Ke Li

Summary

Country: China

Publications

  1. ncbi request reprint Determination of coenzyme Q10 in human seminal plasma by high-performance liquid chromatography and its clinical application
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, Nanjing 210002, Jiangsu, People s Republic of China
    Biomed Chromatogr 20:1082-6. 2006
  2. ncbi request reprint Fingerprint chromatogram analysis of extracts from the leaves of Tripterygium wilfordii Hook. F. by high performance liquid chromatography
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, People s Republic of China
    J Sep Sci 28:653-7. 2005
  3. ncbi request reprint [Simultaneous determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension by HPLC]
    Ke Li
    The Center of Medical Laboratory Science, Nanjing General Hospital of Nanjing Command, People s Liberation Army, Nanjing 210002, China
    Se Pu 23:82-4. 2005
  4. ncbi request reprint HPLC determination of diltiazem in human plasma and its application to pharmacokinetics in humans
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, Clinical School of Medical College, Nanjing University, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, People s Republic of China
    Biomed Chromatogr 17:522-5. 2003
  5. ncbi request reprint Simultaneous determination of matrine, sophoridine and oxymatrine in Sophora flavescens Ait. by high performance liquid chromatography
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, People s Republic of China
    Biomed Chromatogr 18:178-82. 2004
  6. ncbi request reprint High-performance liquid chromatographic detection of lipid peroxidation in human seminal plasma and its application to male infertility
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, PR China
    Clin Chim Acta 346:199-203. 2004
  7. ncbi request reprint [Level of free L-carnitine in human seminal plasma and its correlation with semen quality]
    Ke Li
    PLA Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 13:143-6. 2007
  8. doi request reprint Measurement of oxidized lipoprotein (a) in patients with acute coronary syndromes and stable coronary artery disease by 2 ELISAs: using different capture antibody against oxidized lipoprotein (a) or oxidized LDL
    Jun jun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, PR China
    Clin Biochem 43:571-5. 2010
  9. ncbi request reprint [Correlation of free L-carnitine level with accessory gland markers and its clinical significance]
    Ke Li
    PLA Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 13:507-10. 2007
  10. doi request reprint Plasma oxidized lipoprotein(a) and its immune complexes are present in newborns and children
    Junjun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Chim Acta 407:1-5. 2009

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Determination of coenzyme Q10 in human seminal plasma by high-performance liquid chromatography and its clinical application
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, Nanjing 210002, Jiangsu, People s Republic of China
    Biomed Chromatogr 20:1082-6. 2006
    ..CoQ10 concentrations in the two populations were: 37.1 +/- 12.2 ng/mL in the fertile group and 48.5 +/- 20.4 ng/mL in the infertile group. The large difference (p < 0.01) between the fertile and infertile populations is evident...
  2. ncbi request reprint Fingerprint chromatogram analysis of extracts from the leaves of Tripterygium wilfordii Hook. F. by high performance liquid chromatography
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, People s Republic of China
    J Sep Sci 28:653-7. 2005
    ..The method is suitable for differentiation of extracts from the leaves of TWHF, and can be used as a quality control method for this herb...
  3. ncbi request reprint [Simultaneous determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension by HPLC]
    Ke Li
    The Center of Medical Laboratory Science, Nanjing General Hospital of Nanjing Command, People s Liberation Army, Nanjing 210002, China
    Se Pu 23:82-4. 2005
    ..7% and 100.0%-101.8%, respectively. The method has been successfully applied to the simultaneous determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension...
  4. ncbi request reprint HPLC determination of diltiazem in human plasma and its application to pharmacokinetics in humans
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, Clinical School of Medical College, Nanjing University, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, People s Republic of China
    Biomed Chromatogr 17:522-5. 2003
    ..The results showed that the peak level in plasma approximately averaged 118.5 +/- 14.3 ng/mL at 3.1 +/- 0.4 h, and the areas under the drug concentration curves (AUC) was 793.1 +/- 83.1 ng.h/mL...
  5. ncbi request reprint Simultaneous determination of matrine, sophoridine and oxymatrine in Sophora flavescens Ait. by high performance liquid chromatography
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, People s Republic of China
    Biomed Chromatogr 18:178-82. 2004
    ..samples, respectively. The method has been successfully applied to the simultaneous determination of matrine, sophoridine and oxymatrine in Sophora Flavescens Ait. samples collected in different habitats...
  6. ncbi request reprint High-performance liquid chromatographic detection of lipid peroxidation in human seminal plasma and its application to male infertility
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, PR China
    Clin Chim Acta 346:199-203. 2004
    ..A simple and reliable high-performance liquid chromatographic (HPLC) method has been developed and validated for the analysis of malondialdehyde (MDA) in human seminal plasma...
  7. ncbi request reprint [Level of free L-carnitine in human seminal plasma and its correlation with semen quality]
    Ke Li
    PLA Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 13:143-6. 2007
    ....
  8. doi request reprint Measurement of oxidized lipoprotein (a) in patients with acute coronary syndromes and stable coronary artery disease by 2 ELISAs: using different capture antibody against oxidized lipoprotein (a) or oxidized LDL
    Jun jun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, Nanjing 210002, PR China
    Clin Biochem 43:571-5. 2010
    ..To evaluate clinical value of oxidized lipoprotein(a) [ox-Lp(a)] levels...
  9. ncbi request reprint [Correlation of free L-carnitine level with accessory gland markers and its clinical significance]
    Ke Li
    PLA Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 13:507-10. 2007
    ..To evaluate the correlation of the level of free L-carnitine with accessory gland markers and its clinical significance...
  10. doi request reprint Plasma oxidized lipoprotein(a) and its immune complexes are present in newborns and children
    Junjun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Chim Acta 407:1-5. 2009
    ..We investigated the distribution characteristics of plasma ox-Lp(a) and Lp(a) immune complex [Lp(a)-IC] levels in newborns and children...
  11. ncbi request reprint [Determination of lipid peroxidation in human seminal plasma by high performance liquid chromatography and its diagnostic value of male infertility]
    Ke Li
    The Center of Medical Laboratory Science, Nanjing General Hospital of Nanjing Command, PLA, Nanjing 210002, China
    Se Pu 22:412-5. 2004
    ..Exception of obstructive azoospermic group, MDA concentrations of seminal plasma in control group made very significant difference from those in other infertile groups (P < 0.01)...
  12. doi request reprint Percutaneous coronary intervention results in acute increases in native and oxidized lipoprotein(a) in patients with acute coronary syndrome and stable coronary artery disease
    Jun jun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Biochem 43:1107-11. 2010
    ..To investigate possible changes of native and oxidized lipoprotein(a) [ox-Lp(a)] levels after percutaneous coronary intervention (PCI)...
  13. ncbi request reprint Analysis of lipid peroxidative levels in seminal plasma of infertile men by high-performance liquid chromatography
    Xue Jun Shang
    Laboratory of Reproduction and Genetics, Jinling Hospital, Nanjing, PR China
    Arch Androl 50:411-6. 2004
    ..05). The results suggested that detection of MDA concentrations in seminal plasma by HPLC has an indicative value on the diagnosis of male infertility induced by overproduction of reactive oxygen species in male reproductive system...
  14. doi request reprint Increased serum levels of β₂-GPI-Lp(a) complexes and their association with premature atherosclerosis in patients with rheumatoid arthritis
    Chunni Zhang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medical College, Nanjing University, 210002 Nanjing, PR China
    Clin Chim Acta 412:1332-6. 2011
    ..The concentration of β₂-GPI-Lp(a) and its relationship with premature atherosclerosis were evaluated in rheumatoid arthritis (RA) patients...
  15. doi request reprint Detection of serum beta(2)-GPI-Lp(a) complexes in patients with systemic lupus erythematosus
    Chunni Zhang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medical College, Nanjing University, 210002, Nanjing, PR China
    Clin Chim Acta 411:395-9. 2010
    ..We examined the existence and clinical significance of serum complexes of beta(2)-GPI with Lp(a) in SLE patients...
  16. ncbi request reprint [Biological function of CoQ10 and its effect on the quality of spermatozoa]
    Wei Li
    Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 12:1119-22. 2006
    ..This review describes the biological function of CoQ10 and its effect on the quality of spermatozoa and its effect as an adjunctive therapy on male infertility...
  17. ncbi request reprint Determination of free L-carnitine in human seminal plasma by high performance liquid chromatography with pre-column ultraviolet derivatization and its clinical application in male infertility
    Ke Li
    Institute of Clinical Laboratory Medicine, Jinling Hospital, No 305 East Zhongshan Road, Nanjing 210002, Jiangsu, PR China
    Clin Chim Acta 378:159-63. 2007
    ....
  18. doi request reprint Reference values for serum levels of cholesteryl ester transfer protein and its distribution characteristics in healthy Chinese children and newborns
    Chunni Zhang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002 Nanjing, PR China
    Clin Biochem 41:1107-9. 2008
    ..To investigate the distribution characteristics of serum CETP levels in childhood...
  19. doi request reprint The level of malondialdehyde-modified LDL and LDL immune complexes in patients with rheumatoid arthritis
    Junjun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medical College, Nanjing University, 305, East Zhong Shan Road, Nanjing, 210002, PR China
    Clin Biochem 42:1352-7. 2009
    ..To explore possible associations of malondialdehyde-modified low-density lipoprotein (MDA-LDL) and LDL-immune complexes (LDL-IC) with atherosclerosis in rheumatoid arthritis (RA)...
  20. ncbi request reprint Development of new enzyme-linked immunosorbent assay for oxidized lipoprotein(a) by using purified human oxidized lipoprotein(a) autoantibodies as capture antibody
    Junjun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine College, Nanjing University, PR China
    Clin Chim Acta 385:73-8. 2007
    ..We isolated and identified human autoantibodies against ox-Lp(a) and developed a new ELISA for ox-Lp(a) by using autoantibodies as capture antibody...
  21. ncbi request reprint Simultaneous determination of free and total carnitine in human serum by HPLC with UV detection
    Ke Li
    Department of Medical Laboratory Science, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, Jiangsu, PR China
    J Chromatogr Sci 48:371-4. 2010
    ..Statistics analysis showed that total and free carnitine levels of males were higher than that of females (p < 0.01) while acylcarnitine level had no statistically significant difference (p > 0.05)...
  22. ncbi request reprint [Initial observation on L-carnitine for asthenospermia with epididymal knob]
    Xuejun Shang
    Department of Andrology, Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 10:671-2, 675. 2004
    ..To evaluate the efficacy of L-carnitine on asthenospermia with epididymal knob...
  23. doi request reprint Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma
    Chunni Zhang
    Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China
    Clin Chem 56:1871-9. 2010
    ..In this study, we investigated the serum miRNA profile in ESCC patients to develop a novel diagnostic ESCC biomarker...
  24. ncbi request reprint CETP and oxidized LDL levels increase in dyslipidemic subjects
    Junjun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, 305 East Zhong Shan Road, Nanjing, 210002, PR China
    Clin Biochem 40:995-9. 2007
    ..To explore the possible associations among cholesteryl ester transfer protein (CETP), contents of lipids in low-density lipoprotein (LDL), and in vivo oxidized LDL (Ox-LDL)...
  25. pmc An ENU-induced mutation of Nrg1 causes dilated pupils and a reduction in muscarinic receptors in the sphincter pupillae
    Bing Chen
    Comparative Medicine Center, Yangzhou University, Jiangsu, Yangzhou, China
    PLoS ONE 6:e25176. 2011
    ..However, after genetic confirmation testing, only approximately 50% of the abnormal phenotypes were found to be heritable...
  26. doi request reprint Elevated concentrations of oxidized lipoprotein(a) are associated with the presence and severity of acute coronary syndromes
    Jun jun Wang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Chim Acta 408:79-82. 2009
    ..To investigate possible mechanisms and association of increased oxidized Lp(a) [ox-Lp(a)] levels with presence and extent of acute coronary syndromes (ACS)...
  27. ncbi request reprint Effect of hypoalbuminemia on the increased serum cholesteryl ester transfer protein concentration in children with idiopathic nephrotic syndrome
    Chunni Zhang
    Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China
    Clin Biochem 40:869-75. 2007
    ..To examine the alteration of cholesteryl ester transfer protein (CETP) mass with the regression of albumin level in childhood nephrotic syndrome (NS) in order to clarify the effect of albumin on CETP in NS...
  28. ncbi request reprint Simultaneous determination of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets by reversed-phase ion-pair high performance liquid chromatography
    Ke Li
    The Center of Medical Laboratory Science, Jinling Hospital, Clinical School of Medical College, Nanjing University, No 305 East Zhongshan Road, Jiangsu, People s Republic of China
    Biomed Chromatogr 16:504-7. 2002
    ..9 and 100.4% for the tablets, respectively. The method has been successfully applied to the simultaneous determination of nicotinamide, pyridoxine hydrochloride, thiamine mononitrate and riboflavin in multivitamin with minerals tablets...
  29. ncbi request reprint Ginkgo biloba extract prevents ethanol induced dyslipidemia
    Ping Yao
    Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China
    Am J Chin Med 35:643-52. 2007
    ..EGB pretreatment prevents hyperlipidemia and ameliorates lipid peroxidation induced by ethanol...
  30. ncbi request reprint Identification of the metabolites of 9-nitro-20(S)-camptothecin in rats
    Ke Li
    Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, P R China
    Drug Metab Dispos 31:792-7. 2003
    ..The mercapturic acid conjugate of 10-hydroxy-20(S)-camptothecin (M6) was detected in the urine and feces by LC/MSn..
  31. ncbi request reprint [Determination of 9-nitrocamptothecin in rat plasma and tissues by high performance liquid chromatography]
    Ke Li
    Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang 110016, China
    Yao Xue Xue Bao 38:124-8. 2003
    ..To develop a sensitive, specific and accurate method for quantifying 9-nitrocamptothecin in rat plasma and tissues and to study the distribution of 9-nitrocamptothecin in rat tissues...
  32. ncbi request reprint Determination of scutellarin in rat plasma by high-performance liquid chromatography with ultraviolet detection
    Dafang Zhong
    Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
    J Chromatogr B Analyt Technol Biomed Life Sci 796:439-44. 2003
    ..9981. The method has a good reproducibility, R.S.D. values were below 7.9% for within-day and between-day precision. The method is simple, rapid, and applicable to preliminary pharmacokinetic studies of scutellarin in rats...
  33. ncbi request reprint Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry
    Ke Li
    Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 817:271-5. 2005
    ..The utility of the assay was demonstrated by determining dioscin plasma concentrations in five rats for 120 h following a single oral gavage dose of 90 mg/kg...
  34. ncbi request reprint The effects of Chinese herb Angelica in focal cerebral ischemia injury in the rat
    Jing Wei Yang
    Department of Pathophysiology, Medical College of Wuhan University, Wuhan 430071, China
    Clin Hemorheol Microcirc 32:209-15. 2005
    ..01). These results suggest that Angelica can reduce the number of apoptosis cells by decreasing the expression of Bax protein. This is maybe one of the mechanisms of the therapeutic effect of Angelica on focal cerebral ischemia injury...
  35. ncbi request reprint Sensitive quantification of rifaximin in human plasma by liquid chromatography-tandem mass spectrometry
    Xianhua Zhang
    Department of Pharmacy, Peking University Third Hospital, Beijing 100083, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 850:348-55. 2007
    ..This method provides a rapid, sensitive, specific and robust tool for the quantitative determination of rifaximin in human plasma, which is especially useful for the pharmacokinetic study of rifaximin...
  36. ncbi request reprint Heme oxygenase-1 upregulated by Ginkgo biloba extract: potential protection against ethanol-induced oxidative liver damage
    Ping Yao
    Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China
    Food Chem Toxicol 45:1333-42. 2007
    ..Hence, HO-1 upregulation by EGB may enhance the antioxidative capacity against the ethanol-induced oxidative stress and maintain the cellular redox balance...
  37. ncbi request reprint [Study on the effect of resveratrol on metastasis-associated ability of ovarian carcinoma HO-8910PM cells in vitro]
    Yan Mei Qin
    Institute of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang 524023, China
    Zhong Yao Cai 30:176-8. 2007
    ..To investigate the inhibitory effect of resveratrol on the metastasis-associated ability of human highly metastatic ovarian carcinoma HO-8910PM cells in vitro...
  38. ncbi request reprint Determination and pharmacokinetics of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of yinchenhao tang
    Zhi Guo Yu
    Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People s Republic of China
    J Chromatogr Sci 45:544-8. 2007
    ..29, 1.30, 1.07, and 1.75 h, AUC(-->t) is 919.1, 1215.0, 2035.3, and 2537.9 ng-h/mL, AU(0-->) is 928.5, 1325.9, 2094.4, and 2612.6 ng x h/ mL, respectively...
  39. ncbi request reprint Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton
    Ke Li
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 129:4762-75. 2007
    ..Insights gained during these explorations led to total syntheses of oxysceptrin and nakamuric acid and a successful construction of the carbon skeleton of axinellamine...