Lin Li

Summary

Country: China

Publications

  1. ncbi request reprint [Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle]
    Lin Li
    Department of Pharmacology, School of Pharmaceutical Science, Southern Medical University, Guangzhou 510515, China
    Zhong Yao Cai 31:1514-8. 2008
  2. pmc Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission
    Lin Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China
    Retrovirology 7:37. 2010
  3. pmc 3-hydroxyphthalic anhydride-modified chicken ovalbumin exhibits potent and broad anti-HIV-1 activity: a potential microbicide for preventing sexual transmission of HIV-1
    Lin Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China
    Antimicrob Agents Chemother 54:1700-11. 2010
  4. pmc Combinations of 3-hydroxyphthalic anhydride-modified ovalbumin with antiretroviral drug-based microbicide candidates display synergistic and complementary effects against HIV-1 infection
    Lin Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    J Acquir Immune Defic Syndr 56:384-92. 2011
  5. pmc Natural borneol, a monoterpenoid compound, potentiates selenocystine-induced apoptosis in human hepatocellular carcinoma cells by enhancement of cellular uptake and activation of ROS-mediated DNA damage
    Jianyu Su
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China
    PLoS ONE 8:e63502. 2013
  6. ncbi request reprint [Morroniside inhibits H2O2-induced apoptosis in cultured nerve cells]
    Hou Xi Ai
    Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Zhongguo Zhong Yao Za Zhi 33:2109-12. 2008
  7. doi request reprint Vaginal gel formulation based on theaflavin derivatives as a microbicide to prevent HIV sexual transmission
    Jie Yang
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    AIDS Res Hum Retroviruses 28:1498-508. 2012
  8. doi request reprint Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity
    Wen Wang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China
    Eur J Pharmacol 613:19-23. 2009
  9. ncbi request reprint Peptides derived from HIV-1 gp120 co-receptor binding domain form amyloid fibrils and enhance HIV-1 infection
    Suiyi Tan
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China Lindsley F Kimball Research Institute, New York Blood Center, New York, USA
    FEBS Lett 588:1515-22. 2014
  10. ncbi request reprint [Effects of icariin on beta-amyloid and neurotrophic factors in brain of mitochondrial deficiency model rats]
    Ru Yi Zhang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Zhongguo Zhong Yao Za Zhi 38:1285-9. 2013

Collaborators

Detail Information

Publications45

  1. ncbi request reprint [Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle]
    Lin Li
    Department of Pharmacology, School of Pharmaceutical Science, Southern Medical University, Guangzhou 510515, China
    Zhong Yao Cai 31:1514-8. 2008
    ..To observe the effects of Ganoderma lucidum Spores (GLS) on proliferation and growth cycle in the human hepatoma cell line (HepG2 cells), and study its possible mechanism of activities...
  2. pmc Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission
    Lin Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China
    Retrovirology 7:37. 2010
    ..Here we sought to replace bovine protein with an animal protein of non-bovine origin and substitute HP with another anhydride for the development of anti-HIV microbicide for preventing HIV sexual transmission...
  3. pmc 3-hydroxyphthalic anhydride-modified chicken ovalbumin exhibits potent and broad anti-HIV-1 activity: a potential microbicide for preventing sexual transmission of HIV-1
    Lin Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China
    Antimicrob Agents Chemother 54:1700-11. 2010
    ..Because of the widespread availability and established safety profile of OVA, HP-OVA has good potential to be developed as an effective, safe, and affordable microbicide for prevention of HIV sexual transmission...
  4. pmc Combinations of 3-hydroxyphthalic anhydride-modified ovalbumin with antiretroviral drug-based microbicide candidates display synergistic and complementary effects against HIV-1 infection
    Lin Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    J Acquir Immune Defic Syndr 56:384-92. 2011
    ..We intended to evaluate potential the synergistic anti-HIV-1 effect of HP-OVA in combination with antiretroviral drug (ARV)-based microbicide candidates...
  5. pmc Natural borneol, a monoterpenoid compound, potentiates selenocystine-induced apoptosis in human hepatocellular carcinoma cells by enhancement of cellular uptake and activation of ROS-mediated DNA damage
    Jianyu Su
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China
    PLoS ONE 8:e63502. 2013
    ..NB could be further developed as a chemosensitizer of SeC in treatment of human cancers...
  6. ncbi request reprint [Morroniside inhibits H2O2-induced apoptosis in cultured nerve cells]
    Hou Xi Ai
    Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Zhongguo Zhong Yao Za Zhi 33:2109-12. 2008
    ..To investigate the effects of morroniside on H2O2-induced apoptosis in nerve cells...
  7. doi request reprint Vaginal gel formulation based on theaflavin derivatives as a microbicide to prevent HIV sexual transmission
    Jie Yang
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    AIDS Res Hum Retroviruses 28:1498-508. 2012
    ....
  8. doi request reprint Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity
    Wen Wang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China
    Eur J Pharmacol 613:19-23. 2009
    ..These results suggest that morroniside has protective effects against oxidative stress-induced neurotoxic processes...
  9. ncbi request reprint Peptides derived from HIV-1 gp120 co-receptor binding domain form amyloid fibrils and enhance HIV-1 infection
    Suiyi Tan
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China Lindsley F Kimball Research Institute, New York Blood Center, New York, USA
    FEBS Lett 588:1515-22. 2014
    ..Our findings identify viral derived amyloid fibrils that hold potential for biochemical applications...
  10. ncbi request reprint [Effects of icariin on beta-amyloid and neurotrophic factors in brain of mitochondrial deficiency model rats]
    Ru Yi Zhang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Zhongguo Zhong Yao Za Zhi 38:1285-9. 2013
    ..The results suggested that ICA may have beneficial prospect for the treatment of Alzheimer's disease...
  11. ncbi request reprint [Effects of Shenwu capsule on learning-memory ability and cholinergic function of brain in AD-like rat model induced by chronic infusion of sodium azide by minipump]
    Lan Zhang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Zhongguo Zhong Yao Za Zhi 38:1300-5. 2013
    ..Shenwu capsule indicate effectiveness in AD-like mitochondrial deficiency model rats, so it would be applied in the treatment of AD...
  12. pmc 3-hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate against HIV type 1 entry by targeting both viral envelope glycoprotein gp120 and cellular receptor CD4
    MinMin Li
    1 Center for Clinical Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou, China
    AIDS Res Hum Retroviruses 29:1455-64. 2013
    ..These results suggest that HP-HSA inhibits HIV-1 entry into the target cell by interacting with viral Env gp120 and/or the cellular CD4 receptor, making it a promising microbicide candidate for preventing HIV-1 sexual transmission...
  13. pmc Polyanionic candidate microbicides accelerate the formation of semen-derived amyloid fibrils to enhance HIV-1 infection
    Suiyi Tan
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    PLoS ONE 8:e59777. 2013
    ....
  14. doi request reprint Confirmation and refinement of an autosomal dominant congenital motor nystagmus locus in chromosome 1q31.3-q32.1
    Lin Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    J Hum Genet 57:756-9. 2012
    ..2 and narrows down the linked region to 5.90 cM (5.92 Mb). This study confirms and refines a novel locus for autosomal dominant CMN to chromosome 1q31.3-q32.1 (5.90 cM) and demonstrates its presence in the Chinese population...
  15. pmc Investigation of the interaction of naringin palmitate with bovine serum albumin: spectroscopic analysis and molecular docking
    Xia Zhang
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China
    PLoS ONE 8:e59106. 2013
    ..In this study, the interaction of naringin palmitate with BSA was characterised by spectroscopic and molecular docking techniques...
  16. doi request reprint Mechanical, rheological and release behaviors of a poloxamer 407/ poloxamer 188/carbopol 940 thermosensitive composite hydrogel
    Jianping Chen
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, Guangdong, China
    Molecules 18:12415-25. 2013
    ..The in vitro release showed that an increasing NB/HP-β-CD concentration decreased the release rate of NB from the TCH, but the amount of NB released was more than 96% at 60 min, which showed the TCH had good release behavior. ..
  17. doi request reprint Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity
    Fang ling Sun
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Eur J Pharmacol 660:283-90. 2011
    ....
  18. pmc Is a GnRH antagonist protocol better in PCOS patients? A meta-analysis of RCTs
    Haiyan Lin
    Department of Gynecology and Obstetrics, Sun Yat sen Memorial Hospital of Sun Yat sen University, Guangzhou, China
    PLoS ONE 9:e91796. 2014
    ....
  19. ncbi request reprint [Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia]
    Hai Feng Wei
    Department of Pharmacology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
    Zhong Xi Yi Jie He Xue Bao 6:73-6. 2008
    ..To study the tongue tissue blood oxygen saturation measurement for evaluating tongue manifestation of blood stasis syndrome, and to explore its correlation with blood rheological disorder in a rat model of acute transient brain ischemia...
  20. doi request reprint Effects of Epimedium flavonoids on proliferation and differentiation of neural stem cells in vitro
    Ruiqin Yao
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China
    Neurol Res 32:736-42. 2010
    ....
  21. doi request reprint Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease
    Lan Zhang
    Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, China
    Restor Neurol Neurosci 31:41-52. 2013
    ....
  22. doi request reprint 3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry
    Lin Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
    J Antimicrob Chemother 68:573-6. 2013
    ..But because OVA may cause allergy in some human subjects, here we replaced OVA with human serum albumin (HSA) in designing a new anti-HIV-1 agent, HP-HSA, and then tested its anti-HIV-1 activity and cytotoxicity...
  23. ncbi request reprint HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy
    Suiyi Tan
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    Lab Invest 94:777-87. 2014
    ..Our study highlights the role of HIV-1 in the pathogenesis of HIV/AIDS-related retinopathy and suggests potential therapeutic targets for this ocular complication. ..
  24. doi request reprint Impact of carotid atherosclerosis combined with hypercholesterolemia on cerebral microvessels and brain parenchyma in a new complex rat model
    Lan Zhang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, 100053, China
    Neurochem Res 39:653-60. 2014
    ....
  25. pmc Icariin decreases the expression of APP and BACE-1 and reduces the β-amyloid burden in an APP transgenic mouse model of Alzheimer's disease
    Lan Zhang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Int J Biol Sci 10:181-91. 2014
    ....
  26. doi request reprint Effect of delayed initiation of gonadotropin in luteal long protocol on in vitro fertilization
    Haiyan Lin
    Department of Gynecology and Obstetrics, Sun Yat sen Memorial Hospital of Sun Yat sen University, Guangzhou, China
    Gynecol Endocrinol 29:846-50. 2013
    ..To evaluate whether delayed initiation of gonadotropin in luteal long protocol affected the outcome of in vitro fertilization (IVF)...
  27. ncbi request reprint Granulocyte colony-stimulating factor administration for infertile women with thin endometrium in frozen embryo transfer program
    Yu Li
    1Department of Obstetrics and Gynecology, Reproductive Medicine Centre, Memorial Hospital of Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    Reprod Sci 21:381-5. 2014
    ..05). Our study fails to demonstrate that G-CSF has the potential to improve embryo implantation and clinical pregnancy rate of the infertile women with thin endometrium. ..
  28. ncbi request reprint [Effects of Shenwu capsule and its component tetrahydroxystilbene glucoside on expression of neurotrophic factors in lumbar spinal cord of aged rats]
    Li Zhang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Zhongguo Zhong Yao Za Zhi 34:1557-61. 2009
    ..To investigate the effects of Shenwu capsule (SW) and its component tetrahydroxystilbene glucoside (TSG) on the expression of neurotrophic factors in lumbar spinal cord of aged rats...
  29. ncbi request reprint Morroniside prevents peroxide-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells
    Wen Wang
    Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, 100053, China
    Cell Mol Neurobiol 28:293-305. 2008
    ..4) This study suggested that intracellular GSH appeared to be an important factor in morroniside-mediated cytoprotection against H(2)O(2)-toxicity in SH-SY5Y cells...
  30. doi request reprint Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation
    Ruifang Yang
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
    J Cardiovasc Pharmacol 51:396-401. 2008
    ..Our further mechanistic study revealed that increased JNK phosphorylation stimulated by H2O2 was abolished by STS treatment. In conclusion, inhibition of JNK activation plays a significant role in cardioprotective effects of STS...
  31. ncbi request reprint [Antiviral activity of 3-hydroxyphthalic anhydride-modified ovalbumin against herpes simplex virus 2 in vitro]
    Li Li He
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1175-8. 2011
    ..To investigate the antiviral activity of 3-hydroxyphthalic anhydride-modified ovalbumin (HP-OVA) against herpes simplex virus 2 (HSV-2) in vitro...
  32. doi request reprint Comparative analysis of thermal behavior, isothermal crystallization kinetics and polymorphism of palm oil fractions
    Xia Zhang
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, Guangdong, China
    Molecules 18:1036-52. 2013
    ..According to the polarized light microscope (PLM) images, crystal morphology of PS and PO was different. With the temperature increased, the structure of crystal network of both PS and PO gradually loosened...
  33. pmc Lack of phenotypic effect of triallelic variation in SPATA7 in a family with Leber congenital amaurosis resulting from CRB1 mutations
    Lin Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 17:3326-32. 2011
    ..To identify the causative gene for autosomal recessive Leber congenital amaurosis (LCA) in a Chinese family...
  34. doi request reprint Apolipoprotein B/apolipoprotein A1 ratio is a good predictive marker of metabolic syndrome and pre-metabolic syndrome in Chinese adolescent women with polycystic ovary syndrome
    Qianqian Yin
    Department of Obstetrics and Gynecology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Obstet Gynaecol Res 39:203-9. 2013
    ..We sought to assess if the ApoB/ApoA1 ratio can be used as a predictive marker of MS and pre-MS in Chinese adolescent women with PCOS...
  35. ncbi request reprint Temporal gene expression profile in hippocampus of mice treated with D-galactose
    Haifeng Wei
    Department of Pharmacology, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital of Capital Medical University, 45 Chang chun Street, Xuan Wu District, Beijing, China
    Cell Mol Neurobiol 28:781-94. 2008
    ..4) These findings will contribute to the understanding of the mechanism of learning and memory impairment in mice treated with D-galactose...
  36. ncbi request reprint [Effects of cornel iridoid glycoside on activity of cholinesterases in vitro]
    Si Juan Chu
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Zhongguo Zhong Yao Za Zhi 38:1331-4. 2013
    ..CIG also inhibited the activity of BuChE of human blood plasma, with the IC50 of 2.9 g . L-1. In conclusion, CIG can inhibit the activity of AChE and BuChE in vitro, which may be one of the mechanisms of CIG to treat AD...
  37. ncbi request reprint [Koumine-induced apoptosis of human colonic adenocarcinoma cells: the cell biological mechanism]
    De biao Chi
    School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:994-7. 2007
    ..To investigate the cell biological mechanism of koumine-induced apoptosis of human colonic adenocarcinoma cells...
  38. doi request reprint A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection
    Jie Yang
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    Fitoterapia 83:348-55. 2012
    ..It has a potential to be developed as a safe and affordable topical microbicide for preventing sexual transmission of HIV...
  39. ncbi request reprint [Semen-derived enhancer of viral infection--a key factor in sexual transmission of HIV]
    Jiang Man Duan
    First School of Clinical Medical Sciences, Guangzhou 510515, China
    Bing Du Xue Bao 28:84-8. 2012
    ..The studies on the biological characteristics and mechanisms of SEVI have a big benefit for the prevention and treatment of HIV infection...
  40. ncbi request reprint Preparation of natural borneol/2-hydroxypropyl-β-cyclodextrin inclusion complex and its effect on the absorption of tetramethylpyrazine phosphate in mouse
    Jianyu Su
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, Guangdong, China
    Chem Pharm Bull (Tokyo) 60:736-42. 2012
    ..However, the use of NB/HP-β-CD did not change the in vivo behavior of TMPP. Our results suggest the application potential of NB/HP-β-CD inclusion in pharmaceutics...
  41. doi request reprint Flavor evaluation of yak butter in Tsinghai-Tibet Plateau and isolation of microorganisms contributing flavor
    Songqing Hu
    College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, Guangdong, China
    Anim Sci J 82:122-6. 2011
    ..The microorganisms are expected to be applied in the food industry, especially to produce dairy food with the unique flavor of yak butter...
  42. doi request reprint Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells
    Lu Liu
    Department of Gastrointestinal Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, China
    Cell Immunol 277:66-73. 2012
    ..These results demonstrate a specific immune suppression property of butyrate and supports further investigation for butyrate as a new immunotherapeutic agent...
  43. ncbi request reprint [Effects of epimedium flavonoids on synapse related protein in brains of dementia transgenic mice]
    Jin Chu
    Department of Pharmacology, Xuanwu Hospital of Capital University of Medical Sciences, Education Ministry Key Laboratory for Neurodegenerative Disease, Beijing 100053, China
    Zhonghua Yi Xue Za Zhi 88:31-5. 2008
    ....
  44. ncbi request reprint Effects of Yizhi Capsule on learning and memory disorder and beta-amyloid peptide induced neurotoxicity in rats
    Hang yu Wu
    Department of Pharmacology, First Military Medical University, Guangzhou 510515, China
    Chin J Integr Med 12:137-41. 2006
    ..To explore the effects of Yizhi Capsule (YZC) on learning and memory disorder and beta-amyloid peptide induced neurotoxicity in rats...
  45. ncbi request reprint [The significance of quantification of MDR1 and WT1 gene expression in acute myeloid leukemia]
    Bing Xu
    Department of Hematology, Nanfang Hospital, The Southern Medical University, Guangzhou 510515, China
    Zhonghua Nei Ke Za Zhi 47:221-4. 2008
    ..To study the quantification of MDR1 and WT1 gene expression in patients with de novo acute myeloid leukemia (AML) and to explore the role of these two genes in clinical drug resistance and their correlation with risk stratification...