Research Topics

Genomes and Genes


Bingdong Zhu


Affiliation: Lanzhou University
Country: China


  1. Niu H, Cui P, Shi W, Zhang S, Feng J, Wang Y, et al. Identification of Anti-Persister Activity against Uropathogenic Escherichia coli from a Clinical Drug Library. Antibiotics (Basel). 2015;4:179-87 pubmed publisher
    ..coli persisters in 3 days in vitro while the current UTI antibiotics failed to do so. Our findings may have implications for the development of a more effective treatment for UTIs. ..
  2. Niu H, Cui P, Yee R, Shi W, Zhang S, Feng J, et al. A Clinical Drug Library Screen Identifies Tosufloxacin as Being Highly Active against Staphylococcus aureus Persisters. Antibiotics (Basel). 2015;4:329-36 pubmed publisher
    ..Further studies are needed to evaluate tosufloxacin in animal models and to explain its unique activity against bacterial persisters. Our findings may have implications for improved treatment of persistent bacterial infections. ..
  3. Bai C, He J, Niu H, Hu L, Luo Y, Liu X, et al. Prolonged intervals during Mycobacterium tuberculosis subunit vaccine boosting contributes to eliciting immunity mediated by central memory-like T cells. Tuberculosis (Edinb). 2018;110:104-111 pubmed publisher
    ..It suggests that prolonging the vaccination interval of TB subunit vaccine to some extent contributes to inducing more abundant TCM like cells and providing stronger immune protection against mycobacteria infection. ..
  4. Luo Y, Ma X, Liu X, Lu X, Niu H, Yu H, et al. IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization. Int Immunol. 2016;28:77-85 pubmed publisher
    ..Instead, it induced more serious pathology reaction. In conclusion, IL-28B down-regulates Tregs following EAMMH vaccination but does not improve the protective immune responses. ..
  5. Liu X, Da Z, Wang Y, Niu H, Li R, Yu H, et al. A novel liposome adjuvant DPC mediates Mycobacterium tuberculosis subunit vaccine well to induce cell-mediated immunity and high protective efficacy in mice. Vaccine. 2016;34:1370-8 pubmed publisher
    ..53 ± 0.26log10CFU) at 30 weeks post-vaccination. In conclusion, DPC would be a promising vaccine adjuvant with the ability to stimulate Th1 type cell-mediated immunity, and could be used in TB subunit vaccine. ..
  6. Zhou X, Yao K, Zhang L, Zhang Y, Han Y, Liu H, et al. Identification of Differentiation-Related Proteins in Gastric Adenocarcinoma Tissues by Proteomics. Technol Cancer Res Treat. 2016;15:697-706 pubmed publisher
    ..Some of them would be differentiation-related cancer biomarkers and are associated with tumor metastasis, invasion, and prognosis. ..
  7. Dong X, Luo Y, Gao Q, Lu X, Wang Q, Zhang Y, et al. Effects of MBL-associated serine protease-2 (MASP-2) on liquefaction and ulceration in rabbit skin model of tuberculosis. Microb Pathog. 2016;99:282-286 pubmed publisher
    ..This study suggests that hMASP-2 can induce a protective efficacy in BCG-infected rabbit skin models, which affects both the progress of lesions and the survival of the mycobacteria within them. ..
  8. Niu H, Yee R, Cui P, Tian L, Zhang S, Shi W, et al. Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library. Pathogens. 2017;6: pubmed publisher
    ..We ranked these new drug candidates according to their MICs against the MRSA strain USA300. Our findings may have implications for more effective treatment of MRSA infections. ..
  9. Liu W, Li J, Niu H, Lin X, Li R, Wang Y, et al. Immunogenicity and protective efficacy of multistage vaccine candidates (Mtb8.4-HspX and HspX-Mtb8.4) against Mycobacterium tuberculosis infection in mice. Int Immunopharmacol. 2017;53:83-89 pubmed publisher
    ..The data suggest that the antigen sequential order and dose selection should be considered when a tuberculosis protein vaccine is to be constructed and its immune strategy is to be planned. ..