Wei Jun Kong

Summary

Country: China

Publications

  1. doi request reprint Multi-component analysis of bile acids in natural Calculus bovis and its substitutes by ultrasound-assisted solid-liquid extraction and UPLC-ELSD
    Wei Jun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Analyst 137:5845-53. 2012
  2. doi request reprint Effect of berberine on Escherichia coli, Bacillus subtilis, and their mixtures as determined by isothermal microcalorimetry
    Wei Jun Kong
    China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing, 100039, China
    Appl Microbiol Biotechnol 96:503-10. 2012
  3. doi request reprint Preliminary screening for extraction techniques and bioactive fraction of Coptidis Rhizoma based on microcalorimetry
    Wei Jun Kong
    Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan
    Pharm Biol 49:362-8. 2011
  4. doi request reprint Solid-phase extraction and ultra high-performance liquid chromatography tandem mass spectrometry analysis of the gastrointestinal absorption of emodin in different digestive segments of rats
    Weijun Kong
    China Military Institute of Chinese Materia Medica, Military Hospital of China, Beijing, PR China
    J Sep Sci 34:260-7. 2011
  5. doi request reprint Evaluation of antibacterial effect and mode of Coptidis rhizoma by microcalorimetry coupled with chemometric techniques
    Weijun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    Analyst 137:216-22. 2012
  6. doi request reprint Screening for novel antibacterial agents based on the activities of compounds on metabolism of Escherichia coli: a microcalorimetric study
    Weijun Kong
    China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, PR China
    J Hazard Mater 185:346-52. 2011
  7. doi request reprint Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis
    W J Kong
    PLA Institute of Chinese Materia Medica, Hospital of People s Liberation Army, Beijing 100039, China
    J Appl Microbiol 107:1072-80. 2009
  8. doi request reprint A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract
    Fang Fang
    China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, PR China
    J Ethnopharmacol 137:1492-7. 2011
  9. doi request reprint Spectrum-effect relationships between ultra performance liquid chromatography fingerprints and anti-bacterial activities of Rhizoma coptidis
    Wei Jun Kong
    PLA Institute of Chinese Materia Medica, 302 Hospital of People s Liberation Army, Beijing 100039, PR China
    Anal Chim Acta 634:279-85. 2009
  10. ncbi request reprint [Tissue distribution of free anthraquinones in SD rats after orally administered extracts from raw and prepared rhubarbs]
    Fang Fang
    China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China
    Yao Xue Xue Bao 46:350-4. 2011

Collaborators

Detail Information

Publications22

  1. doi request reprint Multi-component analysis of bile acids in natural Calculus bovis and its substitutes by ultrasound-assisted solid-liquid extraction and UPLC-ELSD
    Wei Jun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China
    Analyst 137:5845-53. 2012
    ..Some substitutes could not be used as the replacers...
  2. doi request reprint Effect of berberine on Escherichia coli, Bacillus subtilis, and their mixtures as determined by isothermal microcalorimetry
    Wei Jun Kong
    China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing, 100039, China
    Appl Microbiol Biotechnol 96:503-10. 2012
    ..69 μg/mL). Berberine might be a good selection of antibacterial agent used in the future. The microcalorimetric method should be strongly suggested in screening novel antibacterial agents for fighting against pathogenic bacteria...
  3. doi request reprint Preliminary screening for extraction techniques and bioactive fraction of Coptidis Rhizoma based on microcalorimetry
    Wei Jun Kong
    Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan
    Pharm Biol 49:362-8. 2011
    ..Extraction techniques may alter the antibacterial activity of Coptidis Rhizoma (C. Rhizoma), which is regarded as characteristic of this herb...
  4. doi request reprint Solid-phase extraction and ultra high-performance liquid chromatography tandem mass spectrometry analysis of the gastrointestinal absorption of emodin in different digestive segments of rats
    Weijun Kong
    China Military Institute of Chinese Materia Medica, Military Hospital of China, Beijing, PR China
    J Sep Sci 34:260-7. 2011
    ..The developed UHPLC-ESI-MS/MS method was appropriate for determining the in vivo absorption of emodin in other herbal medicines or preparations containing this compound...
  5. doi request reprint Evaluation of antibacterial effect and mode of Coptidis rhizoma by microcalorimetry coupled with chemometric techniques
    Weijun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    Analyst 137:216-22. 2012
    ..Our results revealed that the developed microcalorimetry with chemometric techniques had the potential perspective for evaluating the effect and mode of Coptidis rhizoma and other Chinese materia medicas...
  6. doi request reprint Screening for novel antibacterial agents based on the activities of compounds on metabolism of Escherichia coli: a microcalorimetric study
    Weijun Kong
    China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, PR China
    J Hazard Mater 185:346-52. 2011
    ..The microcalorimetric method should be strongly suggested in screening novel antibacterial agents for fighting against multidrug-resistant bacteria...
  7. doi request reprint Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis
    W J Kong
    PLA Institute of Chinese Materia Medica, Hospital of People s Liberation Army, Beijing 100039, China
    J Appl Microbiol 107:1072-80. 2009
    ..Significance and Impact of the Study: This work will provide useful information for the development of chemical biology policy in the use of anti-microbials in food and drug production...
  8. doi request reprint A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract
    Fang Fang
    China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, PR China
    J Ethnopharmacol 137:1492-7. 2011
    ....
  9. doi request reprint Spectrum-effect relationships between ultra performance liquid chromatography fingerprints and anti-bacterial activities of Rhizoma coptidis
    Wei Jun Kong
    PLA Institute of Chinese Materia Medica, 302 Hospital of People s Liberation Army, Beijing 100039, PR China
    Anal Chim Acta 634:279-85. 2009
    ..This work provides a general model of the combination of UPLC and microcalorimetry to study the spectrum-effect relationships of R. coptidis, which can be used to discover principle components of it on bioactivity...
  10. ncbi request reprint [Tissue distribution of free anthraquinones in SD rats after orally administered extracts from raw and prepared rhubarbs]
    Fang Fang
    China Military Institute of Chinese Materia Medica, 302 Military Hospital, Beijing 100039, China
    Yao Xue Xue Bao 46:350-4. 2011
    ..The results were concordant with the traditional Chinese medicine theory of toxicity-attenuating effect of processing...
  11. doi request reprint Toxic effects caused by rhubarb (Rheum palmatum L.) are reversed on immature and aged rats
    Jia bo Wang
    Integrative Medicine Center of 302 Military Hospital, China Military Institute of Chinese Materia Medica, Beijing 100039, PR China
    J Ethnopharmacol 134:216-20. 2011
    ..In this study, an attempt was made to access the safety of rhubarb to both immature and aged rats to provide some references for its clinical usage...
  12. doi request reprint A novel "target constituent knock-out" strategy coupled with TLC, UPLC-ELSD and microcalorimetry for preliminary screening of antibacterial constituents in Calculus bovis
    Wei Jun Kong
    China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 879:3565-73. 2011
    ..bovis, further providing some reference for understanding the pharmacodynamic actions, controlling the quality of Chinese materia medicas (CMMs) and discovering new drugs...
  13. doi request reprint Evaluation of the liver protection and toxicity of Da-Huang-Zhe-Chong pill in rats
    Xiao yan Xing
    China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing, PR China
    Pharm Biol 50:344-50. 2012
    ..Some drugs in this formula have toxicities that might result in some adverse effects of DHZCP...
  14. doi request reprint Investigation of the "dose-time-response" relationships of rhubarb on carbon tetrachloride-induced liver injury in rats
    Xiao yan Xing
    China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, PR China
    J Ethnopharmacol 135:575-81. 2011
    ..The present study investigated the liver protection and toxicity of rhubarb against carbon tetrachloride (CCl4)-induced chronic liver injury in rats...
  15. doi request reprint Investigation on the spectrum-effect relationships of EtOAc extract from Radix Isatidis based on HPLC fingerprints and microcalorimetry
    Wei Jun Kong
    Institute of Chinese Materia Medica, 302 Hospital of People s Liberation Army, Beijing, China
    J Chromatogr B Analyt Technol Biomed Life Sci 871:109-14. 2008
    ....
  16. doi request reprint Applications of microcalorimetry in the antibacterial activity evaluation of various Rhizoma coptidis
    Xue Feng
    China Military Institute of Chinese Materia Medica, Military Hospital of China, Beijing, People s Republic of China
    Pharm Biol 49:348-53. 2011
    ..Various Rhizoma coptidis are commonly used in clinical applications due to their strong antibacterial effect. Objective: The antibacterial effect of various R. coptidis were evaluated by microcalorimetry together with statistical analysis...
  17. doi request reprint The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism
    Yi Qin
    Integrative Medicine Center of 302 Military Hospital, China Military Institute of Chinese Materia Medica, Beijing 100039, PR China
    J Ethnopharmacol 133:1096-102. 2011
    ..The present study investigated the pharmacological effects of different extracts of rhubarb on intestinal function of mice, further to explore possible reasons for the adverse effects of long-term use of rhubarb as a purgative...
  18. doi request reprint Quantitative and chemical fingerprint analysis for quality control of rhizoma Coptidischinensis based on UPLC-PAD combined with chemometrics methods
    Wei Jun Kong
    China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, 100 West, 4th Ring Middle Road, Beijing 100039, PR China
    Phytomedicine 16:950-9. 2009
    ..This study revealed that UPLC-PAD method was simple, sensitive and reliable for quantitative and chemical fingerprint analysis, moreover, for the quality evaluation and control of rhizoma Coptidis...
  19. doi request reprint Action of palmatine on Tetrahymena thermophila BF5 growth investigated by microcalorimetry
    Wei Jun Kong
    PLA Institute of Chinese Materia Medica, 302 Hospital of People s Liberation Army, Beijing, PR China
    J Hazard Mater 168:609-13. 2009
    ..The biomass during T. thermophila BF(5) growth decreased obviously by the addition of palmatine at different concentrations. The investigation of biomass agreed well with the results obtained by means of microcalorimetry...
  20. doi request reprint Analysis of zearalenone and α-zearalenol in 100 foods and medicinal plants determined by HPLC-FLD and positive confirmation by LC-MS-MS
    Wei Jun Kong
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    J Sci Food Agric 93:1584-90. 2013
    ..Samples were extracted with methanol-water (80:20, v/v), and cleaned up by using an immunoaffinity column...
  21. doi request reprint Simultaneous multi-mycotoxin determination in nutmeg by ultrasound-assisted solid-liquid extraction and immunoaffinity column clean-up coupled with liquid chromatography and on-line post-column photochemical derivatization-fluorescence detection
    Wei Jun Kong
    Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, China
    Analyst 138:2729-39. 2013
    ..8% of nutmeg samples at contamination levels of 0.73-16.31 μg kg(-1). At least two different mycotoxins were co-occurred in three samples, and three AFs were simultaneously detected in one sample...
  22. doi request reprint Effect of emodin on Candida albicans growth investigated by microcalorimetry combined with chemometric analysis
    W J Kong
    China Military Institute of Chinese Materia Medica, Military Hospital of China, Beijing, People s Republic of China
    Appl Microbiol Biotechnol 83:1183-90. 2009
    ..This work provided a useful idea of the combination of microcalorimetry and chemometric analysis for investigating the effect of drug and other compounds on microbes...