Wei Li

Summary

Country: China

Publications

  1. ncbi Antitumor properties of taxol in combination with cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian tumor growth in vivo
    Wei Li
    Department of Gynecology, Nanjing Medical University of Hangzhou Hospital, Hangzhou, Zhejiang, China
    Oncol Res 20:49-59. 2012
  2. doi Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo
    Wei Li
    Department of Gynecology and Obstetrics, Nanjing Medical University of Hangzhou Hospital, Hangzhou 310006, PR China
    Med Oncol 25:172-7. 2008
  3. doi Effects of a selective cyclooxygenase-1 inhibitor in SKOV-3 ovarian carcinoma xenograft-bearing mice
    Wei Li
    Department of Gynecology and Obstetrics, Nanjing Medical University of Hangzhou Hospital, Hangzhou, China
    Med Oncol 27:98-104. 2010
  4. doi Effects of a cyclooxygenase-1-selective inhibitor in a mouse model of ovarian cancer, administered alone or in combination with ibuprofen, a nonselective cyclooxygenase inhibitor
    Wei Li
    Department of Gynecology and Obstetrics, Nanjing Medical University of Hangzhou Hospital, 310006, Hangzhou, China
    Med Oncol 26:170-7. 2009
  5. doi VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway
    Wei Li
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China
    Mol Biol Rep 39:8687-94. 2012
  6. doi Impaired nuclear translocation of glucocorticoid receptors: novel findings from psoriatic epidermal keratinocytes
    Xiao Yong Man
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China
    Cell Mol Life Sci 70:2205-20. 2013
  7. doi Regulation of Involucrin in Psoriatic Epidermal Keratinocytes: The Roles of ERK1/2 and GSK-3β
    Jia Qi Chen
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China
    Cell Biochem Biophys 66:523-8. 2013
  8. pmc Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo
    Wei Li
    Department of Gynecology, Nanjing Medical University of Hangzhou Hospital, 261 Huansha Road, Hangzhou, Zhejiang 310006, China E Mails J W H R J X L X J Z M L L L Y Z
    Int J Mol Sci 12:668-81. 2011
  9. ncbi [Association of interferon-γ gene polymorphism and risk of cervical HPV infection]
    Ning Wang
    Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110004, China
    Zhonghua Fu Chan Ke Za Zhi 47:738-41. 2012
  10. doi Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation
    Wei Li
    Department of Gynecology, Shengjing Hospital, China Medical University, Shenyang, China
    Cancer Invest 29:339-46. 2011

Collaborators

Detail Information

Publications84

  1. ncbi Antitumor properties of taxol in combination with cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian tumor growth in vivo
    Wei Li
    Department of Gynecology, Nanjing Medical University of Hangzhou Hospital, Hangzhou, Zhejiang, China
    Oncol Res 20:49-59. 2012
    ....
  2. doi Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo
    Wei Li
    Department of Gynecology and Obstetrics, Nanjing Medical University of Hangzhou Hospital, Hangzhou 310006, PR China
    Med Oncol 25:172-7. 2008
    ..These findings may implicate COX-1 as a suitable target for the treatment of ovarian cancer...
  3. doi Effects of a selective cyclooxygenase-1 inhibitor in SKOV-3 ovarian carcinoma xenograft-bearing mice
    Wei Li
    Department of Gynecology and Obstetrics, Nanjing Medical University of Hangzhou Hospital, Hangzhou, China
    Med Oncol 27:98-104. 2010
    ..01). COX-1, not COX-2, protein levels are elevated in tumor tissues. These findings may implicate COX-1 as a suitable target for the treatment of ovarian cancer and that antiangiogenic therapy can be used to inhibit ovarian cancer growth...
  4. doi Effects of a cyclooxygenase-1-selective inhibitor in a mouse model of ovarian cancer, administered alone or in combination with ibuprofen, a nonselective cyclooxygenase inhibitor
    Wei Li
    Department of Gynecology and Obstetrics, Nanjing Medical University of Hangzhou Hospital, 310006, Hangzhou, China
    Med Oncol 26:170-7. 2009
    ..These studies demonstrate synergism between two COX inhibitors and that antiangiogenic therapy can be used to inhibit ovarian cancer growth...
  5. doi VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway
    Wei Li
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China
    Mol Biol Rep 39:8687-94. 2012
    ..Taken together, human ORS cells express functional VEGF receptor-2 and exogenous VEGF(165) upregulates expression of VEGFR-2 and stimulates proliferation of ORS cells via VEGFR-2 mediated ERK signaling pathway...
  6. doi Impaired nuclear translocation of glucocorticoid receptors: novel findings from psoriatic epidermal keratinocytes
    Xiao Yong Man
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China
    Cell Mol Life Sci 70:2205-20. 2013
    ..Therapeutic strategies designed to accumulate GR in the nucleus, such as IL-13, may be beneficial for the therapy of psoriasis...
  7. doi Regulation of Involucrin in Psoriatic Epidermal Keratinocytes: The Roles of ERK1/2 and GSK-3β
    Jia Qi Chen
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China
    Cell Biochem Biophys 66:523-8. 2013
    ..The ERK1/2 and GSK-3β signaling pathways may play positive roles in regulating epidermal differentiation as observed in psoriasis. ..
  8. pmc Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo
    Wei Li
    Department of Gynecology, Nanjing Medical University of Hangzhou Hospital, 261 Huansha Road, Hangzhou, Zhejiang 310006, China E Mails J W H R J X L X J Z M L L L Y Z
    Int J Mol Sci 12:668-81. 2011
    ..56%, 19.07%, all P < 0.05). These studies indicate that synergism between two COX inhibitors and inhibitor combination treatment has particular potential for chemoprevention of ovarian cancer growth...
  9. ncbi [Association of interferon-γ gene polymorphism and risk of cervical HPV infection]
    Ning Wang
    Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110004, China
    Zhonghua Fu Chan Ke Za Zhi 47:738-41. 2012
    ..To investigate the association of interferon (IFN) γ gene polymorphisms and risk and prognosis of HPV cervical infection...
  10. doi Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation
    Wei Li
    Department of Gynecology, Shengjing Hospital, China Medical University, Shenyang, China
    Cancer Invest 29:339-46. 2011
    ..Furthermore, NNC 55-0396 slowed ovarian cancer formation in nude mice. Therefore the function of T-type Ca(2+) channels is important for the proliferation of human ovarian cancer cells...
  11. ncbi Gastrointestinal stromal tumor with synchronous isolated parenchymal splenic metastasis of ovarian cancer
    Wei Li
    Department of Gynecology, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, China
    Chin Med J (Engl) 124:4372-5. 2011
    ..The coexistence of GIST with other malignancies constitutes an intriguing oncologic model. Surgeons are advised to be alert against possible primary GIST accompanying other neoplasms...
  12. doi VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK
    Wei Li
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, PR China
    Exp Cell Res 318:1633-40. 2012
    ..Taken together, VEGFR-2 is expressed on primary human hair follicle DP cells and VEGF induces proliferation of DP cells through VEGFR-2/ERK pathway, but not p38, JNK or AKT signaling...
  13. doi AD-1, a novel ginsenoside derivative, shows anti-lung cancer activity via activation of p38 MAPK pathway and generation of reactive oxygen species
    Lin Hui Zhang
    Medical College of Zhejiang University, Hangzhou, China
    Biochim Biophys Acta 1830:4148-59. 2013
    ..Ginseng is a traditional Chinese herb that has been used for thousands of years. In the present study, effects and mechanisms of AD-1 were evaluated for its development as a novel anti-lung cancer drug...
  14. doi Procyanidins produce significant attenuation of doxorubicin-induced cardiotoxicity via suppression of oxidative stress
    Wei Li
    Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Zhejiang, China
    Basic Clin Pharmacol Toxicol 104:192-7. 2009
    ..All the above lines of evidence suggest that procyanidins protect cardiomyocytes from doxorubicin-induced cardiotoxicity via suppression of oxidative stress...
  15. pmc Cyclin d1 expression and the inhibitory effect of celecoxib on ovarian tumor growth in vivo
    Wei Li
    Department of Gynecology, Nanjing Medical University of Hangzhou Hospital, 261 Huansha Road, Hangzhou, Zhejiang, 310006, China E Mails H R J X L X J W J Z M L L L Y Z
    Int J Mol Sci 11:3999-4013. 2010
    ..Our results suggest that the antitumor efficacy of Celecoxib against ovarian cancer in mice may in part be mediated through suppression of cyclin D1, which may contribute to its ability to suppress proliferation...
  16. pmc TNF-alpha rs1800629 polymorphism is not associated with HPV infection or cervical cancer in the Chinese population
    Ning Wang
    Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, China
    PLoS ONE 7:e45246. 2012
    ..The aim of this study was to investigate the relationship between the TNF-alpha rs1800629 polymorphism and risk of HPV infection or cervical cancer...
  17. ncbi Expression of cyclooxygenase-2 and inducible nitric oxide synthase correlates with tumor angiogenesis in endometrial carcinoma
    Wei Li
    Department of Gynecology and Obstetrics, First People s Hospital Hangzhou, Hangzhou Zhejiang 310006, PR China
    Med Oncol 22:63-70. 2005
    ....
  18. doi DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells
    Chun Feng Meng
    Department of Gynecology, First Affiliated Hospital, China Medical University, Shenyang, PR China
    Mol Med Rep 4:1273-8. 2011
    ..DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes...
  19. ncbi Prognostic factors in adult granulosa cell tumor of the ovary
    Wei Li
    Department of Gynecology, Shengjing Hospital, China Medical University, Shenyang, China
    Saudi Med J 30:247-52. 2009
    ..To determine the clinicopathologic prognostic factors in adult granulosa cell tumors (GCTs) of the ovary...
  20. ncbi Changes of expressions of VEGF, bFGF, and angiogenesis, and effect of benazepril, bFGF on angiogenesis in acute myocardial infarction model of the rabbits
    Dan Yang Li
    Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China
    Biomed Environ Sci 17:442-51. 2004
    ....
  21. pmc Effects of cyclooxygenase inhibitors in combination with taxol on expression of cyclin d1 and ki-67 in a xenograft model of ovarian carcinoma
    Wei Li
    Department of Gynecology, Nanjing Medical University of Hangzhou Hospital, 261 Huansha Road, Hangzhou 310006, Zhejiang, China E Mails J H C J Z Y X T L W
    Int J Mol Sci 13:9741-53. 2012
    ..The three-drug combination showing a better decreasing tendency in growth-inhibitory effect during the experiment may have been caused by suppressing cyclin D1 expression...
  22. ncbi Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells
    Leina Ma
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
    Cancer Biol Ther 9:554-61. 2010
    ..In this study, we presented a novel strategy for cancer therapy based on gene transfer of miR-122 by adenoviral vector...
  23. doi Regulation of adhesion by vascular endothelial growth factor in HaCaT cells
    Chunming Li
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, China
    Mol Cell Biochem 346:173-8. 2011
    ..These changes of cell adhesion induced by VEGF were blocked by ERK and VEGFR-2 inhibitor. Our findings suggest that VEGF may modulate cell adhesion of HaCaT cells partly through activation of VEGFR-2/ERK1/2 signaling pathways...
  24. ncbi Rapamycin together with herceptin significantly increased anti-tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells
    Lu Hai Wang
    Department of Microbiology, Mount Sinai School of Medicine, New York 10029, NY, USA
    Int J Cancer 121:157-64. 2007
    ..Our results suggest that rapamycin together with herceptin has an enhanced anti-cancer effect and could be developed as an improved therapeutic regimen for breast cancer...
  25. ncbi Optimization of b value in diffusion-weighted MRI for the differential diagnosis of benign and malignant vertebral fractures
    Guangyu Tang
    Department of Radiology, Affiliated Tenth People s Hospital of Tongji University, Shanghai 200072, China
    Skeletal Radiol 36:1035-41. 2007
    ..The objective was to explore the optimal b value in diffusion-weighted imaging (DWI) of MRI for differential diagnosis of benign and malignant vertebral fractures...
  26. ncbi [cDNA microarray-based screening of differentially expressed genes in macrophages in the spleen of patients with portal hypertension and hypersplenism]
    Feng Yan
    Postdoctoral Station, Zhongshan Hospital Affiliated to Shantou University, Shantou 361004, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1548-51. 2006
    ..To identify the differentially expressed genes associated with hypersplenism in patients with portal hypertension...
  27. ncbi Magnetic resonance imaging of the pancreas at 3.0 tesla: qualitative and quantitative comparison with 1.5 tesla
    Robert R Edelman
    Department of Radiology, Evanston, Northwestern Healthcare, Evanston, Illinois 60201, USA
    Invest Radiol 41:175-80. 2006
    ..We sought to perform a preliminary comparison of signal-to-noise ratio (SNR) and image quality for magnetic resonance imaging (MRI) of the pancreas at 1.5 and 3 T...
  28. ncbi A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    Qianben Wang
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 27:380-92. 2007
    ..These collaborating factors, together with AR, form a regulatory hierarchy that governs androgen-dependent gene expression and prostate cancer growth and offer potential new opportunities for therapeutic intervention...
  29. ncbi Microarray blob-defect removal improves array analysis
    Jun S Song
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA, USA
    Bioinformatics 23:966-71. 2007
    ....
  30. ncbi Different mechanisms of lysophosphatidylcholine-induced Ca(2+) mobilization in N2a mouse and SH-SY5Y human neuroblastoma cells
    Xiao Hua Li
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Datunlu Road, Beijing 100101, PR China
    Neurosci Lett 424:22-6. 2007
    ..Moreover, the demyelination effect induced by LPC in mice may be a consequence of its detergent effect on membranes...
  31. ncbi Quiescent subpopulations of human CD34-positive hematopoietic stem cells are preferred targets for stable recombinant adeno-associated virus type 2 transduction
    Helicia Paz
    Division of Virology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
    Hum Gene Ther 18:614-26. 2007
    ..These results represent the first demonstration of rAAV-mediated gene transfer to primitive, quiescent human CD34(+)CD38(-) stem cells and reveal that nondividing CD34(+)CD38(-) HSCs are the optimal CD34(+) targets for rAAV transduction...
  32. pmc Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers
    Tricia L Humphreys
    Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Infect Immun 75:5686-97. 2007
    ..ducreyi. PP DC may promote a dysregulated T-cell response that contributes to phagocytic failure, while RR DC may promote a Th1 response that facilitates bacterial clearance...
  33. ncbi Pregnane glycosides from Cynanchum atratum
    Hong Bai
    Faculty of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    Steroids 73:96-103. 2008
    ..Their structures were determined on the basis of spectroscopic analysis and chemical evidence...
  34. ncbi Latent membrane protein 1 encoded by Epstein-Barr virus induces telomerase activity via p16INK4A/Rb/E2F1 and JNK signaling pathways
    Lin Ding
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Med Virol 79:1153-63. 2007
    ..The present study provides new perspectives on carcinogenesis of nasopharyngeal carcinoma that may be exploited for novel therapeutic strategies...
  35. ncbi Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway
    Mao Ye
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China
    Cancer Lett 258:199-207. 2007
    ..These results are significant in that they provide a mechanistic framework for further exploring the use of grifolin as a novel antitumor agent...
  36. doi Griseusin D, a new pyranonaphthoquinone derivative from a alkaphilic Nocardiopsis sp
    Yi Qing Li
    Laboratory for Conservation and Utilization of Bio Resources, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan, China
    J Antibiot (Tokyo) 60:757-61. 2007
    ..23 and 19.6 microg/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 microg/ml...
  37. ncbi [EB virus encoded latent membrane protein 1 mediated expression of transcription factor Ets-1 in nasopharyngeal carcinoma cells]
    Liang Zeng
    Department of Pathology, Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China
    Zhonghua Zhong Liu Za Zhi 26:454-7. 2004
    ..To elucidate the expression of tanscription factor Ets-1 mediated by EB virus encoded latent membrane protein 1 (LMP1) in nasopharyngeal carcinoma (NPC) cells...
  38. doi Cell competition and its possible relation to cancer
    Nicholas E Baker
    Department of Molecular Genetics, Albet Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 68:5505-7. 2008
    ..Here, we discuss the possible relevance of cell competition to cancer...
  39. pmc Suppression of activation and induction of apoptosis in RAW264.7 cells by amniotic membrane extract
    Hua He
    TissueTech, Inc and the Ocular Surface Center, Miami, Florida 33173, USA
    Invest Ophthalmol Vis Sci 49:4468-75. 2008
    ..Experimentally, the authors and others have reported that AM facilitates macrophage apoptosis. However, it remains unclear whether such anti-inflammatory activity is retained in AM extract (AME)...
  40. doi Effects of antisense RNA targeting of ODC and AdoMetDC on the synthesis of polyamine synthesis and cell growth in prostate cancer cells using a prostatic androgen-dependent promoter in adenovirus
    Wei Li
    Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong, China
    Prostate 68:1354-61. 2008
    ..We also examined the potential of this construct for prostate cancer therapy...
  41. pmc Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma
    Jianjun Chen
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Bioorg Med Chem Lett 18:3183-7. 2008
    ..These structure-activity studies indicated that the thiazolidine ring is very critical for the activity for these series of compounds...
  42. pmc Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection
    Wei Li
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People s Republic of China
    PLoS ONE 3:e1985. 2008
    ..Interleukin (IL)-32 is a recently described pro-inflammatory cytokine that has been reported to be induced by bacteria treatment in culture cells. Little is known about IL-32 production by exogenous pathogens infection in human individuals...
  43. doi Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation
    Qiong Xie
    Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai, P R China
    J Med Chem 51:2027-36. 2008
    ..6 and 5.8 microM, similar to that of propidium (IC 50 = 12.8 microM), which suggests promising disease-modifying agents for the treatment of AD patients...
  44. doi Profiling motility signal-specific genes in primary human keratinocytes
    Chieh Fang Cheng
    Department of Dermatology and the USC Norris Cancer Center, The University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    J Invest Dermatol 128:1981-90. 2008
    ..Three genes, all encoding secreted molecules, were investigated in HK migration. These cell motility-specific gene profiles may prove useful to skin wound healing...
  45. ncbi Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells
    Mun Ock Kim
    Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609 735, Republic of Korea
    Cancer Lett 261:98-107. 2008
    ..We conclude that PD has direct cytotoxic effect on human leukemia cells and suppresses telomerase activity through transcriptional and posttranslational suppression of hTERT...
  46. ncbi Synthesis and antiproliferative activity of thiazolidine analogs for melanoma
    Wei Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Bioorg Med Chem Lett 17:4113-7. 2007
    ....
  47. ncbi Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity
    Wei Li
    Department of Biochemistry, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Glycobiology 17:655-62. 2007
    ..Thus, the structure of N-glycans of ACIII regulates its enzymatic activity and downstream signaling...
  48. ncbi Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
    Jason S Carroll
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell 122:33-43. 2005
    ..Furthermore, knockdown of FoxA1 expression blocks the association of ER with chromatin and estrogen-induced gene expression demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells...
  49. ncbi Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro
    Mao Ye
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China
    FEBS Lett 579:3437-43. 2005
    ....
  50. pmc An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe
    Ru Qiang Liang
    Key Laboratory of Proteomics 320 Yue Yang Road, Shanghai 200031, China
    Nucleic Acids Res 33:e17. 2005
    ..To avoid using high-cost detection equipment, colorimetric detection, a method based on nanogold probe coupled with silver enhancement, was also successfully introduced into miRNA profiling microarray detection...
  51. pmc Soluble lumican glycoprotein purified from human amniotic membrane promotes corneal epithelial wound healing
    Lung Kun Yeh
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 46:479-86. 2005
    ..To purify and characterize the glycoprotein lumican, isolated from human amniotic membrane (AM), and to examine its efficacy in treating corneal epithelium debridement...
  52. ncbi Rosuvastatin attenuates monocyte-endothelial cell interactions and vascular free radical production in hypercholesterolemic mice
    Wei Li
    Division of Cardiovascular Medicine, Stanford University School of Medicine, CA 94305 5246, USA
    J Pharmacol Exp Ther 313:557-62. 2005
    ..Thus, treatment with rosuvastatin has acute anti-inflammatory actions that likely participate in its beneficial actions during atherogenesis...
  53. ncbi Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis
    Wei Li
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1030:427-33. 2004
    ..The increased macrophage apoptosis and nuclear and matrix degradation by lysosomal enzymes in atheroma may play important roles in plaque development and rupture...
  54. pmc Detection of gyrA and parC mutations associated with ciprofloxacin resistance in Neisseria gonorrhoeae by use of oligonucleotide biochip technology
    Wenming Zhou
    Institute of Dermatology, Anhui Medical University, Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, People s Republic of China
    J Clin Microbiol 42:5819-24. 2004
    ..In conclusion, the oligonucleotide biochip technology has potential utility for the rapid and reliable identification of point mutations in the drug resistance genes of N. gonorrhoeae...
  55. ncbi Matrix metalloproteinase-26 is associated with estrogen-dependent malignancies and targets alpha1-antitrypsin serpin
    Wei Li
    Cell Adhesion and Extracellular Matrix Biology Program, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 64:8657-65. 2004
    ..In summary, we hypothesize that MMP-26, by cleaving and inactivating the AAT serpin, operates as a unique functional link that regulates a coordinated interplay between Ser and metalloproteinases in estrogen-dependent neoplasms...
  56. ncbi Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation
    Wei Li
    Department of Hematology and Oncology, First University Hospital, PR China
    Exp Hematol 32:1088-96. 2004
    ..The aim of this study was to investigate the stimulating effect of low-dose radiation (LDR) on bone marrow hematopoietic progenitor cell (HPC) proliferation and peripheral blood mobilization...
  57. ncbi Effect of melatonin on the generation of nitric oxide in murine macrophages
    Shen Zhang
    Department of Laboratory Medicine, Huaihua Medical College, Huaihua 418000, PR China
    Eur J Pharmacol 501:25-30. 2004
    ..The results suggest that melatonin inhibits the expression of inducible nitric oxide synthase by modulating the nuclear factor kappaB pathway...
  58. ncbi Myocardial delayed enhancement imaging using inversion recovery single-shot steady-state free precession: initial experience
    Wei Li
    MRI Research, Department of Radiology, Evanston Hospital and Northwestern University Feinberg School of Medicine, 2650 Ridge Avenue, Evanston, IL 60201, USA
    J Magn Reson Imaging 20:327-30. 2004
    ....
  59. ncbi Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal
    Zhengquan Yu
    Divisions of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Brain Res 1016:163-9. 2004
    ..Perhaps secondary brain damage during a critical post injury period can be prevented by the use of drugs that temporarily raise lysosomal pH, inactivate intralysosomal 3-AP, or stabilize lysosomal membranes against oxidative stress...
  60. pmc Transcriptome analysis of the ArgR regulon in Pseudomonas aeruginosa
    Chung Dar Lu
    Department of Biology, Georgia State University, 24 Peachtree Center Ave, Atlanta, GA 30303, USA
    J Bacteriol 186:3855-61. 2004
    ..These results indicate that ArgR is important in control of arginine and glutamate metabolism and that arginine and ArgR may have a redundant effect in inducing the uptake systems of certain compounds...
  61. ncbi Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR
    Min Li
    Elkins Pancreas Center and Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Surg Res 119:130-7. 2004
    ..In the current study, we used a powerful real-time RT-PCR technique to examine the mRNA expression levels of all five SSTR subtypes in human pancreatic cancer...
  62. pmc CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection
    Shefal S Parikh
    Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Infect Immun 71:6582-90. 2003
    ..Our findings suggest that specific motility deficits in macrophages, dendritic cells, and neutrophils render CapG(-/-) mice more susceptible than CapG(+/+) mice to Listeria infection...
  63. ncbi Neural development of selective attention and response inhibition
    James R Booth
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
    Neuroimage 20:737-51. 2003
    ..The extensive developmental differences on the response inhibition task are consistent with the prolonged maturation of the fronto-striatal network...
  64. ncbi Band artifacts due to bulk motion
    Pippa Storey
    Department of Radiology, MRI Research, Evanston Hospital, vanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Magn Reson Med 48:1028-36. 2002
    ..The fact that the position of the bands changes with the phase-encoding direction suggests that they may be artifacts due to motion of the heart walls during the image acquisition period...
  65. pmc Intrastromal invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated by air exposure
    Tetsuya Kawakita
    TissueTech, Inc, Ocular Surface Center, 7000 SW 97 Ave, Suite 213, Miami, FL 33173, USA
    Am J Pathol 167:381-93. 2005
    ....
  66. ncbi Age-related changes of normal adult brain structure: analysed with diffusion tensor imaging
    Yun Ting Zhang
    Department of Radiology, General Hospital, Tianjin Medical University, Tianjin 300052, China
    Chin Med J (Engl) 118:1059-65. 2005
    ..The objective of this study was to quantify the anisotropy and average diffusion coefficient (DCavg) of the brain in normal adults to demonstrate the microstructure changes of brain with aging...
  67. ncbi [Gene expression profiling of diffuse-type gastric cancer by cDNA microarray]
    Xiao Qing Zhang
    Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Zhong Liu Za Zhi 28:116-9. 2006
    ..To identify cancer-related genes in diffuse-type gastric cancer and to explore its molecular mechanism by cDNA microarray analysis...
  68. ncbi Isolation and expression analysis of testicular type Sox9b in allotetraploid fish
    Jifang Liu
    Key Laboratory of Protein Chemistry and Fish Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, People s Republic of China
    Mar Biotechnol (NY) 9:329-34. 2007
    ..In addition, the diverse tissue-specific expression profiles of Sox9b provided significant molecular evidence for the lineage-specific subfunction partitioning of Sox9 genes...
  69. ncbi [Molecular mechanism of anti-apoptotic action of survivin in NCI-H446 lung cancer cells]
    Yu Qing Chen
    Department of Respiratory Medicine, Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
    Zhonghua Zhong Liu Za Zhi 28:413-7. 2006
    ..To investigate cell apoptosis induced by survivin ASODN and clarify the precise mechanism of anti-apoptotic action of survivin...
  70. ncbi Cytocidal effects of atheromatous plaque components: the death zone revisited
    Wei Li
    Division of Experimental Pathology, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    FASEB J 20:2281-90. 2006
    ..Here we have assessed the cytotoxic effects of nonfractionated gruel and insoluble (ceroid-like) material derived from advanced human atheroma...
  71. ncbi Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues
    Michael L Mohler
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Med Chem 49:5845-8. 2006
    ..Preliminary SAR of this activity was characterized by synthesis and testing of several THI and conformationally flexible variants...
  72. ncbi Selective induction of necrotic cell death in cancer cells by beta-lapachone through activation of DNA damage response pathway
    Xiangao Sun
    Department of Therapeutic Biology, ArQule Biomedical Institute, Norwood, Massachusetts 02062, USA
    Cell Cycle 5:2029-35. 2006
    ..Our data suggest that selective necrotic cell death can be induced through activation of DNA damage response pathways, supporting the idea of selective necrotic cell death as a therapeutic strategy to eliminate cancer cells...
  73. ncbi Molecular cloning and expression analysis of a hepcidin antimicrobial peptide gene from turbot (Scophthalmus maximus)
    Song Lin Chen
    Key Lab for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Nanjing Road 106, Qingdao 266071, China
    Fish Shellfish Immunol 22:172-81. 2007
    ..The hepcidin transcripts were detected in turbot embryonic cell line (TEC). Challenge of TEC cells with the pathogenic bacteria significantly elevated hepcidin mRNA levels...
  74. ncbi Rhodiolosides A-E, monoterpene glycosides from Rhodiola rosea
    Guizhi Ma
    College of Pharmacy, Xinjiang Medical University, 8 Xinyi Road, Urumki 830054, P R China
    Chem Pharm Bull (Tokyo) 54:1229-33. 2006
    ....
  75. ncbi Computational exploration of the activated pathways associated with DNA damage response in breast cancer
    Liting Wen
    Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA
    Proteins 65:103-10. 2006
    ..Our analysis revealed the potential cellular pathways that regulate the signaling events in breast cancer...
  76. pmc Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia
    Teresa Palomero
    Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
    Blood 108:986-92. 2006
    ..Our results indicate that TAL1 may act as a bifunctional transcriptional regulator (activator and repressor) at the top of a complex regulatory network that disrupts normal T-cell homeostasis and contributes to leukemogenesis...
  77. ncbi Identification of CD36 as a new surface marker of marginal zone B cells by transcriptomic analysis
    Ping Zhang
    State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, and Department of Dermatology, Xijng Hospital, Xi an 710032, China
    Mol Immunol 44:332-7. 2007
    ..These results revealed new phenotypic properties of MZ and FO B cells, and would facilitate further studies in the differentiation and functions of these mature B cells...
  78. ncbi [Differential gene expression profile of keloids: a study with cDNA microarray]
    Zhen Fu Hu
    Department of Emergency, Nanfang Hospital, Institute of Molecular Biology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:308-12. 2006
    ..To investigate the differentially expressed genes in keloids in comparison with normal skin using cDNA microarray...
  79. ncbi A normal mucin-binding lectin from the sponge Craniella australiensis
    Chuannan Xiong
    Dalian Institute of Chemical Physics, Chinese Academy of Science, Liaoning Dalian 116023, PR China
    Comp Biochem Physiol C Toxicol Pharmacol 143:9-16. 2006
    ..The lectin reaction is independent of the presence of divalent cations Ca2+ and Mg2+. The sequence of N-terminal residues of CAL was determined as TSSCQSIVVE. The lectin showed a potent mitogenic response towards BALB/c splenocytes...
  80. ncbi rmlB and rmlC genes are essential for growth of mycobacteria
    Wei Li
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116027, PR China
    Biochem Biophys Res Commun 342:170-8. 2006
    ..These results demonstrate that rmlB and rmlC genes are essential for mycobacterial growth, therefore, RmlB and RmlC are essential targets to develop new anti-tuberculosis drugs...
  81. ncbi Methods for the functional genomic analysis of ubiquitin ligases
    Wei Li
    Department of Cell and Molecular Biology, Genomics Institute, Novartis Research Foundation GNF, San Diego, CA 92121, USA
    Methods Enzymol 398:280-91. 2005
    ..This method could be adapted easily to identify E3s that function in other processes and signaling pathways...
  82. ncbi An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects a distinct T cell population
    Wei Li
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202
    Immunity 23:375-86. 2005
    ..Remarkably, the CD4 compartment in such mice is efficiently reconstituted with unique specificity, demonstrating a novel thymocyte-driven pathway of CD4 T cell selection...
  83. ncbi Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, USA
    Chem Biol 12:931-9. 2005
    ....
  84. ncbi New approach for enlargement of medical electronic endoscopic images
    Jianping Wang
    Tsinghua University, Department of Electronic Engineering, Beijing, China
    Appl Opt 41:2158-63. 2002
    ..Experimental results from enlarged endoscopic images are presented that demonstrate that the recursive minimum/maximum method for image enlargement can preserve the fine details with rich edge information and with better visualization...