. ..
  3. pmc SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
    Xing Jie Liang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Cancer Res 6:1499-506. 2008
    ..Our findings therefore suggest that reduced glucose use and altered mitochondrial metabolism mediated by SIRT1 is one of several alterations that contribute to cellular resistance to cisplatin...
  4. pmc Biopharmaceutics and therapeutic potential of engineered nanomaterials
    Xing Jie Liang
    Laboratory of Nanobiomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanosciences and Technology of China, Beijing 100190, P R China
    Curr Drug Metab 9:697-709. 2008
    ..This paper illustrates the potential of nanomedicine by discussing biopharmaceutics of fullerene derivatives and their suitability for diagnostic and therapeutic purposes. Future direction is discussed as well...
  5. pmc Circumventing tumor resistance to chemotherapy by nanotechnology
    Xing Jie Liang
    Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, China
    Methods Mol Biol 596:467-88. 2010
    ..Nanotechnology may help to solve the problems associated with traditional chemotherapy and multidrug resistance...
  6. pmc Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis
    Xing Jie Liang
    Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    Proc Natl Acad Sci U S A 107:7449-54. 2010
    ..The technology can be extended to other challenges related to multidrug resistance often found in cancer treatments...
  7. ncbi request reprint Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo
    Jinfeng Xing
    Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China
    Mini Rev Med Chem 10:126-37. 2010
    ..This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA) in vivo...
  8. ncbi request reprint Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells
    Xing Jie Liang
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 1A 09, 37 Convent Drive, Bethesda, MD 20892 4254, USA
    Exp Cell Res 293:283-91. 2004
    ....
  9. ncbi request reprint Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines
    Xing Jie Liang
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4254, USA
    Cancer Res 63:5909-16. 2003
    ..The reduced accumulation of cytotoxic compounds in the KB-CP cells is presumed to result from the failure of carrier proteins and/or transporters to localize to the plasma membrane...
  10. ncbi request reprint Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance
    Xing Jie Liang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda 20892 4256, Maryland, USA
    Anticancer Res 25:4113-22. 2005
    ..We conclude that K+ and H+ homeostasis are not critical factors in cisplatin resistance since they affect cisplatin resistance differently in KB and BEL-7404 cells...
  11. doi request reprint Ternary complexes of amphiphilic polycaprolactone-graft-poly (N,N-dimethylaminoethyl methacrylate), DNA and polyglutamic acid-graft-poly(ethylene glycol) for gene delivery
    Shutao Guo
    Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
    Biomaterials 32:4283-92. 2011
    ....
  12. doi request reprint Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid
    Wendi Zhang
    School of Chemical Engineering and Technology, Tianjin University, Key Laboratory of Systems Bioengineering, Ministry of Education of China, Tianjin 300072, China
    Biomaterials 34:6495-503. 2013
    ..These results demonstrated that HgP was a promising anionic polymer for coating the polycation/DNA complexes and ternary complexes (HgP coated NP-D) hold promising potential for cancer therapy...
  13. doi request reprint Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger
    Jun Jie Yin
    Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, 11, First North Rd, Zhongguancun, Beijing, People s Republic of China, 100190
    Mol Pharmacol 74:1132-40. 2008
    ....
  14. ncbi request reprint P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential
    Claudina Alemán
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4254, USA
    Cancer Res 63:3084-91. 2003
    ..The changes in these parameters observed in drug-selected cells must reflect other host adaptations to drug selection...
  15. ncbi request reprint Codominance of cisplatin resistance in somatic cell hybrids
    Yu Lan Mary Ying
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4254, USA
    J Cell Physiol 196:63-9. 2003
    ..These dominance data suggest that it might be possible to identify one or more genes responsible for cisplatin resistance by gene transfer from a resistant cell line to a sensitive cell line...
  16. ncbi request reprint Multicellular tumor spheroids as an in vivo-like tumor model for three-dimensional imaging of chemotherapeutic and nano material cellular penetration
    Hui Li Ma
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China
    Mol Imaging 11:487-98. 2012
    ..The development of this image-based, reproducible, and quantifiable in vitro HeLa spheroid screening tool will greatly aid future exploration of chemotherapeutics and nanoparticle delivery into solid tumors...
  17. ncbi request reprint Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum
    Xing Jie Liang
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4256, USA
    J Cell Physiol 202:635-41. 2005
    ....
  18. ncbi request reprint A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells
    Xing Jie Liang
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD 20892 4254, USA
    J Inorg Biochem 98:1599-606. 2004
    ..Multiple mechanisms in CP-r cells keep cytotoxic platinum compounds out of cells through defective expression of cell surface proteins such as transporters and carriers, and decreased expression of proteins involved in endocytosis...
  19. pmc Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte
    Shutao Guo
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    ACS Nano 4:5505-11. 2010
    ..These results demonstrate the feasibility of using charge-reversal functional gold nanoparticles as a means of improving the nucleic acid delivery efficiency...
  20. doi request reprint Superior penetration and retention behavior of 50 nm gold nanoparticles in tumors
    Shuaidong Huo
    School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin, China
    Cancer Res 73:319-30. 2013
    ..Taken together, our findings define an optimal smaller size for nanoparticles that maximizes their effective accumulation in tumor tissue...
  21. ncbi request reprint Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell lines
    Ding Wu Shen
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 1A09, Bethesda, MD 20892 4254, USA
    Mol Pharmacol 66:789-93. 2004
    ....
  22. ncbi request reprint Down-regulation and altered localization of gamma-catenin in cisplatin-resistant adenocarcinoma cells
    Xing Jie Liang
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 1A09, Bethesda, MD 20892 4254, USA
    Mol Pharmacol 65:1217-24. 2004
    ....
  23. doi request reprint Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines
    Xing Jie Liang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Cancer Chemother Pharmacol 62:977-84. 2008
    ....
  24. pmc Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids
    Shubin Jin
    Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, China
    Nanoscale 5:143-6. 2013
    ..The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit...
  25. doi request reprint Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway
    Kangning Yang
    Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, no 11, First North Road, Zhongguancun, Beijing, 100190, China
    Nanoscale 5:1205-12. 2013
    ..Moreover, the in vivo results of the ovariectomized rats further indicated that [Gd@C(82)(OH)(22)](n) nanoparticles effectively improved bone density and prevented osteoporosis...
  26. doi request reprint Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatment
    Anil Kumar
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, PR China
    Biomaterials 33:1180-9. 2012
    ..These results have implications to design and functionalize different molecules onto AuNPs surfaces to make hybrid model system for selective target binding as well as therapeutic effects for cancer treatment...
  27. pmc Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo
    Keyang Huang
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, no 11, First North Road, Zhongguancun, Beijing, China 100190
    ACS Nano 6:4483-93. 2012
    ..This work gives important insights into the design and functionalization of nanoparticles to achieve high levels of accumulation in tumors...
  28. pmc Construction of paclitaxel-loaded poly (2-hydroxyethyl methacrylate)-g-poly (lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activity
    Xiaowei Ma
    Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, People s Republic of China
    Int J Nanomedicine 7:1313-28. 2012
    ....
  29. pmc Endocytic recycling compartments altered in cisplatin-resistant cancer cells
    Xing Jie Liang
    Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 66:2346-53. 2006
    ....
  30. doi request reprint Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo
    Tuo Wei
    Chinese Academy of Sciences CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, no 11, First North Road, Zhongguancun, Beijing, China 100190
    Nano Lett 13:2528-34. 2013
    ..The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo...
  31. pmc Single-walled carbon nanotubes alter cytochrome c electron transfer and modulate mitochondrial function
    Xiaowei Ma
    Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, China
    ACS Nano 6:10486-96. 2012
    ..This work is significant to SWCNTs research because it provides a novel understanding of SWCNTs' disruption of mitochondria function and has important implications for biomedical applications of SWCNTs...
  32. doi request reprint Long genomic DNA amplicons adsorption onto unmodified gold nanoparticles for colorimetric detection of Bacillus anthracis
    Hua Deng
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyijie, Zhongguancun, Beijing 100190, China
    Chem Commun (Camb) 49:51-3. 2013
    ..More importantly, the DNA-Au interaction can be utilized for colorimetric detection of a specific nucleic acid sequence in clinical samples...
  33. pmc Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy
    Hui Yang
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Sci Rep 2:847. 2012
    ..No signs of toxicity were observed. Fetal exposure to nanoparticles in murine pregnancy is, therefore, influenced by both stage of embryonic/placental maturation and nanoparticle surface composition...
  34. doi request reprint Enhanced siRNA delivery and silencing gold-chitosan nanosystem with surface charge-reversal polymer assembly and good biocompatibility
    Lu Han
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, People s Republic of China
    ACS Nano 6:7340-51. 2012
    ....
  35. pmc Biomedical activities of endohedral metallofullerene optimized for nanopharmaceutics
    Jie Meng
    Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, China
    J Nanosci Nanotechnol 10:8610-6. 2010
    ..The review critically analyzed the relevant data instead of fact-listing, and explained the potential for developing Gd@C82(OH)22 into a diagnostic or therapeutic agent...
  36. pmc Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction
    Xue Xue
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, PR China
    Mol Pharm 9:634-44. 2012
    ..Therefore, mitochondria targeting compounds would be more vulnerable and selective to overcome cisplatin resistance due to the unique metabolic properties of CP-r cancer cells...
  37. pmc Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier
    Shutao Guo
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Biomaterials 32:879-89. 2011
    ..These results indicate that PECD NPs have a great potential to be used as efficient polymeric carriers for gene transfection...
  38. doi request reprint Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment
    Xiaowei Ma
    Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, China
    ACS Nano 5:8629-39. 2011
    ..This work is significant to nanoparticle research because it illustrates how nanoparticles can potentially interrupt the autophagic pathway and has important implications for biomedical applications of nanoparticles...
  39. pmc Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistance
    Ding Wu Shen
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 2108, Bethesda, MD 20892 4254, USA
    Mol Pharmacol 69:1383-8. 2006
    ..The finding that a ribosomal protein gene, RPL36, contributes to CP-r should stimulate study of the role of ribosomal proteins in multifactorial mechanisms of cisplatin resistance...
  40. ncbi request reprint The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas
    Teri T B Ngo
    Surgical and Molecular Neuro oncology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Natl Cancer Inst 99:639-52. 2007
    ....
  41. ncbi request reprint The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy
    Matthew D Hall
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Annu Rev Pharmacol Toxicol 48:495-535. 2008
    ..This review suggests a model that helps reconcile the disparate literature by describing multiple pathways for Pt-containing drugs into and out of the cell...
  42. doi request reprint Hydroxypropyl-β-cyclodextrin copolymers and their nanoparticles as doxorubicin delivery system
    Tiewei Wang
    Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chienese Academy of Sciences, Beijing 100190, China
    J Pharm Sci 100:1067-79. 2011
    ..The DOX-loaded copolymer NPs showed comparable anticancer efficacy with the free drug...
  43. doi request reprint Nanoscale drug delivery platforms overcome platinum-based resistance in cancer cells due to abnormal membrane protein trafficking
    Xue Xue
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, People s Republic of China
    ACS Nano 7:10452-64. 2013
    ..This review will focus on the known mechanism of membrane trafficking in cisplatin-resistant cells and the development and employment of nDDPs to improve cell uptake of cisplatin. ..
  44. doi request reprint Gold nanoparticles: emerging paradigm for targeted drug delivery system
    Anil Kumar
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, no 11, First North Road, Zhongguancun, Beijing 100190, China
    Biotechnol Adv 31:593-606. 2013
    ..Hence, this review will shed light on the research, opportunities and challenges for engineering nanomaterials with cancer biology and medicine to develop effective TDDS for treatment of cancer. ..
  45. pmc Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology
    Xue Xue
    National Center for Nanoscience and Technology of China, Beijing 100190, People s Republic of China
    Chin J Cancer 31:100-9. 2012
    ..In this review, we discuss the mechanisms of drug efflux-mediated resistance and the application of multiple nanoparticle-based platforms to overcome chemoresistance and improve therapeutic outcome...
  46. doi request reprint Gold nanoparticles with asymmetric polymerase chain reaction for colorimetric detection of DNA sequence
    Hua Deng
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    Anal Chem 84:1253-8. 2012
    ..Linear amplification minimizes the potential risk of PCR product cross-contamination. The efficiency to detect Bacillus anthracis in clinical samples clearly indicates the practical applicability of this approach...
  47. doi request reprint CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells
    Juan Liu
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyijie, Zhongguancun, Beijing 100190, China
    Chem Commun (Camb) 48:4869-71. 2012
    ..The liposomes were able to release the drug at pH 5.0 by the production of CO(2) gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin...
  48. doi request reprint Salt-responsive self-assembly of luminescent hydrogel with intrinsic gelation-enhanced emission
    Chunqiu Zhang
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No 11 Beiyitiao, Zhongguancun, Beijing 100190, China
    ACS Appl Mater Interfaces 6:757-62. 2014
    ..Grating AIE molecules to stimuli-responsive peptides is a promising approach for the development of self-revealing soft materials for biological applications. ..
  49. pmc AIDS treatment with novel anti-HIV compounds improved by nanotechnology
    Xiaowei Ma
    Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, People s Republic of China
    AAPS J 12:272-8. 2010
    ....
  50. doi request reprint Theranostic nanoparticles engineered for clinic and pharmaceutics
    Xiaowei Ma
    Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, China
    Acc Chem Res 44:1114-22. 2011
    ..In this Account, we describe the development of theranostic nanomaterials with low toxicity and illustrate their potential use as novel nanomedicines in translational research...
  51. ncbi request reprint Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes
    Kevin G Chen
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Pigment Cell Res 18:102-12. 2005
    ..Our findings indicate that expression of ABCB 5alpha/beta might possibly provide two novel molecular markers for differential diagnosis of melanomas and constitute potential molecular targets for therapy of melanomas...
  52. doi request reprint Inhibitory effects of trolox-encapsulated chitosan nanoparticles on tert-butylhydroperoxide induced RAW264.7 apoptosis
    Lu Han
    State Key Lab for Structural Chemistry of Unstable and Stable Species, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China
    Biomaterials 33:8517-28. 2012
    ....
  53. doi request reprint High throughput detection of human neutrophil peptides from serum, saliva, and tear by anthrax lethal factor-modified nanoparticles
    Yuanyuan Zhao
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing 100190, China
    ACS Appl Mater Interfaces 5:8267-72. 2013
    ..We conjugated ALF to the surface of magnetic nanoparticles (MNP) to magnetically isolate the HNPs, and used Zn2+ to control the capture and release HNPs...
  54. pmc Covalent modification of stathmin by CCNU determined by FTMS analysis of modified proteins and tryptic peptides
    Wells W Wu
    Proteomics Core Facility, National Heart, Lung, and Blood Institute, NIH, Building 10, Room 8C103C, 10 Center Drive, Bethesda, MD 20892 1597, USA
    Biochem Biophys Res Commun 367:7-13. 2008
    ..7Da) modification of stathmin. With this combined approach, we determined the stoichiometry as well as sites of CCNU incorporation into the protein, demonstrating differential reactivity of several lysyl residues to CCNU alkylation...
  55. ncbi request reprint Impacts of nanoparticles on cardiovascular diseases: modulating metabolism and function of endothelial cells
    Jie Meng
    Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
    Curr Drug Metab 13:1123-9. 2012
    ....
  56. pmc Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells
    Huan Meng
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences CAS, Beijing 100049, China
    Nanomedicine 8:136-46. 2012
    ..Based on these data, we conclude that f-NPs have antimetastasis effects and speculate that utilization of f-NPs may provide a new strategy for the treatment of tumor metastasis...
  57. doi request reprint Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging
    Cuiji Sun
    CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
    J Am Chem Soc 133:8617-24. 2011
    ..Such agents are ideal for targeted in vitro and in vivo imaging. These results thus open new opportunities for biomolecule-guided nanostructure assembly with great potential for biomedical applications...
  58. doi request reprint Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy
    Xiao Dong Zhang
    Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China
    Adv Healthc Mater 3:133-41. 2014
    ..After the treatment, the small-sized GSH-Au25 NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au25 NCs in the body. ..
  59. pmc Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells
    Xing Jie Liang
    Surgical and Molecular Neuro oncology Unit, National Institute of Neurological Disorders, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
    Cancer Res 68:5267-72. 2008
    ....