Research Topics
| Qi JinSummaryCountry: China Publications
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Publications
The use of global transcriptional analysis to reveal the biological and cellular events involved in distinct development phases of Trichophyton rubrum conidial germinationTao Liu
State Key Lab for Molecular Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China
BMC Genomics 8:100. 2007..Conidia are considered to be the primary cause of infections by Trichophyton rubrum...- Recent dermatophyte divergence revealed by comparative and phylogenetic analysis of mitochondrial genomesYuan Wu
Department of Microbiology and Immunology, Medical School of Xi an Jiaotong University, Shaanxi, 710061, PR China
BMC Genomics 10:238. 2009..However, only one complete dermatophyte mitochondrial genome (E. floccosum) has previously been determined... - Global transcriptional analysis of nitrogen fixation and ammonium repression in root-associated Pseudomonas stutzeri A1501Yongliang Yan
Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Crop Biotechnology, Ministry of Agriculture, Beijing 100081, China
BMC Genomics 11:11. 2010..Although the regulatory cascades that control the transcription of the nif genes in proteobacteria have been well investigated, there are limited data on the kinetics of ammonium-dependent repression of nitrogen fixation... - Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2aHuan Nie
College of Biological Sciences China Agricultural University, Beijing 100094, China
BMC Genomics 7:173. 2006..To investigate the intra-species diversity of S. flexneri genomes further, we have sequenced the complete genome of S. flexneri 5b strain 8401 (abbreviated Sf8401) and compared it with S. flexneri 2a (Sf301)... - Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157Qi Jin
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China
Nucleic Acids Res 30:4432-41. 2002..coli strains. All of these could be subjected to investigations towards novel preventative and treatment strategies against shigellosis... 
Comparison of the virulence plasmid genomes of two strains of Shigella which lost the ability to bind Congo redZhaohui Xiong
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China
Sci China C Life Sci 49:141-8. 2006..Whether these genes determine the Crb function requires continued investigation...- Characterization of ST-4821 complex, a unique Neisseria meningitidis cloneJunping Peng
State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Beijing 100052, China
Genomics 91:78-87. 2008..Genome comparison between the newly emerged hyperinvasive isolates belonging to different serogroups will further our understanding of their respective pathogenetic mechanisms... - The use of comparative genomic hybridization to characterize genome dynamics and diversity among the serotypes of ShigellaJunping Peng
State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Center for Disease Control and Prevention, Beijing 100176, China
BMC Genomics 7:218. 2006..coli K-12 with those of 43 Shigella strains from all lineages... - Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysenteryFan Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Ministry of Public Health, Beijing 100052, China
Nucleic Acids Res 33:6445-58. 2005..became highly specific human pathogens with variable epidemiological and pathological features... - VFDB 2008 release: an enhanced web-based resource for comparative pathogenomicsJian Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100176, China
Nucleic Acids Res 36:D539-42. 2008..VFDB 2008 release offers more user-friendly tools for comparative pathogenomics and it is publicly accessible at http://www.mgc.ac.cn/VFs/... 
Distribution of surface-protein variants of hyperinvasive meningococci in ChinaLi Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, China
J Infect 58:358-67. 2009..The present study investigated the distribution of FetA and PorB variable region (VR) types among meningococci belonging to hyperinvasive lineages circulating in China...- Transcriptional profiles of response to terbinafine in Trichophyton rubrumWenliang Zhang
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100176, China
Appl Microbiol Biotechnol 82:1123-30. 2009..TRB affected transcription of multidrug-resistance genes and some genes encoding ribosomal proteins... - Global transcriptional profiles of Trichophyton rubrum in response to FlucytosineRong Zhao
State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Sci China C Life Sci 52:1173-85. 2009..This is the first analysis of transcriptional profiles in response to 5-FC for T. rubrum. The findings may be valuable for the identification of genes involved in mechanisms of action and mechanisms of antifungal drug resistance of 5-FC... - ShiBASE: an integrated database for comparative genomics of ShigellaJian Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100176, China
Nucleic Acids Res 34:D398-401. 2006..In addition, ShiBASE has a newly developed online comparative visualization service, Shi-align, which enables the alignment of any query sequence with the reference genome sequences... - Genomic compositions and phylogenetic analysis of Shigella boydii subgroupJing Wang
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100176, China
Sci China C Life Sci 49:46-52. 2006..boydii and to find out important clues to pathogenesis research, vaccination and the therapeutic medicine development... - The molecular evolutionary history of Shigella spp. and enteroinvasive Escherichia coliJunping Peng
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing 100730, China
Infect Genet Evol 9:147-52. 2009..EIEC strains are regarded as precursors of 'full-blown'Shigella evolved from E. coli. By gain and loss of functions, Shigella and EIEC became successful human pathogens through convergent evolution from diverse genomic backgrounds... - The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonneiYan Jiang
State Key Laboratory for Molecular Virology and Genetic Engineering, 6 Rongjing Eastern Street, BDA Beijing 100176, China
Plasmid 54:149-59. 2005..The pSS plasmid is a mixture of genes with different origins and functions. The sequence suggests a remarkable history of IS-mediated recombination and acquisition of DNA across a range of bacterial species... - An integrated approach for finding overlooked genes in ShigellaJunping Peng
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China
PLoS ONE 6:e18509. 2011..In order to improve genome annotation, we aimed to identify novel sRNAs and sORFs in Shigella, the principal etiologic agents of bacillary dysentery... - TrED: the Trichophyton rubrum Expression DatabaseJian Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100176, China
BMC Genomics 8:250. 2007..We intend to create an integrated database TrED to facilitate the study of dermatophytes, and enhance the development of effective diagnostic and treatment strategies... - Transcriptional profile induced by furazolidone treatment of Shigella flexneriHua Fu
State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100176, China
Appl Microbiol Biotechnol 77:657-67. 2007..flexneri should be considered... - VFDB 2012 update: toward the genetic diversity and molecular evolution of bacterial virulence factorsLihong Chen
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy Medical Sciences and Peking Union Medical College, Beijing 100176, China
Nucleic Acids Res 40:D641-5. 2012..In addition, the 2012 release of VFDB provides an improved user interface... - Transcriptional profile of the Shigella flexneri response to an alkaloid: berberineHua Fu
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, China
FEMS Microbiol Lett 303:169-75. 2010..These results provide a comprehensive view of the changes in gene expression when S. flexneri was exposed to BC, and shed light on its complicated effects on this pathogen... - Characterization of serogroup C meningococci isolated from 14 provinces of China during 1966-2005 using comparative genomic hybridizationJunping Peng
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing, 100052, China
Sci China C Life Sci 50:1-6. 2007..The results will provide a valuable resource from which one can analyze the genome composition and genetic background of serogroup C meningococci in China... - Subpopulation analysis of heteroresistance to fluoroquinolone in Mycobacterium tuberculosis isolates from Beijing, ChinaXiaobing Zhang
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, China
J Clin Microbiol 50:1471-4. 2012.... - Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approachJian Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, 6 Rongjing Eastern Street, BDA, Beijing 100176, China
J Clin Microbiol 49:3463-9. 2011.... - Complete genome sequence of the neonatal-meningitis-associated Escherichia coli strain CE10Shuting Lu
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy Medical Sciences and Peking Union Medical College, Beijing 100176, China
J Bacteriol 193:7005. 2011..coli strain CE10, a unique K1 strain with a functional type III secretion system. Functional analysis of the genome should enhance our knowledge of the pathogenesis of neonatal E. coli K1 meningitis... - Transcriptional profiles of the response to ketoconazole and amphotericin B in Trichophyton rubrumLu Yu
State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Center for Disease Control and Prevention, Beijing 100176, China
Antimicrob Agents Chemother 51:144-53. 2007..This is the first report of the use of microarray analysis to determine the effects of drug action in T. rubrum... - Research progress in Shigella in the postgenomic eraJunping Peng
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China
Sci China Life Sci 53:1284-90. 2010..This paper reviews contemporary understanding of genomics, transcriptomics, proteomics and the structural biology of Shigella... - Prevalence of drug-resistant tuberculosis in mainland China: systematic review and meta-analysisYu Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
PLoS ONE 6:e20343. 2011..Surveillance of anti-TB drug resistance is important for monitoring TB control strategies. However, the status of drug-resistant TB in China has been reported inconsistently... - SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysisXiangwei Li
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
PLoS ONE 6:e15831. 2011..The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations... - Identification of small interfering RNAs which inhibit the replication of several Enterovirus 71 strains in ChinaZhiqiang Wu
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, No 6 Rongjing East Street, Yi zhuang, Beijing 100176, China
J Virol Methods 159:233-8. 2009..These strategies and results suggest that RNAi has potential therapeutic use for the suppression of EV 71 infection in a broad spectrum of viral strains... - Genotypic analysis of serogroups other than A, B or C of Neisseria meningitidis in ChinaJie Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, China
Scand J Infect Dis 39:819-21. 2007..Among these isolates, none of the well-documented ST complexes found worldwide was present... - Construction, detection and microarray analysis on the Shigella flexneri 2a sitC mutantMoqing Liu
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100176, China
Sci China C Life Sci 48:228-40. 2005..Additionally, the number of these genes and their increase amplitude in MTS are more than those in Sf301. Together, these results confirmed that Sit iron-transport system is important for the growth of Shigella... - [Atypical endometriosis: a clinicopathologic study of 163 cases]Dong Hui Guo
Department of Pathology, Tianjin Central Obstetrics and Gynecology Hospital, Tianjin 300052, China
Zhonghua Fu Chan Ke Za Zhi 43:831-4. 2008..To investigate the clinicopathologic features of atypical endometriosis (AEM) and to discuss the relationship between AEM and tumors... - Rapid identification of small interfering RNA that can effectively inhibit the replication of multiple influenza B virus strainsYongzhen Gao
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100176, China
Antivir Ther 11:431-8. 2006..6 microg ribavirin. These results indicated that RNA interference warrants further study for management of influenza B virus infections... - Genes under positive selection in Mycobacterium tuberculosisYuan Zhang
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China
Comput Biol Chem 35:319-22. 2011..The functional discussion of our findings implied that those positively selected genes were highly involved in antigen variations and immune evasions of Mycobacterium tuberculosis... - [Analysis of secreted proteases of Trichophyton rubrum]Wen Chuan Leng
State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Center for Disease Control and Prevention, Beijing 100176, China
Wei Sheng Wu Xue Bao 45:601-5. 2005..rubrum infection. These results provide a clue to further research on the infection and pathogencity of T. rubrum... - [Inhibition of HIV virus-like particles production by BST-2]Ying Lian Du
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Bing Du Xue Bao 27:319-25. 2011..Consistent with a direct tethering mechanism, we confirmed that proteolysis releases restricted virions and further showed that this removed the ectodomain of BST-2 from the cell surface... - Evaluation of twelve real-time reverse transcriptase PCR primer-probe sets for detection of pandemic influenza A/H1N1 2009 virusYaowu Yang
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology IPB, Chinese Academy of Medical Sciences and Peking Union Medical College CAMS and PUMC, Beijing 100730, China
J Clin Microbiol 49:1434-40. 2011.... - Anal HPV infection in HIV-positive men who have sex with men from ChinaLei Gao
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
PLoS ONE 5:e15256. 2010..However, HIV and anal HPV co-infection among MSM has not been addressed in China... - Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, ChinaDawei Shi
State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China
J Antimicrob Chemother 66:2240-7. 2011..To determine the association between embB mutations and drug resistance, and to further investigate the mechanism of embB mutations involved in the development of ethambutol and multidrug resistance in Mycobacterium tuberculosis... - VFDB: a reference database for bacterial virulence factorsLihong Chen
State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China
Nucleic Acids Res 33:D325-8. 2005..Furthermore, a BLAST search tool against all known VF-related genes is also available. VFDB provides a unified gateway to store, search, retrieve and update information about VFs from various bacterial pathogens... - Identification and characterization of simple sequence repeats in the genomes of Shigella speciesJian Yang
Laboratory of Bioinformatics, Institute of Biophysics, CAS, Datun Road 15, Chaoyang District, 100101 Beijing, China
Gene 322:85-92. 2003..Hence, SSRs may serve as genotyping markers for epidemiological investigations, and may offer insights into evolutionary adaptation of the pathogens... - Therapeutic effect of CpG-enriched plasmid administration on the tight-skin mouse model of sclerodermaYan Shen
Department of Immunology, Yokohama City University School of Medicine, Fukuura 3 9, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
J Autoimmun 24:183-90. 2005..These results suggest that repeated administration of a CpG-enriched plasmid can ameliorate scleroderma-like syndrome by biasing Th1 immunity in young Tsk/+mice... - Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencingShuang-xi Ren
Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Zhang Jiang High Tech Park, Shanghai 201203, China
Nature 422:888-93. 2003.... - GenomeComp: a visualization tool for microbial genome comparisonJian Yang
Laboratory of Bioinformatics, Institute of Biophysics, CAS, Datun Road 15, Chaoyang District, Beijing 100101, PR China
J Microbiol Methods 54:423-6. 2003..This software provides a new visualizing tool for microbe comparative genomics... - Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadiasTaiji Chen
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing, China
Eur J Hum Genet 15:23-8. 2007..Further functional studies are required to make the associations clear between these variants and hypospadias... - The DNA sequence, annotation and analysis of human chromosome 3Donna M Muzny
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nature 440:1194-8. 2006.... - Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)Yue-Qing Zhang
Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai, 200032, China
Mol Microbiol 49:1577-93. 2003..No mec genes, IS256, IS257, were found in ATCC 12228. It is suggested that the absence of the ica operon is a genetic marker in commensal Staphylococcus epidermidis strains which are less likely to become invasive... - Intranasal delivery of chitosan-DNA vaccine generates mucosal SIgA and anti-CVB3 protectionWei Xu
Department of Immunology and Key Laboratory of Molecular Medicine of Ministry of Education, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
Vaccine 22:3603-12. 2004..Together, Our data show that intranasal delivery of chitosan-DNA vaccine successfully induced mucosal SIgA secretion and might be a promising vaccine candidate to protect against CVB3 infection... - LDA--a java-based linkage disequilibrium analyzerKeyue Ding
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (and Peking Union Medical College, National Laboratory of Medical Molecular Biology, Beijing, 100005, People's Republic of China
Bioinformatics 19:2147-8. 2003..chgb.org.cn/lda/lda.htm. SUPPLEMENTARY INFORMATION: Detailed tutorials, LDA help system and examples are distributed within LDA software. For Macintosh OS X user, the Jre version 1.4 can be downloaded from http://connect.apple.com... - Molecular cloning, expression, and purification of SARS-CoV nsp13Zheng Fan
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, National Human Genome Center, Beijing 100005, China
Protein Expr Purif 41:235-40. 2005..The protein was validated by western blot and MS analysis. A large quantity of the nsp13 protein obtained with this method may be useful for further study of its structure and function... - DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progressionXiaojing Sun
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
J Biol Chem 279:32839-47. 2004..Collectively, our experiments indicated that DLP is implicated in not only cell cycle progression but also in a more specific molecular process such as pre-mRNA splicing... - [Cloning, expression and purification of SARS coronavirus PUMC2 strain nucleocapsid protein]Xin-yu Tan
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 10005, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:504-7. 2003..CONCLUSIONS: The SARS coronavirus recombinant N protein obtained by genetic engineering methods can be used for further functional study of SARS coronavirus N protein...