Ling Yi Kong


Country: China


  1. Liu Q, Wu J, Li F, Cai P, Yang X, Kong L, et al. Synthesis and pharmacological evaluation of multi-functional homoisoflavonoid derivatives as potent inhibitors of monoamine oxidase B and cholinesterase for the treatment of Alzheimer's disease. Medchemcomm. 2017;8:1459-1467 pubmed publisher
    ..These results suggested that compound 16 is a promising multifunctional drug candidate with potential effect for the treatment of Alzheimer's disease. ..
  2. Liao S, Li P, Wang J, Zhang Q, Xu D, Yang M, et al. Protection of baicalin against lipopolysaccharide induced liver and kidney injuries based on 1H NMR metabolomic profiling. Toxicol Res (Camb). 2016;5:1148-1159 pubmed publisher
    ..This integrated 1H NMR based metabolomics approach gave us a new insight into the pathology of LPS induced sepsis, and helped in understanding the therapeutic effects of baicalin in a holistic view. ..
  3. Zhao Y, Wang N, Sui Z, Huang C, Zeng Z, Kong L. The Molecular and Structural Basis of O-methylation Reaction in Coumarin Biosynthesis in Peucedanum praeruptorum Dunn. Int J Mol Sci. 2019;20: pubmed publisher
    ..Moreover, the evolutionary relationship between BMT and COMT-S was clarified to facilitate understanding of evolutionary events in the Apiaceae family. ..
  4. Wang W, Zhu D, Luo J, Liu F, Chen C, Zhu T, et al. Taiwanoids A-D, four dimeric diterpenoids featuring tetracyclic [7. 75, 9. 4. 05, 10. 08, 9] octodecane from Taiwania cryptomerioidesim. Org Biomol Chem. 2018;16:9059-9063 pubmed publisher
    ..A possible biosynthetic pathway for compounds 1-4 was proposed. Compounds 2 and 3 exerted a 5.37 and 6.26-fold potentiation effect on bortezmib (BTZ) susceptibility at a tested concentration of 20 μM, respectively. ..
  5. Liu Y, Ao Z, Xu Q, Zhu D, Chen C, Wang X, et al. Hyperpatulols A-I, spirocyclic acylphloroglucinol derivatives with anti-migration activities from the flowers of Hypericum patulum. Bioorg Chem. 2019;87:409-416 pubmed publisher
    ..Further pharmacological studies revealed that 4 could regulate the expression of the proteins Vimentin and E-cadherin. ..
  6. Zhang P, Cui Z, Li Y, Heng L, Wei S, Wang X, et al. Ciliatasecones A-C, three rearranged limonoids from Toona ciliata var. yunnanensis. Org Biomol Chem. 2019;17:555-560 pubmed publisher
    ..Plausible biogenetic pathway speculation indicated that C-9/11 cleavage and oxygen bridge formation played the key roles in the framework rearrangement of 1-3. ..
  7. Xu Q, Chen X, Xu J, Wang S, Luo J, Kong L. Acetophenone derivatives from the roots of Melicope ptelefolia. Fitoterapia. 2019;132:40-45 pubmed publisher
    ..Compouds 2a/2b, 4a/4b and 5 exhibit protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values of 34.4, 55.2 and 66.6 μM, respectively. ..
  8. Tang Y, Shi C, Yang H, Cai P, Liu Q, Yang X, et al. Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease. Eur J Med Chem. 2019;163:307-319 pubmed publisher
    ..In general, 3 and 7 can be considered candidates for potential treatment of AD. ..
  9. Xue G, Zhu D, Han C, Wang X, Luo J, Kong L. Artemisianins A-D, new stereoisomers of seco-guaianolide involved heterodimeric [4+2] adducts from Artemisia argyi induce apoptosis via enhancement of endoplasmic reticulum stress. Bioorg Chem. 2019;84:295-301 pubmed publisher

More Information

Publications104 found, 100 shown here

  1. Xu X, Peng W, Liu C, Li S, Lei J, Wang Z, et al. Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro. Bioorg Med Chem. 2019;27:370-374 pubmed publisher
    ..These findings suggest that natural LSD1 inhibitors, and particularly isoquercitrin, are promising for cancer treatment. ..
  2. Xin X, Chen Y, Zhang H, Li Y, Yang M, Kong L. Cytotoxic seco-cytochalasins from an endophytic Aspergillus sp. harbored in Pinellia ternata tubers. Fitoterapia. 2019;132:53-59 pubmed publisher
    ..8 to 70.2 μM. At the concentration of 16 μM, compound 4 also exerted a 3-fold enhancement of doxorubicin susceptibility on doxorubicin-resistant human breast cancer (MCF-7/DOX) cell line. ..
  3. Sui Z, Luo J, Yao R, Huang C, Zhao Y, Kong L. Functional characterization and correlation analysis of phenylalanine ammonia-lyase (PAL) in coumarin biosynthesis from Peucedanum praeruptorum Dunn. Phytochemistry. 2019;158:35-45 pubmed publisher
    ..Altogether these results highlight the importance of PpPAL in abiotically induced coumarin biosynthesis and provide further insights regarding the structure-function relationships of this protein. ..
  4. Liu F, Wang Z, Zhu T, Wang W, Nie B, Li J, et al. Real-time monitoring of γ-Glutamyltranspeptidase in living cells and in vivo by near-infrared fluorescent probe with large Stokes shift. Talanta. 2019;191:126-132 pubmed publisher
    ..These results indicated that the probe held great promise for real-time sensing and tracking GGT in complex biological systems, which would be useful for basic researches and clinical diagnosis of GGT-related diseases. ..
  5. Zhang Y, Wang S, Luo J, Lin Y, Xu X, Han C, et al. Preparative enantioseparation of synephrine by conventional and pH-zone-refining counter-current chromatography. J Chromatogr A. 2018;1575:122-127 pubmed publisher
    ..The pH-zone-refining CCC was identified as the most efficient enantioseparation technique for synephrine and can be applied for the preparative enantioseparation of other β-amino alcohols. ..
  6. Lu Z, Wang J, Li M, Liu Q, Wei D, Yang M, et al. (1)H NMR-based metabolomics study on a goldfish model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chem Biol Interact. 2014;223:18-26 pubmed publisher
    ..This study also demonstrated the applicability and potential of (1)H NMR-based metabolomics approach for evaluation of animal models of disease induced by chemicals, such as MPTP-induced PD goldfish. ..
  7. Wang S, Zhu D, Nie B, Li J, Zhang Y, Kong L, et al. Cytotoxic withanolides from the aerial parts of Tubocapsicum anomalum. Bioorg Chem. 2018;81:396-404 pubmed publisher
    ..All isolates were evaluated for their cytotoxicity against four human tumor cell lines (HCT-116, HepG2, MCF-7 and A375). Among them, compounds 1-3, 6-8, 14, 16-18 showed cytotoxic activity with IC50 values of 0.24-8.71 μM. ..
  8. Ma K, Wang J, Luo J, Kong L. Six new alkaloids from Melodinus henryi. Fitoterapia. 2015;100:133-8 pubmed publisher
    ..To the best of our knowledge, this is the first report on the determination of the absolute configuration of eburnan-vindolinine-type bisindole alkaloid using this method. ..
  9. Li L, Zhou M, Xue G, Wang W, Zhou X, Wang X, et al. Bioactive seco-abietane rearranged diterpenoids from the aerial parts of Salvia prionitis. Bioorg Chem. 2018;81:454-460 pubmed publisher
    ..7 cells were evaluated. Interestingly, compounds 4 and 9 with a furan-ring showed potent inhibitory activity with IC50 values of 14.56 and 15.11 μM, respectively. ..
  10. Zhang Y, Luo J, Han C, Xu J, Kong L. Bioassay-guided preparative separation of angiotensin-converting enzyme inhibitory C-flavone glycosides from Desmodium styracifolium by recycling complexation high-speed counter-current chromatography. J Pharm Biomed Anal. 2015;102:276-81 pubmed publisher
    ..62 and 58.37 μM. The results demonstrated that the established method was proposed as an excellent strategy to systematically screen and purify active compounds from traditional Chinese medicines. ..
  11. Zhang H, Zhang Y, Chen C, Zhu X, Zhang C, Xia Y, et al. A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer. Cancer Lett. 2018;437:67-78 pubmed publisher
    ..Our results identify DDX21 as a breast cancer metastasis suppressor; blocking miR-218-5p will stabilize DDX21 and epigenetically suppress Snail expression and EMT. ..
  12. Geng Y, Yang L, Zhang C, Kong L. Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells. Food Chem Toxicol. 2014;73:7-16 pubmed publisher
    ..In summary, these results indicate that Icariside II inhibits the proliferation of osteosarcoma cells in vitro and in vivo via EGFR/mTOR signaling pathway. ..
  13. Shan S, Zhang P, Luo J, Kong L. Two new phenolic glycosides isolated from Ginkgo seeds. Chin J Nat Med. 2018;16:505-508 pubmed publisher
    ..Their structures were elucidated by spectroscopic methods (1D and 2D NMR, HR-ESI-MS, and CD), and the comparisons of spectroscopic data with the reported values in the literature. ..
  14. Cai P, Fang S, Yang H, Yang X, Liu Q, Kong L, et al. Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties. Eur J Med Chem. 2018;157:161-176 pubmed publisher
    ..Taken together, those outstanding results highlight the donepezil-BHT hybrid 7d as a promising prototype in the research of innovative compound for AD. ..
  15. Cao X, Wang J, Wang P, Kong L. Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity. Chin J Nat Med. 2014;12:628-31 pubmed publisher
    ..Compound 1 was a new triterpene. Compounds 5 - 7 exhibited potent inhibitory effects on the growth of MCF-7 and HT-29 cells, and the others showed no cytotoxicity. ..
  16. Jiang N, Li S, Xie S, Li Z, Wang K, Wang X, et al. Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease. Eur J Med Chem. 2014;87:540-51 pubmed publisher
    ..Taken together, these results suggest that compound 2 might be a promising lead compound for AD treatment. ..
  17. Wang P, Luo J, Wang X, Fan B, Kong L. New indole glucosides as biosynthetic intermediates of camptothecin from the fruits of Camptotheca acuminata. Fitoterapia. 2015;103:1-8 pubmed publisher
    ..The new compounds 1-6 were screened for their in vitro cytotoxicity but they did not show any exciting result. ..
  18. Li P, Wei D, Wang J, Yang M, Kong L. (1)H NMR metabolomics to study the effects of diazepam on anisatin induced convulsive seizures. J Pharm Biomed Anal. 2016;117:184-94 pubmed publisher
    ..This study should be helpful for our understanding of convulsive seizures, and provide a holistic view of the treatment effects of benzodiazepine on convulsive seizures. ..
  19. Wan C, Luo J, Ren X, Kong L. Interconverting flavonostilbenes with antibacterial activity from Sophora alopecuroides. Phytochemistry. 2015;116:290-297 pubmed publisher
    ..Bioassay results suggested that flavonostilbenes exhibit significant antibacterial and anti-biofilm formation activities against Staphylococcus epidermidis with MIC values ranging from 3.1 to 12.5μg/mL. ..
  20. Xia Y, Ni K, Guo C, Zhang C, Geng Y, Wang Z, et al. Alopecurone B reverses doxorubicin-resistant human osteosarcoma cell line by inhibiting P-glycoprotein and NF-kappa B signaling. Phytomedicine. 2015;22:344-51 pubmed publisher
    ..These studies not only demonstrate that ALOB is a potential agent for reversal of drug resistant cancers, but also testify that ALOB reverses multidrug resistance by inhibiting P-glycoprotein via NF-κB signaling. ..
  21. Han C, Wang S, Li Z, Chen C, Hou J, Xu D, et al. Bioactivity-guided cut countercurrent chromatography for isolation of lysine-specific demethylase 1 inhibitors from Scutellaria baicalensis Georgi. Anal Chim Acta. 2018;1016:59-68 pubmed publisher
    ..By using our bioactivity-guided cut CCC strategy, we successfully isolated six natural LSD1 inhibitors from S. baicalensis Georgi, five of which were identified for the first time as natural LSD1 inhibitors. ..
  22. An F, Sun D, Wang R, Yang M, Luo J, Kong L. Trijugin- and mexicanolide-type limonoids from the fruits of Heynea trijuga that reverse multidrug resistance in MCF-7/DOX cells. Phytochemistry. 2018;151:42-49 pubmed publisher
    ..45, 10.86, and 14.96??M, respectively. ..
  23. Li J, Wang X, Luo J, Kong L. Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods. J Chromatogr Sci. 2015;53:1131-9 pubmed publisher
    ..The collecting time of R. coptidis impacted the plant's alkaloid contents and its anti-inflammatory activity. ..
  24. Xie S, Lan J, Wang X, Jiang N, Dong G, Li Z, et al. Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. Eur J Med Chem. 2015;93:42-50 pubmed publisher
    ..In addition, it showed neuroprotective effect and good ability to penetrate the BBB. Overall, all these results highlighted 6d a promising multifunctional agent for AD treatment. ..
  25. Liu X, Yang M, Wang X, Xie S, Li Z, Kim D, et al. Lignans from the root of Paeonia lactiflora and their anti-β-amyloid aggregation activities. Fitoterapia. 2015;103:136-42 pubmed publisher
    ..1% at 20 μM). In addition, despite large amount of chemical studies performed on genus Paeonia, the lignans were reported for the first time. ..
  26. Yang J, Luo J, Kong L. Determination of α-glucosidase inhibitors from Scutellaria baicalensis using liquid chromatography with quadrupole time of flight tandem mass spectrometry coupled with centrifugal ultrafiltration. Chin J Nat Med. 2015;13:208-14 pubmed publisher
    ..In conclusion, our results indicated that the developed method is a rapid and effective screening method for rat intestinal α-glucosidase inhibitors from complex herbal medicines such as SBG. ..
  27. Geng Y, Zhang C, Shi Y, Xia Y, Guo C, Yang L, et al. Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma. Cancer Lett. 2015;366:19-31 pubmed publisher
    ..In conclusion, these data suggest that IS plays multiple roles as a promising chemotherapeutic agent that induces cell apoptosis involving both mitochondrial and lysosomal damage. ..
  28. Shen C, Luo J, Yang M, Kong L. Anticoagulant flavonoid oligomers from the rhizomes of Alpinia platychilus. Fitoterapia. 2015;106:153-7 pubmed publisher
    ..The anticoagulant assay showed that 2a, 2b and 3 exhibited potent activities to prolong the prothrombin times (PT) and the thrombin times (TT). ..
  29. Chen C, Zhu D, Zhang H, Han C, Xue G, Zhu T, et al. YAP-dependent ubiquitination and degradation of ?-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer. Cell Death Dis. 2018;9:591 pubmed publisher
  30. Wang Y, Yang M, Wang X, Li T, Kong L. Bioactive metabolites from the endophytic fungus Alternaria alternata. Fitoterapia. 2014;99:153-8 pubmed publisher
    ..Compound 4 showed mild cytotoxic activity against human osteosarcoma cells U2OS with IC₅₀ of 28.3 μM. ..
  31. Lan J, Xie S, Li S, Pan L, Wang X, Kong L. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease. Bioorg Med Chem. 2014;22:6089-104 pubmed publisher
    ..In addition, 11 l could chelate metal ions, reduce PC12 cells death induced by oxidative stress and penetrate the blood-brain barrier (BBB). These results suggested that 11 l might be an excellent multifunctional agent for AD treatment. ..
  32. Dong G, Wang J, Guo P, Wei D, Yang M, Kong L. Toxicity assessment of Arisaematis Rhizoma in rats by a (1)H NMR-based metabolomics approach. Mol Biosyst. 2015;11:407-17 pubmed publisher
    ..The metabolomics approach provided a promising tool for the study and better understanding of TCM-induced toxicity dynamically and holistically. ..
  33. Yeon J, Cheng L, He Q, Kong L. A lignin glycoside and a nortriterpenoid from Kadsura coccinea. Chin J Nat Med. 2014;12:782-5 pubmed publisher
    ..Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages. ..
  34. Pan K, Xia X, Guo W, Kong L. Suppressive effects of total alkaloids of Lycopodiastrum casuarinoides on adjuvant-induced arthritis in rats. J Ethnopharmacol. 2015;159:17-22 pubmed publisher
    ..These results indicated that ALC prevented the pathological development of AA in rats. ALC may be a potential candidate for the treatment of inflammation and arthritis. ..
  35. Huang M, Xie S, Jiang N, Lan J, Kong L, Wang X. Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease. Bioorg Med Chem Lett. 2015;25:508-13 pubmed publisher
    ..Taken together, these results suggested that compound 13 might be a promising multifunctional agent for AD treatment. ..
  36. Xie S, Wang X, Jiang N, Yu W, Wang K, Lan J, et al. Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. Eur J Med Chem. 2015;95:153-65 pubmed publisher
    ..Moreover, 14c could penetrate the CNS and show low cell toxicity. Overall, these results suggested that 14c might be an excellent multi-target agent for AD treatment. ..
  37. Luo J, Zhang H, Quasie O, Shan S, Zhang Y, Kong L. Further C-15-acyl phragmalin derivatives from Chukrasia tabularis A. Juss. Phytochemistry. 2015;117:410-6 pubmed publisher
    ..Additionally, all of the isolates were tested for inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages and cytotoxicity in SMMC-7721, MCF-7 and U2OS tumor cells. ..
  38. Li Q, Luo J, Zhang Y, Li Z, Wang X, Yang M, et al. Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons from Stahlianthus involucratus. Chemistry. 2015;21:13206-9 pubmed publisher
    ..4]nonane core observed for the first time in natural products, and 3 is a novel 3',4'-seco-cadinane-dimer. Compounds 1 and 2 exhibited potent cytotoxic activities, and 3 showed notable anti-inflammatory effect. ..
  39. Zhou M, Zhang W, Li R, Guo C, Wei S, Tian X, et al. Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-?B, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells. Phytomedicine. 2018;42:152-163 pubmed publisher
  40. Lin H, Zhang C, Zhang H, Xia Y, Zhang C, Luo J, et al. Physakengose G induces apoptosis via EGFR/mTOR signaling and inhibits autophagic flux in human osteosarcoma cells. Phytomedicine. 2018;42:190-198 pubmed publisher
    ..Moreover, PG induces apoptosis through the mitochondrial pathway and impedes autophagic flux via lysosome dysfunction. Our findings indicate that PG has the potential to play a significant role in the treatment of osteosarcoma. ..
  41. Han C, Zhang C, Ma T, Zhang C, Luo J, Xu X, et al. Hypericin-functionalized graphene oxide for enhanced mitochondria-targeting and synergistic anticancer effect. Acta Biomater. 2018;77:268-281 pubmed publisher
    ..Furthermore, treatment with hypericin/doxorubicin-functionalized graphene oxide had low cellular toxicity. ..
  42. Han C, Luo J, Xu J, Zhang Y, Zhao Y, Xu X, et al. Enantioseparation of aromatic α-hydroxycarboxylic acids: the application of a dinuclear Cu₂(II)-β-cyclodextrin complex as a chiral selector in high speed counter-current chromatography compared with native β-cyclodextrin. J Chromatogr A. 2015;1375:82-91 pubmed publisher
    ..Five of other aromatic α-hydroxycarboxylic acids were also enantioseparated successfully by HSCCC using Cu2-β-CyD as a CS. ..
  43. Yang X, Cai P, Liu Q, Wu J, Yin Y, Wang X, et al. Novel 8-hydroxyquinoline derivatives targeting β-amyloid aggregation, metal chelation and oxidative stress against Alzheimer's disease. Bioorg Med Chem. 2018;26:3191-3201 pubmed publisher
    ..Our findings provide a rationale for the potential application of compound 5b as a lead compound in AD therapy. ..
  44. Zhang Y, Luo J, Wan C, Zhou Z, Kong L. Four New Flavonoids with α-Glucosidase Inhibitory Activities from Morus alba var. tatarica. Chem Biodivers. 2015;12:1768-76 pubmed publisher
    ..All isolates were tested for inhibitory activities against α-glucosidase. Compounds 4, 7, and 8 exhibited a significant degree of inhibition with IC50 values of 5.0 ± 0.3, 7.5 ± 0.5, and 5.9 ± 0.2 μM, respectively. ..
  45. Shi Y, Yang L, Geng Y, Zhang C, Kong L. Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells. Phytomedicine. 2015;22:1139-49 pubmed publisher
    ..Moreover, the combination therapy of CQ and PPI is an effective and promising candidate to be further developed as therapeutic agents in the treatment of liver cancer. ..
  46. An F, Sun D, Wang X, Yang L, Yin Y, Luo J, et al. Trichiconlides CF, four new limonoids with 1,2-seco phragmalin-type carbon skeleton from the fruits of Trichilia connaroides. Fitoterapia. 2018;125:72-77 pubmed publisher
    ..Compounds 5-6 showed moderate inhibitory effects on Hela tumor cell lines with inhibition ratio values of 83.8% and 87.1% at concentration 40?M, respectively. ..
  47. Liu Y, Yang M, Wang X, Li T, Kong L. Caryophyllene sesquiterpenoids from the endophytic fungus, Pestalotiopsis sp. Fitoterapia. 2016;109:119-24 pubmed publisher
    ..Among all the isolates, compound 2 displayed potent inhibitory activity with IC50 value of 19.0 μM during the evaluation of nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells. ..
  48. Shang Z, Yang M, Jian K, Wang X, Kong L. (1) H NMR-Guided Isolation of Formyl-Phloroglucinol Meroterpenoids from the Leaves of Eucalyptus robusta. Chemistry. 2016;22:11778-84 pubmed publisher
    ..Compound 3 significantly blocks cell proliferation in MCF-7 cells and induces MCF-7 cell death through apoptosis. ..
  49. Wang Z, Cai P, Liu Q, Xu D, Yang X, Wu J, et al. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2016;123:282-297 pubmed publisher
    ..Furthermore, the step-through passive avoidance test showed 5c significantly reversed scopolamine-induced memory deficit and no hepatotoxicity in mice. These results indicated that 5c might be a promising drug candidate for AD therapy. ..
  50. Wu L, Wang X, Li R, Zhang Y, Yang M, Luo J, et al. Callistiviminenes A-O: Diverse adducts of ?-triketone and sesqui- or monoterpene from the fruits of Callistemon viminalis. Phytochemistry. 2016;131:140-149 pubmed publisher
    ..Callistiviminenes C and D exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 value of 20.3 ?M and 32.5 ?M, respectively. ..
  51. Zhang C, Luo J, Liu R, Lin R, Yang M, Kong L. 1H NMR spectroscopy-guided isolation of new sucrose esters from Physalis alkekengi var. franchetii and their antibacterial activity. Fitoterapia. 2016;114:138-143 pubmed publisher
    ..5 to 14.9?g/mL. These findings may indicate that the P. alkekengi var. franchetii has potential application as an ingredient in pharmaceuticals. ..
  52. Zhang W, Ma T, Li S, Yang Y, Guo J, Yu W, et al. Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules. Eur J Med Chem. 2017;125:538-550 pubmed publisher
    ..Furthermore, 15in vivo induced significant antitumor responses, and exhibited less toxicity than Doxorubicin. Together, this study described a class of new STAT3 inhibitors as antitumor agents. ..
  53. Wang S, Han C, Wang S, Bai L, Li S, Luo J, et al. Development of a high speed counter-current chromatography system with Cu(II)-chiral ionic liquid complexes and hydroxypropyl-?-cyclodextrin as dual chiral selectors for enantioseparation of naringenin. J Chromatogr A. 2016;1471:155-163 pubmed publisher
  54. Wang Z, Li X, Chen M, Liu F, Han C, Kong L, et al. A strategy for screening of ?-glucosidase inhibitors from Morus alba root bark based on the ligand fishing combined with high-performance liquid chromatography mass spectrometer and molecular docking. Talanta. 2018;180:337-345 pubmed publisher
    ..The results suggest that established method will be applied to a wide range of target protein to screen potential bioactive constituents from herbal medicines. ..
  55. Lv H, Luo J, Zhu M, Zhao H, Kong L. neo-Clerodane diterpenoids from the aerial parts of Teucrium fruticans cultivated in China. Phytochemistry. 2015;119:26-31 pubmed publisher
    ..7 macrophages. None of the compounds displayed cytotoxic activities on the cancer cell lines, and only 15 showed weak NO inhibitory activity. ..
  56. Yaermaimaiti S, Wang P, Luo J, Li R, Kong L. Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects. Fitoterapia. 2016;111:7-11 pubmed publisher
    ..Compounds 1-5 were investigated for their inhibitory effects on NO production in LPS-induced macrophages and 1 showed moderate bioactivity. ..
  57. Lin R, Guan Y, Li R, Xu X, Luo J, Kong L. 13,14-seco-Withanolides from Physalis minima with Potential Anti-inflammatory Activity. Chem Biodivers. 2016;13:884-90 pubmed publisher
    ..7 macrophages. Compounds 2, 3, 5, and 6 showed inhibitory activities, especially for compound 5 with IC50 value of 3.87 ?m. ..
  58. Guo C, Yang L, Luo J, Zhang C, Xia Y, Ma T, et al. Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways. Int Immunopharmacol. 2016;38:349-56 pubmed publisher
    ..Taken together, SG may act as a natural agent to treat some inflammatory diseases by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways. ..
  59. Yang M, Li T, Wang Y, Liu R, Luo J, Kong L. Antimicrobial metabolites from the plant endophytic fungus Penicillium sp. Fitoterapia. 2017;116:72-76 pubmed publisher
    ..Helvolic acid (7) showed potent inhibitory effects against Staphylococcus aureus and Pseudomonas aeruginosa with MIC (minimum inhibitory concentration) values of 5.8 and 4.6?g/mL, respectively. ..
  60. Li R, Gao C, Guo C, Zhou M, Luo J, Kong L. The Anti-inflammatory Activities of Two Major Withanolides from Physalis minima Via Acting on NF-?B, STAT3, and HO-1 in LPS-Stimulated RAW264.7 Cells. Inflammation. 2017;40:401-413 pubmed publisher
    ..minima and suggest that WA and WC can be attractive therapeutic candidates for various inflammatory diseases. ..
  61. Xie S, Lan J, Wang X, Wang Z, Jiang N, Li F, et al. Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease. Bioorg Med Chem. 2016;24:1528-39 pubmed publisher
    ..In addition, 5m showed good ability to cross the BBB and had no toxicity on SH-SY5Y neuroblastoma cells. Collectively, all these results suggested that 5m might be a promising multi-target lead candidate worthy of further pursuit. ..
  62. Xue G, Xia Y, Wang Z, Li L, Luo J, Kong L. neo-Clerodane diterpenoids from Scutellaria barbata mediated inhibition of P-glycoprotein in MCF-7/ADR cells. Eur J Med Chem. 2016;121:238-249 pubmed publisher
    ..In the present study, the structure-activity relationships of neo-clerodane diterpenoids were also discussed. ..
  63. Li S, Zhang W, Yang Y, Ma T, Guo J, Wang S, et al. Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein. Eur J Med Chem. 2016;124:1006-1018 pubmed publisher
    ..In addition, compound 7d orally and significantly suppressed breast cancer 4T1 xenograft tumor growth in vivo, indicating its great potential as an efficacious drug candidate for human cancer therapy. ..
  64. Han C, Li Z, Hou J, Wang Z, Xu D, Xue G, et al. Bioactivity evaluation of natural product α-mangostin as a novel xanthone-based lysine-specific demethylase 1 inhibitor to against tumor metastasis. Bioorg Chem. 2018;76:415-419 pubmed publisher
    ..These findings provides new molecular skeleton for LSD1 inhibitor study and should encourage further modification of α-mangostin to produce more potent LSD1 inhibitors with potential anticancer activity. ..
  65. Zhang Y, Chen C, Zhang Y, Kong L, Luo J. Target discovery of cytotoxic withanolides from Physalis angulata var. villosa via reactivity-based screening. J Pharm Biomed Anal. 2018;151:194-199 pubmed publisher
    ..57-6.29??M. The results suggested that RBS was efficient and accurate for rapid identification of cytotoxic withanolides and could guide isolation of target components from the complex medicinal plant extract. ..
  66. Hu Y, Li Y, Qiu L, Li J, Heng L, Wei S, et al. New triterpenoids with diverse side-chains from the barks of Melia Toosendan. Fitoterapia. 2018;127:62-68 pubmed publisher
    ..7 macrophages, meanwhile, compounds 1 and 4 showed moderate cytotoxicities against U2OS human cancer cell line. ..
  67. Wang Z, Wang R, Xia Y, Kong L, Yang L. Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells. Chin J Nat Med. 2018;16:20-28 pubmed publisher
    ..Taken together, these results indicated that ICT may be a potential candidate in chemotherapy for osteosarcoma. ..
  68. Li X, Jia Y, Wang J, Yang M, Wang K, Kong L. H nuclear magnetic resonance-based metabolomics reveals sex-specific metabolic changes of gastrodin intervention in rats. Asian Pac J Trop Med. 2014;7:811-8 pubmed publisher
    ..This research shows the sex-specific metabolic response to GAS intervention, weather GAS is a healthy dietary supplement for the male merits further investigation. ..
  69. An F, Luo J, Wang X, Yang M, Kong L. Trichiconlides A and B: two novel limonoids from the fruits of Trichilia connaroides. Org Biomol Chem. 2016;14:1231-5 pubmed publisher
    ..1 showed a moderate inhibitory effect on nitric oxide (NO) production. ..
  70. Guo C, Yang L, Wan C, Xia Y, Zhang C, Chen M, et al. Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways. Phytomedicine. 2016;23:1629-1637 pubmed publisher
    ..SG was able to inhibit the neuroinflammation by MAPKs, PI3K/AKT, JAK/STAT and Nrf2/HO-1 signaling pathways and might act as a natural therapeutic agent to be further developed for the treatment of various neuroinflammatory conditions. ..
  71. Shan S, Luo J, Pan K, Zou H, Kong L. Rapid screening and identification of lycodine-type alkaloids in Lycopodiaceae and Huperziaceae plants by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Biomed Chromatogr. 2016;30:1861-1872 pubmed publisher
    ..Copyright © 2016 John Wiley & Sons, Ltd. ..
  72. Wang J, Wang Z, Li X, Li F, Wu J, Kong L, et al. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. Bioorg Med Chem. 2016;24:4324-4338 pubmed publisher
  73. Niu X, Luo J, Xu D, Zou H, Kong L. Hydrogen/deuterium exchange, a unique and effective method for MS fragmentation behavior elucidation of ginkgolides and its application to systematic research in Ginkgo biloba. J Pharm Biomed Anal. 2017;134:181-186 pubmed publisher
    ..biloba (60.6?g/g). This research was the successful application of H/D exchange in natural products, and proved that H/D exchange is a potential method for analysis research of complex TCMs active constituents. ..
  74. Zhang Y, An F, Huang S, Yang L, Gu Y, Luo J, et al. Diverse tritepenoids from the fruits of Walsura robusta and their reversal of multidrug resistance phenotype in human breast cancer cells. Phytochemistry. 2017;136:108-118 pubmed publisher
    ..Walsurin A showed significant effect in sensitization of these resistant cancer cells at non-toxic concentration to doxorubicin with the modulation factor of 62.76. ..
  75. Jian K, Zhang C, Shang Z, Yang L, Kong L. Eucalrobusone C suppresses cell proliferation and induces ROS-dependent mitochondrial apoptosis via the p38 MAPK pathway in hepatocellular carcinoma cells. Phytomedicine. 2017;25:71-82 pubmed publisher
    ..Our findings indicate that EC induces mitochondrial-dependent apoptosis in HCC cells through ROS generation and p38 MAPK activation, making EC a promising candidate for further development as an anticancer agent for HCC cells. ..
  76. Xu D, Lv Y, Wang J, Yang M, Kong L. Deciphering the mechanism of Huang-Lian-Jie-Du-Decoction on the treatment of sepsis by formula decomposition and metabolomics: Enhancement of cholinergic pathways and inhibition of HMGB-1/TLR4/NF-?B signaling. Pharmacol Res. 2017;121:94-113 pubmed publisher
    ..Most of all, metabolites changed specifically between groups of HLJDD and its four variants were related with the exceptional treatment effects of HLJDD. ..
  77. Gombodorj S, Yang M, Shang Z, Liu R, Li T, Yin G, et al. New phenalenone derivatives from Pinellia ternata tubers derived Aspergillus sp. Fitoterapia. 2017;120:72-78 pubmed publisher
    ..In addition, compound 10 exhibited significant antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis with MIC50 values of 1.87, 2.77, and 4.80?g/mL, respectively. ..
  78. Lv Y, Wang J, Xu D, Liao S, Li P, Zhang Q, et al. Comparative study of single/combination use of Huang-Lian-Jie-Du decoction and berberine on their protection on sepsis induced acute liver injury by NMR metabolic profiling. J Pharm Biomed Anal. 2017;145:794-804 pubmed publisher
    ..These findings highlighted the feasibility of the integrated NMR based metabolomics approach to understand the pathogenesis of diseases, the action mechanisms of therapy and the herb-drug interaction. ..
  79. Luo J, Xia Y, Luo J, Li J, Zhang C, Zhang H, et al. GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma. Cancer Lett. 2017;410:112-123 pubmed publisher
    ..Overall, inhibiting GRP78 to strengthen the molecular mechanism of ATF4 via stabilizing CHOP protein may provide a potential vulnerability in OS. ..
  80. Li X, Li Y, Luo J, Zhou Z, Xue G, Kong L. New phloroglucinol derivatives from the whole plant of Hypericum uralum. Fitoterapia. 2017;123:59-64 pubmed publisher
    ..Their capability to reversal the multidrug resistance in doxorubicin-induced resistant MCF-7/DOX sublines showed that compounds 1, 5, 6, 7 exerted a potential effect of doxorubicin susceptibility. ..
  81. Han C, Wang W, Xue G, Xu D, Zhu T, Wang S, et al. Metal ion-improved complexation countercurrent chromatography for enantioseparation of dihydroflavone enantiomers. J Chromatogr A. 2018;1532:1-9 pubmed publisher
    ..This Cu(II) ion-improved complexation HSCCC system exhibited improved performance for chiral separation, and therefore it has great application potential in the preparative enantioseparation of other compounds with similar skeletons. ..
  82. Li M, Wang J, Lu Z, Wei D, Yang M, Kong L. NMR-based metabolomics approach to study the toxicity of lambda-cyhalothrin to goldfish (Carassius auratus). Aquat Toxicol. 2014;146:82-92 pubmed publisher
  83. Shen C, Luo J, Yang M, Kong L. Sesquiterpene dimers from the roots of Chloranthus holostegius with moderate anti-inflammatory activity. Phytochemistry. 2017;137:117-122 pubmed publisher
    ..All isolates were tested for inhibitory effects on the NO production of the liposaccharide (LPS)-induced RAW 264.7 macrophages, and showed moderate activity with IC50 values at 3.5-35.4 ?M. ..
  84. Ma T, Wang Z, Zhang Y, Luo J, Kong L. Bioassay-Guided Isolation of Anti-Inflammatory Components from the Bulbs of Lilium brownii var. viridulum and Identifying the Underlying Mechanism through Acting on the NF-κB/MAPKs Pathway. Molecules. 2017;22: pubmed publisher
    ..Our findings also advanced the understanding of LB as a traditional herbal medicine for the prevention and treatment of inflammation. ..
  85. Li F, Wu J, Wang J, Yang X, Cai P, Liu Q, et al. Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease. Bioorg Med Chem. 2017;25:3815-3826 pubmed publisher
    ..62). In addition, s19 could reduce PC12 cells death induced by oxidative stress and penetrate the blood-brain barrier (BBB). Taken together, these results suggested that s19 might be a promising multitargeted compound for AD treatment. ..
  86. Ma T, Zhang Y, Zhang C, Luo J, Kong L. Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells. Biochem Pharmacol. 2017;143:90-106 pubmed publisher
    ..Taken together, these results indicate that downregulation of TIGAR increased PB-induced apoptosis and autophagosomes associated cell death through promoting ROS generation in MDA-MB-231 and MCF-7 cells. ..
  87. Wang J, Cai P, Yang X, Li F, Wu J, Kong L, et al. Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. Eur J Med Chem. 2017;139:68-83 pubmed publisher
    ..Overall, all of these outstanding in vitro results in combination with promising in vivo outcomes highlighted derivative 7f as the lead structure worthy of further investigation. ..
  88. Quasie O, Li H, Luo J, Kong L. Two new phragmalin-type limonoids orthoesters from Entandrophragma candollei. Chin J Nat Med. 2017;15:680-683 pubmed publisher
    ..Compound 1 was a rare C-15 enolic acyl phragmalin-type limonoid orthoester. Compounds 1 and 2 exhibited weak inhibitory effects on NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells. ..
  89. Wang Z, Wu J, Yang X, Cai P, Liu Q, Wang K, et al. Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson's disease. Bioorg Med Chem. 2016;24:5929-5940 pubmed publisher
    ..The results indicated that 13 is an effective and promising candidate to be further developed as disease-modifying drug for Parkinson's disease therapy. ..
  90. Wang X, Yang C, Luo J, Zhang C, Luo J, Yang M, et al. Experimental and theoretical calculation studies on the structure elucidation and absolute configuration of calyxins from Alpinia katsumadai. Fitoterapia. 2017;119:121-129 pubmed publisher
    ..The antiproliferative activity of the six compounds against NCI-H460, HeLa, SMMC-7721 and HCT-116 cell lines was also reported, and most of them showed moderate to strong activities. ..
  91. Yang H, Cai P, Liu Q, Yang X, Li F, Wang J, et al. Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-? aggregation for the treatment of Alzheimer's disease. Eur J Med Chem. 2017;138:715-728 pubmed publisher
    ..Collectively, these findings demonstrate that compound 4x was an effective and promising candidate for AD therapy. ..
  92. Zhang C, Luo J, Liu R, Lin R, Yang M, Kong L. Physakengoses K-Q, seven new sucrose esters from Physalis alkekengi var. franchetii. Carbohydr Res. 2017;449:120-124 pubmed publisher
    ..Among the isolated sucrose esters, compounds 1-5 showed potent antibacterial activity with MIC values ranging from 2.16 to 12.76 μg/mL. ..