- Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)Nan Li
Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Faculty of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, PR China
BMC Microbiol 9:129. 2009..pneumoniae, VicR/K is the unique one essential for bacterium growth, and block agents to which, if can be found, may be developed as effective antibiotics against S. pneumoniae infection...
- Immunization with a combination of three pneumococcal proteins confers additive and broad protection against Streptococcus pneumoniae Infections in MiceKaifeng Wu
Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Ministry of Education, Chongqing Medical University, Chongqing 400016, People s Republic of China
Infect Immun 78:1276-83. 2010..These results indicate that system immunization with the combination of pneumococcal antigens could provide an additive and broad protection against Streptococcus pneumoniae in pneumonia and sepsis infection models...
- [Histidine kinase (YycG) protein of Streptococcus pneumoniae: homology modeling and analysis]Nan Li
Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing University of Medical Science, Chongqing 400016, China
Sheng Wu Gong Cheng Xue Bao 25:207-14. 2009..We have successfully constructed a reliable model of YycG protein. The model can be used as a starting point for designing antibacterial drugs...