Lixin Li


Country: China


  1. Liu C, Gu C, Huang W, Sheng X, Du J, Li Y. Targeted UPLC-MS/MS high-throughput metabolomics approach to assess the purine and pyrimidine metabolism. J Chromatogr B Analyt Technol Biomed Life Sci. 2019;1113:98-106 pubmed publisher
    ..99) were acquired. The successful development of this method provides a feasible protocol for a large-scale metabolomics study and it also lays the foundation of quantitative analysis in endogenous analytes. ..
  2. Fan S, Gu K, Wu Y, Luo H, Wang Y, Zhang T, et al. Liquiritinapioside - A mineralocorticoid-like substance from liquorice. Food Chem. 2019;289:419-425 pubmed publisher
    ..Overall, the attained results showed that LA could induce the activation of the TGF-β1/p38 MAPK signalling pathway through the MR to induce H9c2 cell fibrosis. ..
  3. Cai X, Du J, Li L, Zhang P, Zhou H, Tan X, et al. Clinical metabolomics analysis of therapeutic mechanism of Tongmai Yangxin Pill on stable angina. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1100-1101:106-112 pubmed publisher
    ..And it also lays a foundation for the use of TMYX clinically. ..
  4. Xu Y, Zhao Y, Guo X, Li Y, Zhang Y. Plasma metabolic profiling analysis of neurotoxicity induced by oxaliplatin using metabonomics and multivariate data analysis. Toxicol Res (Camb). 2018;7:529-537 pubmed publisher
    ..The biomarkers found in this study are significant for the study of neurotoxicity. ..
  5. Zhao H, Liu Y, Li Z, Song Y, Cai X, Liu Y, et al. Identification of essential hypertension biomarkers in human urine by non-targeted metabolomics based on UPLC-Q-TOF/MS. Clin Chim Acta. 2018;486:192-198 pubmed publisher
  6. Wang Y, Guo X, Xie J, Hou Z, Li Y. A GC-MS Based Metabonomics Study of Rheumatoid Arthritis and the Interventional Effects of the Simiaowan in Rats. Molecules. 2015;20:21364-72 pubmed publisher
    ..Metabonomics may prove to be a valuable tool for determining the efficacy of complex traditional prescriptions. ..
  7. Li A, Guo X, Xie J, Liu X, Zhang Z, Li Y, et al. Validation of biomarkers in cardiotoxicity induced by Periplocin on neonatal rat cardiomyocytes using UPLC-Q-TOF/MS combined with a support vector machine. J Pharm Biomed Anal. 2016;123:179-85 pubmed publisher
    ..Additionally, we demonstrate that an UPLC-Q-TOF/MS-based metabolomic approach is a powerful tool and provides a promising approach for assessing the toxicity of traditional Chinese medicine and drug safety screening. ..
  8. Zhang Z, Zhang Y, Yin J, Li Y. An integrated strategy for the rapid extraction and screening of phosphatidylcholines and lysophosphatidylcholines using semi-automatic solid phase extraction and data processing technology. J Chromatogr A. 2016;1461:192-7 pubmed publisher
    ..Our method provides a novel strategy for the rapid extraction and analysis of functional phospholipids. In addition, this study will promote further study of phospholipids in disease research. ..
  9. Yin J, Xie J, Guo X, Ju L, Li Y, Zhang Y. Plasma metabolic profiling analysis of cyclophosphamide-induced cardiotoxicity using metabolomics coupled with UPLC/Q-TOF-MS and ROC curve. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1033-1034:428-435 pubmed publisher
    ..These metabolites could act as sensitive biomarkers for CY-induced cardiotoxicity and be useful for investigating toxic mechanisms. They may also lay a foundation for clinical use of cyclophosphamide. ..

More Information


  1. Shao X, Wang K, Liu X, Gu C, Zhang P, Xie J, et al. Screening and verifying endometrial carcinoma diagnostic biomarkers based on a urine metabolomic profiling study using UPLC-Q-TOF/MS. Clin Chim Acta. 2016;463:200-206 pubmed publisher
    ..The EOC diagnostic biomarker group can provide a clinical reference for diagnosing EOC and insight into the diagnosis of other diseases in the clinic. ..
  2. Zhou H, Zhang P, Hou Z, Xie J, Wang Y, Yang B, et al. Research on the Relationships between Endogenous Biomarkers and Exogenous Toxic Substances of Acute Toxicity in Radix Aconiti. Molecules. 2016;21: pubmed
    ..Research on these relationships provides an innovative way to interpret the toxic mechanism of traditional Chinese medicine, and plays a positive role in the overall study of TCM toxicity. ..
  3. Yang B, Wang Y, Shan L, Zou J, Wu Y, Yang F, et al. A Novel and Practical Chromatographic "Fingerprint-ROC-SVM" Strategy Applied to Quality Analysis of Traditional Chinese Medicine Injections: Using KuDieZi Injection as a Case Study. Molecules. 2017;22: pubmed publisher
    ..It indicated that the novel and practical chromatographic "Fingerprint-ROC-SVM" strategy could be further applied to facilitate the development of the quality analysis of TCM injections. ..
  4. Yang S, Shan L, Luo H, Sheng X, Du J, Li Y. Rapid Classification and Identification of Chemical Components of Schisandra Chinensis by UPLC-Q-TOF/MS Combined with Data Post-Processing. Molecules. 2017;22: pubmed publisher