Cai L, Li C, Tang W, Liu M, Chen W, Qiu Y, et al
. Therapeutic Effect of Penta-acetyl Geniposide on Adjuvant-Induced Arthritis in Rats: Involvement of Inducing Synovial Apoptosis and Inhibiting NF-κB Signal Pathway. Inflammation. 2018;41:2184-2195 pubmed publisher
..In conclusion, (Ac)5GP showed a potent anti-arthritic effect on AIA rats via inducing synovial apoptosis and inhibiting NF-κB activation in synovial tissues. ..
Cai L, Li R, Tang W, Meng G, Hu X, Wu T. Antidepressant-like effect of geniposide on chronic unpredictable mild stress-induced depressive rats by regulating the hypothalamus-pituitary-adrenal axis. Eur Neuropsychopharmacol. 2015;25:1332-41 pubmed publisher
..These aforementioned therapeutic effects of geniposide were essentially similar to fluoxetine. Our results indicated that geniposide possessed potent antidepressant-like properties that may be mediated by its effects on the HPA axis. ..
Cai L, Lei C, Li R, Chen W, Li C. Aquaporin-4 Blockage by siRNA Protects Rat Articular Chondrocytes from IL-1?-induced Apoptosis by Inhibiting p38 MAPK Signal Pathway. Ann Clin Lab Sci. 2017;47:563-571 pubmed
..Our results provide experimental evidence that AQP4 inhibition contributes to preventing chondrocyte apoptosis in joint diseases such as RA and provide a novel therapeutic target for RA...