Research Topics
| Xing Jie LiangSummaryCountry: China Publications
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Detail Information
Publications
Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysisJie Meng
Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, 100190, China
Nanoscale 3:4713-9. 2011..Their possible anti-tumor mechanisms were also discussed. The present study may provide new insight into the mechanism of action of these nanoparticles...
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolismXing Jie Liang
Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Mol Cancer Res 6:1499-506. 2008..Our findings therefore suggest that reduced glucose use and altered mitochondrial metabolism mediated by SIRT1 is one of several alterations that contribute to cellular resistance to cisplatin...- Circumventing tumor resistance to chemotherapy by nanotechnologyXing Jie Liang
Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, China
Methods Mol Biol 596:467-88. 2010..Nanotechnology may help to solve the problems associated with traditional chemotherapy and multidrug resistance... - Biopharmaceutics and therapeutic potential of engineered nanomaterialsXing Jie Liang
Laboratory of Nanobiomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanosciences and Technology of China, Beijing 100190, P R China
Curr Drug Metab 9:697-709. 2008..This paper illustrates the potential of nanomedicine by discussing biopharmaceutics of fullerene derivatives and their suitability for diagnostic and therapeutic purposes. Future direction is discussed as well... - Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosisXing Jie Liang
Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
Proc Natl Acad Sci U S A 107:7449-54. 2010..The technology can be extended to other challenges related to multidrug resistance often found in cancer treatments... 
Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivoJinfeng Xing
Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China
Mini Rev Med Chem 10:126-37. 2010..This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA) in vivo...- Ternary complexes of amphiphilic polycaprolactone-graft-poly (N,N-dimethylaminoethyl methacrylate), DNA and polyglutamic acid-graft-poly(ethylene glycol) for gene deliveryShutao Guo
Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
Biomaterials 32:4283-92. 2011.... - Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavengerJun Jie Yin
Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, 11, First North Rd, Zhongguancun, Beijing, People s Republic of China, 100190
Mol Pharmacol 74:1132-40. 2008.... - P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potentialClaudina Alemán
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4254, USA
Cancer Res 63:3084-91. 2003..The changes in these parameters observed in drug-selected cells must reflect other host adaptations to drug selection... - Multicellular tumor spheroids as an in vivo-like tumor model for three-dimensional imaging of chemotherapeutic and nano material cellular penetrationHui Li Ma
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, China
Mol Imaging 11:487-98. 2012..The development of this image-based, reproducible, and quantifiable in vitro HeLa spheroid screening tool will greatly aid future exploration of chemotherapeutics and nanoparticle delivery into solid tumors... - Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyteShutao Guo
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
ACS Nano 4:5505-11. 2010..These results demonstrate the feasibility of using charge-reversal functional gold nanoparticles as a means of improving the nucleic acid delivery efficiency... - Superior penetration and retention behavior of 50 nm gold nanoparticles in tumorsShuaidong Huo
School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin, China
Cancer Res 73:319-30. 2013..Taken together, our findings define an optimal smaller size for nanoparticles that maximizes their effective accumulation in tumor tissue... - Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell linesXing Jie Liang
Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Cancer Chemother Pharmacol 62:977-84. 2008.... - Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatmentAnil Kumar
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, PR China
Biomaterials 33:1180-9. 2012..These results have implications to design and functionalize different molecules onto AuNPs surfaces to make hybrid model system for selective target binding as well as therapeutic effects for cancer treatment... - Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivoKeyang Huang
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, no 11, First North Road, Zhongguancun, Beijing, China 100190
ACS Nano 6:4483-93. 2012..This work gives important insights into the design and functionalization of nanoparticles to achieve high levels of accumulation in tumors... - Construction of paclitaxel-loaded poly (2-hydroxyethyl methacrylate)-g-poly (lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activityXiaowei Ma
Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, People s Republic of China
Int J Nanomedicine 7:1313-28. 2012.... - Enhanced siRNA delivery and silencing gold-chitosan nanosystem with surface charge-reversal polymer assembly and good biocompatibilityLu Han
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, People s Republic of China
ACS Nano 6:7340-51. 2012.... - Biomedical activities of endohedral metallofullerene optimized for nanopharmaceuticsJie Meng
Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, China
J Nanosci Nanotechnol 10:8610-6. 2010..The review critically analyzed the relevant data instead of fact-listing, and explained the potential for developing Gd@C82(OH)22 into a diagnostic or therapeutic agent... - The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureasTeri T B Ngo
Surgical and Molecular Neuro oncology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
J Natl Cancer Inst 99:639-52. 2007.... - The role of cellular accumulation in determining sensitivity to platinum-based chemotherapyMatthew D Hall
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
Annu Rev Pharmacol Toxicol 48:495-535. 2008..This review suggests a model that helps reconcile the disparate literature by describing multiple pathways for Pt-containing drugs into and out of the cell... - Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunctionXue Xue
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, PR China
Mol Pharm 9:634-44. 2012..Therefore, mitochondria targeting compounds would be more vulnerable and selective to overcome cisplatin resistance due to the unique metabolic properties of CP-r cancer cells... - Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathwayKangning Yang
Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, no 11, First North Road, Zhongguancun, Beijing, 100190, China
Nanoscale 5:1205-12. 2013..Moreover, the in vivo results of the ovariectomized rats further indicated that [Gd@C(82)(OH)(22)](n) nanoparticles effectively improved bone density and prevented osteoporosis... - Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairmentXiaowei Ma
Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, China
ACS Nano 5:8629-39. 2011..This work is significant to nanoparticle research because it illustrates how nanoparticles can potentially interrupt the autophagic pathway and has important implications for biomedical applications of nanoparticles... - Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroidsShubin Jin
Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, China
Nanoscale 5:143-6. 2013..The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit... - Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrierShutao Guo
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Biomaterials 32:879-89. 2011..These results indicate that PECD NPs have a great potential to be used as efficient polymeric carriers for gene transfection... - Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancyHui Yang
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Sci Rep 2:847. 2012..No signs of toxicity were observed. Fetal exposure to nanoparticles in murine pregnancy is, therefore, influenced by both stage of embryonic/placental maturation and nanoparticle surface composition... - Hydroxypropyl-β-cyclodextrin copolymers and their nanoparticles as doxorubicin delivery systemTiewei Wang
Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chienese Academy of Sciences, Beijing 100190, China
J Pharm Sci 100:1067-79. 2011..The DOX-loaded copolymer NPs showed comparable anticancer efficacy with the free drug... - Overcoming drug efflux-based multidrug resistance in cancer with nanotechnologyXue Xue
National Center for Nanoscience and Technology of China, Beijing 100190, People s Republic of China
Chin J Cancer 31:100-9. 2012..In this review, we discuss the mechanisms of drug efflux-mediated resistance and the application of multiple nanoparticle-based platforms to overcome chemoresistance and improve therapeutic outcome... - Gold nanoparticles with asymmetric polymerase chain reaction for colorimetric detection of DNA sequenceHua Deng
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
Anal Chem 84:1253-8. 2012..Linear amplification minimizes the potential risk of PCR product cross-contamination. The efficiency to detect Bacillus anthracis in clinical samples clearly indicates the practical applicability of this approach... - CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cellsJuan Liu
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyijie, Zhongguancun, Beijing 100190, China
Chem Commun (Camb) 48:4869-71. 2012..The liposomes were able to release the drug at pH 5.0 by the production of CO(2) gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin... - Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistanceXing-Jie Liang
Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda 20892-4256, Maryland, USA
Anticancer Res 25:4113-22. 2005..We conclude that K+ and H+ homeostasis are not critical factors in cisplatin resistance since they affect cisplatin resistance differently in KB and BEL-7404 cells... - Long genomic DNA amplicons adsorption onto unmodified gold nanoparticles for colorimetric detection of Bacillus anthracisHua Deng
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyijie, Zhongguancun, Beijing 100190, China
Chem Commun (Camb) 49:51-3. 2013..More importantly, the DNA-Au interaction can be utilized for colorimetric detection of a specific nucleic acid sequence in clinical samples... - AIDS treatment with novel anti-HIV compounds improved by nanotechnologyXiaowei Ma
Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, Beijing, People s Republic of China
AAPS J 12:272-8. 2010.... - Single-walled carbon nanotubes alter cytochrome c electron transfer and modulate mitochondrial functionXiaowei Ma
Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, China
ACS Nano 6:10486-96. 2012..This work is significant to SWCNTs research because it provides a novel understanding of SWCNTs' disruption of mitochondria function and has important implications for biomedical applications of SWCNTs... - Theranostic nanoparticles engineered for clinic and pharmaceuticsXiaowei Ma
Laboratory of Nanomedicine and Nanosafety, Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology, China
Acc Chem Res 44:1114-22. 2011..In this Account, we describe the development of theranostic nanomaterials with low toxicity and illustrate their potential use as novel nanomedicines in translational research... - Covalent modification of stathmin by CCNU determined by FTMS analysis of modified proteins and tryptic peptidesWells W Wu
Proteomics Core Facility, National Heart, Lung, and Blood Institute, NIH, Building 10, Room 8C103C, 10 Center Drive, Bethesda, MD 20892 1597, USA
Biochem Biophys Res Commun 367:7-13. 2008..7Da) modification of stathmin. With this combined approach, we determined the stoichiometry as well as sites of CCNU incorporation into the protein, demonstrating differential reactivity of several lysyl residues to CCNU alkylation... - Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytesKevin G Chen
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Pigment Cell Res 18:102-12. 2005..Our findings indicate that expression of ABCB 5alpha/beta might possibly provide two novel molecular markers for differential diagnosis of melanomas and constitute potential molecular targets for therapy of melanomas... - Down-regulation and altered localization of gamma-catenin in cisplatin-resistant adenocarcinoma cellsXing-Jie Liang
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 1A09, Bethesda, MD 20892-4254, USA
Mol Pharmacol 65:1217-24. 2004.... - Inhibitory effects of trolox-encapsulated chitosan nanoparticles on tert-butylhydroperoxide induced RAW264.7 apoptosisLu Han
State Key Lab for Structural Chemistry of Unstable and Stable Species, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China
Biomaterials 33:8517-28. 2012.... - Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cellsHuan Meng
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences CAS, Beijing 100049, China
Nanomedicine 8:136-46. 2012.... - Codominance of cisplatin resistance in somatic cell hybridsYu-Lan Mary Ying
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4254, USA
J Cell Physiol 196:63-9. 2003..These dominance data suggest that it might be possible to identify one or more genes responsible for cisplatin resistance by gene transfer from a resistant cell line to a sensitive cell line... - Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell linesDing-Wu Shen
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 1A09, Bethesda, MD 20892-4254, USA
Mol Pharmacol 66:789-93. 2004.... - Impacts of nanoparticles on cardiovascular diseases: modulating metabolism and function of endothelial cellsJie Meng
Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China
Curr Drug Metab 13:1123-9. 2012.... - Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cellsXing Jie Liang
Surgical and Molecular Neuro oncology Unit, National Institute of Neurological Disorders, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
Cancer Res 68:5267-72. 2008.... - Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imagingCuiji Sun
CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
J Am Chem Soc 133:8617-24. 2011..Such agents are ideal for targeted in vitro and in vivo imaging. These results thus open new opportunities for biomolecule-guided nanostructure assembly with great potential for biomedical applications... - Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell linesXing-Jie Liang
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4254, USA
Cancer Res 63:5909-16. 2003..The reduced accumulation of cytotoxic compounds in the KB-CP cells is presumed to result from the failure of carrier proteins and/or transporters to localize to the plasma membrane... - Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinumXing-Jie Liang
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-4256, USA
J Cell Physiol 202:635-41. 2005.... - Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistanceDing-Wu Shen
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 2108, Bethesda, MD 20892-4254, USA
Mol Pharmacol 69:1383-8. 2006..The finding that a ribosomal protein gene, RPL36, contributes to CP-r should stimulate study of the role of ribosomal proteins in multifactorial mechanisms of cisplatin resistance... - Endocytic recycling compartments altered in cisplatin-resistant cancer cellsXing-Jie Liang
Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 66:2346-53. 2006.... - Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cellsXing-Jie Liang
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 1A-09, 37 Convent Drive, Bethesda, MD 20892-4254, USA
Exp Cell Res 293:283-91. 2004.... - A pleiotropic defect reducing drug accumulation in cisplatin-resistant cellsXing-Jie Liang
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD 20892-4254, USA
J Inorg Biochem 98:1599-606. 2004..Multiple mechanisms in CP-r cells keep cytotoxic platinum compounds out of cells through defective expression of cell surface proteins such as transporters and carriers, and decreased expression of proteins involved in endocytosis...